Cited by 168Neurotransmitter Receptor Influence on BehaviorNeurogenesis and neuroplasticity mechanismsNeural and Behavioral Psychology Studies

Monoamine-sensitive developmental periods impacting adult emotional and cognitive behaviors

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Suri, Deepika, Teixeira, Cátia M, Cagliostro, Martha K Caffrey, Mahadevia, Darshini, Ansorge, Mark S·2015·Neuropsychopharmacology

Abstract

Development passes through sensitive periods, during which plasticity allows for genetic and environmental factors to exert indelible influence on the maturation of the organism. In the context of central nervous system development, such sensitive periods shape the formation of neurocircuits that mediate, regulate, and control behavior. This general mechanism allows for development to be guided by both the genetic blueprint as well as the environmental context. While allowing for adaptation, such sensitive periods are also vulnerability windows during which external and internal factors can confer risk to disorders by derailing otherwise resilient developmental programs. Here we review developmental periods that are sensitive to monoamine signaling and impact adult behaviors of relevance to psychiatry. Specifically, we review (1) a serotonin-sensitive period that impacts sensory system development, (2) a serotonin-sensitive period that impacts cognition, anxiety- and depression-related behaviors, and (3) a dopamine- and serotonin-sensitive period affecting aggression, impulsivity and behavioral response to psychostimulants. We discuss preclinical data to provide mechanistic insight, as well as epidemiological and clinical data to point out translational relevance. The field of translational developmental neuroscience has progressed exponentially providing solid conceptual advances and unprecedented mechanistic insight. With such knowledge at hand and important methodological innovation ongoing, the field is poised for breakthroughs elucidating the developmental origins of neuropsychiatric disorders, and thus understanding pathophysiology. Such knowledge of sensitive periods that determine the developmental trajectory of complex behaviors is a necessary step towards improving prevention and treatment approaches for neuropsychiatric disorders.

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Crossref · 10.1038/npp.2014.231

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  • Accumulating animal data demonstrate that developmental periods sensitive to serotonergic and dopaminergic signaling affect later-life somatosensory, anxiety/depression-like, and aggressive behavior.

    “But, accumulating animal data demonstrate developmental periods sensitive to serotonergic and dopaminergic signaling affect later-life somatosensory, anxiety/depression-like and aggressive behavior (Suri et al., 2015).”

    From Serotonin and neuroplasticity – Links between molecular, functional and structural pathophysiology in depression (2017) · cites this paper as Suri et al., 2015

    The Introduction and Outlook (page numbers unavailable) describe monoamine-sensitive developmental periods affecting adult anxiety/depression-like behavior and aggression. They describe the somatosensory finding as altered sensory-system development and cortex maturation, not later-life somatosensory behavior. (LLM, conf=0.88)

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Authors
Suri, D., Teixeira, C. M., Cagliostro, M. K. C., Mahadevia, D., & Ansorge, M. S.
Affiliations
  • Columbia University (US)
  • New York State Psychiatric Institute (US)
Corresponding author
Ansorge, Mark S
Venue
Neuropsychopharmacology
Published
2014-09-02
Volume
40
Issue
1
Pages
88-112
ISSN
  • 0893-133X (ISSN-L)
  • 1740-634X
OpenAlex
W2033849577
Cited by
167
References
434
Citations by year
2026: 12 · 2025: 17 · 2024: 20 · 2023: 9 · 2022: 17 · 2021: 22 · 2020: 16 · 2019: 13 · 2018: 11 · 2017: 12 · 2016: 4 · 2015: 12 · 2014: 2
FWCI
1.14
Type
journal article
Language
en
Open access
Locations
  • Neuropsychopharmacology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Mental Health (MH099118, R01MH080116, R00MH083044, R01MH099118, P50MH90966, P50MH090966)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
sensitive period, monoamine signaling, serotonin, dopamine, sensory system development, cognitive development, anxiety, depression, aggression, impulsivity, developmental plasticity
MeSH terms
Adult, Animals, Brain, Cognition, Emotions, Humans, Neuronal Plasticity, Biogenic Monoamines

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