Cited by 613Cholinesterase and Neurodegenerative DiseasesBioactive natural compoundsPhytochemistry and Biological Activities

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Acetylcholinesterase inhibitors from plants and fungi

Houghton, Peter J., Ren, Yuhao, Howes, Melanie-Jayne·2006·Natural Product Reports

DOI 10.1039/b508966m

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Abstract

This review describes 183 compounds obtained from plants and fungi which have been shown to inhibit acetylcholinesterase. The mechanism of action of cholinesterase, together with the binding sites, and, where this is known, the mode of action of inhibitors is described. The relative activities of the different compounds are recorded. The strongest inhibitors are generally alkaloids although some meroterpenoids from fungi have also been found to be active and display better selectivity.

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Authors: Houghton, P. J., Ren, Y., & Howes, M.-J.
Affiliations: King's College London (GB)
Royal Botanic Gardens, Kew (GB)
Corresponding author: Houghton, Peter J.
ORCID: Houghton, Peter J.
Ren, Yuhao
Howes, Melanie-Jayne
Venue: Natural Product Reports
Publisher: Royal Society of Chemistry (RSC)
Published: 2006
Volume: 23
Issue: 2
Pages: 181
ISSN: 0265-0568 (ISSN-L)
1460-4752
DOI: 10.1039/b508966m
OpenAlex: W2126399705
Cited by: 584
References: 112
Citations by year: 2026: 8 · 2025: 26 · 2024: 29 · 2023: 31 · 2022: 39 · 2021: 38 · 2020: 30 · 2019: 30 · 2018: 35 · 2017: 29 · 2016: 41 · 2015: 33 · 2014: 35 · 2013: 37 · 2012: 21
FWCI: 2.30
Type: journal article
Language: en
Open access: closed
Locations: Natural Product Reports (publishedVersion)
PubMed (publishedVersion)
Research Portal (King's College London) (submittedVersion)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Cholinesterase and Neurodegenerative Diseases
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Drug Discovery › Bioactive natural compounds
Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
Keywords: acetylcholinesterase inhibitors, plant natural products, fungal natural products, alkaloids, meroterpenoids, binding sites, enzyme selectivity, bioactive compounds
MeSH terms: Biological Products, Cholinesterase Inhibitors, Fungi, Plants, Medicinal, Molecular Structure

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Acetylcholinesterase inhibitors from plants and fungi

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