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Cited by 21Neurotransmitter Receptor Influence on BehaviorStress Responses and CortisolNeuroendocrine regulation and behavior

Effect of voluntary alcohol consumption on Maoa expression in the mesocorticolimbic brain of adult male rats previously exposed to prolonged maternal separation

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Bendre, M, Comasco, E, Nylander, I, Nilsson, K W·2015·Translational Psychiatry
DOI 10.1038/tp.2015.186PMC PMC5068586
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Abstract

Discordant associations between monoamine oxidase A (MAOA) genotype and high alcohol drinking have been reported in human and non-human primates. Environmental influences likely moderate genetic susceptibility. The biological basis for this interplay remains elusive, and inconsistencies call for translational studies in which conditions can be controlled and brain tissue is accessible. The present study investigated whether early life stress and subsequent adult episodic alcohol consumption affect Maoa expression in stress- and reward-related brain regions in the rat. Outbred Wistar rats were exposed to rearing conditions associated with stress (prolonged maternal separation) or no stress during early life, and given free choice between alcohol and/or water in adulthood. Transcript levels of Maoa were assessed in the ventral tegmental area, nucleus accumbens (NAc), medial prefrontal cortex, cingulate cortex, amygdala and dorsal striatum (DS). Blood was collected to assess corticosterone levels. After alcohol consumption, lower blood corticosterone and Maoa expression in the NAc and DS were found in rats exposed to early life stress compared with control rats. An interaction between early life stress and voluntary alcohol intake was found in the NAc. Alcohol intake before death correlated negatively with Maoa expression in DS in high alcohol-drinking rats exposed to early life stress. Maoa expression is sensitive to adulthood voluntary alcohol consumption in the presence of early life stress in outbred rats. These findings add knowledge of the molecular basis of the previously reported associations between early life stress, MAOA and susceptibility to alcohol misuse.

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  • In rats undergoing maternal separation, low levels of MAOA correlate with higher voluntary alcohol consumption.

    “In rats that undergo maternal separation, low levels of MAOA correlate to higher voluntary alcohol consumption (Bendre et al. 2015).”

    From Decoding the bidirectional links between alcohol misuse and aggression: toward a unified translational framework (2026) · cites this paper as Bendre et al. 2015

    The Abstract (page unavailable) reports a negative correlation between alcohol intake and Maoa expression in the dorsal striatum of high alcohol-drinking rats exposed to early-life stress. The citing sentence omits those restrictions and refers broadly to MAOA levels in rats undergoing maternal separation; the paper measured Maoa transcript expression, not MAOA protein levels. (LLM, conf=0.85)

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Research works printed but not linked: 88

  1. Rehm J, Mathers C, Popova S, Thavorncharoensap M, Teerawattananon Y, Patra J. Global burden of disease and injury and economic cost attributable to alcohol use and alcohol-use disorders. Lancet 2009; 373: 2223–2233. 19560604
  2. Spanagel R, Noori HR, Heilig M. Stress and alcohol interactions: animal studies and clinical significance. Trends Neurosci 2014; 37: 219–227. 24636458
  3. Koob GF. Theoretical frameworks and mechanistic aspects of alcohol addiction: alcohol addiction as a reward deficit disorder. Curr Top Behav Neurosci 2013; 13: 3–30. 21744309 PMC3448980
  4. Contet C. Gene expression under the influence: transcriptional profiling of ethanol in the brain. Curr Psychopharmacol 2012; 1: 301–314. 24078902 PMC3783024
  5. Porrino LJ, Whitlow CT, Samson HH. Effects of the self-administration of ethanol and ethanol/sucrose on rates of local cerebral glucose utilization in rats. Brain Res 1998; 791: 18–26. 9593807
  6. Vilpoux C, Warnault V, Pierrefiche O, Daoust M, Naassila M. Ethanol-sensitive brain regions in rat and mouse: a cartographic review, using immediate early gene expression. Alcohol Clin Exp Res 2009; 33: 945–969. 19302091
  7. Spanagel R. Alcoholism: a systems approach from molecular physiology to addictive behavior. Physiol Rev 2009; 89: 649–705. 19342616
  8. Robison AJ, Nestler EJ. Transcriptional and epigenetic mechanisms of addiction. Nat Rev Neurosci 2011; 12: 623–637. 21989194 PMC3272277
  9. Sari Y, Johnson VR, Weedman JM. Role of the serotonergic system in alcohol dependence: from animal models to clinics. Prog Mol Biol Transl Sci 2011; 98: 401–443. 21199778 PMC3508458
  10. Marcinkiewcz CA. Serotonergic systems in the pathophysiology of ethanol dependence: relevance to clinical alcoholism. ACS Chem Neurosci 2015; 6: 1026–1039. 25654315 PMC10265695
  11. Koob GF, Volkow ND. Neurocircuitry of addiction. Neuropsychopharmacology 2010; 35: 217–238. 19710631 PMC2805560
  12. Brand I, Fliegel S, Spanagel R, Noori HR. Global ethanol-induced enhancements of monoaminergic neurotransmission: a meta-analysis study. Alcohol Clin Exp Res 2013; 37: 2048–2057. 23808660
  13. Healey JC, Winder DG, Kash TL. Chronic ethanol exposure leads to divergent control of dopaminergic synapses in distinct target regions. Alcohol 2008; 42: 179–190. 18358675 PMC2855295
  14. Budygin EA, John CE, Mateo Y, Daunais JB, Friedman DP, Grant KA et al. Chronic ethanol exposure alters presynaptic dopamine function in the striatum of monkeys: a preliminary study. Synapse 2003; 50: 266–268. 14515345
  15. Brodie MS. Increased ethanol excitation of dopaminergic neurons of the ventral tegmental area after chronic ethanol treatment. Alcohol Clin Exp Res 2002; 26: 1024–1030. 12170113
  16. Ollat H, Parvez H, Parvez S. Alcohol and central neurotransmission. Neurochem Int 1988; 13: 275–300. 19651084
  17. Rimondini R, Arlinde C, Sommer W, Heilig M. Long-lasting increase in voluntary ethanol consumption and transcriptional regulation in the rat brain after intermittent exposure to alcohol. FASEB J 2002; 16: 27–35. 11772933
  18. Jonsson S, Ericson M, Soderpalm B. Modest long-term ethanol consumption affects expression of neurotransmitter receptor genes in the rat nucleus accumbens. Alcohol Clin Exp Res 2014; 38: 722–729. 24224855
  19. Ducci F, Goldman D. Genetic approaches to addiction: genes and alcohol. Addiction 2008; 103: 1414–1428. 18422824 PMC2665791
  20. De Bellis MD. Developmental traumatology: a contributory mechanism for alcohol and substance use disorders. Psychoneuroendocrinology 2002; 27: 155–170. 11750776
  21. Becker HC, Lopez MF, Doremus-Fitzwater TL. Effects of stress on alcohol drinking: a review of animal studies. Psychopharmacology 2011; 218: 131–156. 21850445 PMC3247761
  22. Meaney MJ. Maternal care, gene expression, and the transmission of individual differences in stress reactivity across generations. Annu Rev Neurosci 2001; 24: 1161–1192. 11520931
  23. Molet J, Maras PM, Avishai-Eliner S, Baram TZ. Naturalistic rodent models of chronic early-life stress. Dev Psychobiol 2014; 56: 1675–1688. 24910169 PMC4777289
  24. Spivey JM, Padilla E, Shumake JD, Gonzalez-Lima F. Effects of maternal separation, early handling, and gonadal sex on regional metabolic capacity of the preweanling rat brain. Brain Res 2011; 1367: 198–206. 20969837 PMC3004994
  25. Maccari S, Krugers HJ, Morley-Fletcher S, Szyf M, Brunton PJ. The consequences of early-life adversity: neurobiological, behavioural and epigenetic adaptations. J Neuroendocrinol 2014; 26: 707–723. 25039443
  26. Barr CS. Non-human primate models of alcohol-related phenotypes: the influence of genetic and environmental factors. Curr Top Behav Neurosci 2013; 13: 223–249. 21706389
  27. Enoch MA. Genetic and environmental influences on the development of alcoholism: resilience vs. risk. Ann NY Acad Sci 2006; 1094: 193–201. 17347351
  28. Shih JC, Chen K, Ridd MJ. Monoamine oxidase: from genes to behavior. Annu Rev Neurosci 1999; 22: 197–217. 10202537 PMC2844879
  29. Berry MD, Juorio AV, Paterson IA. The functional role of monoamine oxidases A and B in the mammalian central nervous system. Prog Neurobiol 1994; 42: 375–391. 8058968
  30. Brunner HG, Nelen M, Breakefield XO, Ropers HH, van Oost BA. Abnormal behavior associated with a point mutation in the structural gene for monoamine oxidase A. Science 1993; 262: 578–580. 8211186
  31. Denney RM, Koch H, Craig IW. Association between monoamine oxidase A activity in human male skin fibroblasts and genotype of the MAOA promoter-associated variable number tandem repeat. Human Genet 1999; 105: 542–551. 10647887
  32. Sabol SZ, Hu S, Hamer D. A functional polymorphism in the monoamine oxidase A gene promoter. Human Genet 1998; 103: 273–279. 9799080
  33. Fowler JS, Alia-Klein N, Kriplani A, Logan J, Williams B, Zhu W et al. Evidence that brain MAO A activity does not correspond to MAO A genotype in healthy male subjects. Biol Psychiatry 2007; 62: 355–358. 17141746 PMC2712611
  34. Shumay E, Logan J, Volkow ND, Fowler JS. Evidence that the methylation state of the monoamine oxidase A (MAOA) gene predicts brain activity of MAO A enzyme in healthy men. Epigenetics 2012; 7: 1151–1160. 22948232 PMC3469457
  35. Cervera-Juanes R, Wilhem LJ, Park B, Lee R, Locke J, Helms C et al. MAOA expression predicts vulnerability for alcohol use. Mol Psychiatry advance online publication, 7 July 2015; doi:10.1038/mp.2015.93. PMC4705001 26148813 · DOI
  36. Oreland L, Nilsson K, Damberg M, Hallman J. Monoamine oxidases: activities, genotypes and the shaping of behaviour. J Neural Transm 2007; 114: 817–822. 17426915
  37. Nilsson KW, Sjoberg RL, Damberg M, Leppert J, Ohrvik J, Alm PO et al. Role of monoamine oxidase A genotype and psychosocial factors in male adolescent criminal activity. Biol Psychiatry 2006; 59: 121–127. 16125147
  38. Caspi A, McClay J, Moffitt TE, Mill J, Martin J, Craig IW et al. Role of genotype in the cycle of violence in maltreated children. Science 2002; 297: 851–854. 12161658
  39. Guindalini C, Scivoletto S, Ferreira RG, Nishimura A, Zilberman ML, Peluso MM et al. Association of MAO A polymorphism and alcoholism in Brazilian females. Psychiatr Genet 2005; 15: 141–144. 15900229
  40. Contini V, Marques FZ, Garcia CE, Hutz MH, Bau CH. MAOA-uVNTR polymorphism in a Brazilian sample: further support for the association with impulsive behaviors and alcohol dependence. Am J Med Genet B Neuropsychiatr Genet 2006; 141B: 305–308. 16526025
  41. Nilsson KW, Sjoberg RL, Wargelius HL, Leppert J, Lindstrom L, Oreland L. The monoamine oxidase A (MAO-A) gene, family function and maltreatment as predictors of destructive behaviour during male adolescent alcohol consumption. Addiction 2007; 102: 389–398. 17298646
  42. Ducci F, Enoch MA, Hodgkinson C, Xu K, Catena M, Robin RW et al. Interaction between a functional MAOA locus and childhood sexual abuse predicts alcoholism and antisocial personality disorder in adult women. Mol Psychiatry 2008; 13: 334–347. 17592478
  43. Nilsson KW, Wargelius HL, Sjoberg RL, Leppert J, Oreland L. The MAO-A gene, platelet MAO-B activity and psychosocial environment in adolescent female alcohol-related problem behaviour. Drug Alcohol Depend 2008; 93: 51–62. 18029114
  44. Nilsson KW, Comasco E, Aslund C, Nordquist N, Leppert J, Oreland L. MAOA genotype, family relations and sexual abuse in relation to adolescent alcohol consumption. Addict Biol 2011; 16: 347–355. 20731636
  45. Ducci F, Newman TK, Funt S, Brown GL, Virkkunen M, Goldman D. A functional polymorphism in the MAOA gene promoter (MAOA-LPR) predicts central dopamine function and body mass index. Mol Psychiatry 2006; 11: 858–866. 16770335
  46. Samochowiec J, Lesch KP, Rottmann M, Smolka M, Syagailo YV, Okladnova O et al. Association of a regulatory polymorphism in the promoter region of the monoamine oxidase A gene with antisocial alcoholism. Psychiatr Res 1999; 86: 67–72. 10359483
  47. Newman TK, Syagailo YV, Barr CS, Wendland JR, Champoux M, Graessle M et al. Monoamine oxidase A gene promoter variation and rearing experience influences aggressive behavior in rhesus monkeys. Biol Psychiatry 2005; 57: 167–172. 15652876
  48. Barr CS, Schwandt ML, Newman TK, Higley JD. The use of adolescent nonhuman primates to model human alcohol intake: neurobiological, genetic, and psychological variables. Ann NY Acad Sci 2004; 1021: 221–233. 15251892
  49. Haberstick BC, Lessem JM, Hewitt JK, Smolen A, Hopfer CJ, Halpern CT et al. MAOA genotype, childhood maltreatment, and their interaction in the etiology of adult antisocial behaviors. Biol Psychiatry 2014; 75: 25–30. 23726513 PMC3815496
  50. Goldman D, Rosser AA. MAOA-environment interactions: results may vary. Biol Psychiatry 2014; 75: 2–3. 24314060 PMC5895079
  51. Koller G, Bondy B, Preuss UW, Bottlender M, Soyka M. No association between a polymorphism in the promoter region of the MAOA gene with antisocial personality traits in alcoholics. Alcohol Alcohol 2003; 38: 31–34. 12554604
  52. Pautassi RM, Camarini R, Quadros IM, Miczek KA, Israel Y. Genetic and environmental influences on ethanol consumption: perspectives from preclinical research. Alcohol Clin Exp Res 2010; 34: 976–987. 20374217 PMC4404761
  53. Nylander I, Roman E. Is the rodent maternal separation model a valid and effective model for studies on the early-life impact on ethanol consumption? Psychopharmacology (Berl) 2013; 229: 555–569. 23982922 PMC3782650
  54. Gustafsson L, Nylander I. Time-dependent alterations in ethanol intake in male wistar rats exposed to short and prolonged daily maternal separation in a 4-bottle free-choice paradigm. Alcohol Clin Exp Res 2006; 30: 2008–2016. 17117966
  55. Ruijter JM, Ramakers C, Hoogaars WM, Karlen Y, Bakker O, van den Hoff MJ et al. Amplification efficiency: linking baseline and bias in the analysis of quantitative PCR data. Nucleic Acids Res 2009; 37: e45. 19237396 PMC2665230
  56. Daoura L, Haaker J, Nylander I. Early environmental factors differentially affect voluntary ethanol consumption in adolescent and adult male rats. Alcohol Clin Exp Res 2011; 35: 506–515. 21143247
  57. Vitalis T, Fouquet C, Alvarez C, Seif I, Price D, Gaspar P et al. Developmental expression of monoamine oxidases A and B in the central and peripheral nervous systems of the mouse. J Comp Neurol 2002; 442: 331–347. 11793338
  58. Gaspar P, Cases O, Maroteaux L. The developmental role of serotonin: news from mouse molecular genetics. Nat Rev Neurosci 2003; 4: 1002–1012. 14618156
  59. Cases O, Seif I, Grimsby J, Gaspar P, Chen K, Pournin S et al. Aggressive behavior and altered amounts of brain serotonin and norepinephrine in mice lacking MAOA. Science 1995; 268: 1763–1766. 7792602 PMC2844866
  60. Tzschentke TM, Schmidt WJ. Functional relationship among medial prefrontal cortex, nucleus accumbens, and ventral tegmental area in locomotion and reward. Crit Rev Neurobiol 2000; 14: 131–142. 11513242
  61. Grunewald M, Johnson S, Lu D, Wang Z, Lomberk G, Albert PR et al. Mechanistic role for a novel glucocorticoid-KLF11 (TIEG2) protein pathway in stress-induced monoamine oxidase A expression. J Biol Chem 2012; 287: 24195–24206. 22628545 PMC3397846
  62. Marquez C, Poirier GL, Cordero MI, Larsen MH, Groner A, Marquis J et al. Peripuberty stress leads to abnormal aggression, altered amygdala and orbitofrontal reactivity and increased prefrontal MAOA gene expression. Transl Psychiatry 2013; 3: e216. 23321813 PMC3566724
  63. Oreland L, Wiberg A, Winblad B, Fowler CJ, Gottfries CG, Kiianmaa K. The activity of monoamine oxidase -A and -B in brains from chronic alcoholics. J Neural Transm 1983; 56: 73–83. 6854311
  64. Sherif F, Wahlstrom G, Oreland L. Brain GABA-transaminase and monoamine oxidase after chronic ethanol treatment in rats. Alcohol Clin Exp Res 1993; 17: 1313–1318. 8116848
  65. Wiberg A, Wahlstroom G, Oreland L. Brain monoamine oxidase activity after chronic ethanol treatment of rats. Psychopharmacology 1977; 52: 111–113. 407593
  66. Fils-Aime ML, Eckardt MJ, George DT, Brown GL, Mefford I, Linnoila M. Early-onset alcoholics have lower cerebrospinal fluid 5-hydroxyindoleacetic acid levels than late-onset alcoholics. Arch Gen Psychiatry 1996; 53: 211–216. 8611057
  67. Sher L, Oquendo MA, Grunebaum MF, Burke AK, Huang YY, Mann JJ. CSF monoamine metabolites and lethality of suicide attempts in depressed patients with alcohol dependence. Eur Neuropsychopharmacol 2007; 17: 12–15. 16762535 PMC3869621
  68. Oreland S, Raudkivi K, Oreland L, Harro J, Arborelius L, Nylander I. Ethanol-induced effects on the dopamine and serotonin systems in adult Wistar rats are dependent on early-life experiences. Brain Res 2011; 1405: 57–68. 21741625
  69. Gongwer MA, Murphy JM, McBride WJ, Lumeng L, Li TK. Regional brain contents of serotonin, dopamine and their metabolites in the selectively bred high- and low-alcohol drinking lines of rats. Alcohol 1989; 6: 317–320. 2475142
  70. Murphy JM, McBride WJ, Lumeng L, Li TK. Regional brain levels of monoamines in alcohol-preferring and -nonpreferring lines of rats. Pharmacol Biochem Behav 1982; 16: 145–149. 6173885
  71. Murphy JM, McBride WJ, Lumeng L, Li TK. Contents of monoamines in forebrain regions of alcohol-preferring (P) and -nonpreferring (NP) lines of rats. Pharmacol Biochem Behav 1987; 26: 389–392. 2437596
  72. Banki CM. Factors influencing monoamine metabolites and tryptophan in patients with alcohol dependence. J Neural Transm 1981; 50: 89–101. 6165805
  73. Roman E, Nylander I. The impact of emotional stress early in life on adult voluntary ethanol intake-results of maternal separation in rats. Stress 2005; 8: 157–174. 16323264
  74. Momeni S, Roman E. Subgroup-dependent effects of voluntary alcohol intake on behavioral profiles in outbred Wistar rats. Behav Brain Res 2014; 275: 288–296. 25200519
  75. Crabbe JC, Harris RA, Koob GF. Preclinical studies of alcohol binge drinking. Ann NY Acadof Sci 2011; 1216: 24–40. PMC3076900 21272009
  76. Palm S, Nylander I. Alcohol-induced changes in opioid peptide levels in adolescent rats are dependent on housing conditions. Alcohol Clin Exp Res 2014; 38: 2978–2987. 25515651 PMC4312983
  77. Simms JA, Steensland P, Medina B, Abernathy KE, Chandler LJ, Wise R et al. Intermittent access to 20% ethanol induces high ethanol consumption in Long-Evans and Wistar rats. Alcohol Clin Exp Res 2008; 32: 1816–1823. 18671810 PMC3151464
  78. Rhodes JS, Best K, Belknap JK, Finn DA, Crabbe JC. Evaluation of a simple model of ethanol drinking to intoxication in C57BL/6J mice. Physiol Behav 2005; 84: 53–63. 15642607
  79. Becker HC. Animal models of excessive alcohol consumption in rodents. Curr Top Behav Neurosci 2013; 13: 355–377. 22371267
  80. Wise RA. Voluntary ethanol intake in rats following exposure to ethanol on various schedules. Psychopharmacologia 1973; 29: 203–210. 4702273
  81. Carnicella S, Ron D, Barak S. Intermittent ethanol access schedule in rats as a preclinical model of alcohol abuse. Alcohol 2014; 48: 243–252. 24721195 PMC4102254
  82. Liu W, Crews FT. Adolescent intermittent ethanol exposure enhances ethanol activation of the nucleus accumbens while blunting the prefrontal cortex responses in adult rat. Neuroscience 2015; 293: 92–108. 25727639 PMC4821202
  83. Roman E, Ploj K, Nylander I. Maternal separation has no effect on voluntary ethanol intake in female Wistar rats. Alcohol 2004; 33: 31–39. 15353171
  84. Toffoletto S, Lanzenberger R, Gingnell M, Sundstrom-Poromaa I, Comasco E. Emotional and cognitive functional imaging of estrogen and progesterone effects in the female human brain: a systematic review. Psychoneuroendocrinology 2014; 50: 28–52. 25222701
  85. Barth C, Villringer A, Sacher J. Sex hormones affect neurotransmitters and shape the adult female brain during hormonal transition periods. Front Neurosci 2015; 9: 37. 25750611 PMC4335177
  86. Gundlah C, Lu NZ, Bethea CL. Ovarian steroid regulation of monoamine oxidase-A and -B mRNAs in the macaque dorsal raphe and hypothalamic nuclei. Psychopharmacology 2002; 160: 271–282. 11889496
  87. Nakagawa S. A farewell to Bonferroni: the problems of low statistical power and publication bias. Behav Ecol 2004; 15: 1044–1045.
  88. Perneger TV. What's wrong with Bonferroni adjustments. Br Med J 1998; 316: 1236–1238. 9553006 PMC1112991

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Authors
Bendre, M., Comasco, E., Nylander, I., & Nilsson, K. W.
Affiliations
Uppsala University (SE)
Corresponding author
  • Comasco, E
  • Nylander, I
ORCID
Venue
Translational Psychiatry
Publisher
Springer Science and Business Media LLC
Published
2015-12-08
Volume
5
Issue
12
Pages
e690-e690
ISSN
2158-3188 (ISSN-L)
DOI
10.1038/tp.2015.186
PMC
PMC5068586
OpenAlex
W2193828563
Cited by
21
References
3
Citations by year
2025: 1 · 2024: 4 · 2023: 3 · 2022: 1 · 2021: 1 · 2020: 2 · 2019: 1 · 2018: 2 · 2017: 3 · 2016: 3
FWCI
1.24
Type
journal article
Language
en
Open access
Licence
Locations
  • Translational Psychiatry (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • KTH Publication Database DiVA (KTH Royal Institute of Technology) (submittedVersion, other-oa)
Funders
  • Forskningsrådet för Arbetsliv och Socialvetenskap (2011-0627)
  • Fredrik och Ingrid Thurings Stiftelse
  • Vetenskapsrådet (K2012‐61X‐22090‐01‐3)
  • ERAB: The European Foundation for Alcohol Research (EA 11 30)
  • Systembolaget Aktiebolag
  • Landstinget Västmanland
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
Keywords
monoamine oxidase A, voluntary ethanol consumption, early life stress, maternal separation, mesocorticolimbic system, nucleus accumbens, dorsal striatum, corticosterone, gene-environment interaction, brain reward system
MeSH terms
Alcohol Drinking, Ethanol, Animals, Behavior, Animal, Brain, Female, Male, Maternal Deprivation, Monoamine Oxidase, Reward, Stress, Psychological, Gene Expression, Polymerase Chain Reaction, Rats, Wistar, Rats

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