Interactive effects of oligofructose and obesity predisposition on gut hormones and microbiota in diet-induced obese rats
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OBJECTIVE: Oligofructose (OFS) is a prebiotic that reduces energy intake and fat mass via changes in gut satiety hormones and microbiota. The effects of OFS may vary depending on predisposition to obesity. The aim of this study was to examine the effect of OFS in diet-induced obese (DIO) and diet-resistant (DR) rats. METHODS: Adult, male DIO, and DR rats were randomized to: high-fat/high-sucrose (HFS) diet or HFS diet + 10% OFS for 6 weeks. Body composition, food intake, gut microbiota, plasma gut hormones, and cannabinoid CB(1) receptor expression in the nodose ganglia were measured. RESULTS: OFS reduced body weight, energy intake, and fat mass in both phenotypes (P < 0.05). Select gut microbiota differed in DIO versus DR rats (P < 0.05), the differences being eliminated by OFS. OFS did not modify plasma ghrelin or CB(1) expression in nodose ganglia, but plasma levels of GIP were reduced and PYY were elevated (P < 0.05) by OFS. CONCLUSIONS: OFS was able to reduce body weight and adiposity in both prone and resistant obese phenotypes. OFS-induced changes in gut microbiota profiles in DIO and DR rats, along with changes in gut hormone levels, likely contribute to the sustained lower body weights.
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Oligofructose does not change plasma ghrelin levels in obese rats fed high fat/high sucrose diet.
“However, oligofructose does not change plasma ghrelin levels in obese rats fed a high fat/high sucrose diet [203].”
From Anxiety, depression, and the microbiome: A role for gut peptides (2018) · cites this paper as [203]
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- Authors
- Cluny, N. L., Eller, L. K., Keenan, C. M., Reimer, R. A., & Sharkey, K. A.
- Affiliations
- University of Calgary (CA)
- Corresponding author
- Reimer, Raylene A.
- Venue
- Obesity
- Publisher
- Wiley
- Published
- 2015-03-27
- Volume
- 23
- Issue
- 4
- Pages
- 769-778
- ISSN
- 1930-7381 (ISSN-L)
- 1930-739X
- OpenAlex
- W2164308461
- Cited by
- 72
- References
- 40
- Citations by year
- 2025: 5 · 2024: 4 · 2023: 7 · 2022: 8 · 2021: 8 · 2020: 12 · 2019: 6 · 2018: 7 · 2017: 4 · 2016: 8 · 2015: 3
- FWCI
- 7.06
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Obesity (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Canadian Institutes of Health Research (MOP 115076-1, MOP 38185, OTG 88592)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- fructooligosaccharides, prebiotics, diet-induced obesity, obesity predisposition, gut microbiota, gastrointestinal hormones, ghrelin, glucagon-like peptide-1, peptide YY, CB1 receptor, nodose ganglion, high-fat high-sugar diet, adiposity, energy intake, body weight
- MeSH terms
- Animals, Body Composition, Body Weight, Diet, Dietary Fats, Eating, Gastrointestinal Hormones, Male, Obesity, Oligosaccharides, Satiation, Rats, Sprague-Dawley, Adiposity, Rats, Glucagon-Like Peptide 1, Ghrelin, Prebiotics, Microbiota
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