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Paramagnetic lanthanide complexes as PARACEST agents for medical imaging
Open accessAbstract
This tutorial review examines the fundamental aspects of a new class of contrast media for MRI based upon the chemical shift saturation transfer (CEST) mechanism. Several paramagnetic versions called PARACEST agents have shown utility as responsive agents for reporting physiological or metabolic information by MRI. It is shown that basic NMR exchange theory can be used to predict how parameters such as chemical shift, bound water lifetimes, and relaxation rates can be optimized to maximize the sensitivity of PARACEST agents.
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Citations
Cited by
Lanthanide Probes for Bioresponsive Imaging
Heffern, M. C., Matosziuk, L. M., & Meade, T. J. (2014) · Chemical Reviews · doi:10.1021/cr400477t · Cited by 1,202
Chemical exchange saturation transfer (CEST): what is in a name and what isn't?
van Zijl, P. C. M., & Yadav, N. N. (2011) · Magnetic Resonance in Medicine · doi:10.1002/mrm.22761 · Cited by 1,155
Causes and Consequences of Increased Glucose Metabolism of Cancers
Gillies, R. J., Robey, I., & Gatenby, R. A. (2008) · Journal of Nuclear Medicine · doi:10.2967/jnumed.107.047258 · Cited by 623
Viral Nanoparticles for Drug Delivery, Imaging, Immunotherapy, and Theranostic Applications
Chung, Y. H., Cai, H., & Steinmetz, N. F. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.06.024 · Cited by 391
Natural D ‐glucose as a biodegradable MRI contrast agent for detecting cancer
Chan, K. W. Y., McMahon, M. T., Kato, Y., Liu, G., Bulte, J. W. M., Bhujwalla, Z. M., Artemov, D., & van Zijl, P. C. M. (2012) · Magnetic Resonance in Medicine · doi:10.1002/mrm.24520 · Cited by 337
Metadata
- Authors
- Woods, M., Woessner, D. E., & Sherry, A. D.
- Venue
- Chemical Society Reviews
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2006
- Volume
- 35
- Issue
- 6
- Pages
- 500
- ISSN
- 0306-0012 (ISSN-L)
- 1460-4744
- OpenAlex
- W2159412453
- Cited by
- 393
- References
- 0
- FWCI
- 1.95
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
