Acne, Microbiome, and Probiotics: The Gut–Skin Axis
Open accessAbstract
The objective of this narrative review was to check the influence of the human microbiota in the pathogenesis of acne and how the treatment with probiotics as adjuvant or alternative therapy affects the evolution of acne vulgaris. Acne is a chronic inflammatory skin disease involving the pilosebaceous units. The pathogenesis of acne is complex and multifactorial involving genetic, metabolic, and hormonal factors in which both skin and gut microbiota are implicated. Numerous studies have shown the bidirectionality between the intestinal microbiota and skin homeostasis, a communication mainly established by modifying the immune system. Increased data on the mechanisms of action regarding the relevance of Cutibacterium acnes, as well as the importance of the gut–skin axis, are becoming known. Diverse and varied in vitro studies have shown the potential beneficial effects of probiotics in this context. Clinical trials with both topical and oral probiotics are scarce, although they have shown positive results, especially with oral probiotics through the modulation of the intestinal microbiota, generating an anti-inflammatory response and restoring intestinal integrity, or through metabolic pathways involving insulin-like growth factor I (IGF-1). Given the aggressiveness of some standard acne treatments, probiotics should continue to be investigated as an alternative or adjuvant therapy.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
S. thermophiles has been shown to be beneficial in the production of lipids (ceramides in the stratum corneum), which help the skin to maintain moisture, and also phytosphingosine, which helps fight C. acnes.
“Also, S. thermophiles has been shown to be beneficial in the production of lipids (ceramides in the stratum corneum), which help the skin to maintain moisture, and also phytosphingosine, which helps fight C. acnes [132].”
From The Potential Impact of Probiotics on Human Health: An Update on Their Health-Promoting Properties (2024) · cites this paper as [132]
B. adolescentis SPM0308, due to antimicrobial activity, proved to be effective in controlling the growth of both C. acnes and S. aureus.
“In addition, B. adolescentis SPM0308, due to antimicrobial activity, proved to be effective in controlling the growth of both C. acnes and S. aureus [132].”
From The Potential Impact of Probiotics on Human Health: An Update on Their Health-Promoting Properties (2024) · cites this paper as [132]
Certain strains such as L. salivarius LS03, Lactococcus, and Streptococcus salivari produce bacteriocins that inhibit the growth of Cutibacterium acnes.
“In vitro investigations have shown that certain strains such as L. salivarius LS03, Lactococcus, and Streptococcus salivari produce bacteriocins that inhibit the growth of Cutibacterium acnes [132].”
From The Potential Impact of Probiotics on Human Health: An Update on Their Health-Promoting Properties (2024) · cites this paper as [132]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Vos, T., Flaxman, A. D., Naghavi, M., Lozano, R., Michaud, C., Ezzati, M., Shibuya, K., Salomon, J. A., Abdalla, S., Aboyans, V., et al. (2012) · The Lancet · doi:10.1016/s0140-6736(12)61729-2 · Cited by 8,291 · see citing works
Changes of Intestinal Functions in Liver Cirrhosis
Fukui, H., & Wiest, R. (2016) · Inflammatory Intestinal Diseases · doi:10.1159/000444436 · Cited by 6,820 · see citing works
The regulation of IL-10 production by immune cells
Saraiva, M., & O’Garra, A. (2010) · Nature reviews. Immunology · doi:10.1038/nri2711 · Cited by 3,185 · see citing works
Byrd, A. L., Belkaid, Y., & Segre, J. A. (2018) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2017.157 · Cited by 2,806 · see citing works
The gut-liver axis in liver disease: Pathophysiological basis for therapy
Albillos, A., de Gottardi, A., & Rescigno, M. (2020) · Journal of Hepatology · doi:10.1016/j.jhep.2019.10.003 · Cited by 2,166 · see citing works
You are what you eat: Diet, health and the gut microbiota
Zmora, N., Suez, J., & Elinav, E. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-018-0061-2 · Cited by 1,792 · see citing works
Emerging Pathogenic Links Between Microbiota and the Gut-Lung Axis
Budden, K. F., Gellatly, S. L., Wood, D. L. A., Cooper, M. A., Morrison, M., Hugenholtz, P., & Hansbro, P. M. (2017) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2016.142 · Cited by 1,606 · see citing works
Biogeography and individuality shape function in the human skin metagenome
Program, N. C. S., Oh, J., Byrd, A. L., Deming, C., Conlan, S., Kong, H. H., & Segre, J. A. (2014) · Nature · doi:10.1038/nature13786 · Cited by 1,148 · see citing works
Bhate, K., & Williams, H. C. (2012) · British Journal of Dermatology · doi:10.1111/bjd.12149 · Cited by 911 · see citing works
Amino acid signalling upstream of mTOR
Jewell, J. L., Russell, R. C., & Guan, K.-L. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3522 · Cited by 894 · see citing works
Mayer, E. A., Nance, K., & Chen, S. (2022) · Annual Review of Medicine · doi:10.1146/annurev-med-042320-014032 · Cited by 813 · see citing works
Propionibacterium acnes Strain Populations in the Human Skin Microbiome Associated with Acne
Fitz‐Gibbon, S. T., Tomida, S., Chiu, B.-H., Nguyen, L., Du, C., Liu, M., Elashoff, D. A., Erfe, M. C. B., Loncaric, A., Kim, J., et al. (2013) · Journal of Investigative Dermatology · doi:10.1038/jid.2013.21 · Cited by 777 · see citing works
The gut microbiome as a major regulator of the gut-skin axis
Salem, I., Ramser, A., Isham, N., & Ghannoum, M. A. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.01459 · Cited by 707 · see citing works
Pessemier, B. D., Grine, L., Debaere, M., Maes, A., Paetzold, B., & Callewaert, C. (2021) · Microorganisms · doi:10.3390/microorganisms9020353 · Cited by 661 · see citing works
Dréno, B., Pécastaings, S., Corvec, S., Veraldi, S., Khammari, A., & Roques, C. G. (2018) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.15043 · Cited by 584 · see citing works
Inflammatory Events Are Involved in Acne Lesion Initiation
Jeremy, A. H. T., Holland, D. B., Roberts, S. G., Thomson, K. F., & Cunliffe, W. J. (2003) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2003.12321.x · Cited by 541 · cited 1× · see citing works
“An infiltration of CD4 cells has been evidenced in the pilosebaceous follicle in the initial stages of acne; CD3, CD4, and macrophage cells were found from the beginning of formation of the microcomedone [91].”
BackgroundSystematic review of the epidemiology of acne vulgaris
Heng, A. H. S., & Chew, F. T. (2020) · Scientific Reports · doi:10.1038/s41598-020-62715-3 · Cited by 502 · see citing works
Acne vulgaris: a disease of Western civilization
Cordain, L., Lindeberg, S., Hurtado, M., Hill, K., Eaton, S. B., & Brand-Miller, J. (2002) · Archives of Dermatology · doi:10.1001/archderm.138.12.1584 · Cited by 500 · see citing works
The gut-skin axis in health and disease: A paradigm with therapeutic implications
O'Neill, C. A., Monteleone, G., McLaughlin, J. T., & Paus, R. (2016) · BioEssays · doi:10.1002/bies.201600008 · Cited by 449 · see citing works
Tuchayi, S. M., Makrantonaki, E., Ganceviciene, R., Dessinioti, C., Feldman, S. R., & Zouboulis, C. C. (2015) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2015.29 · Cited by 432 · see citing works
Balić, A., Vlašić, D., Žužul, K., Marinović, B., & Bukvić Mokos, Z. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21030741 · Cited by 400 · see citing works
What is new in the pathophysiology of acne, an overview
Dréno, B. (2017) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.14374 · Cited by 382 · see citing works
Steroidogenesis in the skin: Implications for local immune functions
Slominski, A., Zbytek, B., Nikolakis, G., Manna, P. R., Skobowiat, C., Zmijewski, M., Li, W., Janjetovic, Z., Postlethwaite, A., Zouboulis, C. C., et al. (2013) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2013.02.006 · Cited by 369 · see citing works
Induction of toll-like receptors by Propionibacterium acnes
Jugeau, S., Tenaud, I., Knol, A., Jarrousse, V., Quereux, G., Khammari, A., & Dréno, B. (2005) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2005.06933.x · Cited by 328 · see citing works
Bacterial skin commensals and their role as host guardians
Christensen, G. J. M., & Brüggemann, H. (2013) · Beneficial Microbes · doi:10.3920/bm2012.0062 · Cited by 317 · see citing works
Cutibacterium acnes as an Opportunistic Pathogen: An Update of Its Virulence-Associated Factors
Mayslich, C., Grange, P., & Dupin, N. (2021) · Microorganisms · doi:10.3390/microorganisms9020303 · Cited by 304 · see citing works
Wang, Y., Kuo, S., Shu, M., Yu, J., Huang, S., Dai, A., Two, A. M., Gallo, R. L., & Huang, C. (2013) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-013-5394-8 · Cited by 299 · see citing works
Control of Immunity by the Microbiota
Ansaldo, E., Farley, T. K., & Belkaid, Y. (2021) · Annual Review of Immunology · doi:10.1146/annurev-immunol-093019-112348 · Cited by 299 · see citing works
Cosseau, C., Devine, D. A., Dullaghan, E., Gardy, J. L., Chikatamarla, A., Gellatly, S., Yu, L. L., Pistolic, J., Falsafi, R., Tagg, J., et al. (2008) · Infection and Immunity · doi:10.1128/iai.00188-08 · Cited by 293 · see citing works
Association of Psoriasis With Inflammatory Bowel Disease
Fu, Y., Lee, C., & Chi, C. (2018) · JAMA Dermatology · doi:10.1001/jamadermatol.2018.3631 · Cited by 286 · see citing works
Lomholt, H. B., & Kilian, M. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012277 · Cited by 280 · see citing works
Alestas, T., Ganceviciene, R., Fimmel, S., Müller-Decker, K., & Zouboulis, C. C. (2006) · Journal of Molecular Medicine · doi:10.1007/s00109-005-0715-8 · Cited by 269 · see citing works
Smith, T. M., Gilliland, K. L., Clawson, G. A., & Thiboutot, D. M. (2007) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5701155 · Cited by 262 · see citing works
The balance of metagenomic elements shapes the skin microbiome in acne and health
Barnard, E., Shi, B., Kang, D., Craft, N. A., & Li, H. (2016) · Scientific Reports · doi:10.1038/srep39491 · Cited by 261 · see citing works
Linking diet to acne metabolomics, inflammation, and comedogenesis: an update
Melnik, B. (2015) · Clinical, Cosmetic and Investigational Dermatology · doi:10.2147/ccid.s69135 · Cited by 259 · see citing works
Kang, S., Cho, S., Chung, J. H., Hammerberg, C., Fisher, G. J., & Voorhees, J. J. (2005) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)62479-0 · Cited by 251 · see citing works
Ramage, G., Tunney, M. M., Patrick, S., et al. (2003) · Biomaterials · doi:10.1016/s0142-9612(03)00173-x · Cited by 245 · see citing works
Snodgrass, R. G., Huang, S., Choi, I.-W., Rutledge, J. C., & Hwang, D. H. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1300298 · Cited by 243 · see citing works
McDowell, A., Barnard, E., Nagy, I., Gao, A., Tomida, S., Li, H., Eady, E. A., Cove, J. H., Nord, C. E., & Patrick, S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041480 · Cited by 239 · see citing works
IL-1β Drives Inflammatory Responses to Propionibacterium acnes In Vitro and In Vivo
Kistowska, M., Gehrke, S., Jankovic, D. L., Kerl, K., Fettelschoss‐Gabriel, A., Feldmeyer, L., Fenini, G., Kolios, A. G. A., Navarini, A. A., Gancevičienė, R., et al. (2013) · Journal of Investigative Dermatology · doi:10.1038/jid.2013.438 · Cited by 239 · see citing works
An increased incidence of Propionibacterium acnes biofilms in acne vulgaris: a case-control study
Jahns, A. C., Lundskog, B., Gancevičienė, R., Palmer, R. H., Golovleva, I., Zouboulis, C. C., McDowell, A., Patrick, S., & Alexeyev, O. A. (2012) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2012.10897.x · Cited by 237 · see citing works
Nakatsuji, T., Kao, M. C., Zhang, L., Zouboulis, C. C., Gallo, R. L., & Huang, C.-M. (2010) · Journal of Investigative Dermatology · doi:10.1038/jid.2009.384 · Cited by 230 · see citing works
Graham, G. M., Farrar, M. D., Cruse-Sawyer, J. E., Holland, K. T., & Ingham, E. (2004) · British Journal of Dermatology · doi:10.1046/j.1365-2133.2004.05762.x · Cited by 228 · see citing works
Post-adolescent acne: a review of clinical features
Goulden, V., Clark, S. M., & Cunliffe, W. J. (1997) · British Journal of Dermatology · doi:10.1046/j.1365-2133.1997.d01-1144.x · Cited by 227 · see citing works
The Short-Chain Fatty Acid Sodium Butyrate Functions as a Regulator of the Skin Immune System
Schwarz, A., Bruhs, A., & Schwarz, T. (2016) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2016.11.014 · Cited by 221 · see citing works
Imperato‐McGinley, J., Gautier, T., Cai, L., Yee, B., Epstein, J., & Pochi, P. E. (1993) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.76.2.8381804 · Cited by 220 · see citing works
Biofilm formation by Propionibacterium acnes is a characteristic of invasive isolates
Holmberg, A. H., Lood, R., Mörgelin, M., et al. (2009) · Clinical Microbiology and Infection · doi:10.1111/j.1469-0691.2009.02747.x · Cited by 202 · see citing works
Tomida, S., Nguyen, L., Chiu, B.-H., Liu, J., Sodergren, E. J., Weinstock, G. M., & Li, H. (2013) · mBio · doi:10.1128/mbio.00003-13 · Cited by 199 · see citing works
Kang, B. S., Seo, J., Lee, G.-S., Jung-Hwa, K., Kim, S. Y., Han, Y. W., Kang, H., Kim, H. O., Rhee, J. H., Chung, M.-J., et al. (2009) · The Journal of Microbiology · doi:10.1007/s12275-008-0179-y · Cited by 195 · see citing works
Free fatty acids as modulators of the NLRP3 inflammasome in obesity/type 2 diabetes
Legrand-Poels, S., Esser, N., L’homme, L., Scheen, A., Paquot, N., & Piette, J. (2014) · Biochemical Pharmacology · doi:10.1016/j.bcp.2014.08.013 · Cited by 194 · see citing works
Post-adolescent acne: a review of clinical features
Goulden, V., Clark, S. M., & Cunliffe, W. J. (1997) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1997.tb08748.x · Cited by 192 · see citing works
The skin microbiome and the gut-skin axis
Sinha, S., Lin, G. H. Y., & Ferenczi, K. (2021) · Clinics in Dermatology · doi:10.1016/j.clindermatol.2021.08.021 · Cited by 189 · see citing works
Living in Your Skin: Microbes, Molecules, and Mechanisms
Swaney, M. H., & Kalan, L. (2021) · Infection and Immunity · doi:10.1128/iai.00695-20 · Cited by 187 · see citing works
Mechanism of androgen receptor action
Li, J., & Al‐Azzawi, F. (2009) · Maturitas · doi:10.1016/j.maturitas.2009.03.008 · Cited by 182 · see citing works
Understanding innate immunity and inflammation in acne: implications for management
Dréno, B., Gollnick, H. P. M., Kang, S., Thiboutot, D. M., Bettoli, V., Torres, V., Leyden, J., & the Global Alliance to Improve Outcomes in Acne (2015) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.13190 · Cited by 181 · see citing works
Jung, G. W., Tse, J. E., Guiha, I., & Rao, J. (2013) · Journal of Cutaneous Medicine and Surgery · doi:10.2310/7750.2012.12026 · Cited by 173 · see citing works
Jung, M., Lee, J., Shin, N., Kim, M., Hyun, D., Yun, J., Kim, P. S., Whon, T. W., & Bae, J. (2016) · Scientific Reports · doi:10.1038/srep30887 · Cited by 173 · see citing works
Juul, A., Holm, K., Kastrup, K. W., Pedersen, S. A., Michaelsen, K. F., Scheike, T., Rasmussen, S. B., Müller, J., & Skakkebæk, N. E. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.8.4137 · Cited by 161 · see citing works
Patients with Acne Vulgaris Have a Distinct Gut Microbiota in Comparison with Healthy Controls
Deng, Y., Wang, H., Zhou, J. W., Mou, Y., Wang, G., & Xiong, X. (2018) · Acta Dermato Venereologica · doi:10.2340/00015555-2968 · Cited by 158 · see citing works
What's new in the physiopathology of acne?
Suh, D. H., & Kwon, H. H. (2015) · British Journal of Dermatology · doi:10.1111/bjd.13634 · Cited by 154 · see citing works
Topical Probiotics: More Than a Skin Deep
Habeebuddin, M., Karnati, R. K., Shiroorkar, P. N., Sreeharsha, N., Asdaq, S. M. B., Anwer, M. K., & Fattepur, S. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14030557 · Cited by 154 · see citing works
A new phylogenetic group of Propionibacterium acnes
McDowell, A., Perry, A. L., Lambert, P. A., et al. (2008) · Journal of Medical Microbiology · doi:10.1099/jmm.0.47489-0 · Cited by 151 · see citing works
McDowell, A., Nagy, I., Magyari, M., Barnard, E., & Patrick, S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0070897 · Cited by 149 · see citing works
Fabbrocini, G., Bertona, M., Picazo, Ó., Pareja-Galeano, H., Monfrecola, G., & Emanuele, E. (2016) · Beneficial Microbes · doi:10.3920/bm2016.0089 · Cited by 149 · see citing works
Valanne, S., McDowell, A., Ramage, G., et al. (2005) · Microbiology · doi:10.1099/mic.0.27788-0 · Cited by 146 · see citing works
Ottaviani, M., Camera, E., & Picardo, M. (2010) · Mediators of Inflammation · doi:10.1155/2010/858176 · Cited by 143 · see citing works
Kim, J., Ko, Y., Park, Y.-K., Kim, N.-I., Ha, W.-K., & Cho, Y. (2010) · Nutrition · doi:10.1016/j.nut.2010.05.011 · Cited by 138 · see citing works
Agamia, N., Abdallah, D., Sorour, O., Mourad, B. H., & Younan, D. N. A. (2016) · British Journal of Dermatology · doi:10.1111/bjd.14409 · Cited by 138 · see citing works
Topical application of probiotics in skin: adhesion, antimicrobial and antibiofilmin vitroassays
Lopes, E., Moreira, D. A., Gullón, P., Gullón, B., Cardelle‐Cobas, A., & Tavaria, F. K. (2016) · Journal of Applied Microbiology · doi:10.1111/jam.13349 · Cited by 125 · see citing works
Gut microbiota alterations in moderate to severe acne vulgaris patients
Yan, H., Zhao, H., Guo, D., Zhu, P., Zhang, C., & Jiang, W. (2018) · The Journal of Dermatology · doi:10.1111/1346-8138.14586 · Cited by 124 · see citing works
Dietary glycemic factors, insulin resistance, and adiponectin levels in acne vulgaris
Çerman, A. A., Aktaş, E., Altunay, İ. K., Arıcı, J. E., Tulunay, A., & Ozturk, F. Y. (2016) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2016.02.1220 · Cited by 123 · see citing works
Bienenfeld, A., Azarchi, S., Sicco, K. L., Marchbein, S., Shapiro, J., & Nagler, A. R. (2018) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2018.08.062 · Cited by 121 · see citing works
Pavicic, T., Wollenweber, U., Farwick, M., & Korting, H. C. (2007) · International Journal of Cosmetic Science · doi:10.1111/j.1467-2494.2007.00378.x · Cited by 120 · see citing works
THE EFFECT ON THE SKIN OF EMOTIONAL AND NERVOUS STATES
STOKES, J. H. (1930) · Archives of Dermatology and Syphilology · doi:10.1001/archderm.1930.01440180008002 · Cited by 118 · see citing works
Yu, Y., Champer, J., Agak, G. W., Kao, S., Modlin, R. L., & Kim, J. J. (2016) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2016.06.615 · Cited by 118 · see citing works
mTORC1 and mTORC2 regulate skin morphogenesis and epidermal barrier formation
Ding, X., Bloch, W., Iden, S., Rüegg, M. A., Hall, M. N., Leptin, M., Partridge, L., & Eming, S. A. (2016) · Nature Communications · doi:10.1038/ncomms13226 · Cited by 116 · see citing works
Johnson, T., Kang, D., Barnard, E., & Li, H. (2016) · mSphere · doi:10.1128/msphere.00023-15 · Cited by 112 · see citing works
Adult-onset acne: prevalence, impact, and management challenges
Rocha, M., & Bagatin, E. (2018) · Clinical Cosmetic and Investigational Dermatology · doi:10.2147/ccid.s137794 · Cited by 110 · see citing works
Marzio, L. D., Cinque, B., Simone, C. D., & Cifone, M. G. (1999) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.1999.00633.x · Cited by 108 · see citing works
Mechanistic target of rapamycin (mTOR) expression is increased in acne patients' skin
Monfrecola, G., Lembo, S., Caiazzo, G., et al. (2015) · Experimental Dermatology · doi:10.1111/exd.12885 · Cited by 107 · see citing works
Zouboulis, C. C., Schagen, S., & Alestas, T. (2008) · Archives of Dermatological Research · doi:10.1007/s00403-008-0879-5 · Cited by 104 · see citing works
Guéniche, A., Benyacoub, J., Philippe, D., Bastien, P., Kusy, N., Breton, L., Blum, S., & Castiel‐Higounenc, I. (2010) · PubMed · doi:10.1684/ejd.2010.1108 · Cited by 101 · see citing works
Identification of Bacterial DNA in the Peripheral Blood of Patients With Active Psoriasis
Ramírez-Boscá, A., Navarro‐López, V., Martínez‐Andrés, A., Such, J. M., Francés, R., de la Parte, J. H., & Asín‐Llorca, M. (2015) · JAMA Dermatology · doi:10.1001/jamadermatol.2014.5585 · Cited by 99 · see citing works
Self-citationGut microbiota and mTOR signaling: Insight on a new pathophysiological interaction
Noureldein, M. H., & Eid, A. A. (2018) · Microbial Pathogenesis · doi:10.1016/j.micpath.2018.03.021 · Cited by 98 · see citing works
Coenye, T., Spittaels, K.-J., & Achermann, Y. (2021) · Biofilm · doi:10.1016/j.bioflm.2021.100063 · Cited by 98 · see citing works
Al‐Ghazzewi, F. H., & Tester, R. F. (2009) · International Journal of Cosmetic Science · doi:10.1111/j.1468-2494.2009.00555.x · Cited by 94 · see citing works
Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris
Navarini, A. A., Simpson, M. A., Weale, M. E., Knight, J., Carlavan, I., Reiniche, P., Burden, A. D., Layton, A., Bataille, V. A., Allen, M., et al. (2014) · Nature Communications · doi:10.1038/ncomms5020 · Cited by 91 · see citing works
Effect of insulin-like growth factor-1 deficiency or administration on the occurrence of acne
Ben‐Amitai, D., & Laron, Z. (2011) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/j.1468-3083.2010.03896.x · Cited by 88 · see citing works
Melnik, B. (2012) · Dermato-Endocrinology · doi:10.4161/derm.19828 · Cited by 88 · see citing works
Juul, A. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.82.8.2497 · Cited by 87 · see citing works
Diet and acne: review of the evidence from 2009 to 2020
Dall’Oglio, F., Nasca, M. R., Fiorentini, F., & Micali, G. (2021) · International Journal of Dermatology · doi:10.1111/ijd.15390 · Cited by 85 · see citing works
Predominant Role of mTOR Signaling in Skin Diseases with Therapeutic Potential
Karagianni, F., Pavlidis, A., Malakou, L. S., Piperi, C., & Papadavid, E. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031693 · Cited by 83 · see citing works
Innate immune defense system of the skin
Afshar, M., & Gallo, R. L. (2013) · Veterinary Dermatology · doi:10.1111/j.1365-3164.2012.01082.x · Cited by 82 · see citing works
Acne: prevalence and relationship with dietary habits in Eskisehir, Turkey
Koku Aksu, A. E., Metintas, S., Saracoglu, Z. N., Gurel, G., Sabuncu, I., Arikan, I., & Kalyoncu, C. (2012) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/j.1468-3083.2011.04329.x · Cited by 78 · see citing works
Two new susceptibility loci 1q24.2 and 11p11.2 confer risk to severe acne
He, L., Wu, W., Yang, J., Cheng, H., Zuo, X.-B., Lai, W., Gao, T., Ma, C.-L., Luo, N., Huang, J., et al. (2014) · Nature Communications · doi:10.1038/ncomms3870 · Cited by 77 · see citing works
Bowe, W. P., Filip, J. C., DiRienzo, J. M., Volgina, A., & Margolis, D. J. (2006) · PubMed · Cited by 73 · see citing works
TLR-2 Recognizes Propionibacterium acnes CAMP Factor 1 from Highly Inflammatory Strains
Lheure, C., Grange, P., Ollagnier, G., Morand, P., Désiré, N., Sayon, S., Corvec, S., Raingeaud, J., Marcelin, A., Cálvez, V., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0167237 · Cited by 71 · see citing works
Porphyrin Production and Regulation in Cutaneous Propionibacteria
Barnard, E., Johnson, T., Ngo, T., Arora, U., Leuterio, G., McDowell, A., & Li, H. (2020) · mSphere · doi:10.1128/msphere.00793-19 · Cited by 70 · see citing works
Genome-wide association meta-analysis identifies 29 new acne susceptibility loci
Mitchell, B. L., Saklatvala, J. R., Dand, N., Hagenbeek, F. A., Li, X., Min, J. L., Thomas, L. F., Bartels, M., Hottenga, J., Lupton, M. K., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-28252-5 · Cited by 70 · see citing works
Nazipi, S., Stødkilde, K., Scavenius, C., & Brüggemann, H. (2017) · Microorganisms · doi:10.3390/microorganisms5030057 · Cited by 68 · see citing works
Lomholt, H. B., Scholz, C. F. P., Brüggemann, H., Tettelin, H., & Kilian, M. (2017) · Anaerobe · doi:10.1016/j.anaerobe.2017.04.006 · Cited by 66 · see citing works
Effect of bacteriocin produced by Lactococcus sp. HY 449 on skin-inflammatory bacteria
Oh, S., Kim, S. H., Ko, Y., Sim, J.-H., Kim, K. S., Lee, S., Park, S., & Kim, Y. J. (2005) · Food and Chemical Toxicology · doi:10.1016/j.fct.2005.08.030 · Cited by 64 · see citing works
Bek-Thomsen, M., Lomholt, H. B., Scavenius, C., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0107908 · Cited by 64 · see citing works
Thompson, K. G., Rainer, B. M., Antonescu, C. M., Florea, L., Mongodin, E. F., Kang, S., & Chien, A. L.-L. (2020) · Annals of Dermatology · doi:10.5021/ad.2020.32.1.21 · Cited by 63 · see citing works
Ermertcan, A. T., Öztürk, F., & Gündüz, K. (2011) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/j.1468-3083.2011.04049.x · Cited by 62 · see citing works
Transcriptomic analysis of Propionibacterium acnes biofilms in vitro
Jahns, A. C., Eilers, H., & Alexeyev, O. A. (2016) · Anaerobe · doi:10.1016/j.anaerobe.2016.10.001 · Cited by 60 · see citing works
Intestinal-borne dermatoses significantly improved by oral application ofEscherichia coliNissle 1917
Манжалій, Е., Hornuß, D., & Stremmel, W. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i23.5415 · Cited by 59 · see citing works
Shamloul, G., & Khachemoune, A. (2020) · Dermatologic Therapy · doi:10.1111/dth.14695 · Cited by 54 · see citing works
Probiotics in the Therapeutic Arsenal of Dermatologists
Navarro‐López, V., Núñez-Delegido, E., Ruzafa-Costas, B., Sánchez-Pellicer, P., Agüera-Santos, J., & Navarro-Moratalla, L. (2021) · Microorganisms · doi:10.3390/microorganisms9071513 · Cited by 54 · see citing works
Self-citationSathikulpakdee, S., Kanokrungsee, S., Vitheejongjaroen, P., Kamanamool, N., Udompataikul, M., & Taweechotipatr, M. (2022) · Journal of Cosmetic Dermatology · doi:10.1111/jocd.14971 · Cited by 51 · see citing works
Effect of bacteriocin produced by Lactococcus sp. HY 449 on skin-inflammatory bacteria
Oh, S., Kim, S. H., Ko, Y., Sim, J.-H., Kim, K. S., Lee, S., Park, S., & Kim, Y. J. (2006) · Food and Chemical Toxicology · doi:10.1016/j.fct.2005.08.008 · Cited by 51 · see citing works
Propionibacterium acnes phylotypes and acne severity: an observational prospective study
Paugam, C., Corvec, S., Saint-Jean, M., et al. (2017) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.14206 · Cited by 50 · see citing works
Acne, quorum sensing and danger
Lwin, S. M., Kimber, I., & McFadden, J. P. (2014) · Clinical and Experimental Dermatology · doi:10.1111/ced.12252 · Cited by 49 · see citing works
A systemic type i 5 α-reductase inhibitor is ineffective in the treatment of acne vulgaris
Leyden, J., Bergfeld, W., Drake, L., Dunlap, F., Goldman, M. P., Gottlieb, A. B., Heffernan, M. P., Hickman, J. G., Hordinsky, M., Jarrett, M., et al. (2004) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2003.07.021 · Cited by 48 · see citing works
Rinaldi, F., Marotta, L., Mascolo, A., Amoruso, A., Pane, M., Giuliani, G., & Pinto, D. (2022) · Dermatology and Therapy · doi:10.1007/s13555-021-00664-z · Cited by 48 · see citing works
Adaptation of acneic and non acneic strains of Cutibacterium acnes to sebum‐like environment
Borrel, V., Gannesen, A. V., Barreau, M., et al. (2019) · MicrobiologyOpen · doi:10.1002/mbo3.841 · Cited by 44 · see citing works
Cobián, N., Garlet, A., Hidalgo-Cantabrana, C., & Barrangou, R. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.758749 · Cited by 43 · see citing works
Kwon, H. H., Yoon, J. Y., Park, S. Y., et al. (2013) · British Journal of Dermatology · doi:10.1111/bjd.12486 · Cited by 42 · see citing works
Mirdamadi, Y., Bommhardt, U., Goihl, A., Guttek, K., Zouboulis, C. C., Quist, S., & Gollnick, H. P. M. (2017) · Dermato-Endocrinology · doi:10.1080/19381980.2017.1356518 · Cited by 41 · see citing works
Espinoza-Monje, M., Campos, J., Alvarez Villamil, E., Jerez, A., Dentice Maidana, S., Elean, M., Salva, S., Kitazawa, H., Villena, J., & García-Cancino, A. (2021) · Microorganisms · doi:10.3390/microorganisms9071486 · Cited by 36 · see citing works
[Impact of the impaired intestinal microflora on the course of acne vulgaris].
Volkova, L. A., Il, K., & Kabanova, I. N. (2001) · PubMed · Cited by 35 · see citing works
Sex hormones and acne: State of the art
Hu, T., Wei, Z., Ju, Q., & Chen, W. (2021) · JDDG Journal der Deutschen Dermatologischen Gesellschaft · doi:10.1111/ddg.14426 · Cited by 35 · see citing works
Farrar, M. D., Ingham, E., & Holland, K. T. (2000) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2000.tb09337.x · Cited by 34 · see citing works
Lee, D., Kim, M. J., Ham, J.-W., et al. (2012) · Archives of Pharmacal Research · doi:10.1007/s12272-012-0614-9 · Cited by 32 · see citing works
Developing an in vitro artificial sebum model to study Propionibacterium acnes biofilms
Spittaels, K.-J., & Coenye, T. (2017) · Anaerobe · doi:10.1016/j.anaerobe.2017.11.002 · Cited by 32 · see citing works
Melnik, B. C. (2010) · PubMed · Cited by 31 · see citing works
The Effect of Oral Probiotic on the Interleukin-10 Serum Levels of Acne Vulgaris
Rahmayani, T., Putra, I. B., & Jusuf, N. K. (2019) · Open Access Macedonian Journal of Medical Sciences · doi:10.3889/oamjms.2019.718 · Cited by 31 · see citing works
Mayslich, C., Grange, P., Castela, M., Marcelin, A., Cálvez, V., & Dupin, N. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23095065 · Cited by 31 · see citing works
Heritability and GWAS Analyses of Acne in Australian Adolescent Twins
Mina-Vargas, A., Colodro‐Conde, L., Grasby, K. L., Zhu, G., Gordon, S. D., Medland, S. E., & Martin, N. G. (2017) · Twin Research and Human Genetics · doi:10.1017/thg.2017.58 · Cited by 29 · see citing works
Inhibition of 5α-Reductase Activity in SZ95 Sebocytes and HaCaT Keratinocytes <i>In Vitro</i>
Seiffert, K., Seltmann, H., Fritsch, M., & Zouboulis, C. (2007) · Hormone and Metabolic Research · doi:10.1055/s-2007-961814 · Cited by 28 · see citing works
Fibrin microclot formation in patients with acne
Juhlin, L., & MICHAELSSON, G. (1983) · Acta Dermato Venereologica · doi:10.2340/0001555563538540 · Cited by 26 · see citing works
Sardana, K., Bansal, P., Sharma, L. K., Garga, U. C., & Vats, G. (2020) · International Journal of Dermatology · doi:10.1111/ijd.14748 · Cited by 25 · see citing works
Epidemiology of acne vulgaris in 18-year-old male army conscripts in a South Brazilian city
Pereira Duquia, R., da Silva dos Santos, I., de Almeida Jr., H., Martins Souza, P. R., de Avelar Breunig, J., & Zouboulis, C. C. (2017) · Dermatology · doi:10.1159/000475775 · Cited by 24 · see citing works
Chae, M., Kim, B. J., Na, J., Kim, S., Lee, J. O., Kim, Y., Lee, E., Cho, D., Roh, J., & Kim, W.-G. (2021) · Frontiers in Bioscience-Elite · doi:10.52586/e881 · Cited by 24 · see citing works
Deidda, F., Amoruso, A., Nicola, S., Graziano, T., Pane, M., & Mogna, L. (2018) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000001053 · Cited by 23 · see citing works
Huang, Y., Liu, L., Chen, L., Zhou, L., Xiong, X., & Deng, Y. (2021) · Annals of Dermatology · doi:10.5021/ad.2021.33.6.531 · Cited by 20 · see citing works
Postmenopausal hyperandrogenism
Yoldemir, T. (2021) · Climacteric · doi:10.1080/13697137.2021.1915273 · Cited by 18 · see citing works
Comparative Studies of Enteric Bacterial Flora in Acne Vulgaris1
Loveman, D. E., Noojin, R. O., & Winkler, C. H. (1955) · Journal of Investigative Dermatology · doi:10.1038/jid.1955.110 · Cited by 17 · see citing works
Tolino, E., Skroza, N., Mambrin, A., Bernardini, N., Zuber, S., Balduzzi, V., Marchesiello, A., Proietti, I., & Potenza, C. (2018) · Giornale Italiano di Dermatologia e Venereologia · doi:10.23736/s0392-0488.18.05710-3 · Cited by 16 · see citing works
Influence of lactoferrin on Propionibacterium acnes ‐induced inflammation in vitro and in vivo
Su, Y., Cui, W., & Wei, H. (2020) · Dermatologic Therapy · doi:10.1111/dth.14483 · Cited by 14 · see citing works
Elsaie, M. L., & Aly, D. G. (2022) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-92616-8_6 · Cited by 9 · see citing works
Rainer, B. M., Thompson, K. G., Antonescu, C. M., Florea, L., Mongodin, E. F., Kang, S., & Chien, A. L.-L. (2020) · Journal of Dermatological Treatment · doi:10.1080/09546634.2020.1720583 · Cited by 4 · see citing works
Acné féminine : maladie dermatologique ou maladie endocrinienne ?
Vexiau, P., & Chivot, M. (2002) · Gynécologie Obstétrique & Fertilité · doi:10.1016/s1297-9589(01)00255-7 · Cited by 2 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
The Potential Impact of Probiotics on Human Health: An Update on Their Health-Promoting Properties
Maftei, N.-M., Raileanu, C. R., Balta, A. A., Ambrose, L., Boev, M., Marin, D. B., & Lisa, E. L. (2024) · Microorganisms · doi:10.3390/microorganisms12020234 · Cited by 381 · see citing works
- Authors
- Sánchez-Pellicer, P., Navarro-Moratalla, L., Núñez-Delegido, E., Ruzafa-Costas, B., Agüera-Santos, J., & Navarro-López, V.
- Affiliations
- Universidad Católica de Murcia (ES)
- MiBioPath Research Group, Department of Clinical Medicine, Health Sciences Faculty, Catholic University of Murcia, Campus de los Jerónimos 135, 30107 Murcia, Spain
- ORCID
- Venue
- Microorganisms
- Publisher
- MDPI AG
- Published
- 2022-06-27
- Volume
- 10
- Issue
- 7
- Pages
- 1303
- ISSN
- 2076-2607 (ISSN-L)
- PMC
- PMC9318165
- OpenAlex
- W4283657416
- Cited by
- 137
- References
- 143
- Citations by year
- 2026: 26 · 2025: 42 · 2024: 36 · 2023: 28 · 2022: 5
- FWCI
- 4.94
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Microorganisms (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Acne and Rosacea Treatments and Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Keywords
- acne, gut-skin axis, gut microbiota, probiotics, Propionibacterium acnes, pilosebaceous unit, skin inflammation, intestinal barrier integrity, insulin-like growth factor I, adjuvant therapy, topical probiotics, oral probiotics
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
