Cardiovascular and antiobesity effects of resveratrol mediated through the gut microbiota
Open accessAbstract
Encouraging scientific research into the health effects of dietary bioactive resveratrol has been confounded by its rapid first-pass metabolism, which leads to low in vivo bioavailability. Preliminary studies have shown that resveratrol can modulate gut microbiota composition, undergo biotransformation to active metabolites via the intestinal microbiota, or affect gut barrier function. In rodents, resveratrol can modify the relative Bacteroidetes:Firmicutes ratio and reverse the gut microbial dysbiosis caused by a high-fat diet. By upregulating the expression of genes involved in maintaining tight junctions between intestinal cells, resveratrol contributes to gut barrier integrity. The composition of the gut microbiome and rapid metabolism of resveratrol determines the production of resveratrol metabolites, which are found at greater concentrations in humans after ingestion than their parent molecule and can have similar biological effects. Resveratrol may affect cardiovascular risk factors such as elevated blood cholesterol or trimethylamine N-oxide concentrations. Modulating the composition of the gut microbiota by resveratrol may affect central energy metabolism and modify concentrations of satiety hormones to produce antiobesity effects. Encouraging research from animal models could be tested in humans.
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Resveratrol may remodel the gut microbiome to yield cardiovascular benefits, antiobesity effects, and improvements in glucose homeostasis.
“Recent evidence suggests that resveratrol, for example, may act to remodel the gut microbiome to yield cardiovascular benefits, antiobesity effects, and improvements in glucose homeostasis (Chen et al., 2016;Bird et al., 2017;Sung et al., 2017).”
From Gut reactions: Breaking down xenobiotic–microbiome interactions (2019) · cites this paper as Bird et al., 2017
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- Authors
- Bird, J. K., Raederstorff, D., Weber, P., & Steinert, R. E.
- Affiliations
- University Hospital Zurich (CH)
- Corresponding author
- Bird, Julia K
- Venue
- Advances in Nutrition
- Publisher
- Elsevier BV
- Published
- 2017-11
- Volume
- 8
- Issue
- 6
- Pages
- 839-849
- ISSN
- 2156-5376 (ISSN-L)
- 2161-8313
- PMC
- PMC5682996
- OpenAlex
- W2773619793
- Cited by
- 136
- References
- 91
- Citations by year
- 2026: 7 · 2025: 16 · 2024: 12 · 2023: 15 · 2022: 14 · 2021: 19 · 2020: 17 · 2019: 19 · 2018: 17
- FWCI
- 1.66
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Advances in Nutrition (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion, other-oa)
- RERO DOC (Universität Bern) (submittedVersion)
- CINECA IRIS Institutial research information system (University of Pisa) (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion, other-oa)
- Zurich Open Repository and Archive (University of Zurich)
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Keywords
- resveratrol, gut microbiota, cardiovascular health, anti-obesity, first-pass metabolism, bioavailability, microbial transformation, intestinal barrier, tight junctions, Firmicutes/Bacteroidetes ratio, high-fat diet, trimethylamine N-oxide, serum cholesterol, satiety hormones, energy metabolism
- MeSH terms
- Gastrointestinal Microbiome, Resveratrol, Animals, Cardiovascular Diseases, Energy Metabolism, Humans, Intestinal Mucosa, Obesity, Stilbenes, Anti-Obesity Agents, Diet, High-Fat
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