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Computer-Aided Diagnosis with Deep Learning Architecture: Applications to Breast Lesions in US Images and Pulmonary Nodules in CT Scans
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This paper performs a comprehensive study on the deep-learning-based computer-aided diagnosis (CADx) for the differential diagnosis of benign and malignant nodules/lesions by avoiding the potential errors caused by inaccurate image processing results (e.g., boundary segmentation), as well as the classification bias resulting from a less robust feature set, as involved in most conventional CADx algorithms. Specifically, the stacked denoising auto-encoder (SDAE) is exploited on the two CADx applications for the differentiation of breast ultrasound lesions and lung CT nodules. The SDAE architecture is well equipped with the automatic feature exploration mechanism and noise tolerance advantage, and hence may be suitable to deal with the intrinsically noisy property of medical image data from various imaging modalities. To show the outperformance of SDAE-based CADx over the conventional scheme, two latest conventional CADx algorithms are implemented for comparison. 10 times of 10-fold cross-validations are conducted to illustrate the efficacy of the SDAE-based CADx algorithm. The experimental results show the significant performance boost by the SDAE-based CADx algorithm over the two conventional methods, suggesting that deep learning techniques can potentially change the design paradigm of the CADx systems without the need of explicit design and selection of problem-oriented features.
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“In addition, the stacked denoising auto-encoder (SDAE) [88], a combination of the point-wise gated Boltzmann machine (PGBM) and RBM [89], and the GoogLeNet CNN [90] have been applied to breast US or shear-wave elastography images for breast cancer diagnosis; all of these obtained a superior performance when compared with human experts.”
From Deep Learning in Medical Ultrasound Analysis: A Review (2019) · cites this paper as [88]
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Metadata
- Authors
- Cheng, J.-Z., Ni, D., Chou, Y.-H., Qin, J., Tiu, C.-M., Chang, Y.-C., Huang, C.-S., Shen, D., & Chen, C.-M.
- Affiliations
- Shenzhen University (CN)
- Taipei Veterans General Hospital (TW)
- National Taiwan University (TW)
- University of North Carolina at Chapel Hill (US)
- Corresponding author
- Chou, Yi-Hong
- Shen, Dinggang
- Chen, Chung-Ming
- ORCID
- Venue
- Scientific Reports
- Published
- 2016-04-15
- Volume
- 6
- Issue
- 1
- Pages
- 24454-24454
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC4832199
- OpenAlex
- W2341106171
- Cited by
- 755
- References
- 48
- Citations by year
- 2026: 9 · 2025: 32 · 2024: 78 · 2023: 59 · 2022: 100 · 2021: 120 · 2020: 103 · 2019: 110 · 2018: 87 · 2017: 45 · 2016: 11
- FWCI
- 68.59
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
- UNC Libraries
- Funders
- National Science Council (NSC 100)
- Shenzhen Fundamental Research Program (JCYJ20130329105033277, JCYJ20150525092940982, 81571758, JCYJ20140509172609164, JSE201109150013A)
- National Cancer Institute (R01CA206100)
- Topics
- Physical Sciences › Computer Science › Artificial Intelligence › AI in cancer detection
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Radiomics and Machine Learning in Medical Imaging
- Physical Sciences › Computer Science › Computer Vision and Pattern Recognition › Medical Image Segmentation Techniques
- Keywords
- computer-aided diagnosis, stacked denoising autoencoder, pulmonary nodules, benign versus malignant differentiation, medical image denoising, feature extraction, noise immunity, differential diagnosis
- MeSH terms
- Machine Learning, Algorithms, Breast, Solitary Pulmonary Nodule, Diagnosis, Computer-Assisted, Female, Humans, Tomography, X-Ray Computed, Ultrasonography, Reproducibility of Results, Datasets as Topic
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