Monoamine-sensitive developmental periods impacting adult emotional and cognitive behaviors
Open accessAbstract
Development passes through sensitive periods, during which plasticity allows for genetic and environmental factors to exert indelible influence on the maturation of the organism. In the context of central nervous system development, such sensitive periods shape the formation of neurocircuits that mediate, regulate, and control behavior. This general mechanism allows for development to be guided by both the genetic blueprint as well as the environmental context. While allowing for adaptation, such sensitive periods are also vulnerability windows during which external and internal factors can confer risk to disorders by derailing otherwise resilient developmental programs. Here we review developmental periods that are sensitive to monoamine signaling and impact adult behaviors of relevance to psychiatry. Specifically, we review (1) a serotonin-sensitive period that impacts sensory system development, (2) a serotonin-sensitive period that impacts cognition, anxiety- and depression-related behaviors, and (3) a dopamine- and serotonin-sensitive period affecting aggression, impulsivity and behavioral response to psychostimulants. We discuss preclinical data to provide mechanistic insight, as well as epidemiological and clinical data to point out translational relevance. The field of translational developmental neuroscience has progressed exponentially providing solid conceptual advances and unprecedented mechanistic insight. With such knowledge at hand and important methodological innovation ongoing, the field is poised for breakthroughs elucidating the developmental origins of neuropsychiatric disorders, and thus understanding pathophysiology. Such knowledge of sensitive periods that determine the developmental trajectory of complex behaviors is a necessary step towards improving prevention and treatment approaches for neuropsychiatric disorders.
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Accumulating animal data demonstrate that developmental periods sensitive to serotonergic and dopaminergic signaling affect later-life somatosensory, anxiety/depression-like, and aggressive behavior.
“But, accumulating animal data demonstrate developmental periods sensitive to serotonergic and dopaminergic signaling affect later-life somatosensory, anxiety/depression-like and aggressive behavior (Suri et al., 2015).”
From Serotonin and neuroplasticity – Links between molecular, functional and structural pathophysiology in depression (2017) · cites this paper as Suri et al., 2015
The Introduction and Outlook (page numbers unavailable) describe monoamine-sensitive developmental periods affecting adult anxiety/depression-like behavior and aggression. They describe the somatosensory finding as altered sensory-system development and cortex maturation, not later-life somatosensory behavior. (LLM, conf=0.88)
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Baudat, M., de Kort, A. R., van den Hove, D., & Joosten, E. A. J. (2021) · European Journal of Neuroscience · doi:10.1111/ejn.15544 · Cited by 10 · see citing works
Serotonin acts through multiple cellular targets during an olfactory critical period
Mallick, A., Tan, H., Epstein, J., Ng, C. M. J., Cook, O. M., Gaudry, Q., & Dacks, A. M. (2024) · iScience · doi:10.1016/j.isci.2024.111083 · Cited by 10 · see citing works
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Monoamines and their Derivatives on GPCRs: Potential Therapy for Alzheimer’s Disease
Farfán‐García, E. D., Márquez-Gómez, R., Barrón‐González, M., Pérez‐Capistran, T., Rosales‐Hernández, M. C., Pinto‐Almazán, R., & Soriano-Ursua, M. A. (2019) · Current Alzheimer Research · doi:10.2174/1570159x17666190409144558 · Cited by 10 · see citing works
The development of the serotonergic and dopaminergic systems during chicken mid-late embryogenesis
Huang, X., Kuang, S., Applegate, T. J., Lin, T.-L., & Cheng, H. W. (2019) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2019.110472 · Cited by 9 · see citing works
Reduced Motivation in Perinatal Fluoxetine-Treated Mice: A Hypodopaminergic Phenotype
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- Authors
- Suri, D., Teixeira, C. M., Cagliostro, M. K. C., Mahadevia, D., & Ansorge, M. S.
- Affiliations
- Columbia University (US)
- New York State Psychiatric Institute (US)
- Corresponding author
- Ansorge, Mark S
- Venue
- Neuropsychopharmacology
- Published
- 2014-09-02
- Volume
- 40
- Issue
- 1
- Pages
- 88-112
- ISSN
- 0893-133X (ISSN-L)
- 1740-634X
- PMC
- PMC4262911
- OpenAlex
- W2033849577
- Cited by
- 167
- References
- 434
- Citations by year
- 2026: 12 · 2025: 17 · 2024: 20 · 2023: 9 · 2022: 17 · 2021: 22 · 2020: 16 · 2019: 13 · 2018: 11 · 2017: 12 · 2016: 4 · 2015: 12 · 2014: 2
- FWCI
- 1.14
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Neuropsychopharmacology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (MH099118, R01MH080116, R00MH083044, R01MH099118, P50MH90966, P50MH090966)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- sensitive period, monoamine signaling, serotonin, dopamine, sensory system development, cognitive development, anxiety, depression, aggression, impulsivity, developmental plasticity
- MeSH terms
- Adult, Animals, Brain, Cognition, Emotions, Humans, Neuronal Plasticity, Biogenic Monoamines
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