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The wMel strain of Wolbachia Reduces Transmission of Zika virus by Aedes aegypti

Open access
Aliota, Matthew T., Peinado, Stephen A., Velez, Ivan Dario, Osorio, Jorge E.·2016·Scientific Reports

Abstract

Zika virus (ZIKV) is causing an explosive outbreak of febrile disease in the Americas. There are no effective antiviral therapies or licensed vaccines for this virus and mosquito control strategies have not been adequate to contain the virus. A promising candidate for arbovirus control and prevention relies on the introduction of the intracellular bacterium Wolbachia into Aedes aegypti mosquitoes. This primarily has been proposed as a tool to control dengue virus (DENV) transmission; however, evidence suggests Wolbachia infections confer protection for Ae. aegypti against other arboviruses. At present, it is unknown whether or not ZIKV can infect, disseminate and be transmitted by Wolbachia-infected Ae. aegypti. Using Ae. aegypti infected with the w Mel strain of Wolbachia that are being released in Medellin, Colombia, we report that these mosquitoes have reduced vector competence for ZIKV. These results support the use of Wolbachia biocontrol as a multivalent strategy against Ae. aegypti-transmitted viruses.

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Metadata

Authors
Aliota, M. T., Peinado, S. A., Velez, I. D., & Osorio, J. E.
Venue
Scientific Reports
Published
2016-07-01
Volume
6
Issue
1
Pages
28792-28792
ISSN
2045-2322 (ISSN-L)
OpenAlex
W2462225304
Cited by
322
References
4
FWCI
42.62
Type
journal article
Language
en
Open access
gold

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