The age-associated loss of ischemic preconditioning in the kidney is accompanied by mitochondrial dysfunction, increased protein acetylation and decreased autophagy

Jankauskas, Stanislovas S.; Pevzner, Irina B.; Andrianova, Nadezda V.; Zorova, Ljubava D.; Popkov, Vasily A.; Silachev, Denis N.; Kolosova, Nataliya G.; Plotnikov, Egor Y.; Zorov, Dmitry B.

doi:10.1038/srep44430

The age-associated loss of ischemic preconditioning in the kidney is accompanied by mitochondrial dysfunction, increased protein acetylation and decreased autophagy

In young rats, ischemic preconditioning (IPC), which consists of 4 cycles of ischemia and reperfusion alleviated kidney injury caused by 40-min ischemia. However,old rats lost their ability to protect the ischemic kidney by IPC. A similar aged phenotype was demonstrated in 6-month-old OXYS rats h…