FXR agonist obeticholic acid reduces hepatic inflammation and fibrosis in a rat model of toxic cirrhosis
Verbeke, Len, Mannaerts, Inge, Schierwagen, Robert, Govaere, Olivier, Klein, Sabine, Vander Elst, Ingrid, Windmolders, Petra, Farre, Ricard, Wenes, Mathias, Mazzone, Massimiliano, Nevens, Frederik, van Grunsven, Leo A., Trebicka, Jonel, Laleman, Wim·2016·Scientific Reports
Cited by (238)
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