Novel regulators of hepatic macrophages in liver fibrosis

Hepatocellular carcinoma

Llovet, J. M., Kelley, R. K., Villanueva, A., Singal, A. G., Pikarsky, E., Roayaie, S., Lencioni, R., Koike, K., Zucman-Rossi, J., & Finn, R. S. (2021) · Nature Reviews Disease Primers · doi:10.1038/s41572-020-00240-3 · Cited by 7,055 · see citing works

Macrophage plasticity, polarization, and function in health and disease

Shapouri‐Moghaddam, A., Mohammadian, S., Vazini, H., Taghadosi, M., Esmaeili, S., Mardani, F., Seifi, B., Mohammadi, A., Afshari, J. T., & Sahebkar, A. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.26429 · Cited by 4,930 · see citing works

Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches

Welsh, J. A., Goberdhan, D. C. I., O'Driscoll, L., Buzas, E. I., Blenkiron, C., Bussolati, B., Cai, H., Di Vizio, D., Driedonks, T. A. P., Erdbrügger, U., et al. (2024) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12404 · Cited by 4,663 · see citing works

Metabolic regulation of gene expression by histone lactylation

Zhang, D., Tang, Z., Huang, H., Zhou, G., Cui, C., Weng, Y., Liu, W., Kim, S., Lee, S., Perez-Neut, M., et al. (2019) · Nature · doi:10.1038/s41586-019-1678-1 · Cited by 4,371 · see citing works

Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors

Gomez Perdiguero, E., Klapproth, K., Schulz, C., Busch, K., Azzoni, E., Crozet, L., Garner, H., Trouillet, C., de Bruijn, M. F., Geissmann, F., et al. (2015) · Nature · doi:10.1038/nature13989 · Cited by 2,339 · see citing works

Molecular and cellular mechanisms of liver fibrosis and its regression

Kisseleva, T., & Brenner, D. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-020-00372-7 · Cited by 2,024 · see citing works

Mechanisms and disease consequences of nonalcoholic fatty liver disease

Loomba, R., Friedman, S. L., & Shulman, G. I. (2021) · Cell · doi:10.1016/j.cell.2021.04.015 · Cited by 2,002 · see citing works

Resolving the fibrotic niche of human liver cirrhosis at single-cell level

Ramachandran, P., Dobie, R., Wilson-Kanamori, J. R., Dora, E. F., Henderson, B. E. P., Luu, N. T., Portman, J. R., Matchett, K. P., Brice, M., Marwick, J. A., et al. (2019) · Nature · doi:10.1038/s41586-019-1631-3 · Cited by 1,784 · see citing works

Single cell RNA sequencing of human liver reveals distinct intrahepatic macrophage populations

MacParland, S. A., Liu, J. C., Ma, X.-Z., Innes, B. T., Bartczak, A. M., Gage, B. K., Manuel, J., Khuu, N., Echeverri, J., Linares, I., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-06318-7 · Cited by 1,552 · see citing works

Liver fibrosis: Pathophysiology, pathogenetic targets and clinical issues

Parola, M., & Pinzani, M. (2018) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2018.09.002 · Cited by 1,183 · see citing works

The role of JAK/STAT signaling pathway and its inhibitors in diseases.

Xin, P., Xu, X., Deng, C., Liu, S., Wang, Y., Zhou, X., Ma, H., Wei, D., & Sun, S. (2020) · International Immunopharmacology · doi:10.1016/j.intimp.2020.106210 · Cited by 1,010 · see citing works

Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)

Cossarizza, A., Chang, H., Radbruch, A., Acs, A., Adam, D., Adam‐Klages, S., Agace, W. W., Aghaeepour, N., Akdiş, M., Allez, M., et al. (2019) · European Journal of Immunology · doi:10.1002/eji.201970107 · Cited by 982 · see citing works

Hepatic inflammation and fibrosis: Functional links and key pathways

Seki, E., & Schwabe, R. F. (2015) · Hepatology · doi:10.1002/hep.27332 · Cited by 972 · see citing works

MCP-1: Function, regulation, and involvement in disease

Singh, S., Anshita, D., & Ravichandiran, V. (2021) · International Immunopharmacology · doi:10.1016/j.intimp.2021.107598 · Cited by 887 · see citing works

Hepatic inflammatory responses in liver fibrosis

Hammerich, L., & Tacke, F. (2023) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-023-00807-x · Cited by 803 · see citing works

A Randomized, Controlled Trial of the Pan-PPAR Agonist Lanifibranor in NASH

Francque, S. M., Bedossa, P., Ratziu, V., Anstee, Q. M., Bugianesi, E., Sanyal, A. J., Loomba, R., Harrison, S. A., Balabanska, R., Mateva, L., et al. (2021) · New England Journal of Medicine · doi:10.1056/nejmoa2036205 · Cited by 801 · see citing works

Landscape of Intercellular Crosstalk in Healthy and NASH Liver Revealed by Single-Cell Secretome Gene Analysis

Xiong, X., Kuang, H., Ansari, S., Liu, T., Gong, J., Wang, S., Zhao, X.-Y., Ji, Y., Li, C., Guo, L., et al. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.07.028 · Cited by 784 · see citing works

Hepatic macrophages in liver homeostasis and diseases-diversity, plasticity and therapeutic opportunities

Wen, Y., Lambrecht, J., Ju, C., & Tacke, F. (2021) · Cellular & Molecular Immunology · doi:10.1038/s41423-020-00558-8 · Cited by 695 · see citing works

A randomized, placebo-controlled trial of cenicriviroc for treatment of nonalcoholic steatohepatitis with fibrosis

Friedman, S. L., Ratziu, V., Harrison, S. A., Abdelmalek, M. F., Aithal, G. P., Caballeria, J., Francque, S., Farrell, G., Kowdley, K. V., Craxi, A., et al. (2018) · Hepatology · doi:10.1002/hep.29477 · Cited by 671 · see citing works

Stellate Cells, Hepatocytes, and Endothelial Cells Imprint the Kupffer Cell Identity on Monocytes Colonizing the Liver Macrophage Niche

Bonnardel, J., T’Jonck, W., Gaublomme, D., Browaeys, R., Scott, C. L., Martens, L., Vanneste, B., De Prijck, S., Nedospasov, S. A., Kremer, A., et al. (2019) · Immunity · doi:10.1016/j.immuni.2019.08.017 · Cited by 631 · see citing works

Osteopontin Expression Identifies a Subset of Recruited Macrophages Distinct from Kupffer Cells in the Fatty Liver

Remmerie, A., Martens, L., Thoné, T., Castoldi, A., Seurinck, R., Pavie, B., Roels, J., Vanneste, B., De Prijck, S., Vanhockerhout, M., et al. (2020) · Immunity · doi:10.1016/j.immuni.2020.08.004 · Cited by 592 · see citing works

Immune cell-mediated features of non-alcoholic steatohepatitis

Huby, T., & Gautier, E. L. (2022) · Nature Reviews Immunology · doi:10.1038/s41577-021-00639-3 · Cited by 573 · see citing works

Liver sinusoidal endothelial cells — gatekeepers of hepatic immunity

Shetty, S., Lalor, P. F., & Adams, D. H. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-018-0020-y · Cited by 523 · see citing works

Randomized, Controlled Trial of the FGF21 Analogue Pegozafermin in NASH

Loomba, R., Sanyal, A. J., Kowdley, K. V., Bhatt, D. L., Alkhouri, N., Frias, J. P., Bedossa, P., Harrison, S. A., Lazas, D., Barish, R., et al. (2023) · New England Journal of Medicine · doi:10.1056/nejmoa2304286 · Cited by 522 · see citing works

Understanding lipotoxicity in NAFLD pathogenesis: is CD36 a key driver?

Rada, P., González‐Rodríguez, Á., García‐Monzón, C., & Valverde, Á. M. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-03003-w · Cited by 522 · see citing works

Lipid-Induced Signaling Causes Release of Inflammatory Extracellular Vesicles From Hepatocytes

Hirsova, P., Ibrahim, S. H., Krishnan, A., Verma, V. K., Bronk, S. F., Werneburg, N. W., Charlton, M., Shah, V. H., Malhi, H., & Gores, G. J. (2016) · Gastroenterology · doi:10.1053/j.gastro.2015.12.037 · Cited by 510 · see citing works

Metabolic reprogramming in liver fibrosis

Horn, P., & Tacke, F. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2024.05.003 · Cited by 432 · see citing works

The Power of Plasticity—Metabolic Regulation of Hepatic Stellate Cells

Trivedi, P., Wang, S., & Friedman, S. L. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2020.10.026 · Cited by 427 · see citing works

Liver-Derived Signals Sequentially Reprogram Myeloid Enhancers to Initiate and Maintain Kupffer Cell Identity

Sakai, M., Troutman, T. D., Seidman, J. S., Ouyang, Z., Spann, N. J., Abe, Y., Ego, K. M., Bruni, C. M., Deng, Z., Schlachetzki, J. C. M., et al. (2019) · Immunity · doi:10.1016/j.immuni.2019.09.002 · Cited by 418 · see citing works

Expression of STING Is Increased in Liver Tissues From Patients With NAFLD and Promotes Macrophage-Mediated Hepatic Inflammation and Fibrosis in Mice

Luo, X., Li, H., Ma, L., Zhou, J., Guo, X., Woo, S.-L., Pei, Y., Knight, L. R., Deveau, M., Chen, Y., et al. (2018) · Gastroenterology · doi:10.1053/j.gastro.2018.09.010 · Cited by 415 · see citing works

Dynamic shifts in the composition of resident and recruited macrophages influence tissue remodeling in NASH

Daemen, S., Gainullina, A., Kalugotla, G., He, L., Chan, M. M., Beals, J. W., Liss, K. H., Klein, S., Feldstein, A. E., Finck, B. N., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2020.108626 · Cited by 378 · see citing works

Neutrophils promote the development of reparative macrophages mediated by ROS to orchestrate liver repair

Yang, W., Tao, Y., Wu, Y., Zhao, X., Ye, W., Zhao, D., Fu, L., Tian, C., Yang, J., He, F., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-09046-8 · Cited by 367 · see citing works

Role of liver sinusoidal endothelial cells in non-alcoholic fatty liver disease

Hammoutene, A., & Rautou, P.-E. (2019) · Journal of Hepatology · doi:10.1016/j.jhep.2019.02.012 · Cited by 364 · see citing works

Hepatic stellate cells in physiology and pathology

Kamm, D. R., & McCommis, K. S. (2022) · The Journal of Physiology · doi:10.1113/jp281061 · Cited by 351 · see citing works

Differential Effects of Selective- and Pan-PPAR Agonists on Experimental Steatohepatitis and Hepatic Macrophages(☆)

Lefere, S., Puengel, T., Hundertmark, J., Penners, C., Frank, A. K., Guillot, A., de Muynck, K., Heymann, F., Adarbes, V., Defrêne, E., et al. (2020) · Journal of Hepatology · doi:10.1016/j.jhep.2020.04.025 · Cited by 310 · see citing works

Single‐Cell, Single‐Nucleus, and Spatial RNA Sequencing of the Human Liver Identifies Cholangiocyte and Mesenchymal Heterogeneity

Andrews, T. S., Atif, J., Liu, J. C., Perciani, C. T., Ma, X., Thoeni, C., Slyper, M., Eraslan, G., Segerstolpe, A., Manuel, J., et al. (2022) · Hepatology Communications · doi:10.1002/hep4.1854 · Cited by 307 · see citing works

The pro-inflammatory effects of miR-155 promote liver fibrosis and alcohol-induced steatohepatitis

Bala, S., Csák, T., Saha, B., Zatsiorsky, J., Kodys, K., Catalano, D. E., Satishchandran, A., & Szabó, G. (2016) · Journal of Hepatology · doi:10.1016/j.jhep.2016.01.035 · Cited by 305 · see citing works

TGF ‐β as a driver of fibrosis: physiological roles and therapeutic opportunities

Budi, E. H., Schaub, J. R., Decaris, M. L., Turner, S., & Derynck, R. (2021) · The Journal of Pathology · doi:10.1002/path.5680 · Cited by 300 · see citing works

Cellular and Molecular Mechanisms Underlying Liver Fibrosis Regression

Caligiuri, A., Gentilini, A., Pastore, M., Gitto, S., & Marra, F. (2021) · Cells · doi:10.3390/cells10102759 · Cited by 273 · see citing works

Neutrophils contribute to spontaneous resolution of liver inflammation and fibrosis via microRNA-223

Calvente, C. J., Tameda, M., Johnson, C. D., del Pilar, H., Lin, Y. C., Adronikou, N., De Mollerat Du Jeu, X., Llorente, C., Boyer, J., & Feldstein, A. E. (2019) · Journal of Clinical Investigation · doi:10.1172/jci122258 · Cited by 268 · see citing works

Macrophage autophagy protects against liver fibrosis in mice

Lodder, J., Denaës, T., Chobert, M.-N., Wan, J., El-Benna, J., Pawlotsky, J.-M., Lotersztajn, S., & Teixeira-Clerc, F. (2015) · Autophagy · doi:10.1080/15548627.2015.1058473 · Cited by 266 · see citing works

Accumulation of polystyrene microplastics induces liver fibrosis by activating cGAS/STING pathway

Shen, R., Yang, K., Cheng, X., Guo, C., Xing, X., Sun, H., Liu, D., Liu, X., & Wang, D. (2022) · Environmental Pollution · doi:10.1016/j.envpol.2022.118986 · Cited by 266 · see citing works

Fibroblast growth factor 21 attenuates iron overload-induced liver injury and fibrosis by inhibiting ferroptosis

Wu, A., Feng, B., Yu, J., Yan, L., Che, L., Zhuo, Y., Luo, Y., Yu, B., Wu, D., & Chen, D. (2021) · Redox Biology · doi:10.1016/j.redox.2021.102131 · Cited by 261 · see citing works

miR-142-5p and miR-130a-3p are regulated by IL-4 and IL-13 and control profibrogenic macrophage program

Su, S., Zhao, Q., He, C., Huang, D., Liu, J., Chen, F., Chen, J., Liao, J.-Y., Cui, X., Zeng, Y., et al. (2015) · Nature Communications · doi:10.1038/ncomms9523 · Cited by 253 · see citing works

FSTL1 promotes liver fibrosis by reprogramming macrophage function through modulating the intracellular function of PKM2

Rao, J., Wang, H., Ni, M., Wang, Z., Wang, Z., Wei, S., Liu, M., Wang, P., Qiu, J., Zhang, L., et al. (2022) · Gut · doi:10.1136/gutjnl-2021-325150 · Cited by 241 · see citing works

PDGF signaling pathway in hepatic fibrosis pathogenesis and therapeutics

Ying, H., Chen, Q., Zhang, W., Zhang, H., Ma, Y., Zhang, S., Fang, J., & Yu, C.-H. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.7641 · Cited by 238 · see citing works

FXR agonist obeticholic acid reduces hepatic inflammation and fibrosis in a rat model of toxic cirrhosis

Verbeke, L., Mannaerts, I., Schierwagen, R., Govaere, O., Klein, S., Vander Elst, I., Windmolders, P., Farre, R., Wenes, M., Mazzone, M., et al. (2016) · Scientific Reports · doi:10.1038/srep33453 · Cited by 236 · see citing works

A subset of Kupffer cells regulates metabolism through the expression of CD36

Blériot, C., Barreby, E., Dunsmore, G., Ballaire, R., Chakarov, S., Ficht, X., De Simone, G., Andreata, F., Fumagalli, V., Guo, W., et al. (2021) · Immunity · doi:10.1016/j.immuni.2021.08.006 · Cited by 236 · see citing works

Therapeutic Targeting of Hepatic Macrophages for the Treatment of Liver Diseases

van der Heide, D., Weiskirchen, R., & Bansal, R. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02852 · Cited by 234 · see citing works

Danger-Associated Molecular Patterns (DAMPs): Molecular Triggers for Sterile Inflammation in the Liver

Mihm, S. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19103104 · Cited by 232 · see citing works

Mitochondrial dysfunction in fibrotic diseases

Li, X., Zhang, W. Y., Cao, Q., Wang, Z., Zhao, M., Xu, L., & Zhuang, Q. (2020) · Cell Death Discovery · doi:10.1038/s41420-020-00316-9 · Cited by 226 · see citing works

Pharmacological Inhibition of CCR2/5 Signaling Prevents and Reverses Alcohol‐Induced Liver Damage, Steatosis, and Inflammation in Mice

Ambade, A., Lowe, P., Kodys, K., Catalano, D. E., Gyöngyösi, B., Cho, Y., Iracheta‐Vellve, A., Adejumo, A., Saha, B., Calenda, C. D., et al. (2018) · Hepatology · doi:10.1002/hep.30249 · Cited by 213 · see citing works

Annexin A5 regulates hepatic macrophage polarization via directly targeting PKM2 and ameliorates NASH

Xu, F., Guo, M., Huang, W., Feng, L., Zhu, J., Luo, K., Gao, J., Zheng, B., Kong, L.-D., Pang, T., et al. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101634 · Cited by 196 · see citing works

Integrin β1-enriched extracellular vesicles mediate monocyte adhesion and promote liver inflammation in murine NASH

Guo, Q., Furuta, K., Lucien, F., Sanchez, L. H. G., Hirsova, P., Krishnan, A., Kabashima, A., Pavelko, K. D., Madden, B. J., Alhuwaish, H., et al. (2019) · Journal of Hepatology · doi:10.1016/j.jhep.2019.07.019 · Cited by 181 · see citing works

Lactic acid induces transcriptional repression of macrophage inflammatory response via histone acetylation

Shi, W., Cassmann, T. J., Bhagwate, A. V., Hitosugi, T., & Ip, W. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.113746 · Cited by 181 · see citing works

Hepatic stellate cell senescence in liver fibrosis: Characteristics, mechanisms and perspectives

Zhang, M., Salas, S. S., Damba, T., Borghesan, M., Demaria, M., & Moshage, H. J. (2021) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2021.111572 · Cited by 180 · see citing works

Macrophage activation and polarization in post-infarction cardiac remodeling

Энхэевна, Г. А., Rogovskaya, Y. V., Сергеевич, Ш. В., Ребенкова, М. С., Kzhyshkowska, J. G., Popov, S. V., Karpov, R. S., & Ryabov, V. V. (2017) · Journal of Biomedical Science · doi:10.1186/s12929-017-0322-3 · Cited by 174 · see citing works

Cholesterol crystallization within hepatocyte lipid droplets and its role in murine NASH

Ioannou, G. N., Subramanian, S., Chait, A., Haigh, W. G., Yeh, M. M., Farrell, G. C., Lee, S. P., & Savard, C. E. (2017) · Journal of Lipid Research · doi:10.1194/jlr.m072454 · Cited by 173 · see citing works

MicroRNAs in non-alcoholic fatty liver disease: Progress and perspectives

Hochreuter, M. Y., Dall, M., Treebak, J. T., & Barrès, R. (2022) · Molecular Metabolism · doi:10.1016/j.molmet.2022.101581 · Cited by 171 · see citing works

Mucosal-associated invariant T cells promote inflammation and intestinal dysbiosis leading to metabolic dysfunction during obesity

Toubal, A., Kiaf, B., Beaudoin, L., Cagninacci, L., Rhimi, M., Fruchet, B., da Silva, J., Corbett, A. J., Simoni, Y., Lantz, O., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-17307-0 · Cited by 165 · see citing works

Hepatocyte HSPA12A inhibits macrophage chemotaxis and activation to attenuate liver ischemia/reperfusion injury via suppressing glycolysis-mediated HMGB1 lactylation and secretion of hepatocytes

Du, S., Zhang, X., Jia, Y., Peng, P., Kong, Q., Jiang, S., Li, Y., Li, C., Ding, Z., & Liu, L. (2023) · Theranostics · doi:10.7150/thno.82607 · Cited by 158 · see citing works

Mesenchymal stem cells and induced bone marrow-derived macrophages synergistically improve liver fibrosis in mice

Watanabe, Y., Tsuchiya, A., Seino, S., Kawata, Y., Kojima, Y., Ikarashi, S., Starkey Lewis, P. J., Lu, W.-Y., Kikuta, J., Kawai, H., et al. (2019) · Stem Cells Translational Medicine · doi:10.1002/sctm.18-0105 · Cited by 155 · see citing works

Functions of macrophage colony-stimulating factor (CSF1) in development, homeostasis, and tissue repair

Sehgal, A., Irvine, K. M., & Hume, D. A. (2021) · Seminars in Immunology · doi:10.1016/j.smim.2021.101509 · Cited by 154 · see citing works

Sphingosine kinase 1 promotes liver fibrosis by preventing miR‐19b‐3p‐mediated inhibition of CCR2

Lan, T., Li, C., Yang, G., Sun, Y., Zhuang, L., Ou, Y., Li, H., Wang, G., Kisseleva, T., Brenner, D., et al. (2018) · Hepatology · doi:10.1002/hep.29885 · Cited by 153 · see citing works

CCL20 mediates lipopolysaccharide induced liver injury and is a potential driver of inflammation and fibrosis in alcoholic hepatitis

Affò, S., Morales‐Ibanez, O., Rodrigo‐Torres, D., Altamirano, J., Blaya, D., Dapito, D. H., Millán, C., Coll, M., Caviglia, J. M., Arroyo, V., et al. (2014) · Gut · doi:10.1136/gutjnl-2013-306098 · Cited by 147 · see citing works

Lipid-associated macrophages' promotion of fibrosis resolution during MASH regression requires TREM2

Ganguly, S., Rosenthal, S. B., Ishizuka, K., Troutman, T. D., Rohm, T. V., Khader, N., Aleman-Muench, G., Sano, Y., Archilei, S., Soroosh, P., et al. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2405746121 · Cited by 145 · see citing works

Mesenchymal stem cell-derived exosomes protect against liver fibrosis via delivering miR-148a to target KLF6/STAT3 pathway in macrophages

Tian, S., Zhou, X., Zhang, M., Cui, L., Li, B., Liu, Y., Su, R., Sun, K., Hu, Y., Yang, F., et al. (2022) · Stem Cell Research & Therapy · doi:10.1186/s13287-022-03010-y · Cited by 144 · see citing works

Fibroblast Activation Protein Activates Macrophages and Promotes Parenchymal Liver Inflammation and Fibrosis

Yang, A.-T., Kim, Y.-O., Yan, X.-Z., Abe, H., Aslam, M., Park, K.-S., Zhao, X.-Y., Jia, J.-D., Klein, T., You, H., et al. (2023) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2022.12.005 · Cited by 144 · see citing works

Hepatocyte-Macrophage Acetoacetate Shuttle Protects Against Tissue Fibrosis

Puchalska, P., Martin, S. E., Huang, X., Lengfeld, J. E., Daniel, B., Graham, M. J., Han, X., Nagy, L., Patti, G. J., & Crawford, P. A. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2018.10.015 · Cited by 138 · see citing works

TLR4-dependent fibroblast activation drives persistent organ fibrosis in skin and lung

Bhattacharyya, S., Wang, W., Qin, W., Cheng, K., Coulup, S. K., Chavez, S. A., Jiang, S., Raparia, K., de Almeida, L., Stehlik, C., et al. (2018) · JCI Insight · doi:10.1172/jci.insight.98850 · Cited by 135 · see citing works

STING signaling sensing of DRP1-dependent mtDNA release in kupffer cells contributes to lipopolysaccharide-induced liver injury in mice

Zhang, Q., Wei, J., Liu, Z., Huang, X., Sun, M., Lai, W., Chen, Z., Wu, J., Chen, Y., Guo, X., et al. (2022) · Redox Biology · doi:10.1016/j.redox.2022.102367 · Cited by 135 · see citing works

Matrix metalloproteinases induce extracellular matrix degradation through various pathways to alleviate hepatic fibrosis

Shan, L., Wang, F., Zhai, D., Meng, X., Liu, J., & Lv, X. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114472 · Cited by 135 · see citing works

IL-4 Receptor Alpha Signaling through Macrophages Differentially Regulates Liver Fibrosis Progression and Reversal

Weng, S.-Y., Wang, X., Vijayan, S., Tang, Y., Kim, Y. O., Padberg, K., Regen, T., Molokanova, O., Chen, T., Bopp, T., et al. (2018) · EBioMedicine · doi:10.1016/j.ebiom.2018.01.028 · Cited by 128 · see citing works

MiR-690 treatment causes decreased fibrosis and steatosis and restores specific Kupffer cell functions in NASH

Gao, H., Jin, Z., Bandyopadhyay, G. K., Rocha, K. C. E., Liu, X., Zhao, H., Zhang, D., Jouihan, H. A., Pourshahian, S., Kisseleva, T., et al. (2022) · Cell Metabolism · doi:10.1016/j.cmet.2022.05.008 · Cited by 127 · see citing works

Myeloid Cell PKM2 Deletion Enhances Efferocytosis and Reduces Atherosclerosis

Doddapattar, P., Dev, R., Ghatge, M., Patel, R. B., Jain, M. K., Dhanesha, N., Lentz, S. R., & Chauhan, A. K. (2022) · Circulation Research · doi:10.1161/circresaha.121.320704 · Cited by 126 · see citing works

Macrophage galactose lectin is critical for Kupffer cells to clear aged platelets

Deppermann, C., Kratofil, R. M., Peiseler, M., David, B. A., Zindel, J., Castanheira, F. V. S., van der Wal, F., Carestia, A., Jenne, C., Marth, J., et al. (2020) · Journal of Experimental Medicine · doi:10.1084/jem.20190723 · Cited by 125 · see citing works

Functional Roles of Chemokine Receptor CCR2 and Its Ligands in Liver Disease

She, S., Ren, L., Chen, P., Wang, M., Chen, D., Wang, Y., & Chen, H. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.812431 · Cited by 125 · see citing works

Spatial transcriptomics of healthy and fibrotic human liver at single-cell resolution

Watson, B. R., Paul, B., Rahman, R. U., Amir-Zilberstein, L., Segerstolpe, Å., Epstein, E. T., Murphy, S., Geistlinger, L., Lee, T., Shih, A., et al. (2025) · Nature Communications · doi:10.1038/s41467-024-55325-4 · Cited by 123 · see citing works

Kupffer cell–like syncytia replenish resident macrophage function in the fibrotic liver

Peiseler, M., Araujo David, B., Zindel, J., Surewaard, B. G. J., Lee, W.-Y., Heymann, F., Nusse, Y., Castanheira, F. V. S., Shim, R., Guillot, A., et al. (2023) · Science · doi:10.1126/science.abq5202 · Cited by 123 · see citing works

XBP1-mediated activation of the STING signalling pathway in macrophages contributes to liver fibrosis progression

Wang, Q., Bu, Q.-F., Liu, M., Zhang, R., Gu, J., Li, L., Zhou, J.-R., Liang, Y., Su, W., Liu, Z., et al. (2022) · JHEP Reports · doi:10.1016/j.jhepr.2022.100555 · Cited by 122 · see citing works

STING expression in monocyte-derived macrophages is associated with the progression of liver inflammation and fibrosis in patients with nonalcoholic fatty liver disease

Wang, X., Rao, H., Zhao, J., Wee, A., Li, X., Fei, R., Huang, R., Wu, C., Liu, F., & Wei, L. (2019) · Laboratory Investigation · doi:10.1038/s41374-019-0342-6 · Cited by 119 · see citing works

Cholangiocyte-Derived Exosomal lncRNA H19 Promotes Macrophage Activation and Hepatic Inflammation under Cholestatic Conditions

Li, X., Liu, R., Wang, Y., Zhu, W., Zhao, D., Wang, X., Yang, H., Gurley, E. C., Chen, W., Hylemon, P. B., et al. (2020) · Cells · doi:10.3390/cells9010190 · Cited by 117 · see citing works

Crosstalk Between Liver Macrophages and Surrounding Cells in Nonalcoholic Steatohepatitis

Li, H., Zhou, Y., Wang, H., Zhang, M., Qiu, P., Zhang, M., Zhang, R., Zhao, Q., & Liu, J. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01169 · Cited by 114 · see citing works

Macrophage in liver Fibrosis: Identities and mechanisms

Wang, Z., Du, K., Jin, N., Tang, B., & Zhang, W. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.110357 · Cited by 114 · see citing works

MyD88 in hepatic stellate cells enhances liver fibrosis via promoting macrophage M1 polarization

Zhang, J., Liu, Y., Chen, H., Yuan, Q., Wang, J., Niu, M., Hou, L., Gu, J., & Zhang, J. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-04802-z · Cited by 112 · see citing works

Increased Tim-3 expression alleviates liver injury by regulating macrophage activation in MCD-induced NASH mice

Du, X., Wu, Z., Xu, Y., Liu, Y., Liu, W., Wang, T., Li, C., Zhang, C., Yi, F., Gao, L., et al. (2018) · Cellular and Molecular Immunology · doi:10.1038/s41423-018-0032-0 · Cited by 107 · see citing works

Silencing lncRNA Lfar1 alleviates the classical activation and pyoptosis of macrophage in hepatic fibrosis

Zhang, K., Shi, Z., Zhang, M., Dong, X., Zheng, L., Li, G., Han, X., Yao, Z., Han, T., & Wei, H. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-2323-5 · Cited by 106 · see citing works

Lactate and lactylation in macrophage metabolic reprogramming: current progress and outstanding issues

Xu, B., Liu, Y., Li, N., & Geng, Q. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1395786 · Cited by 106 · see citing works

Covalent inhibition of pyruvate kinase M2 reprograms metabolic and inflammatory pathways in hepatic macrophages against non-alcoholic fatty liver disease

Fan, N., Zhang, X., Zhao, W., Zhao, J., Luo, D., Sun, Y., Li, D., Zhao, C., Wang, Y., Zhang, H., et al. (2022) · International Journal of Biological Sciences · doi:10.7150/ijbs.73890 · Cited by 104 · see citing works

Circ‐MALAT1 Functions as Both an mRNA Translation Brake and a microRNA Sponge to Promote Self‐Renewal of Hepatocellular Cancer Stem Cells

Chen, L., Kong, R., Wu, C., Wang, S., Liu, Z., Liu, S., Shuiping, L., Chen, T. X., Mao, C., & Liu, S. (2019) · Advanced Science · doi:10.1002/advs.201900949 · Cited by 102 · see citing works

Macrophage Sphingosine 1-Phosphate Receptor 2 Blockade Attenuates Liver Inflammation and Fibrogenesis Triggered by NLRP3 Inflammasome

Hou, L., Yang, L., Chang, N., Zhao, X., Zhou, X., Dong, C., Liu, F., Yang, L., & Li, L. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01149 · Cited by 102 · see citing works

Histidine‐rich glycoprotein promotes macrophage activation and inflammation in chronic liver disease

Bartneck, M., Fech, V., Ehling, J., Govaere, O., Warzecha, K. T., Hittatiya, K., Vucur, M., Gautheron, J., Luedde, T., Trautwein, C., et al. (2016) · Hepatology · doi:10.1002/hep.28418 · Cited by 101 · see citing works

Endothelial p300 Promotes Portal Hypertension and Hepatic Fibrosis Through C‐C Motif Chemokine Ligand 2–Mediated Angiocrine Signaling

Gao, J., Wei, B., Liu, M., Hirsova, P., Sehrawat, T. S., Cao, S., Hu, X., Xue, F., Yaqoob, U., Kang, N., et al. (2021) · Hepatology · doi:10.1002/hep.31617 · Cited by 100 · see citing works

Nuclear receptors linking metabolism, inflammation, and fibrosis in nonalcoholic fatty liver disease

Puengel, T., Liu, H., Guillot, A., Heymann, F., Tacke, F., & Peiseler, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23052668 · Cited by 95 · see citing works

MAIT cell inhibition promotes liver fibrosis regression via macrophage phenotype reprogramming

Mabire, M., Hegde, P., Hammoutene, A., Wan, J., Caër, C., Sayegh, R. A., Cadoux, M., Allaire, M., Weiss, E., Thibault-Sogorb, T., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-37453-5 · Cited by 93 · see citing works

Roles of Matrix Metalloproteinases and Their Natural Inhibitors in Metabolism: Insights into Health and Disease

Molière, S., Jaulin, A., Tomasetto, C., & Dali‐Youcef, N. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241310649 · Cited by 93 · see citing works

The Role of Myeloid-Derived Cells in the Progression of Liver Disease

Weston, C. J., Zimmermann, H. W., & Adams, D. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00893 · Cited by 91 · see citing works

Inhibition of monoacylglycerol lipase, an anti-inflammatory and antifibrogenic strategy in the liver

Habib, A., Chokr, D., Wan, J., Hegde, P., Mabire, M., Siebert, M., Ribeiro-Parenti, L., Le Gall, M., Lettéron, P., Pilard, N., et al. (2019) · Gut · doi:10.1136/gutjnl-2018-316137 · Cited by 91 · see citing works

TIM‐4 interference in Kupffer cells against CCL4‐induced liver fibrosis by mediating Akt1/Mitophagy signalling pathway

Wu, H., Chen, G., Wang, J., Deng, M., Yuan, F., & Gong, J. (2019) · Cell Proliferation · doi:10.1111/cpr.12731 · Cited by 89 · see citing works

The Notch signaling pathway regulates macrophage polarization in liver diseases

Chen, W., Liu, Y., Chen, J., Ma, Y., Song, Y., Cen, Y., You, M., & Yang, G. (2021) · International Immunopharmacology · doi:10.1016/j.intimp.2021.107938 · Cited by 87 · see citing works

The Medium-Chain Fatty Acid Receptor GPR84 Mediates Myeloid Cell Infiltration Promoting Steatohepatitis and Fibrosis

Puengel, T., Vos, S. D., Hundertmark, J., Kohlhepp, M. S., Güldiken, N., Pujuguet, P., Auberval, M., Marsais, F., Shoji, K. F., Sanière, L., et al. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9041140 · Cited by 86 · see citing works

New Drugs for Hepatic Fibrosis

Shan, L., Wang, F., Zhai, D., Meng, X., Liu, J., & Lv, X. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.874408 · Cited by 85 · see citing works

Neutrophils alleviate fibrosis in the CCl4-induced mouse chronic liver injury model

Saijou, E., Enomoto, Y., Matsuda, M., Yuet‐Yin Kok, C., Akira, S., Tanaka, M., & Miyajima, A. (2018) · Hepatology Communications · doi:10.1002/hep4.1178 · Cited by 84 · see citing works

STING signaling activation inhibits HBV replication and attenuates the severity of liver injury and HBV-induced fibrosis

Li, Y., He, M., Wang, Z., Duan, Z., Guo, Z., Wang, Z., Gong, R., Chu, T., Cai, J., & Gao, B. (2021) · Cellular and Molecular Immunology · doi:10.1038/s41423-021-00801-w · Cited by 83 · see citing works

Recent advances of sterile inflammation and inter-organ cross-talk in alcoholic liver disease

Shim, Y., & Jeong, W. (2020) · Experimental & Molecular Medicine · doi:10.1038/s12276-020-0438-5 · Cited by 81 · see citing works

GDF15 Ameliorates Liver Fibrosis by Metabolic Reprogramming of Macrophages to Acquire Anti-Inflammatory Properties

Li, X., Huai, Q., Zhu, C., Zhang, X., Xu, W., Dai, H., & Wang, H. (2023) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2023.07.009 · Cited by 80 · see citing works

Notch-mediated hepatocyte MCP-1 secretion causes liver fibrosis

Kang, J., Postigo, J., Kim, K., Zhu, C., Yu, J., Meroni, M., Mayfield, B., Bartolomé, A., Dapito, D. H., Ferrante, A. W., et al. (2023) · JCI Insight · doi:10.1172/jci.insight.165369 · Cited by 79 · see citing works

Astragalus Polysaccharide RAP Induces Macrophage Phenotype Polarization to M1 via the Notch Signaling Pathway

Wei, W., Li, Z., Bian, Z., & Han, Q. (2019) · Molecules · doi:10.3390/molecules24102016 · Cited by 78 · see citing works

LC3-associated phagocytosis protects against inflammation and liver fibrosis via immunoreceptor inhibitory signaling

Wan, J., Weiss, E., Ben Mkaddem, S., Mabire, M., Choinier, P.-M., Picq, O., Thibault-Sogorb, T., Hegde, P., Pishvaie, D., Bens, M., et al. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aaw8523 · Cited by 77 · see citing works

Metabolism of hepatic stellate cells in chronic liver diseases: emerging molecular and therapeutic interventions

Yan, M., Cui, Y., & Xiang, Q. (2025) · Theranostics · doi:10.7150/thno.106597 · Cited by 76 · see citing works

Pharmacological targets of metabolism in disease: Opportunities from macrophages

Castegna, A., Gissi, R., Menga, A., Montopoli, M., Favia, M., Viola, A., & Canton, M. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107521 · Cited by 75 · see citing works

CCL20 is up-regulated in non-alcoholic fatty liver disease fibrosis and is produced by hepatic stellate cells in response to fatty acid loading

Chu, X., Jin, Q., Chen, H., Wood, G. C., Petrick, A. T., Strodel, W. E., Gabrielsen, J. D., Benotti, P. N., Mirshahi, T., Carey, D. J., et al. (2018) · Journal of Translational Medicine · doi:10.1186/s12967-018-1490-y · Cited by 74 · see citing works

HSPA12A Is a Novel Player in Nonalcoholic Steatohepatitis via Promoting Nuclear PKM2-Mediated M1 Macrophage Polarization

Kong, Q., Li, N., Cheng, H., Zhang, X., Cao, X., Qi, T., Dai, L., Zhang, Z., Chen, X., Li, C., et al. (2018) · Diabetes · doi:10.2337/db18-0035 · Cited by 74 · see citing works

PSMP/MSMP promotes hepatic fibrosis through CCR2 and represents a novel therapeutic target

She, S., Wu, X., Zheng, D., Pei, X., Ma, J., Sun, Y., Zhou, J., Nong, L., Guo, C., Lv, P., et al. (2019) · Journal of Hepatology · doi:10.1016/j.jhep.2019.09.033 · Cited by 74 · see citing works

FGF21 protects against hepatic lipotoxicity and macrophage activation to attenuate fibrogenesis in nonalcoholic steatohepatitis

Liu, C., Schönke, M., Spoorenberg, B., Lambooij, J. M., van der Zande, H. J. P., Zhou, E., Tushuizen, M. E., Andréasson, A., Park, A., Oldham, S. N., et al. (2023) · eLife · doi:10.7554/elife.83075 · Cited by 72 · see citing works

Crosstalk between hepatic stellate cells and surrounding cells in hepatic fibrosis

Yang, F., Li, H., Li, Y., Hao, Y., Wang, C., Jia, P. P., Chen, X., Ma, S., & Xiao, Z. (2021) · International Immunopharmacology · doi:10.1016/j.intimp.2021.108051 · Cited by 71 · see citing works

Role of macrophages in experimental liver injury and repair in mice (Review)

Dong, X., Liu, J., Xu, Y., & Cao, H. (2019) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2019.7450 · Cited by 70 · see citing works

METTL14 downregulation drives S100A4+ monocyte-derived macrophages via MyD88/NF-κB pathway to promote MAFLD progression

Wang, Y.-F., Zhang, W.-L., Li, Z.-X., Liu, Y., Tan, J., Yin, H.-Z., Zhang, Z.-C., Piao, X.-J., Ruan, M.-H., Dai, Z.-H., et al. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01797-1 · Cited by 69 · see citing works

SGLT2 inhibitors ameliorate NAFLD in mice via downregulating PFKFB3, suppressing glycolysis and modulating macrophage polarization

Lin, X.-F., Cui, X.-N., Yang, J., Jiang, Y.-F., Wei, T.-J., Xia, L., Liao, X.-Y., Li, F., Wang, D.-D., Li, J., et al. (2024) · Acta Pharmacologica Sinica · doi:10.1038/s41401-024-01389-3 · Cited by 69 · see citing works

Autophagy deficiency promotes M1 macrophage polarization to exacerbate acute liver injury via ATG5 repression during aging

Liu, R., Cui, J., Sun, Y., Xu, W., Wang, Z., Wu, M., Dong, H., Yang, C., Hong, S., Yin, S., et al. (2021) · Cell Death Discovery · doi:10.1038/s41420-021-00797-2 · Cited by 68 · see citing works

Multiplexing Nanodrug Ameliorates Liver Fibrosis via ROS Elimination and Inflammation Suppression

Xu, Y., Chen, J., Jiang, W., Zhao, Y., Yang, C., Wu, Y., Li, Q., & Zhu, C. (2021) · Small · doi:10.1002/smll.202102848 · Cited by 65 · see citing works

Csi-let-7a-5p delivered by extracellular vesicles from a liver fluke activates M1-like macrophages and exacerbates biliary injuries

Yan, C., Zhou, Q.-Y., Wu, J., Xu, N., Du, Y., Li, J., Liu, J., Koda, S., Zhang, B., Yu, Q., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2102206118 · Cited by 65 · see citing works

miR‐21‐regulated M2 polarization of macrophage is involved in arsenicosis‐induced hepatic fibrosis through the activation of hepatic stellate cells

Xue, J., Xiao, T., Wei, S., Sun, J., Zou, Z., Shi, M., Sun, Q., Dai, X., Wu, L. Y., Li, J., et al. (2021) · Journal of Cellular Physiology · doi:10.1002/jcp.30288 · Cited by 64 · see citing works

Macrophage-specific FGF12 promotes liver fibrosis progression in mice

Li, S., Zhou, B., Xue, M., Zhu, J., Tong, G., Fan, J., Zhu, K., Hu, Z., Chen, R., Dong, Y., et al. (2023) · Hepatology · doi:10.1002/hep.32640 · Cited by 62 · see citing works

The Spleen Promotes the Secretion of CCL2 and Supports an M1 Dominant Phenotype in Hepatic Macrophages During Liver Fibrosis

Li, L., Wei, W., Li, Z., Chen, H., Li, Y., Jiang, W., Chen, W., Kong, G., Yang, J. J., & Li, Z. (2018) · Cellular Physiology and Biochemistry · doi:10.1159/000495276 · Cited by 62 · see citing works

Margatoxin mitigates CCl4‑induced hepatic fibrosis in mice via macrophage polarization, cytokine secretion and STAT signaling

Wu, B., Liu, J., Li, Y., & Li, J. (2019) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2019.4395 · Cited by 62 · see citing works

HMGB1: An overview of its roles in the pathogenesis of liver disease

Ni, Y.-A., Chen, H., Nie, H., Zheng, B., & Gong, Q. (2021) · Journal of Leukocyte Biology · doi:10.1002/jlb.3mr0121-277r · Cited by 60 · see citing works

The Agonists of Peroxisome Proliferator-Activated Receptor-γ for Liver Fibrosis

Li, J., Guo, C., & Wu, J. (2021) · Drug Design Development and Therapy · doi:10.2147/dddt.s310163 · Cited by 55 · see citing works

MiR-130a-3p Alleviates Liver Fibrosis by Suppressing HSCs Activation and Skewing Macrophage to Ly6Clo Phenotype

Liu, L., Wang, P., Wang, Y.-S., Zhang, Y., Li, C., Yang, Z.-Y., Liu, Z.-H., Zhan, T., Xu, J., & Xia, C.-M. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.696069 · Cited by 54 · see citing works

Atf3-mediated metabolic reprogramming in hepatic macrophage orchestrates metabolic dysfunction–associated steatohepatitis

Hu, S., Li, R., Gong, D., Hu, P., Xu, J., Ai, Y., Zhao, X., Hu, C., Xu, M., Liu, C., et al. (2024) · Science Advances · doi:10.1126/sciadv.ado3141 · Cited by 54 · see citing works

Macrophages harness hepatocyte glutamate to boost liver regeneration

Rigual, M. D. M., Angulo-Aguado, M., Zagorac, S., Álvarez-Díaz, R., Benítez-Mondéjar, M., Yi, F., Martínez-Garay, C., Santos-de-Frutos, K., Kim, E., Campos-Olivas, R., et al. (2025) · Nature · doi:10.1038/s41586-025-08778-6 · Cited by 53 · see citing works

Mesenchymal stem cells attenuate liver fibrosis by targeting Ly6Chi/lo macrophages through activating the cytokine-paracrine and apoptotic pathways

Li, Y.-H., Shen, S., Shao, T., Jin, M., Fan, D., Lin, A., Xiang, L., & Shao, J. (2021) · Cell Death Discovery · doi:10.1038/s41420-021-00584-z · Cited by 51 · see citing works

The Crosstalk Between Liver Sinusoidal Endothelial Cells and Hepatic Microenvironment in NASH Related Liver Fibrosis

Du, W., & Wang, L. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.936196 · Cited by 51 · see citing works

MANF brakes TLR4 signaling by competitively binding S100A8 with S100A9 to regulate macrophage phenotypes in hepatic fibrosis

Hou, C., Wang, D., Zhao, M., Ballar, P., Zhang, X., Mei, Q., Wang, W., Li, X., Sheng, Q., Liu, J., et al. (2023) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2023.07.027 · Cited by 51 · see citing works

RIP3 deficiency alleviates liver fibrosis by inhibiting ROCK1–TLR4–NF‐κB pathway in macrophages

Song, W., Zhou, H., Wang, Q., Zhou, S., Li, C., Liu, R., Qiu, J., Shi, C., & Lü, L. (2019) · The FASEB Journal · doi:10.1096/fj.201900752r · Cited by 50 · see citing works

Mitochondrial DNA and the STING pathway are required for hepatic stellate cell activation

Arumugam, S., Li, B., Boodapati, S. L. T., Nathanson, M. H., Sun, B., Ouyang, X., & Mehal, W. Z. (2023) · Hepatology · doi:10.1097/hep.0000000000000388 · Cited by 50 · see citing works

Single‐cell RNA sequencing reveals the heterogeneity and intercellular communication of hepatic stellate cells and macrophages during liver fibrosis

Cheng, S. G., Zou, Y., Zhang, M., Bai, S., Tao, K., Wu, J., Shi, Y., Wu, Y., Lu, Y., He, K., et al. (2023) · MedComm · doi:10.1002/mco2.378 · Cited by 50 · see citing works

Circ_1639 induces cells inflammation responses by sponging miR-122 and regulating TNFRSF13C expression in alcoholic liver disease

Lü, X., Liu, Y., Xuan, W., Ye, J., Yao, H., Huang, C., & Li, J. (2019) · Toxicology Letters · doi:10.1016/j.toxlet.2019.07.021 · Cited by 45 · see citing works

Hexokinase 2-mediated metabolic stress and inflammation burden of liver macrophages via histone lactylation in MASLD

Li, J., Chen, X., Song, S., Jiang, W., Geng, T., Wang, T., Xu, Y. H., Zhu, Y., Lu, J., Xia, Y., et al. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115350 · Cited by 45 · see citing works

Silencing of lncRNA SNHG20 delays the progression of nonalcoholic fatty liver disease to hepatocellular carcinoma via regulating liver Kupffer cells polarization

Wang, B., Li, X., Hu, W., Zhou, Y., & Din, Y. (2019) · IUBMB Life · doi:10.1002/iub.2137 · Cited by 45 · see citing works

Liver macrophages in healthy and diseased liver

Abdullah, Z., & Knolle, P. A. (2017) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-017-1954-6 · Cited by 44 · see citing works

Targeting fatty acid metabolism for fibrotic disorders

Hwang, S., & Chung, K. W. (2021) · Archives of Pharmacal Research · doi:10.1007/s12272-021-01352-4 · Cited by 44 · see citing works

LncRNA FTX represses the progression of non-alcoholic fatty liver disease to hepatocellular carcinoma via regulating the M1/M2 polarization of Kupffer cells

Wu, H., Zhong, Z., Wang, A., Yuan, C., Ning, K., Hu, H., Wang, C., & Yin, X. (2020) · Cancer Cell International · doi:10.1186/s12935-020-01354-0 · Cited by 43 · see citing works

NLRP3 activation in neutrophils induces lethal autoinflammation, liver inflammation, and fibrosis

Kaufmann, B. K., Leszczynska, A., Reca, A., Booshehri, L. M., Onyuru, J., Tan, Z., Wree, A., Friess, H., Hartmann, D., Papouchado, B. G., et al. (2022) · EMBO Reports · doi:10.15252/embr.202154446 · Cited by 43 · see citing works

Deletion of Protein Kinase D3 Promotes Liver Fibrosis in Mice

Zhang, S., Liu, H., Yin, M., Pei, X., Haußer, A., Ishikawa, E., Yamasaki, S., & Jin, Z. G. (2020) · Hepatology · doi:10.1002/hep.31176 · Cited by 41 · see citing works

MicroRNA: role in macrophage polarization and the pathogenesis of the liver fibrosis

Yu, W., Wang, S., Wang, Y., Chen, H., Nie, H., Liu, L., Zou, X., Gong, Q., & Zheng, B. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1147710 · Cited by 41 · see citing works

Differential expression of circular RNAs in hepatic tissue in a model of liver fibrosis and functional analysis of their target genes

Zhou, Y., Lv, X., Qu, H., Zhao, K., Fu, L., Zhu, L., Ye, G., & Guo, J. (2018) · Hepatology Research · doi:10.1111/hepr.13284 · Cited by 41 · see citing works

Salvianolic Acid B Alleviates Liver Injury by Regulating Lactate-Mediated Histone Lactylation in Macrophages

Hu, S., Yang, Z., Li, L., Yan, Q.-W., Hu, Y., Zhou, F., Tan, Y., & Pei, G. (2024) · Molecules · doi:10.3390/molecules29010236 · Cited by 40 · see citing works

Interleukin-22 regulating Kupffer cell polarization through STAT3/Erk/Akt crosstalk pathways to extenuate liver fibrosis

Su, S.-B., Qin, S.-Y., Xian, X.-L., Huang, F.-F., Huang, Q.-L., ZhangDi, H.-J., & Jiang, H.-X. (2021) · Life Sciences · doi:10.1016/j.lfs.2020.118677 · Cited by 40 · see citing works

Spatial dimension of macrophage heterogeneity in liver diseases

Guillot, A., & Tacke, F. (2023) · eGastroenterology · doi:10.1136/egastro-2023-000003 · Cited by 40 · see citing works

Redox-sensitive activation of CCL7 by BRG1 in hepatocytes during liver injury

Kong, M., Dong, W., Zhu, Y., Fan, Z., Miao, X., Guo, Y., Li, C., Duan, Y., Lu, Y., Li, Z., et al. (2021) · Redox Biology · doi:10.1016/j.redox.2021.102079 · Cited by 37 · see citing works

Harnessing metabolism of hepatic macrophages to aid liver regeneration

Liu, R., Scimeca, M., Sun, Q., Melino, G., Mauriello, A., Shao, C., Bernassola, F., Bove, P., Candi, E., Valentina, R., et al. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-06066-7 · Cited by 37 · see citing works

The versatility of macrophage heterogeneity in liver fibrosis

Gao, C.-C., Bai, J., Han, H., & Qin, H. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.968879 · Cited by 37 · see citing works

The P2X7 Receptor and NLRP3 Axis in Non-Alcoholic Fatty Liver Disease: A Brief Review

Rossato, M., Vincenzo, A. D., Pagano, C., Hadi, H. E., & Vettor, R. (2020) · Cells · doi:10.3390/cells9041047 · Cited by 36 · see citing works

c-Rel orchestrates energy-dependent epithelial and macrophage reprogramming in fibrosis

Leslie, J., Macia, M. G., Luli, S., Worrell, J. C., Reilly, W. J., Paish, H. L., Knox, A., Barksby, B. S., Gee, L., Zaki, M. Y. W., et al. (2020) · Nature Metabolism · doi:10.1038/s42255-020-00306-2 · Cited by 36 · see citing works

Peroxidasin Deficiency Re-programs Macrophages Toward Pro-fibrolysis Function and Promotes Collagen Resolution in Liver

Sojoodi, M., Erstad, D. J., Barrett, S. C., Salloum, S., Zhu, S., Qian, T., Colon, S., Gale, E. M., Jordan, V. C., Wang, Y., et al. (2022) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2022.01.015 · Cited by 35 · see citing works

Neutrophil extracellular traps facilitate liver inflammation/fibrosis progression by entering macrophages and triggering AIM2 inflammasome-dependent pyroptosis

Zhang, Y., Wu, R., Zhan, X., Wang, X., Xiang, L.-W., Duan, Y., You, Y., Zhang, Y., Wu, R., Zhang, Y., et al. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-024-01944-9 · Cited by 34 · see citing works

Hepatocyte CYR61 polarizes profibrotic macrophages to orchestrate NASH fibrosis

Mooring, M., Yeung, G. A., Luukkonen, P., Liu, S., Akbar, M. W., Zhang, G. J., Balogun, O., Yu, X., Mo, R., Nejak-Bowen, K., et al. (2023) · Science Translational Medicine · doi:10.1126/scitranslmed.ade3157 · Cited by 33 · see citing works

Hepatocyte ERBB3 and EGFR are required for maximal CCl 4 -induced liver fibrosis

Scheving, L. A., Zhang, X., Threadgill, D. W., & Russell, W. E. (2016) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00423.2015 · Cited by 33 · see citing works

Spleen-derived lipocalin-2 in the portal vein regulates Kupffer cells activation and attenuates the development of liver fibrosis in mice

Aoyama, T., Kuwahara‐Arai, K., Uchiyama, A., Kon, K., Okubo, H., Yamashina, S., Ikejima, K., Kokubu, S., Miyazaki, A., & Watanabe, S. (2017) · Laboratory Investigation · doi:10.1038/labinvest.2017.44 · Cited by 32 · see citing works

CircRNAs: Decrypting the novel targets of fibrosis and aging

Yang, Y., Lei, W., Jiang, S., Ding, B., Wang, C., Chen, Y., Shi, W., Wu, Z., & Tian, Y. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101390 · Cited by 32 · see citing works

WZ66, a novel acetyl-CoA carboxylase inhibitor, alleviates nonalcoholic steatohepatitis (NASH) in mice

Gao, Y., Qian, M., Wei, Q., Duan, X., Wang, S.-L., Hu, H., Liu, J., Pan, C., Zhang, S.-Q., Qi, L., et al. (2019) · Acta Pharmacologica Sinica · doi:10.1038/s41401-019-0310-0 · Cited by 31 · see citing works

Exogenous interleukin-33 promotes hepatocellular carcinoma growth by remodelling the tumour microenvironment

Wang, W., Wu, J., Ji, M., & Wu, C. (2020) · Journal of Translational Medicine · doi:10.1186/s12967-020-02661-w · Cited by 30 · see citing works

C-C motif chemokine receptor 2 inhibition reduces liver fibrosis by restoring the immune cell landscape

Guo, Y., Zhao, C., Dai, W., Wang, B., Lai, E., Xiao, Y., Tang, C., Huang, Z., & Gao, J. (2023) · International Journal of Biological Sciences · doi:10.7150/ijbs.83530 · Cited by 30 · see citing works

Essential role of suppressor of cytokine signaling 1 (SOCS1) in hepatocytes and macrophages in the regulation of liver fibrosis

Mafanda, E. K., Kandhi, R., Bobbala, D., Khan, M. G. M., Nandi, M., Menéndez, A., Ramanathan, S., & Ilangumaran, S. (2018) · Cytokine · doi:10.1016/j.cyto.2018.07.032 · Cited by 28 · see citing works

USP25 stabilizes STAT6 to promote IL-4-induced macrophage M2 polarization and fibrosis

Xu, Y., Liu, J., Wang, J., Wang, J., Lan, P., & Wang, T. (2024) · International Journal of Biological Sciences · doi:10.7150/ijbs.99345 · Cited by 28 · see citing works

MyD88 in Macrophages Enhances Liver Fibrosis by Activation of NLRP3 Inflammasome in HSCs

Ge, S., Yang, W. P., Chen, H., Yuan, Q., Liu, S., Zhao, Y., & Zhang, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222212413 · Cited by 27 · see citing works

Mechanistic role of long non-coding RNAs in the pathogenesis of metabolic dysfunction-associated steatotic liver disease and fibrosis

Wade, H., Pan, K., Zhang, B., Zheng, W., & Su, Q. (2024) · eGastroenterology · doi:10.1136/egastro-2024-100115 · Cited by 27 · see citing works

Expansion of macrophage and liver sinusoidal endothelial cell subpopulations during non-alcoholic steatohepatitis progression

Shen, Z., Shen, B., Dai, W., Zhou, C., Luo, X., Guo, Y., Wang, J., Xu, X., Sun, Z., Cai, X., et al. (2023) · iScience · doi:10.1016/j.isci.2023.106572 · Cited by 26 · see citing works

The role of macrophages in liver fibrosis: composition, heterogeneity, and therapeutic strategies

Ma, X., Qiu, J., Zou, S., Tan, L., & Miao, T. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1494250 · Cited by 26 · see citing works

Macrophage-specific MyD88 deletion and pharmacological inhibition prevents liver damage in non-alcoholic fatty liver disease via reducing inflammatory response

Yang, B., Luo, W., Wang, M., Tang, Y., Zhu, W., Jin, L., Wang, M., Wang, Y., Zhang, Y., Zuo, W., et al. (2022) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2022.166480 · Cited by 24 · see citing works

lncRNA Helf promotes hepatic inflammation and fibrosis by interacting with PTBP1 to facilitate PIK3R5 mRNA stabilization

Han, X., Guo, B., Zhao, S., Li, Y., Zhu, J., He, Y., Wang, J., Yao, Q., Shao, S., Zheng, L., et al. (2023) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-023-00492-3 · Cited by 24 · see citing works

ASH1L in Hepatoma Cells and Hepatic Stellate Cells Promotes Fibrosis‐Associated Hepatocellular Carcinoma by Modulating Tumor‐Associated Macrophages

Du, Y., Wu, S., Xi, S., Xu, W. F., Sun, L.-Z., Yan, J., Gao, H., Wang, Y., Zheng, J., Wang, F., et al. (2024) · Advanced Science · doi:10.1002/advs.202404756 · Cited by 24 · see citing works

Key role of macrophages in the progression of hepatic fibrosis

Ran, J., Yin, S., Issa, R., Zhao, Q., Zhu, G., Zhang, H., Zhang, Q., Wu, C., & Li, J. (2024) · Hepatology Communications · doi:10.1097/hc9.0000000000000602 · Cited by 24 · see citing works

Sphingosine Kinase 1 Aggravates Liver Fibrosis by Mediating Macrophage Recruitment and Polarization

Ding, X., Zhang, X., Cao, J., Chen, S., Chen, Y., Yuan, K., Chen, B., Yang, G., Li, S., Yang, J., et al. (2024) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2024.101406 · Cited by 23 · see citing works

Circular RNAs in liver diseases: Mechanisms and therapeutic targets

Fu, L., Wang, S., Hu, M., Jiang, Z., Shen, L.-L., Zhou, Y., Guo, J.-M., & Hu, Y. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118707 · Cited by 23 · see citing works

Fibrinogen-like protein 2 promotes proinflammatory macrophage polarization and mitochondrial dysfunction in liver fibrosis

Tao, R., Han, M., Yuan, W., Xiao, F., Huang, J., Wang, X., Luo, X., Yan, W., Wan, X., & Ning, Q. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2022.109631 · Cited by 23 · see citing works

TREM2-expressing macrophages in liver diseases

Wang, X., Qiu, Z., Zhong, Z., & Liang, S. (2025) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2025.04.009 · Cited by 23 · see citing works

Saturated Fat-Mediated Upregulation of IL-32 and CCL20 in Hepatocytes Contributes to Higher Expression of These Fibrosis-Driving Molecules in MASLD

Schilcher, K., Dayoub, R., Kubitza, M., Riepl, J., Klein, K., Buechler, C., Melter, M., & Weiß, T. S. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241713222 · Cited by 22 · see citing works

Decreased ferroportin in hepatocytes promotes macrophages polarize towards an M2-like phenotype and liver fibrosis

Cai, C., Zeng, D., Gao, Q., Ma, L., Zeng, B., Zhou, Y., & Wang, H. (2021) · Scientific Reports · doi:10.1038/s41598-021-92839-z · Cited by 22 · see citing works

Splenectomy enhances the Ly6Clow phenotype in hepatic macrophages by activating the ERK1/2 pathway during liver fibrosis

Zheng, Z., Wang, H., Li, L., Zhang, S., Zhang, C., Zhang, H., Ji, F., Liu, X., Zhu, K., Kong, G., et al. (2020) · International Immunopharmacology · doi:10.1016/j.intimp.2020.106762 · Cited by 21 · see citing works

Deficient chaperone‐mediated autophagy in macrophage aggravates inflammation of nonalcoholic steatohepatitis by targeting Nup85

Zhang, M., Tian, S.-Y., Ma, S.-Y., Zhou, X., Zheng, X.-H., Li, B., Guo, G.-Y., Yu, J. H., Su, R., Yang, F.-F., et al. (2023) · Liver international (Print) · doi:10.1111/liv.15547 · Cited by 21 · see citing works

MiR-155-5p-SOCS1/JAK1/STAT1 participates in hepatic lymphangiogenesis in liver fibrosis and cirrhosis by regulating M1 macrophage polarization

Bi, J., Liu, J., Chen, X., Shi, N., Wu, H., Tang, H., & Mao, J. (2023) · Human & Experimental Toxicology · doi:10.1177/09603271221141695 · Cited by 21 · see citing works

Chemokine Receptor Ccr6 Deficiency Alters Hepatic Inflammatory Cell Recruitment and Promotes Liver Inflammation and Fibrosis

Affò, S., Rodrigo‐Torres, D., Blaya, D., Morales‐Ibanez, O., Coll, M., Millán, C., Altamirano, J., Arroyo, V., Caballería, J., Bataller, R. A., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0145147 · Cited by 20 · see citing works

TJ-M2010-5, A self-developed MyD88 inhibitor, attenuates liver fibrosis by inhibiting the NF-κB pathway

Xie, Y., Du, D., Zhang, L., Yang, Y., Zou, Z., Li, Z., Zhou, L., Shang, R., & Zhou, P. (2022) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2022.109839 · Cited by 19 · see citing works

Autophagy affects hepatic fibrosis progression by regulating macrophage polarization and exosome secretion

Hu, Z., Chen, G., Yan, C., Li, Z., Wu, T., Li, L., & Zhang, S. (2023) · Environmental Toxicology · doi:10.1002/tox.23795 · Cited by 18 · see citing works

E2F2 Reprograms Macrophage Function By Modulating Material and Energy Metabolism in the Progression of Metabolic Dysfunction‐Associated Steatohepatitis

Liu, Z., Wang, H., Liang, Y., Liu, M., Huang, Q.-Y., Wang, M., Zhou, J.-R., Bu, Q.-F., Zhou, H., & Lu, L. (2024) · Advancement of science · doi:10.1002/advs.202410880 · Cited by 15 · see citing works

Sphingosine 1-Phosphate Receptor Blockade Affects Pro-Inflammatory Bone Marrow-Derived Macrophages and Relieves Mouse Fatty Liver Injury

Yang, J., Chang, N., Yang, L., Ji, X., Zhou, X., Tian, L., Ma, Y., Yang, Y., Liu, Y., Yang, L., et al. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20194695 · Cited by 14 · see citing works

Inhibition of IL-33 signaling ameliorate hepatic fibrosis with decreasing MCP-1 in a mouse model of diabetes and non-alcoholic steatohepatitis; comparison for luseogliflozin, an SGLT2 inhibitor

Wakamatsu, S., Jojima, T., Hashiguchi, M., Kishi, H., Niitani, T., Sakurai, S., Iijima, T., Kogai, T., Tomaru, T., Usui, I., et al. (2023) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2023.108650 · Cited by 13 · see citing works

Therapeutic Targeting of PKM2 Ameliorates NASH Fibrosis Progression in A Macrophage-Specific and Liver-Specific Manner

Qu, H., Zhang, D., Liu, J., Deng, J., Xie, R., Zhang, K.-K., Li, H., Tao, P., Wang, G., Sun, J., et al. (2024) · Engineering · doi:10.1016/j.eng.2024.05.005 · Cited by 13 · see citing works

N6-Methyladenosine modification of circDcbld2 in Kupffer cells promotes hepatic fibrosis via targeting miR-144-3p/Et-1 axis

Zhu, S., Chen, X., Sun, L., Li, X., Chen, Y., Li, L., Suo, X.-G., Xu, C., Ji, M.-L., Wang, J., et al. (2024) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2024.11.003 · Cited by 13 · see citing works

Single-cell RNA seq identifies Plg-RKT-PLG as signals inducing phenotypic transformation of scar-associated macrophage in liver fibrosis

Yang, Y., Li, W., Liu, C., Liu, J., Yang, L., Yue, W., Yang, L., Xue, R., Zhang, K., Zhang, H., et al. (2023) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2023.166754 · Cited by 12 · see citing works

Hepatic stellate cell-intrinsic role of SOCS1 in controlling hepatic fibrogenic response and the pro-inflammatory macrophage compartment during liver fibrosis

Kandhi, R., Yeganeh, M., Yoshimura, A., Menéndez, A., Ramanathan, S., & Ilangumaran, S. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1259246 · Cited by 11 · see citing works

FABP7 in Hepatic Macrophages Promotes Fibroblast Activation and CD4 ⁺ T‐Cell Migration by Regulating M2 Polarization During Liver Fibrosis

Miyazaki, H., Wannakul, T., Yang, S., Yang, D., Karasawa, A., Shishido, A., Cao, R., Yamamoto, Y., Kagawa, Y., Kobayashi, S., et al. (2025) · Journal of Immunology Research · doi:10.1155/jimr/6987981 · Cited by 9 · see citing works

TIMP-1 Promotes Expression of MCP-1 and Macrophage Migration by Inducing Fli-1 in Experimental Liver Fibrosis

Huang, X., Wang, X.-F., Wang, Y., Shen, S., Chen, W., Liu, T., Wang, P., Fan, X., Liu, L., Jia, J.-D., et al. (2024) · Journal of Clinical and Translational Hepatology · doi:10.14218/jcth.2023.00514 · Cited by 9 · see citing works

Macrophage miR-4524a-5p/TBP promotes β-TrCP -TIM3 complex activation and TGFβ release and aggravates NAFLD-associated fibrosis

Li, C., Fang, L., Su, X., Zhang, J., Xiong, H., Yu, H., Zhu, Z., Lin, X., Min, K., Wu, D., et al. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-07574-4 · Cited by 9 · see citing works

Reduction of alternative polarization of macrophages by short-term activated hepatic stellate cell-derived small extracellular vesicles

Sun, Y., Zhao, M., Cheng, L., He, X., Shen, S., Lv, J., Zhang, J., Shao, Q., Yin, W., Zhao, F., et al. (2025) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-025-03380-0 · Cited by 8 · see citing works

The possible pathogenesis of liver fibrosis: therapeutic potential of natural polyphenols

Niu, C., Zhang, J., & Okolo, P. I., III (2024) · Pharmacological Reports · doi:10.1007/s43440-024-00638-w · Cited by 7 · see citing works

Design, molecular characterization and therapeutic investigation of a novel CCR8 peptide antagonist that attenuates acute liver injury by inhibiting infiltration and activation of macrophages

Geervliet, E., Arora, S., Donohue, D. S., Pinheiro, C. A. D. A., Terstappen, L. W. M. M., Schasfoort, R. B. M., Paez, J. I., Kumar, R., & Bansal, R. (2025) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2025.02.018 · Cited by 6 · see citing works

Macrophage duality in liver diseases: heterogeneity, plasticity, and the quest for precision therapeutics

Chen, L., Chen, Y., Zhao, M., Yang, X., Sutte, K., Lu, M., Chen, J., Zheng, X., Yang, D., & Liu, J. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1814879 · Cited by 1 · see citing works

Glyphosate Induces Liver Macrophage Pyroptosis via Mitochondrial Damage-Mediated cGAS-STING Activation

Yu, X., Ren, J., Kang, Y., Wang, S., Dou, J., & Yu, Y. (2026) · Toxics · doi:10.3390/toxics14060461 · Cited by 1 · see citing works

NAFLD-associated immune remodeling in colorectal cancer liver metastasis: mechanisms and implications for immunotherapy

Wang, H., & Gu, G. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1863647 · Cited by 1 · see citing works

Liver Macrophages in the Pathogenesis of Viral Hepatitis

Tsomidis, I., Tsakou, A., Voumvouraki, A., & Kouroumalis, E. (2026) · Current Issues in Molecular Biology · doi:10.3390/cimb48070687 · Cited by 2 · see citing works

Comparative Analysis of Classical and Emerging Experimental Animal Models of Liver Injury: A Comprehensive Review

Salman, I. N., Jabbar, R. K., Emad, I., Hassan, Z. A. A., Harbi, A. M., Khudhair, A. Y., Hussein, M. A. M., Hamid, A. M., Amir, M. A. A., Ali, M. W., et al. (2026) · Journal of Applied Toxicology · doi:10.1002/jat.70268

The Potential Role of THR-β Agonizts in Reversing Liver Fibrosis and Cirrhosis Across Etiologies

Lankarani, K. B. (2026) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000002361

Macrophages diverge into profibrotic SAMs and proresolving ReM2 cells to regulate liver fibrosis

Zhang, D., Liu, X., Ma, D., Liao, L., Duan, F., Wang, Y., Zhang, T., Liu, J., Dong, W., Jin, J. N., et al. (2026) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2611441123

Hepatocyte NAT10-mediated ac4C regulation contributes to TGFβ1-associated Kupffer cell –HSC communication in steatotic liver disease

Zeng, M., Guan, Q., Guo, Y., Cheng, H., Zhou, X., Cai, H., & Li, B. (2026) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2026.154477

Mechanisms underlying the role of the oral-gut-liver axis in the promotion of liver fibrosis by periodontal disease: an interacting network of inflammation, microbiota, and barrier function

Li, S.-X., Gao, Z.-H., Ma, Y.-T., Zhang, J.-Q., & Wei, W. (2026) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2026.1942882

Exposure-shaped immunometabolic networks in chronic liver disease: translating multi-omics and artificial intelligence into preventive biomarkers

Wang, H., Tang, Q., Hu, J., Li, J., & Huang, Q. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1866951

Maladaptive Liver Regeneration in Chronic Liver Disease: Cellular Mechanisms Linking Ductular Reaction, Parenchymal Extinction, and Extracellular Matrix Remodelling

Szymonik, M., Krasucka, N., Krupa, M., Małek, D., Płaza-Kościańczuk, J., Kleinrok, J., Pająk, W., Rusztyn, K., Mazur, M., & Korolczuk, A. (2026) · Journal of Personalized Medicine · doi:10.3390/jpm16100526

Cannabidiol suppresses M2-like macrophage polarization via TRPV4/RhoA/ROCK signaling to alleviate hepatic fibrosis

Zhao, P., Liu, Y., Wang, L., Yuan, M., Wang, X., He, P., & Wang, Y. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1951332

Hepatic macrophages: Key players in the development and progression of liver fibrosis

Cheng, D., Chai, J., Wang, H., Fu, L., Peng, S., & Ni, X. (2021) · Liver International · doi:10.1111/liv.14940 · Cited by 188 · see citing works

Key role of macrophages in the progression of hepatic fibrosis

Ran, J., Yin, S., Issa, R., Zhao, Q., Zhu, G., Zhang, H., Zhang, Q., Wu, C., & Li, J. (2024) · Hepatology Communications · doi:10.1097/hc9.0000000000000602 · Cited by 24 · see citing works

Macrophages Serve as Bidirectional Regulators and Potential Therapeutic Targets for Liver Fibrosis

Liang, W. H., Huang, X., & Shi, J. (2023) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-023-01173-w · Cited by 7 · see citing works

New insights into therapeutic strategies for targeting hepatic macrophages to alleviate liver fibrosis

Zhang, J., Xie, Z., Zhu, X., Xu, C., Lin, J., Zhao, M., & Cheng, Y. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.114864 · Cited by 11 · see citing works

Role of Macrophages in Liver Fibrosis.

Sun, C., & Matsukawa, A. (2024) · PubMed · doi:10.18926/amo/66664 · Cited by 9 · see citing works