The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Merging the potential of microbial genetics with biological and chemical diversity: an even brighter future for marine natural product drug discovery
Abstract
Marine invertebrates and a growing number of marine bacteria are the sources of novel, bioactive secondary metabolites. Structurally, many of these compounds appear to be biosynthesized by polyketide synthases (PKS) and/or nonribosomal peptide synthetases (NRPS) that have also been found in terrestrial microbes. This review highlights scientific advances from 1999-2003 in the emerging field of molecular genetics of polyketide and nonribosomal peptide natural products isolated from marine organisms. The implications of this research towards the development of marine secondary metabolites as a sustainable source of new drugs are discussed.
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Citations
Cites
SAR11 clade dominates ocean surface bacterioplankton communities
Morris, R. M., Rappé, M. S., Connon, S. A., Vergin, K. L., Siebold, W. A., Carlson, C. A., & Giovannoni, S. J. (2002) · Nature · doi:10.1038/nature01240 · Cited by 1,129
Golakoti, T., Ogino, J., Heltzel, C. E., Le Husebo, T., Jensen, C. M., Larsen, L. K., Patterson, G. M. L., Moore, R. E., Mooberry, S. L., Corbett, T. H., et al. (1995) · Journal of the American Chemical Society · doi:10.1021/ja00154a002 · Cited by 186
Cited by
Marine natural products as anticancer drugs
Simmons, T. L., Andrianasolo, E., McPhail, K., Flatt, P., & Gerwick, W. H. (2005) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.333.4.2 · Cited by 597
Combinatorial biosynthesis of reduced polyketides
Weissman, K. J., & Leadlay, P. F. (2005) · Nature Reviews Microbiology · doi:10.1038/nrmicro1287 · Cited by 466
Bhadury, P., Mohammad, B. T., & Wright, P. C. (2006) · Journal of Industrial Microbiology & Biotechnology · doi:10.1007/s10295-005-0070-3 · Cited by 250
Metadata
- Authors
- Salomon, C. E., Magarvey, N. A., & Sherman, D. H.
- Venue
- Natural Product Reports
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2004
- Volume
- 21
- Issue
- 1
- Pages
- 105
- ISSN
- 0265-0568 (ISSN-L)
- 1460-4752
- OpenAlex
- W2156367506
- Cited by
- 171
- References
- 2
- FWCI
- 8.02
- Type
- journal article
- Language
- en
- Open access
- closed
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- Salomon, C. E., Magarvey, N. A., & Sherman, D. H. (2004). Merging the potential of microbial genetics with biological and chemical diversity: an even brighter future for marine natural product drug discovery. Natural Product Reports. https://doi.org/10.1039/b301384g
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
