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Discovery of two novel ALKBH5 selective inhibitors that exhibit uncompetitive or competitive type and suppress the growth activity of glioblastoma multiforme

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ALKBH1 promotes lung cancer by regulating m6A RNA demethylation

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DNA adenine methylation in eukaryotes: Enzymatic mark or a form of DNA damage?

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Hepatic FTO expression is increased in NASH and its silencing attenuates palmitic acid-induced lipotoxicity

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Update: Mechanisms Underlying N 6 -Methyladenosine Modification of Eukaryotic mRNA

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N6-Methyladenosine in RNA and DNA: An Epitranscriptomic and Epigenetic Player Implicated in Determination of Stem Cell Fate

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The emerging roles of N6-methyladenosine RNA methylation in human cancers

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The dynamics of FTO binding and demethylation from the m6A motifs

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Intelligent demethylase-driven DNAzyme sensor for highly reliable metal-ion imaging in living cells

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Calculations of pKa Values for a Series of Naturally Occurring Modified Nucleobases

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The Role of m6A RNA Methylation in Cancer: Implication for Nature Products Anti-Cancer Research

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RNA N6-methyladenosine modification in female reproductive biology and pathophysiology

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It's complicated… m6A-dependent regulation of gene expression in cancer

Fitzsimmons, C. M., & Batista, P. J. (2018) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2018.09.010 · Cited by 49 · see citing works

Sequence-specific m6A demethylation in RNA by FTO fused to RCas9

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m6A methylation: Critical roles in aging and neurological diseases

Fan, Y., Lv, X., Chen, Z., Peng, Y., & Zhang, M. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2023.1102147 · Cited by 48 · see citing works

MePMe-seq: antibody-free simultaneous m6A and m5C mapping in mRNA by metabolic propargyl labeling and sequencing

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Small changes, big implications: The impact of m6A RNA methylation on gene expression in pluripotency and development

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N6-Methyladenosine: A Potential Breakthrough for Human Cancer

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SFPQ Is an FTO-Binding Protein that Facilitates the Demethylation Substrate Preference

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Targeting RNA N6-methyladenosine modification: a precise weapon in overcoming tumor immune escape

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A fluorescent methylation-switchable probe for highly sensitive analysis of FTO N 6 -methyladenosine demethylase activity in cells

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Melatonin: Regulation of Biomolecular Condensates in Neurodegenerative Disorders

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Human 2-oxoglutarate-dependent oxygenases: nutrient sensors, stress responders, and disease mediators

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Multiprotein Dynamic Combinatorial Chemistry: A Strategy for the Simultaneous Discovery of Subfamily‐Selective Inhibitors for Nucleic Acid Demethylases FTO and ALKBH3

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A Census and Categorization Method of Epitranscriptomic Marks

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Reduced nucleic acid methylation impairs meiotic maturation and developmental potency of pig oocytes

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Multifaceted Functions and Novel Insight Into the Regulatory Role of RNA N6-Methyladenosine Modification in Musculoskeletal Disorders

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miRNA-mediated loss of m6A increases nascent translation in glioblastoma

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Mammalian DNA N6-methyladenosine: Challenges and new insights

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Unraveling the RNA modification code with mass spectrometry

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Evolutionary conservation of the DRACH signatures of potential N6-methyladenosine (m6A) sites among influenza A viruses

Bayoumi, M. M., & Munir, M. (2021) · Scientific Reports · doi:10.1038/s41598-021-84007-0 · Cited by 38 · see citing works

The crucial mechanism and therapeutic implication of RNA methylation in bone pathophysiology

Yang, C. H., Dong, Z., Ling, Z., & Chen, Y. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101641 · Cited by 38 · see citing works

Progression of m6A in the tumor microenvironment: hypoxia, immune and metabolic reprogramming

Han, X., Zhu, Y., Ke, J., Zhai, Y., Huang, M., Zhang, X., He, H., Zhang, X., Zhao, X., Guo, K., et al. (2024) · Cell Death Discovery · doi:10.1038/s41420-024-02092-2 · Cited by 38 · see citing works

RNA N6‐methyladenosine modification in the lethal teamwork of cancer stem cells and the tumor immune microenvironment: Current landscape and therapeutic potential

Zhang, Z., Zhang, C., Luo, Y., Zhang, G., Wu, P., Sun, N., & He, J. (2021) · Clinical and Translational Medicine · doi:10.1002/ctm2.525 · Cited by 35 · see citing works

Oncogenic and Tumor-Suppressive Functions of the RNA Demethylase FTO

Zuidhof, H. R., & Calkhoven, C. F. (2022) · Cancer Research · doi:10.1158/0008-5472.can-21-3710 · Cited by 33 · see citing works

Deciphering glioma epitranscriptome: focus on RNA modifications

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Long noncoding RNA pncRNA-D reduces cyclin D1 gene expression and arrests cell cycle through RNA m6A modification

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The m6A-epitranscriptome in brain plasticity, learning and memory.

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Epigenetic control of skeletal muscle atrophy

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Emerging Role of m6 A Methylome in Brain Development: Implications for Neurological Disorders and Potential Treatment

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Biochemical Characterization of AP Lyase and m6A Demethylase Activities of Human AlkB Homologue 1 (ALKBH1)

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Inhibition of AlkB Nucleic Acid Demethylases: Promising New Epigenetic Targets

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The Molecular Basis of Human ALKBH3 Mediated RNA N 1 ‐methyladenosine (m 1 A) Demethylation

Zhang, L., Duan, H., Paduch, M., Hu, J., Zhang, C., Mu, Y., Lin, H., He, C., Kossiakoff, A. A., Jia, G., et al. (2023) · Angewandte Chemie International Edition · doi:10.1002/anie.202313900 · Cited by 29 · see citing works

N 6 -methyladenosine binding induces a metal-centered rearrangement that activates the human RNA demethylase Alkbh5

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N 6 -adenine DNA methylation demystified in eukaryotic genome: From biology to pathology

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D-2-HG Inhibits IDH1mut Glioma Growth via FTO Inhibition and Resultant m6A Hypermethylation

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Structural Insights Into m6A-Erasers: A Step Toward Understanding Molecule Specificity and Potential Antiviral Targeting

Bayoumi, M. M., & Munir, M. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.587108 · Cited by 24 · see citing works

A general strategy exploiting m5C duplex-remodelling effect for selective detection of RNA and DNA m5C methyltransferase activity in cells

Yang, T., Low, J. J. A., & Woon, E. C. Y. (2019) · Nucleic Acids Research · doi:10.1093/nar/gkz1047 · Cited by 24 · see citing works

Relevance of N6-methyladenosine regulators for transcriptome: Implications for development and the cardiovascular system

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Augmentation of the RNA m6A reader signature is associated with poor survival by enhancing cell proliferation and EMT across cancer types

Oh, J., Hwa, C., Jang, D., Shin, S., Lee, S.-J., Kim, J., Lee, S. E., Jung, H., Oh, Y., Jang, G., et al. (2022) · Experimental and Molecular Medicine · doi:10.1038/s12276-022-00795-z · Cited by 20 · see citing works

RNA N6-Methyladenosine Modifications and Its Roles in Alzheimer’s Disease

Zhang, R., Zhang, Y., Guo, F., Li, S., & Cui, H. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.820378 · Cited by 19 · see citing works

An α-ketoglutarate conformational switch controls iron accessibility, activation, and substrate selection of the human FTO protein

Burns, D., Khatiwada, B., Singh, A., Purslow, J. A., Potoyan, D. A., & Venditti, V. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2404457121 · Cited by 18 · see citing works

The role of regulators of RNA m6A methylation in lung cancer

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Transcriptome-wide study revealed m6A and miRNA regulation of embryonic breast muscle development in Wenchang chickens

Gu, L., Jiang, Q., Chen, Y., Zheng, X., Zhou, H., & Xu, T. (2022) · Frontiers in Veterinary Science · doi:10.3389/fvets.2022.934728 · Cited by 17 · see citing works

Recruitment of the m6A/m6Am demethylase FTO to target RNAs by the telomeric zinc finger protein ZBTB48

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Clustering Count-based RNA Methylation Data Using a Nonparametric Generative Model

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Melatonin: Regulation of Viral Phase Separation and Epitranscriptomics in Post-Acute Sequelae of COVID-19

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Altered m6A RNA methylation governs denervation-induced muscle atrophy by regulating ubiquitin proteasome pathway

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Revealing the catalytic strategy of FTO

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Methylation Landscape: Targeting Writer or Eraser to Discover Anti-Cancer Drug

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Chemical Strategies to Modulate and Manipulate RNA Epigenetic Modifications

Cheng, L. (2025) · Accounts of Chemical Research · doi:10.1021/acs.accounts.4c00844 · Cited by 14 · see citing works

N-terminal fusion of the N-terminal domain of bacterial enzyme I facilitates recombinant expression and purification of the human RNA demethylases FTO and Alkbh5

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Adenosine N6-Methylation Upregulates the Expression of Human CYP2B6 by Altering the Chromatin StatusPreprint

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Targeting RNA modifications with pharmacological agents: New frontiers in cancer therapy

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Epigenetic Modification 6‐Methyladenosine Can Impact the Potency and Specificity of siRNA

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Structures of human m6A RNA demethylases: FTO and ALKBH5

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Atomic Mutagenesis of N6-Methyladenosine Reveals Distinct Recognition Modes by Human m6A Reader and Eraser Proteins

Seitz, F., Jungnickel, T., Kleiber, N., Kretschmer, J., Dietzsch, J., Adelmann, J., Bohnsack, K. E., Bohnsack, M. T., & Höbartner, C. (2024) · Journal of the American Chemical Society · doi:10.1021/jacs.4c00626 · Cited by 13 · see citing works

RNA Demethylation by FTO and ALKBH5

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Structural and Functional Characterization of the Proteins Responsible for N6-Methyladenosine Modification and Recognition

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Preparation of Human Nuclear RNA m6A Methyltransferases and Demethylases and Biochemical Characterization of Their Catalytic Activity

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