The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Scaled deployment of Wolbachia to protect the community from dengue and other Aedes transmitted arboviruses
Open accessAbstract
Background: A number of new technologies are under development for the control of mosquito transmitted viruses, such as dengue, chikungunya and Zika that all require the release of modified mosquitoes into the environment. None of these technologies has been able to demonstrate evidence that they can be implemented at a scale beyond small pilots. Here we report the first successful citywide scaled deployment of Wolbachia in the northern Australian city of Townsville. Methods: The w Mel strain of Wolbachia was backcrossed into a local Aedes aegypti genotype and mass reared mosquitoes were deployed as eggs using mosquito release containers (MRCs). In initial stages these releases were undertaken by program staff but in later stages this was replaced by direct community release including the development of a school program that saw children undertake releases. Mosquito monitoring was undertaken with Biogents Sentinel (BGS) traps and individual mosquitoes were screened for the presence of Wolbachia with a Taqman qPCR or LAMP diagnostic assay. Dengue case notifications from Queensland Health Communicable Disease Branch were used to track dengue cases in the city before and after release. Results: Wolbachia was successfully established into local Ae. aegypti mosquitoes across 66 km 2 in four stages over 28 months with full community support. A feature of the program was the development of a scaled approach to community engagement. Wolbachia frequencies have remained stable since deployment and to date no local dengue transmission has been confirmed in any area of Townsville after Wolbachia has established, despite local transmission events every year for the prior 13 years and an epidemiological context of increasing imported cases. Conclusion: Deployment of Wolbachia into Ae. aegypti populations can be readily scaled to areas of ~60km 2 quickly and cost effectively and appears in this context to be effective at stopping local dengue transmission
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Citations
Cites
A Wolbachia Symbiont in Aedes aegypti Limits Infection with Dengue, Chikungunya, and Plasmodium
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Self-citationSuccessful establishment of Wolbachia in Aedes populations to suppress dengue transmission
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Self-citationThe wMel Wolbachia strain blocks dengue and invades caged Aedes aegypti populations
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Self-citationWolbachia Blocks Currently Circulating Zika Virus Isolates in Brazilian Aedes aegypti Mosquitoes
Dutra, H. L. C., Rocha, M. N., Dias, F. B. S., Mansur, S. B., Caragata, E. P., & Moreira, L. A. (2016) · Cell Host & Microbe · doi:10.1016/j.chom.2016.04.021 · Cited by 515
van den Hurk, A. F., Hall-Mendelin, S., Pyke, A. T., Frentiu, F. D., McElroy, K., Day, A., Higgs, S., & O'Neill, S. L. (2012) · PLoS Neglected Tropical Diseases · doi:10.1371/journal.pntd.0001892 · Cited by 416
Self-citationLimited Dengue Virus Replication in Field-Collected Aedes aegypti Mosquitoes Infected with Wolbachia
Frentiu, F. D., Zakir, T., Walker, T., Popovici, J., Pyke, A. T., van den Hurk, A., McGraw, E. A., & O'Neill, S. L. (2014) · PLoS Neglected Tropical Diseases · doi:10.1371/journal.pntd.0002688 · Cited by 344
Self-citationThe wMel strain of Wolbachia Reduces Transmission of Zika virus by Aedes aegypti
Aliota, M. T., Peinado, S. A., Velez, I. D., & Osorio, J. E. (2016) · Scientific Reports · doi:10.1038/srep28792 · Cited by 322
Stability of the wMel Wolbachia Infection following Invasion into Aedes aegypti Populations
Hoffmann, A. A., Iturbe-Ormaetxe, I., Callahan, A. G., Phillips, B. L., Billington, K., Axford, J. K., Montgomery, B., Turley, A. P., & O'Neill, S. L. (2014) · PLoS Neglected Tropical Diseases · doi:10.1371/journal.pntd.0003115 · Cited by 315
Self-citationControlling vector-borne diseases by releasing modified mosquitoes
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Self-citationWolbachia Infections in Aedes aegypti Differ Markedly in Their Response to Cyclical Heat Stress
Ross, P. A., Wiwatanaratanabutr, I., Axford, J. K., White, V. L., Endersby-Harshman, N. M., & Hoffmann, A. A. (2017) · PLOS Pathogens · doi:10.1371/journal.ppat.1006006 · Cited by 283
Cited by
The importance of vector control for the control and elimination of vector-borne diseases
Wilson, A. L., Courtenay, O., Kelly-Hope, L. A., Scott, T. W., Takken, W., Torr, S. J., & Lindsay, S. W. (2020) · PLOS Neglected Tropical Diseases · doi:10.1371/journal.pntd.0007831 · Cited by 874
Efficacy of Wolbachia-Infected Mosquito Deployments for the Control of Dengue
Utarini, A., Indriani, C., Ahmad, R. A., Tantowijoyo, W., Arguni, E., Ansari, M. R., Supriyati, E., Wardana, D. S., Meitika, Y., Ernesia, I., et al. (2021) · New England Journal of Medicine · doi:10.1056/nejmoa2030243 · Cited by 649
Self-citationThe Global Expansion of Dengue: How Aedes aegypti Mosquitoes Enabled the First Pandemic Arbovirus
Brady, O. J., & Hay, S. I. (2020) · Annual Review of Entomology · doi:10.1146/annurev-ento-011019-024918 · Cited by 405
Establishment of Wolbachia Strain wAlbB in Malaysian Populations of Aedes aegypti for Dengue Control
Nazni, W. A., Hoffmann, A. A., NoorAfizah, A., Cheong, Y. L., Mancini, M. V., Golding, N., Kamarul, G. M. R., Arif, M. A. K., Thohir, H., NurSyamimi, H., et al. (2019) · Current Biology · doi:10.1016/j.cub.2019.11.007 · Cited by 389
Metadata
- Authors
- O'Neill, S. L., Ryan, P. A., Turley, A. P., Wilson, G., Retzki, K., Iturbe-Ormaetxe, I., Dong, Y., Kenny, N., Paton, C. J., Ritchie, S. A., Brown-Kenyon, J., Stanford, D., Wittmeier, N., Jewell, N. P., Tanamas, S. K., Anders, K. L., & Simmons, C. P.
- Venue
- Gates Open Research
- Publisher
- F1000 Research Ltd
- Published
- 2019-08-13
- Volume
- 2
- Pages
- 36
- ISSN
- 2572-4754 (ISSN-L)
- OpenAlex
- W2898688728
- Cited by
- 293
- References
- 19
- FWCI
- 37.02
- Type
- journal article
- Language
- en
- Open access
- gold
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- O'Neill, S. L., Ryan, P. A., Turley, A. P., Wilson, G., Retzki, K., Iturbe-Ormaetxe, I., Dong, Y., Kenny, N., Paton, C. J., Ritchie, S. A., Brown-Kenyon, J., Stanford, D., Wittmeier, N., Jewell, N. P., Tanamas, S. K., Anders, K. L., & Simmons, C. P. (2019). Scaled deployment of Wolbachia to protect the community from dengue and other Aedes transmitted arboviruses. Gates Open Research. https://doi.org/10.12688/gatesopenres.12844.3
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
