The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Chronic Repression of mTOR Complex 2 Induces Changes in the Gut Microbiota of Diet-induced Obese Mice
Open accessAbstract
Alterations in the gut microbiota play a crucial role in host physiology and metabolism; however, the molecular pathways underlying these changes in diet-induced obesity are unclear. Mechanistic target of rapamycin (mTOR) signaling pathway is associated with metabolic disorders such as obesity and type 2 diabetes (T2D). Therefore, we examined whether changes in the regulation of mTOR signaling induced by diet (a high-fat diet [HFD] or normal-chow diet) and/or therapeutics (resveratrol [a specific inhibitor of mTOR complex 1] or rapamycin [an inhibitor of both mTOR complex 1 and 2]) altered the composition of the gut microbiota in mice. Oral administration of resveratrol prevented glucose intolerance and fat accumulation in HFD-fed mice, whereas rapamycin significantly impaired glucose tolerance and exacerbated intestinal inflammation. The abundance of Lactococcus, Clostridium XI, Oscillibacter, and Hydrogenoanaerobacterium increased under the HFD condition; however, the abundance of these species declined after resveratrol treatment. Conversely, the abundance of unclassified Marinilabiliaceae and Turicibacter decreased in response to a HFD or rapamycin. Taken together, these results demonstrated that changes in the composition of intestinal microbiota induced by changes in mTOR activity correlate with obese and diabetic phenotypes.
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Cited by
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Metadata
- Authors
- Jung, M.-J., Lee, J., Shin, N.-R., Kim, M.-S., Hyun, D.-W., Yun, J.-H., Kim, P. S., Whon, T. W., & Bae, J.-W.
- Venue
- Scientific Reports
- Published
- 2016-07-29
- Volume
- 6
- Issue
- 1
- Pages
- 30887-30887
- ISSN
- 2045-2322 (ISSN-L)
- OpenAlex
- W2502391919
- Cited by
- 175
- References
- 16
- FWCI
- 7.82
- Type
- journal article
- Language
- en
- Open access
- gold
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