Acetylcholinesterase inhibitors from plants

Mukherjee, Pulok K.; Kumar, Venkatesan; Mal, Mainak; Houghton, Peter J.

doi:10.1016/j.phymed.2007.02.002

Cited by 809Cholinesterase and Neurodegenerative DiseasesMedicinal Plants and NeuroprotectionBioactive natural compounds

Acetylcholinesterase inhibitors from plants

Mukherjee, Pulok K., Kumar, Venkatesan, Mal, Mainak, Houghton, Peter J.·2007·Phytomedicine

DOI 10.1016/j.phymed.2007.02.002

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Abstract

Inhibition of acetylcholinesterase (AChE), the key enzyme in the breakdown of acetylcholine, is considered as a promising strategy for the treatment of neurological disorders such as Alzheimer's disease, senile dementia, ataxia and myasthenia gravis. A potential source of AChE inhibitors is certainly provided by the abundance of plants in nature. This article aims to provide a comprehensive literature survey of plants that have been tested for AChE inhibitory activity. Numerous phytoconstituents and promising plant species as AChE inhibitors are being reported in this communication.

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Secondary metabolites such as alkaloids, terpenoids, coumarins, and flavonoids have been reported to have potent AChE inhibitory activity.
“The secondary metabolites of the various classes such as alkaloids, terpenoids, coumarins, flavonoids, etc. have been reported to have potent AChEinhibitory activity [71,72,73,74].”
From Acetylcholinesterase Inhibitory Potential of Various Sesquiterpene Analogues for Alzheimer’s Disease Therapy (2021) · cites this paper as [73]

A new and rapid colorimetric determination of acetylcholinesterase activity
Ellman, G. L., Courtney, K. D., Andres, V., & Featherstone, R. M. (1961) · Biochemical Pharmacology · doi:10.1016/0006-2952(61)90145-9 · Cited by 27,221 · see citing works
SELECTIVE LOSS OF CENTRAL CHOLINERGIC NEURONS IN ALZHEIMER'S DISEASE
DAVIES, P. (1976) · The Lancet · doi:10.1016/s0140-6736(76)91936-x · Cited by 3,565 · see citing works
APRIORITY
Asher, R. (1961) · The Lancet · doi:10.1016/s0140-6736(61)91217-x · Cited by 1,290 · see citing works
Efficacy of galantamine in probable vascular dementia and Alzheimer's disease combined with cerebrovascular disease: a randomised trial
Erkinjuntti, T., Kurz, A., Gauthier, S., Bullock, R., Lilienfeld, S., & Damaraju, C. V. (2002) · The Lancet · doi:10.1016/s0140-6736(02)08267-3 · Cited by 752 · see citing works
Principles of Medicinal Chemistry
Delgado, J. N. (1975) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.2600641047 · Cited by 723 · see citing works
Principles of medicinal chemistry
Foye, W. O. (1974) · Cited by 476 · see citing works
Screening for acetylcholinesterase inhibitors from Amaryllidaceae using silica gel thin-layer chromatography in combination with bioactivity staining
Rhee, I. K., van de Meent, M. H. M., Ingkaninan, K., & Verpoorte, R. (2001) · Journal of Chromatography A · doi:10.1016/s0021-9673(01)00624-0 · Cited by 465 · see citing works
In-vitro Inhibition of Human Erythrocyte Acetylcholinesterase by Salvia lavandulaefolia Essential Oil and Constituent Terpenes
Perry, N. S. L., Houghton, P. J., Theobald, A. E., Jenner, P. G., & Perry, E. K. (2000) · Journal of Pharmacy and Pharmacology · doi:10.1211/0022357001774598 · Cited by 458 · see citing works
Self-citation
Plants used in Chinese and Indian traditional medicine for improvement of memory and cognitive function
Howes, M. R., & Houghton, P. J. (2003) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(03)00128-x · Cited by 443 · see citing works
Self-citation
Presynaptic Cholinergic Dysfunction in Patients with Dementia
Sims, N. R., Bowen, D. M., Allen, S. J., Smith, C., Neary, D., Thomas, D. J., & DAVISON, A. N. (1983) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1983.tb11311.x · Cited by 421 · see citing works
Plants with traditional uses and activities, relevant to the management of Alzheimer's disease and other cognitive disorders
Howes, M. R., Perry, N. S. L., & Houghton, P. J. (2003) · Phytotherapy Research · doi:10.1002/ptr.1280 · Cited by 418 · see citing works
Self-citation
"Compendium of pharmaceuticals and specialties".
Krogh, C. (1983) · PubMed · Cited by 410 · see citing works
The cholinergic system in Alzheimer's disease
Kása, P., Rakonczay, Z., & Gulya, K. (1997) · Progress in Neurobiology · doi:10.1016/s0301-0082(97)00028-2 · Cited by 410 · see citing works
Galantamine
Scott, L. J., & Goa, K. L. (2000) · Drugs · doi:10.2165/00003495-200060050-00008 · Cited by 383 · see citing works
Structure of acetylcholinesterase complexed with the nootropic alkaloid, (–)-huperzine A
Raves, M. L., Harel, M., Pang, Y., Silman, I., Kozikowski, A. P., & Sussman, J. L. (1997) · Nature Structural & Molecular Biology · doi:10.1038/nsb0197-57 · Cited by 373 · see citing works
Screening for acetylcholinesterase inhibitory activity in plants used in Thai traditional rejuvenating and neurotonic remedies
Ingkaninan, K., Temkitthawon, P., Chuenchom, K., Yuyaem, T., & Thongnoi, W. (2003) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2003.08.008 · Cited by 367 · see citing works
Acetylcholinesterase inhibitory activity of some Amaryllidaceae alkaloids and Narcissus extracts
López, S., Bastida, J., Viladomat, F., & Codina, C. J. (2002) · Life Sciences · doi:10.1016/s0024-3205(02)02034-9 · Cited by 359 · see citing works
New Perspectives on Alzheimer's Disease
Price, D. L. (1986) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.09.030186.002421 · Cited by 352 · see citing works
A rapid TLC bioautographic method for the detection of acetylcholinesterase and butyrylcholinesterase inhibitors in plants
Marston, A., Kissling, J., & Hostettmann, K. (2002) · Phytochemical Analysis · doi:10.1002/pca.623 · Cited by 345 · see citing works
Acetylcholinesterase and butyrylcholinesterase inhibitory activity of some Turkish medicinal plants
Orhan, İ. E., Şener, B., Choudhary, M. I., & Khalid, A. (2004) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2003.11.016 · Cited by 302 · see citing works
Chapter 53: Brain selective inhibition of acetylcholinesterase: a novel approach to therapy for Alzheimer's disease
Enz, A., Amstutz, R., Boddeke, H. W. G. M., Gmelin, G., & Malanowski, J. (1993) · Progress in brain research · doi:10.1016/s0079-6123(08)62429-2 · Cited by 301 · see citing works
A comparative study in rodents of standardized extracts of Bacopa monniera and Ginkgo biloba
Das, A., Shanker, G., Nath, C., Pal, R., Singh, S., & Singh, H. K. (2002) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(02)00940-1 · Cited by 264 · see citing works
Neocortical cholinergic activities differentiate Lewy body dementia from classical Alzheimer's disease.
Perry, E., Haroutunian, V., Davis, K., Levy, R., Lantos, P., Eagger, S., Honavar, M., Dean, A., Griffiths, M., & McKeith, I. (1994) · NeuroReport · doi:10.1097/00001756-199403000-00002 · Cited by 264 · see citing works
Cortical biopsy in Alzheimer's disease: Diagnostic accuracy and neurochemical, neuropathological, and cognitive correlations
DeKosky, S. T., Harbaugh, R. E., Schmitt, F. A., Bakay, R. A. E., Chui, H. C., Knopman, D. S., Reeder, T. M., Shetter, A. G., Senter, H. J., Markesbery, W. R., et al. (1992) · Annals of Neurology · doi:10.1002/ana.410320505 · Cited by 222 · see citing works
High-performance liquid chromatography with on-line coupled UV, mass spectrometric and biochemical detection for identification of acetylcholinesterase inhibitors from natural products
Ingkaninan, K., de Best, C. M., van der Heijden, R., Hofte, A. J. P., Karabatak, B., Irth, H., Tjaden, U. R., van der Greef, J., & Verpoorte, R. (2000) · Journal of Chromatography A · doi:10.1016/s0021-9673(99)01292-3 · Cited by 219 · see citing works
Screening of Korean herbal medicines used to improve cognitive function for anti-cholinesterase activity
Oh, M., Houghton, P. J., Whang, W. K., & Cho, J. (2004) · Phytomedicine · doi:10.1016/j.phymed.2004.03.001 · Cited by 194 · see citing works
Self-citation
Ginkgo extract or cholinesterase inhibitors in patients with dementia: What clinical trials and guidelines fail to consider
Schulz, V. (2003) · Phytomedicine · doi:10.1078/1433-187x-00302 · Cited by 164 · see citing works
In-vitro activity of S. lavandulaefolia (Spanish sage) relevant to treatment of Alzheimer's disease
Perry, N. S. L., Houghton, P. J., Sampson, J., Theobald, A. E., Hart, S., Lis‐Balchin, M., Hoult, J. R. S., Evans, P., Jenner, P. G., Milligan, S. R., et al. (2001) · Journal of Pharmacy and Pharmacology · doi:10.1211/0022357011777846 · Cited by 159 · see citing works
Self-citation
Bioactive natural products as a potential source of new pharmacophores. A theory of memory
Rahman, A., & Choudhary, M. I. (2001) · Pure and Applied Chemistry · doi:10.1351/pac200173030555 · Cited by 155 · see citing works
The acetylcholinesterase-inhibitory activity of steroidal glycoalkaloids and their aglycones
Roddick, J. G. (1989) · Phytochemistry · doi:10.1016/s0031-9422(00)98055-5 · Cited by 138 · see citing works
Evaluation of Indian Traditional Medicine
Mukherjee, P. K. (2001) · Drug Information Journal · doi:10.1177/009286150103500235 · Cited by 138 · see citing works
Self-citation
Cholinergic therapy for Down's syndrome
Kishnani, P. S., Sullivan, J. A., Walter, B. K., Spiridigliozzi, G. A., Doraiswamy, P. M., & Krishnan, K. (1999) · The Lancet · doi:10.1016/s0140-6736(98)05285-4 · Cited by 122 · see citing works
Inhibitory Effect of Ursolic Acid Purified from Origanum majorana L. on the Acetylcholinesterase
Chung, Y.-K., Heo, H. J., Kim, E.-K., Kim, H.-K., Huh, T., Lim, Y., Kim, S.-K., & Shin, D.-H. (2001) · Molecules and Cells · doi:10.1016/s1016-8478(23)17016-6 · Cited by 121 · see citing works
Indole alkaloids from Tabernaemontana australis (Müell. Arg) Miers that inhibit acetylcholinesterase enzyme
Andrade, M. T., Lima, J. A., Pinto, A. C., Rezende, C. M., Carvalho, M. P., & Epifanio, R. D. A. (2005) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2005.03.045 · Cited by 117 · see citing works
Medicinal Plants and Alzheimer's Disease: Integrating Ethnobotanical and Contemporary Scientific Evidence
Perry, E. K., Pickering, A. T., Wang, W. W., Houghton, P., & Perry, N. S. L. (1998) · The Journal of Alternative and Complementary Medicine · doi:10.1089/acm.1998.4.419 · Cited by 113 · see citing works
Self-citation
Drug treatments for Alzheimer's disease
KELLY, C. A., Harvey, R. J., & Cayton, H. (1997) · BMJ · doi:10.1136/bmj.314.7082.693 · Cited by 111 · see citing works
Personal paper: New drug treatment for Alzheimer's disease: lessons for healthcare policy
Melzer, D. R. (1998) · BMJ · doi:10.1136/bmj.316.7133.762 · Cited by 105 · see citing works
Long-term stabilizing effect of cholinesterase inhibitors in the therapy of Alzheimer’ disease
Giacobini, E. (2002) · Journal of neural transmission. Supplementum · doi:10.1007/978-3-7091-6139-5_17 · Cited by 91 · see citing works
Rivastigmine, a brain-region selective acetylcholinesterase inhibitor for treating Alzheimer’s disease: review and current status
Gottwald, M. D., & Rozanski, R. I. (1999) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.8.10.1673 · Cited by 91 · see citing works
Reversal of scopolamine-induced deficits in radial maze performance by (−)-huperzine A: comparison with E2020 and tacrine
Wang, T., & Tang, X. C. (1998) · European Journal of Pharmacology · doi:10.1016/s0014-2999(98)00199-x · Cited by 82 · see citing works
Cholinergic therapies in Alzheimer's disease
Siddiqui, M. F., & Levey, A. I. (1999) · Drugs of the Future · doi:10.1358/dof.1999.024.04.668318 · Cited by 78 · see citing works
Screening of Non‐Alkaloidal Natural Compounds as Acetylcholinesterase Inhibitors
Brühlmann, C., Marston, A., Hostettmann, K., Carrupt, P., & Testa, B. (2004) · Chemistry & Biodiversity · doi:10.1002/cbdv.200490064 · Cited by 77 · see citing works
Acetylcholinesterase inhibitors from the aerial parts ofCorydalis speciosa
Kim, D. K., Lee, K. T., Baek, N., Kim, S., Park, H. W., Lim, J., Shin, T. Y., Eom, D. O., Yang, J. H., & Eun, J. S. (2004) · Archives of Pharmacal Research · doi:10.1007/bf02975117 · Cited by 75 · see citing works
Xanthones fromGentiana campestrisas New Acetylcholinesterase Inhibitors
Urbain, A., Marston, A., Queiroz, E. F., Ndjoko, K., & Hostettmann, K. (2004) · Planta Medica · doi:10.1055/s-2004-832632 · Cited by 74 · see citing works
(+)-.ALPHA.-Viniferin, a Stilbene Trimer from Caragana chamlague, Inhibits Acetylcholinesterase.
Sung, S. H., Kang, S. Y., Lee, K. Y., Park, M. J., Kim, J. H., Park, J. H., Kim, Y. C., Kim, J., & Kim, Y. C. (2002) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.25.125 · Cited by 71 · see citing works
Cholinergic therapy in dementia
Whitehouse, P. J. (2009) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1993.tb04254.x · Cited by 63 · see citing works
Determination of inhibitors’ potency (IC50) by a direct high-performance liquid chromatographic method on an immobilised acetylcholinesterase column
Andrisano, V., Bartolini, M., Gotti, R., Cavrini, V., & Félix, G. (2001) · Journal of Chromatography B Biomedical Sciences and Applications · doi:10.1016/s0378-4347(00)00571-5 · Cited by 61 · see citing works
Invited Review Anticholinesterases: dramatic aspects of their use and misuse
Karczmar, A. G. (1998) · Neurochemistry International · doi:10.1016/s0197-0186(97)00123-x · Cited by 61 · see citing works
Ptychopetalum olacoides, a traditional Amazonian “nerve tonic”, possesses anticholinesterase activity
Siqueira, I. R., Fochesatto, C., da Silva, A. L., Nunes, D. S., Battastini, A. M. O., Netto, C. A., & Elisabetsky, E. (2003) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(03)00113-8 · Cited by 60 · see citing works
Comparison of the effects of natural and synthetic huperzine-A on rat brain cholinergic function in vitro and in vivo
Tang, X.-C., Kindel, G. H., Kozikowski, A. P., & Hanin, I. (1994) · Journal of Ethnopharmacology · doi:10.1016/0378-8741(94)01182-6 · Cited by 60 · see citing works
Cholinesterase inhibitory and spasmolytic potential of steroidal alkaloids
Khalid, A., Ul‐Haq, Z., Ghayur, M. N., Feroz, F., Rahman, A., Gilani, A. H., & Choudhary, M. I. (2004) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2004.08.003 · Cited by 59 · see citing works
Acetylcholinesterase inhibitors from the roots ofangelica dahurica
Kim, D. K., Lim, J., Yang, J. H., Eom, D. O., Eun, J. S., & Leem, K. H. (2002) · Archives of Pharmacal Research · doi:10.1007/bf02977004 · Cited by 58 · see citing works
Inhibitory effect of corynoline isolated from the aerial parts ofcorydalis incisa on the acetylcholinesterase
Kim, D. K. (2002) · Archives of Pharmacal Research · doi:10.1007/bf02976997 · Cited by 50 · see citing works
New Acetylcholinesterase‐Inhibitory Pregnane Glycosides of Cynanchum atratum Roots
Lee, K. Y., Sung, S. H., & Kim, Y. C. (2003) · Helvetica Chimica Acta · doi:10.1002/hlca.200390047 · Cited by 49 · see citing works
Role of tyrosine 337 in the binding of huperzine A to the active site of human acetylcholinesterase.
Ashani, Y., Grunwald, J., Kronman, C., Velan, B., & Avigdor Shafferman, C. (1994) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)10030-8 · Cited by 48 · see citing works
Acetylcholine Esterase Inhibitors inRhodiola rosea
Hillhouse, B. J., Ming, D. S., French, C. J., & Towers, G. H. N. (2004) · Pharmaceutical Biology · doi:10.1080/13880200490505636 · Cited by 37 · see citing works
Enantiomeric resolution of galanthamine and related drugs used in anti-Alzheimer therapy by means of capillary zone electrophoresis employing derivatized cyclodextrin selectors
Rizzi, A. M., Schuh, R., Brückner, A., Cvitkovich, B., Kremser, L., Jordis, U., Fröhlich, J., Küenburg, B., & Czollner, L. (1999) · Journal of Chromatography B Biomedical Sciences and Applications · doi:10.1016/s0378-4347(99)00186-3 · Cited by 30 · see citing works
In vitro Inhibition of Acetylcholinesterase, Butyrylxcholinesterase and Lipoxygenase by Crude Extract of Myricaria elegans Royle
Ahmad, W., Ahmad, B., Ahmad, M., Iqbal, Z. M., Nisar, M. F., & Ahmad, M. S. (2003) · Journal of Biological Sciences · doi:10.3923/jbs.2003.1046.1049 · Cited by 25 · see citing works
Blockade on sodium, potassium, and calcium channels by a new antiarrhythmic agent CPU 86017
Dai, D., Yu, F., Li, H., Tang, Y., An, L., Huang, W., Peng, S., Hao, X., Zhou, B., & Hu, C. (1996) · Drug Development Research · doi:10.1002/(sici)1098-2299(199610)39:2 · Cited by 24 · see citing works
KEY PAPERS IN GERIATRIC PSYCHIATRY. SERIES EDITOR: ALISTAIR BURNS The Association Between Quantitative Measures of Dementia and of Senile Change in the Cerebral Grey Matter of Elderly Subjects. G. Blessed, B. Tomlinson and M. Roth,British Journal of Psychiatry (1968)114, 797-811.
Burns, A. S., Blessed, G., & Byrne, E. J. (1996) · International Journal of Geriatric Psychiatry · doi:10.1002/(sici)1099-1166(199612)11:12 · Cited by 9 · see citing works

Flagged first, then by citations

2 of the 62 references couldn’t be matched to a known paper.

Sorted by citations

Herbal extracts and phytochemicals: Plant secondary metabolites and the enhancement of human brain function
Kennedy, D. O., & Wightman, E. L. (2011) · Advances in Nutrition · doi:10.3945/an.110.000117 · Cited by 684 · see citing works
Natural products and drug discovery
Ji, H., Li, X., & Zhang, H. (2009) · EMBO Reports · doi:10.1038/embor.2009.12 · Cited by 648 · see citing works
The Ayurvedic medicine Clitoria ternatea—From traditional use to scientific assessment
Mukherjee, P. K., Kumar, V., Kumar, N. S., & Heinrich, M. (2008) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2008.09.009 · Cited by 369 · see citing works
Self-citation
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Murray, A. P., Faraoni, M. B., Castro, M., Alza, N. P., & Cavallaro, V. (2013) · Current Neuropharmacology · doi:10.2174/1570159x11311040004 · Cited by 352 · see citing works
Plants traditionally used in age related brain disorders—A survey of ethnobotanical literature
Adams, M. A., Gmünder, F., & Hamburger, M. O. (2007) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2007.07.016 · Cited by 328 · see citing works
Ficus carica L.: Metabolic and biological screening
Oliveira, A. P., Valentão, P., Pereira, J. A., Silva, B. M., Tavares, F., & Andrade, P. B. (2009) · Food and Chemical Toxicology · doi:10.1016/j.fct.2009.09.004 · Cited by 309 · see citing works
Antioxidant and Antiacetylcholinesterase Activities of Some Commercial Essential Oils and Their Major Compounds
Aazza, S., Lyoussi, B., & Miguel, M. G. (2011) · Molecules · doi:10.3390/molecules16097672 · Cited by 256 · see citing works
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Chaudhari, A. K., Singh, V. K., Kedia, A., Das, S., & Dubey, N. K. (2021) · Environmental Science and Pollution Research · doi:10.1007/s11356-021-12841-w · Cited by 242 · see citing works
Acetylcholinesterase Inhibitory, Antioxidant and Phytochemical Properties of Selected Medicinal Plants of the Lamiaceae Family
Vladimir-Knežević, S., Blažeković, B., Kindl, M., Vladić, J., Lower-Nedza, A., & Brantner, A. (2014) · Molecules · doi:10.3390/molecules19010767 · Cited by 238 · see citing works
Structure–activity relationship investigation of coumarin–chalcone hybrids with diverse side-chains as acetylcholinesterase and butyrylcholinesterase inhibitors
Kang, L., Gao, X.-H., Liu, H., Men, X., Wu, H.-N., Cui, P., Oldfield, E., & Yan, J.-Y. (2018) · Molecular Diversity · doi:10.1007/s11030-018-9839-y · Cited by 238 · see citing works
In Vitro Screening for Anti-Cholinesterase and Antioxidant Activity of Methanolic Extracts of Ayurvedic Medicinal Plants Used for Cognitive Disorders
Mathew, M., & Subramanian, S. (2014) · PLoS ONE · doi:10.1371/journal.pone.0086804 · Cited by 237 · see citing works
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Sarıkürkçü, C., Zengin, G., Oskay, M., Uysal, Ş., Ceylan, R., & Aktümsek, A. (2015) · Industrial Crops and Products · doi:10.1016/j.indcrop.2015.03.030 · Cited by 230 · see citing works
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Ncube, B., & Staden, J. V. (2015) · Molecules · doi:10.3390/molecules200712698 · Cited by 148 · see citing works
In silicoTarget Fishing for Rationalized Ligand Discovery Exemplified on Constituents ofRuta graveolens
Rollinger, J. M., Schuster, D., Danzl, B., Schwaiger, S., Markt, P., Schmidtke, M., Gertsch, J., Raduner, S., Wolber, G., Langer, T., et al. (2008) · Planta Medica · doi:10.1055/s-0028-1088397 · Cited by 141 · see citing works
Natural Monoterpenes: Much More Than Only a Scent
Wojtunik‐Kulesza, K. A., Kasprzak, K., Oniszczuk, T., & Oniszczuk, A. (2019) · Chemistry & Biodiversity · doi:10.1002/cbdv.201900434 · Cited by 137 · see citing works
Evaluation of Citrus aurantifolia peel and leaves extracts for their chemical composition, antioxidant and anti‐cholinesterase activities
Loizzo, M. R., Tundis, R., Bonesi, M., Menichini, F., Luca, D. D., Colica, C., & Menichini, F. (2012) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.5708 · Cited by 133 · see citing works
Comparative chemical profiling, cholinesterase inhibitions and anti-radicals properties of essential oils from Polygonum hydropiper L: A Preliminary anti- Alzheimer’s study
Ayaz, M., Junaid, M., Ullah, F., Sadiq, A., Khan, M. A., Ahmad, W., Shah, M. R., Imran, M., & Ahmad, S. (2015) · Lipids in Health and Disease · doi:10.1186/s12944-015-0145-8 · Cited by 128 · see citing works
Polyphenols Beyond Barriers: A Glimpse into the Brain
Figueira, I., Menezes, R., Macedo, D., Costa, I., & dos Santos, C. N. (2016) · Current Neuropharmacology · doi:10.2174/1570159x14666161026151545 · Cited by 129 · see citing works
Microalgae of different phyla display antioxidant, metal chelating and acetylcholinesterase inhibitory activities
Custódio, L. M. B., Justo, T., Silvestre, L., Barradas, A. M., Vizetto‐Duarte, C., Pereira, H., Barreira, L. A., Rauter, A. P., Alberício, F., & Varela, J. C. S. (2011) · Food Chemistry · doi:10.1016/j.foodchem.2011.08.047 · Cited by 125 · see citing works
Salvia officinalis essential oil: Chemical analysis and evaluation of anti-enzymatic and antioxidant bioactivities
Euch, S. K. E., Hassine, D. B., Cazaux, S., Bouzouita, N., & Bouajila, J. (2018) · South African Journal of Botany · doi:10.1016/j.sajb.2018.07.010 · Cited by 128 · see citing works
Evaluation of Antioxidant, Antidiabetic and Anticholinesterase Activities of Smallanthus sonchifolius Landraces and Correlation with Their Phytochemical Profiles
Russo, D., Valentão, P., Andrade, P. B., Fernández-Cusimamani, E., & Milella, L. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms160817696 · Cited by 123 · see citing works
Polyphenols as acetylcholinesterase inhibitors: Structural specificity and impact on human disease
Roseiro, L. B., Rauter, A. P., & Serralheiro, M. L. (2012) · Nutrition and Aging · doi:10.3233/nua-2012-0006 · Cited by 122 · see citing works
Monoterpenoid extract of sage ( <i>Salvia lavandulaefolia</i> ) with cholinesterase inhibiting properties improves cognitive performance and mood in healthy adults
Kennedy, D. O., Dodd, F. L., Robertson, B. C., Okello, E. J., Reay, J. L., Scholey, A. B., & Haskell, C. F. (2011) · Journal of Psychopharmacology · doi:10.1177/0269881110385594 · Cited by 123 · see citing works
Anti-Alzheimer's disease potential of coumarins from Angelica decursiva and Artemisia capillaris and structure-activity analysis
Ali, M. Y., Jannat, S., Jung, H. A., Choi, R. J., Roy, A., & Choi, J. S. (2016) · Asian Pacific Journal of Tropical Medicine · doi:10.1016/j.apjtm.2016.01.014 · Cited by 122 · see citing works
Antioxidant, antiacetylcholinesterase and antimicrobial activities of Cymbopogon schoenanthus L. Spreng (lemon grass) from Tunisia
Khadhri, A., Neffati, M., Smiti, S., Fale, P. L. V., Lino, A. R. L., Serralheiro, M. L., & Araújo, M. E. (2009) · LWT · doi:10.1016/j.lwt.2009.08.004 · Cited by 121 · see citing works
Inhibition of flavonoids on acetylcholine esterase: binding and structure–activity relationship
Xie, Y., Yang, W., Chen, X., & Xiao, J. (2014) · Food & Function · doi:10.1039/c4fo00287c · Cited by 119 · see citing works
Antioxidant capacity and phenolic contents of some Mediterranean medicinal plants and their potential role in the inhibition of cyclooxygenase-1 and acetylcholinesterase activities
Amessis‐Ouchemoukh, N., Madani, K., Fale, P. L. V., Serralheiro, M. L., & Araújo, M. E. (2014) · Industrial Crops and Products · doi:10.1016/j.indcrop.2013.12.008 · Cited by 118 · see citing works
Plant-mediated gold nanoparticles by Dracocephalum kotschyi as anticholinesterase agent: Synthesis, characterization, and evaluation of anticancer and antibacterial activity
Dorosti, N., & Jamshidi, F. (2016) · Journal of Applied Biomedicine · doi:10.1016/j.jab.2016.03.001 · Cited by 116 · see citing works
Glycine max (L.) Merr., Vigna radiata L. and Medicago sativa L. sprouts: A natural source of bioactive compounds
Silva, L. R., Pereira, M. J., Azevedo, J., Gonçalves, R. F., Valentão, P., de Pinho, P. G., & Andrade, P. B. (2012) · Food Research International · doi:10.1016/j.foodres.2012.10.025 · Cited by 114 · see citing works
In-vitro anti-cholinesterase activity of essential oil from four tropical medicinal plants
Owokotomo, I. A., Ekundayo, O., Abayomi, T. G., & Chukwuka, A. V. (2015) · Toxicology Reports · doi:10.1016/j.toxrep.2015.05.003 · Cited by 116 · see citing works
Rosmarinic acid, scutellarein 4′-methyl ether 7-O-glucuronide and (16S)-coleon E are the main compounds responsible for the antiacetylcholinesterase and antioxidant activity in herbal tea of Plectranthus barbatus (“falso boldo”)
Fale, P. L. V., Borges, C., Madeira, P. J. A., Ascensão, L., Araújo, M. E., Florêncio, M. H., & Serralheiro, M. L. (2008) · Food Chemistry · doi:10.1016/j.foodchem.2008.10.015 · Cited by 113 · see citing works
Acetylcholinesterase Inhibitory Potential of Various Sesquiterpene Analogues for Alzheimer’s Disease Therapy
Arya, A., Chahal, R., Rao, R., Rahman, M. H., Kaushik, D., Akhtar, M. F., Saleem, A., Khalifa, S. M. A., El-Seedi, H. R., Kamel, M., et al. (2021) · Biomolecules · doi:10.3390/biom11030350 · Cited by 111 · see citing works
Acetylcholinesterase enzyme inhibitory potential of standardized extract of Trigonella foenum graecum L and its constituents
Satheeshkumar, N., Mukherjee, P. K., Bhadra, S., & Saha, B. P. (2009) · Phytomedicine · doi:10.1016/j.phymed.2009.06.006 · Cited by 107 · see citing works
Self-citation
Cholinesterase inhibitors from botanicals
Ahmed, F., Ghalib, R. M., Sasikala, P., & Ahmed, K. M. (2013) · Pharmacognosy Reviews/Bioinformatics Trends/Pharmacognosy review · doi:10.4103/0973-7847.120511 · Cited by 107 · see citing works
Huperzine A from Huperzia serrata: a review of its sources, chemistry, pharmacology and toxicology
Ferreira, A., Rodrigues, M., Fortuna, A. C., Falcão, A. C., & Alves, G. (2014) · Phytochemistry Reviews · doi:10.1007/s11101-014-9384-y · Cited by 106 · see citing works
Cinnamon, a promising prospect towards Alzheimer’s disease
Momtaz, S., Hassani, S., Khan, F., Ziaee, M., & Abdollahi, M. R. (2017) · Pharmacological Research · doi:10.1016/j.phrs.2017.12.011 · Cited by 106 · see citing works
Pharmacological importance of Clitoria ternatea - A review
Al‐Snafi, A. E. (2016) · Cited by 105 · see citing works
Biochemical Effects of Petroselinum crispum (Umbellifereae) Essential Oil on the Pyrethroid Resistant Strains of Aedes aegypti (Diptera: Culicidae)
Intirach, J., Junkum, A., Lumjuan, N., Chaithong, U., Somboon, P., Jitpakdi, A., Riyong, D., Champakaew, D., Muangmoon, R., Chansang, A., et al. (2018) · Insects · doi:10.3390/insects10010001 · Cited by 106 · see citing works
Chemistry and functional properties in prevention of neurodegenerative disorders of five Cistus species essential oils
Loizzo, M. R., Jemia, M. B., Senatore, F., Bruno, M., Menichini, F., & Tundis, R. (2013) · Food and Chemical Toxicology · doi:10.1016/j.fct.2013.06.040 · Cited by 104 · see citing works
Acetylcholinesterase inhibitors from southern African plants: An overview of ethnobotanical, pharmacological potential and phytochemical research including and beyond Alzheimer's disease treatment
Masondo, N. A., Stafford, G. I., Aremu, A. O., & Makunga, N. P. (2018) · South African Journal of Botany · doi:10.1016/j.sajb.2018.09.011 · Cited by 102 · see citing works
Antioxidant and antiacetylcholinesterase activities of essential oils from Cymbopogon schoenanthus L. Spreng. Determination of chemical composition by GC–mass spectrometry and 13C NMR
Khadhri, A., Serralheiro, M. L., Nogueira, J. M. F., Neffati, M., Smiti, S., & Araújo, M. E. (2008) · Food Chemistry · doi:10.1016/j.foodchem.2007.12.070 · Cited by 99 · see citing works
Design, synthesis and evaluation of pyrazole bearing α-aminophosphonate derivatives as potential acetylcholinesterase inhibitors against Alzheimer’s disease
Shaikh, S., Dhavan, P. P., Pavale, G., Ramana, M. M. V., & Jadhav, B. L. (2020) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2020.103589 · Cited by 96 · see citing works
Determination of total phenol content, antioxidant activity and acetylcholinesterase inhibition in selected mushrooms from Turkey
Orhan, İ. E., & Üstün, O. (2010) · Journal of Food Composition and Analysis · doi:10.1016/j.jfca.2010.11.005 · Cited by 96 · see citing works
Insecticidal and repellent activities of Cymbopogon citratus (Poaceae) essential oil and its terpenoids (citral and geranyl acetate) against Ulomoides dermestoides
Plata‐Rueda, A., Martínez, L. C., Rolim, G. D. S., Coelho, R. P., dos Santos, M. H., Tavares, W. D. S., Zanuncio, J. C., & Serrão, J. É. (2020) · Crop Protection · doi:10.1016/j.cropro.2020.105299 · Cited by 95 · see citing works
Effects of curcuminoids identified in rhizomes of Curcuma longa on BACE-1 inhibitory and behavioral activity and lifespan of Alzheimer’s disease Drosophila models
Wang, X., Kim, J., Lee, S.-B., Kim, Y., Jung, M. Y., Kwon, H. W., & Ahn, Y. (2014) · BMC Complementary and Alternative Medicine · doi:10.1186/1472-6882-14-88 · Cited by 94 · see citing works
Fatty acid composition and biological activities of Isochrysis galbana T-ISO, Tetraselmis sp. and Scenedesmus sp.: possible application in the pharmaceutical and functional food industries
Custódio, L. M. B., Soares, F., Pereira, H., Barreira, L. A., Vizetto‐Duarte, C., Rodrigues, M. J., Rauter, A. P., Alberício, F., & Varela, J. C. S. (2013) · Journal of Applied Phycology · doi:10.1007/s10811-013-0098-0 · Cited by 93 · see citing works
Neuroprotective effects of bergenin in Alzheimer’s disease: Investigation through molecular docking, in vitro and in vivo studies
Barai, P., Raval, N. J., Acharya, S. R., Borisa, A., Bhatt, H., & Acharya, N. S. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.08.010 · Cited by 92 · see citing works
Antioxidant and acetylcholinesterase-inhibitory properties of long-term stored medicinal plants
Amoo, S. O., Aremu, A. O., Moyo, M., & Staden, J. V. (2012) · BMC Complementary and Alternative Medicine · doi:10.1186/1472-6882-12-87 · Cited by 92 · see citing works
Contemporary Anticholinesterase Pharmaceuticals of Natural Origin and Their Synthetic Analogues for the Treatment of Alzheimers Disease
Orhan, G., Orhan, I., Subutay-Oztekin, N., Ak, F., & Sener, B. (2009) · Recent Patents on CNS Drug Discovery · doi:10.2174/157488909787002582 · Cited by 90 · see citing works
Phenolic acids from malt are efficient acetylcholinesterase and butyrylcholinesterase inhibitors
Szwajgier, D., & Borowiec, K. (2012) · Journal of the Institute of Brewing · doi:10.1002/jib.5 · Cited by 90 · see citing works
Natural acetylcholinesterase inhibitors: A multi-targeted therapeutic potential in Alzheimer's disease
Kumar, G., K., P. G., Poornima, D. V., Shantaram, M., & Ranjita, G. (2024) · European Journal of Medicinal Chemistry Reports · doi:10.1016/j.ejmcr.2024.100154 · Cited by 88 · see citing works
Phytochemical analysis and biological properties of Cyperus rotundus L.
Kandikattu, H. K., Razack, S., Nallamuthu, I., & Khanum, F. (2013) · Industrial Crops and Products · doi:10.1016/j.indcrop.2013.11.040 · Cited by 88 · see citing works
Chemotaxonomy: A Tool for Plant Classification
Singh, R. (2016) · Journal of Medicinal Plants Studies · Cited by 88 · see citing works
Antioxidant and antiacetylcholinesterase activities of chard (Beta vulgaris L. var. cicla)
Saçan, Ö., & Yanardağ, R. (2010) · Food and Chemical Toxicology · doi:10.1016/j.fct.2010.02.022 · Cited by 86 · see citing works
Assessment of acetylcholinesterase and tyrosinase inhibitory and antioxidant activity of Alchemilla vulgaris and Filipendula ulmaria extracts
Neagu, E., Păun, G., Albu, C., & Radu, G. L. (2015) · Journal of the Taiwan Institute of Chemical Engineers · doi:10.1016/j.jtice.2015.01.026 · Cited by 83 · see citing works
Essential Oil from Lemon Peels Inhibit Key Enzymes Linked to Neurodegenerative Conditions and Pro-oxidant Induced Lipid Peroxidation
Oboh, G., Olasehinde, T. A., & Ademosun, A. O. (2014) · Journal of Oleo Science · doi:10.5650/jos.ess13166 · Cited by 82 · see citing works
Drug discovery and development with plant-derived compounds
Potterat, O., & Hamburger, M. O. (2007) · Birkhäuser Basel eBooks · doi:10.1007/978-3-7643-8117-2_2 · Cited by 82 · see citing works
Phenolic, flavonoid contents, anticholinesterase and antioxidant evaluation of Iris germanica var; florentina
Ullah, F., Ayaz, M., Sadiq, A., Hussain, A., Ahmad, S., Imran, M., & Zeb, A. (2015) · Natural Product Research · doi:10.1080/14786419.2015.1057585 · Cited by 82 · see citing works
The protective role of plant biophenols in mechanisms of Alzheimer's disease
Omar, S. H., Scott, C., Hamlin, A. S., & Obied, H. K. (2017) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2017.02.016 · Cited by 82 · see citing works
High‐Throughput Label‐Free Enzymatic Assays Using Desorption Electrospray‐Ionization Mass Spectrometry
Morato, N. M., Holden, D. T., & Cooks, R. G. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.202009598 · Cited by 81 · see citing works
Structural features, antioxidant and acetylcholinesterase inhibitory activities of polysaccharides from stem of Physalis alkekengi L.
Liu, X., Bian, J., Li, D., Liu, C., Xu, S., Zhang, G., Zhang, L., & Gao, P. (2018) · Industrial Crops and Products · doi:10.1016/j.indcrop.2018.12.047 · Cited by 81 · see citing works
Phytochemical characterization, in vitro and in silico approaches for three Hypericum species
Llorent-Martínez, E. J., Zengin, G., Lobine, D., Molina‐García, L., Mollica, A., & Mahomoodally, M. F. (2018) · New Journal of Chemistry · doi:10.1039/c8nj00347e · Cited by 80 · see citing works
Myrtenal inhibits acetylcholinesterase, a known Alzheimer target
Kaufmann, D., Dogra, A. K., & Wink, M. (2011) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.2011.01344.x · Cited by 80 · see citing works
Biophenols: Enzymes (β-secretase, Cholinesterases, histone deacetylase and tyrosinase) inhibitors from olive (Olea europaea L.)
Omar, S. H., Scott, C., Hamlin, A. S., & Obied, H. K. (2018) · Fitoterapia · doi:10.1016/j.fitote.2018.05.011 · Cited by 80 · see citing works
Alkaloids from Stems of Esenbeckia leiocarpa Engl. (Rutaceae) as Potential Treatment for Alzheimer Disease
Cardoso-Lopes, E. M., Maier, J. A., da Silva, M. R., Regasini, L. O., Simote, S. Y., Lopes, N. P., Pirani, J. R., Bolzani, V. D. S., & Young, M. C. M. (2010) · Molecules · doi:10.3390/molecules15129205 · Cited by 80 · see citing works
Synthesis, characterization, crystal structures, theoretical calculations and biological evaluations of novel substituted tacrine derivatives as cholinesterase and carbonic anhydrase enzymes inhibitors
Ökten, S., Ekiz, M., Koçyiğit, Ü. M., Tutar, A., Çeli̇k, İ., Akkurt, M., Gökalp, F., Taslımı, P., & Gülçın, İ. (2018) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2018.08.063 · Cited by 78 · see citing works
Acute Toxicity and Sublethal Effects of Lemongrass Essential Oil and Their Components against the Granary Weevil, Sitophilus granarius
Plata‐Rueda, A., Rolim, G. D. S., Wilcken, C. F., Zanuncio, J. C., Serrão, J. É., & Martínez, L. C. (2020) · Insects · doi:10.3390/insects11060379 · Cited by 78 · see citing works
Molecular docking and investigation of 4-(benzylideneamino)- and 4-(benzylamino)-benzenesulfonamide derivatives as potent AChE inhibitors
Işık, M., Demir, Y., Durgun, M., Türkeş, C., Necip, A., & Beydemir, Ş. (2019) · Chemical Papers · doi:10.1007/s11696-019-00988-3 · Cited by 77 · see citing works
Inhibition of cholinesterase by essential oil from food plant
Chaiyana, W., & Okonogi, S. (2012) · Phytomedicine · doi:10.1016/j.phymed.2012.03.010 · Cited by 77 · see citing works
Anti-Alzheimer’s disease activity of compounds from the root bark of Morus alba L.
Kuk, E. B., Jo, A. R., Oh, S. I., Sohn, H. S., Seong, S. H., Roy, A., Choi, J. S., & Jung, H. A. (2017) · Archives of Pharmacal Research · doi:10.1007/s12272-017-0891-4 · Cited by 76 · see citing works
Current pharmacotherapy and putative disease-modifying therapy for Alzheimer’s disease
Kulshreshtha, A., & Piplani, P. (2016) · Neurological Sciences · doi:10.1007/s10072-016-2625-7 · Cited by 75 · see citing works
In vitro antioxidant and cholinesterase inhibitory activities of Elatostema papillosum leaves and correlation with their phytochemical profiles: a study relevant to the treatment of Alzheimer’s disease
Reza, A. S. M. A., Hossain, M. S., Akhter, S., Rahman, M. R., Nasrin, S., Uddin, M. J., Sadik, G., & Alam, A. H. M. K. (2018) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-018-2182-0 · Cited by 74 · see citing works
Chemical composition, biological and cytotoxic activities of Cistus salviifolius flower buds and leaves extracts
Euch, S. K. E., Bouajila, J., & Bouzouita, N. (2015) · Industrial Crops and Products · doi:10.1016/j.indcrop.2015.08.033 · Cited by 74 · see citing works
Insecticidal activity of essential oil from orange peels (Citrus sinensis) against Tribolium confusum, Callosobruchus maculatus and Sitophilus oryzae and its inhibitory effects on acetylcholinesterase and Na+/K+-ATPase activities
Oboh, G., Ademosun, A. O., Olumuyiwa, T. A., Olasehinde, T. A., Ademiluyi, A. O., & Adeyemo, A. C. (2017) · Phytoparasitica · doi:10.1007/s12600-017-0620-z · Cited by 74 · see citing works
Effects and possible mechanisms of action of acacetin on the behavior and eye morphology of Drosophila models of Alzheimer’s disease
Wang, X., Perumalsamy, H., Kwon, H. W., Na, Y., & Ahn, Y. (2015) · Scientific Reports · doi:10.1038/srep16127 · Cited by 75 · see citing works
Antioxidant and anticholinesterase effects of the ethanol extract, ethanol extract fractions and total alkaloids from the cultivated Ruta chalepensis
Gali, L., & Bedjou, F. (2018) · South African Journal of Botany · doi:10.1016/j.sajb.2018.04.011 · Cited by 73 · see citing works
Coumarin linked heterocyclic hybrids: A promising approach to develop multi target drugs for Alzheimer's disease
Husain, A., Al Balushi, K., Akhtar, M. J., & Khan, S. A. (2021) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2021.130618 · Cited by 73 · see citing works
Sea fennel (Crithmum maritimum L.): phytochemical profile, antioxidative, cholinesterase inhibitory and vasodilatory activity
Mekinić, I. G., Blažević, I., Mudnić, I., Burčul, F., Grga, M., Skroza, D., Jerčić, I., Ljubenkov, I., Boban, M., Miloš, M., et al. (2016) · Journal of Food Science and Technology · doi:10.1007/s13197-016-2283-z · Cited by 73 · see citing works
New Beverages of Lemon Juice Enriched with the Exotic Berries Maqui, Açaı, and Blackthorn: Bioactive Components and in Vitro Biological Properties
Gironés‐Vilaplana, A., Valentão, P., Moreno, D. A., Ferreres, F., García‐Viguera, C., & Andrade, P. B. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf300873k · Cited by 72 · see citing works
Crepis foetida L. subsp. rhoeadifolia (Bieb.) Celak. as a source of multifunctional agents: Cytotoxic and phytochemical evaluation
Zengin, G., Sarıkürkçü, C., Uyar, P., Aktümsek, A., Uysal, Ş., Kocak, M. S., & Ceylan, R. (2015) · Journal of Functional Foods · doi:10.1016/j.jff.2015.06.041 · Cited by 73 · see citing works
The synthesis of novel sulfamides derived from β-benzylphenethylamines as acetylcholinesterase, butyrylcholinesterase and carbonic anhydrase enzymes inhibitors
Akıncıoğlu, A., Kocaman, E., Akıncıoğlu, H., Salmas, R. E., Durdağı, S., Gülçın, İ., Supuran, C. T., & Göksu, S. (2017) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2017.08.012 · Cited by 70 · see citing works
Anti-Acetylcholinesterase Activities of Mono-Herbal Extracts and Exhibited Synergistic Effects of the Phytoconstituents: A Biochemical and Computational Study
Balkrishna, A., Pokhrel, S., Tomer, M., Verma, S., Kumar, A., Nain, P., Gupta, A. K., & Varshney, A. (2019) · Molecules · doi:10.3390/molecules24224175 · Cited by 70 · see citing works
A caryophyllene oxide and other potential anticholinesterase and anticancer agent in Salvia verticillata subsp. amasiaca (Freyn & Bornm.) Bornm. (Lamiaceae)
Karakaya, S., Yılmaz, S. V., Tozlu, Ö. Ö., Koca, M., Pınar, N. M., Demırcı, B., Yıldırım, K., Sytar, O., Türkez, H., & Başer, K. H. C. (2020) · Journal of Essential Oil Research · doi:10.1080/10412905.2020.1813212 · Cited by 69 · see citing works
Anticholinesterase and Antioxidant Activities of Fucoxanthin Purified from the Microalga Phaeodactylum Tricornutum
Kawee‐ai, A., Kuntiya, A., & Kim, S. M. (2013) · Natural Product Communications · doi:10.1177/1934578x1300801010 · Cited by 68 · see citing works
Neuroactive Multifunctional Tacrine Congeners with Cholinesterase, Anti-Amyloid Aggregation and Neuroprotective Properties
Kožurková, M., Hamuľaková, S., Gažová, Z., Paulíková, H., & Kristián, P. (2011) · Pharmaceuticals · doi:10.3390/ph4020382 · Cited by 68 · see citing works
Medicinal plants with cholinesterase inhibitory activity: A Review
Adewusi, E. A., Moodley, N., & Steenkamp, V. (2010) · UpSpace Institutional Repository (University of Pretoria) · Cited by 68 · see citing works
Nutritional and bioactive potential of seagrasses: A review
Kim, D. H., Mahomoodally, M. F., Sadeer, N. B., Park, G. S., Zengin, G., Palaniveloo, K., Khalil, A. A., Rauf, A., & Rengasamy, K. R. R. (2020) · South African Journal of Botany · doi:10.1016/j.sajb.2020.10.018 · Cited by 67 · see citing works
Antioxidant and Anticholinesterase Potential of SixThymusSpecies
Kindl, M., Blažeković, B., Bučar, F., & Vladimir‐Knežević, S. (2015) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2015/403950 · Cited by 66 · see citing works

Acetylcholinesterase inhibition by medicinal plants: A Review
Ranjan, N., & Kumari, M. (2017) · Annals of Plant Sciences · doi:10.21746/aps.2017.06.003 · Cited by 26 · see citing works
ISSN 1684–5315 © 2010 Academic Journals Review Medicinal plants with cholinesterase inhibitory activity: A Review
Adewusi, E. A., Moodley, N., & Steenkamp, V. (2016)
Medicinal plants with cholinesterase inhibitory activity: A Review
Adewusi, E. A., Moodley, N., & Steenkamp, V. (2010) · UpSpace Institutional Repository (University of Pretoria) · Cited by 68 · see citing works
SOME PLANTS AS A SOURCE OF ACETYL CHOLINESTERASE INHIBITORS: A REVIEW
Deka, P., Kumar, A., Nayak, B. K., & Eloziia, N. (2017) · International Research Journal of Pharmacy · doi:10.7897/2230-8407.08565 · Cited by 7 · see citing works
Review Medicinal plants with cholinesterase inhibitory activity: A Review
Adewusi, E. A., Moodley, N., & Steenkamp, V. (2016)

Authors: Mukherjee, P. K., Kumar, V., Mal, M., & Houghton, P. J.
Affiliations: Jadavpur University (IN)
King's College London (GB)
Corresponding author: Mukherjee, Pulok K.
ORCID: Mukherjee, Pulok K.
Mal, Mainak
Houghton, Peter J.
Venue: Phytomedicine
Publisher: Elsevier BV
Published: 2007-04
Volume: 14
Issue: 4
Pages: 289-300
ISSN: 0944-7113 (ISSN-L)
DOI: 10.1016/j.phymed.2007.02.002
OpenAlex: W2060288971
Cited by: 809
References: 62
Citations by year: 2026: 19 · 2025: 38 · 2024: 45 · 2023: 55 · 2022: 56 · 2021: 50 · 2020: 59 · 2019: 44 · 2018: 51 · 2017: 54 · 2016: 61 · 2015: 56 · 2014: 50 · 2013: 35 · 2012: 41
FWCI: 14.70
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Phytomedicine (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pharmacology › Cholinesterase and Neurodegenerative Diseases
Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioactive natural compounds
Keywords: acetylcholinesterase inhibitors, phytochemicals, phytochemical constituents, Alzheimer's disease, senile dementia, myasthenia gravis, ataxia, acetylcholine, plant species screening
MeSH terms: Alzheimer Disease, Cholinesterase Inhibitors, Humans, Phytotherapy, Plant Extracts, Plants, Medicinal

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Acetylcholinesterase inhibitors from plants

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