The DOI matches its Crossref record; 112 of the 112 references it cites were found in a registry or an index.
Acetylcholinesterase inhibitors from plants and fungi
Abstract
This review describes 183 compounds obtained from plants and fungi which have been shown to inhibit acetylcholinesterase. The mechanism of action of cholinesterase, together with the binding sites, and, where this is known, the mode of action of inhibitors is described. The relative activities of the different compounds are recorded. The strongest inhibitors are generally alkaloids although some meroterpenoids from fungi have also been found to be active and display better selectivity.
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“The secondary metabolites of the various classes such as alkaloids, terpenoids, coumarins, flavonoids, etc. have been reported to have potent AChEinhibitory activity [71,72,73,74].”
From Acetylcholinesterase Inhibitory Potential of Various Sesquiterpene Analogues for Alzheimer’s Disease Therapy (2021) · cites this paper as [71]
Citations
Cites
A new and rapid colorimetric determination of acetylcholinesterase activity
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Crystal Structure of Human Butyrylcholinesterase and of Its Complexes with Substrate and Products
Nicolet, Y., Lockridge, O., Masson, P., Fontecilla-Camps, J. C., & Nachon, F. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210241200 · Cited by 851
Heinrich, M., & Teoh, H. L. (2004) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2004.02.012 · Cited by 587
Cholinesterase inhibitors: new roles and therapeutic alternatives
Giacobini, E. (2004) · Pharmacological Research · doi:10.1016/j.phrs.2003.11.017 · Cited by 572
Acetylcholinesterase: ‘classical’ and ‘non-classical’ functions and pharmacology
Silman, I., & Sussman, J. L. (2005) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2005.01.014 · Cited by 540
Rhee, I. K., van de Meent, M. H. M., Ingkaninan, K., & Verpoorte, R. (2001) · Journal of Chromatography A · doi:10.1016/s0021-9673(01)00624-0 · Cited by 465
Perry, N. S. L., Houghton, P. J., Theobald, A. E., Jenner, P. G., & Perry, E. K. (2000) · Journal of Pharmacy and Pharmacology · doi:10.1211/0022357001774598 · Cited by 458
Self-citation2-Pyrone natural products and mimetics: isolation, characterisation and biological activity
McGlacken, G. P., & Fairlamb, I. J. S. (2005) · Natural Product Reports · doi:10.1039/b416651p · Cited by 367
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Rajendran, S., & Sriranjini, V. (2007) · Journal of Stored Products Research · doi:10.1016/j.jspr.2007.08.003 · Cited by 817
Neag, M. A., Mocan, A., Echeverría, J., Pop, R. M., Bocsan, C. I., Crişan, G., & Buzoianu, A. D. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00557 · Cited by 562
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Mode of inhibition of acetylcholinesterase by monoterpenoids and implications for pest control
López, M. D., & Pascual‐Villalobos, M. J. (2009) · Industrial Crops and Products · doi:10.1016/j.indcrop.2009.11.005 · Cited by 451
Natural products as a source of Alzheimer's drug leads
Williams, P., Sorribas, A., & Howes, M.-J. R. (2011) · Nat. Prod. Rep. · doi:10.1039/c0np00027b · Cited by 404
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Metadata
- Authors
- Houghton, P. J., Ren, Y., & Howes, M.-J.
- Affiliations
- King's College London (GB)
- Royal Botanic Gardens, Kew (GB)
- Corresponding author
- Houghton, Peter J.
- Venue
- Natural Product Reports
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2006
- Volume
- 23
- Issue
- 2
- Pages
- 181
- ISSN
- 0265-0568 (ISSN-L)
- 1460-4752
- OpenAlex
- W2126399705
- Cited by
- 584
- References
- 112
- Citations by year
- 2026: 8 · 2025: 26 · 2024: 29 · 2023: 31 · 2022: 39 · 2021: 38 · 2020: 30 · 2019: 30 · 2018: 35 · 2017: 29 · 2016: 41 · 2015: 33 · 2014: 35 · 2013: 37 · 2012: 21
- FWCI
- 2.30
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Natural Product Reports (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (submittedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Cholinesterase and Neurodegenerative Diseases
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Drug Discovery › Bioactive natural compounds
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
- Keywords
- acetylcholinesterase inhibitors, plant natural products, fungal natural products, alkaloids, meroterpenoids, binding sites, enzyme selectivity, bioactive compounds
- MeSH terms
- Biological Products, Cholinesterase Inhibitors, Fungi, Plants, Medicinal, Molecular Structure
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