Natural products to drugs: natural product-derived compounds in clinical trials

Drugs of the 21st century: telithromycin (HMR 3647)--the first ketolide

Ackermann, G., & Rodloff, A. C. (2003) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkg123 · Cited by 123

Microvascular mechanisms by which the combretastatin A-4 derivative AC7700 (AVE8062) induces tumour blood flow stasis

Hori, K., & Saito, S. (2003) · British Journal of Cancer · doi:10.1038/sj.bjc.6601261 · Cited by 123

Glycylcyclines: third-generation tetracycline antibiotics

Chopra, I. (2001) · Current Opinion in Pharmacology · doi:10.1016/s1471-4892(01)00081-9 · Cited by 122

Pharmacological Enhancement of Mutated α-Glucosidase Activity in Fibroblasts from Patients with Pompe Disease

Parenti, G., Zuppaldi, A., Pittis, M. G., Tuzzi, M. R., Annunziata, I., Meroni, G., Porto, C., Donaudy, F., Rossi, B., Rossi, M., et al. (2007) · Molecular Therapy · doi:10.1038/sj.mt.6300074 · Cited by 121

Identification of a mutant human topoisomerase I with intact catalytic activity and resistance to 9-nitro-camptothecin.

Rubin, E. H., Pantazis, P., Bharti, A. K., Toppmeyer, D., Giovanella, B. C., & Kufe, D. W. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)41964-8 · Cited by 120

Biochemical Characterization of the Interactions of the Novel Pleuromutilin Derivative Retapamulin with Bacterial Ribosomes

Yan, K., Madden, L., Choudhry, A. E., Voigt, C. S., Copeland, R. A., & Gontarek, R. R. (2006) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00184-06 · Cited by 120

Neurotrophic 3,9-Bis[(alkylthio)methyl]- and -Bis(alkoxymethyl)-K-252a Derivatives

Kaneko, M., Saito, Y., Saito, H., Matsumoto, T., Matsuda, Y., Vaught, J. L., Dionne, C. A., Angeles, T. S., Glicksman, M. A., Neff, N. T., et al. (1997) · Journal of Medicinal Chemistry · doi:10.1021/jm970031d · Cited by 119

Novel antifungal β-amino acids: synthesis and activity against Candida albicans

Mittendorf, J., Kunisch, F., Matzke, M., et al. (2003) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/s0960-894x(02)00958-7 · Cited by 119

Anabaseine Is a Potent Agonist on Muscle and Neuronal Alpha-Bungarotoxin-Sensitive Nicotinic Receptors

Kem, W. R., Mahnir, V. M., Papke, R. L., & Lingle, C. J. (1997) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37134-4 · Cited by 119

Cispentacin, a new antifungal antibiotic. II. In vitro and in vivo antifungal activities.

OKI, T., HIRANO, M., TOMATSU, K., Numata, K.-I., & Kamei, H. (1989) · The Journal of Antibiotics · doi:10.7164/antibiotics.42.1756 · Cited by 119

The Treatment of Amebiasis with Fumagillin

Killough, J. H., Magill, G. B., & Smith, R. C. G. (1952) · Science · doi:10.1126/science.115.2977.71 · Cited by 118

Glycylcyclines. 1. A new generation of potent antibacterial agents through modification of 9-aminotetracyclines

Sum, P., LEE, V. J., TESTA, R. T., Hlavka, J. J., Ellestad, G. A., Bloom, J. D., Gluzman, Y., & Tally, F. P. (1994) · Journal of Medicinal Chemistry · doi:10.1021/jm00027a023 · Cited by 118

Bryostatin-1: Pharmacology and Therapeutic Potential as a CNS Drug

Sun, M., & Alkon, D. L. (2006) · CNS Drug Reviews · doi:10.1111/j.1527-3458.2006.00001.x · Cited by 117

Intravenous ancrod for acute ischaemic stroke in the European Stroke Treatment with Ancrod Trial: a randomised controlled trial

Hennerici, M. G., Kay, R., Bogousslavsky, J., Lenzi, G. L., Verstraete, M., & Orgogozo, J. M. (2006) · The Lancet · doi:10.1016/s0140-6736(06)69776-6 · Cited by 117

PG490-88, a derivative of triptolide, causes tumor regression and sensitizes tumors to chemotherapy.

Fidler, J. M., Li, K., Chung, C. T., Wei, K., Ross, J. A., Gao, M., & Rosen, G. (2003) · PubMed · Cited by 117

Activities of Doripenem (S-4661) against Drug-Resistant Clinical Pathogens

Jones, R. N., Huynh, H. K., & Biedenbach, D. J. (2004) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.48.8.3136-3140.2004 · Cited by 116

Structure of the saponin adjuvant QS-21 and its base-catalyzed isomerization product by 1H and natural abundance 13C NMR spectroscopy

Jacobsen, N. E., Fairbrother, W. J., Kensil, C. R., Lim, A., Wheeler, D. A., & Powell, M. F. (1996) · Carbohydrate Research · doi:10.1016/0008-6215(95)00278-2 · Cited by 115

Semisynthetic Chemical Modification of the Antifungal Lipopeptide Echinocandin B (ECB): Structure-Activity Studies of the Lipophilic and Geometric Parameters of Polyarylated Acyl Analogs of ECB

Debono, M., Turner, W. W., LaGrandeur, L., et al. (1995) · Journal of Medicinal Chemistry · doi:10.1021/jm00017a012 · Cited by 114

QS-21 structure/function studies: effect of acylation on adjuvant activity

Liu, G., Anderson, C., Scaltreto, H., Barbon, J., & Kensil, C. R. (2002) · Vaccine · doi:10.1016/s0264-410x(02)00209-8 · Cited by 114

Glycopeptides in clinical development: pharmacological profile and clinical perspectives

Françoise Van Bambeke, A. (2004) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2004.04.006 · Cited by 114

Review of UCN‐01 Development: A Lesson in the Importance of Clinical Pharmacology

Fuse, E., Kuwabara, T., Sparreboom, A., Sausville, E. A., & Figg, W. D. (2005) · The Journal of Clinical Pharmacology · doi:10.1177/0091270005274549 · Cited by 113

Novel Erythromycin Derivatives with Aryl Groups Tethered to the C-6 Position Are Potent Protein Synthesis Inhibitors and Active against Multidrug-Resistant Respiratory Pathogens

Ma, Z., Clark, R. F., Brazzale, A., Wang, S., Rupp, M., Li, L., Griesgraber, G. W., Zhang, S., Yong, H., Phan, L., et al. (2001) · Journal of Medicinal Chemistry · doi:10.1021/jm0102349 · Cited by 112

Syntheses and Structure−Activity Relationships of Taxoids Derived from 14β-Hydroxy-10-deacetylbaccatin III

Ojima, I., Slater, J. C., Kuduk, S. D., Takeuchi, C. S., Gimi, R. H., Sun, C., Park, Y. H., Pera, P. J., Veith, J. M., & Bernacki, R. J. (1997) · Journal of Medicinal Chemistry · doi:10.1021/jm960563e · Cited by 112

REDISCOVERING NATURAL PRODUCTS

ROUHI, A. M. (2003) · Chemical & Engineering News · doi:10.1021/cen-v081n041.p077 · Cited by 112

Nonlinear accumulation in the brain of the new taxoid TXD258 following saturation of P‐glycoprotein at the blood–brain barrier in mice and rats

Cisternino, S., Bourasset, F., Archimbaud, Y., Sémiond, D., Sanderink, G., & Scherrmann, J. (2003) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705150 · Cited by 111

Monoclonal Antibodies in the Treatment of Non-Hodgkin???s Lymphoma

Fanale, M. A., & Younes, A. (2007) · Drugs · doi:10.2165/00003495-200767030-00002 · Cited by 111

Vancomycin resistance: occurrence, mechanisms and strategies to combat it

Boneca, I. G., & Chiosis, G. (2003) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.7.3.311 · Cited by 111

Synthesis and Antitumor Activity of Novel Dolastatin 10 Analogs.

MIYAZAKI, K., Kobayashi, M., Natsume, T., Gondo, M., Mikami, T., SAKAKIBARA, K., & Tsukagoshi, S. (1995) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.43.1706 · Cited by 111

Natural Product-Based Anti-HIV Drug Discovery and Development Facilitated by the NCI Developmental Therapeutics Program

Yang, S. S., Cragg, G. M. L., Newman, D. J., & Bader, J. P. (2001) · Journal of Natural Products · doi:10.1021/np0003995 · Cited by 110

The discovery and development of antiinflammatory drugs

Brune, K., & Hinz, B. (2004) · Arthritis & Rheumatism · doi:10.1002/art.20424 · Cited by 110

From toxicological problem to therapeutic use: The discovery of the mode of action of 2‐(2‐nitro‐4‐trifluoromethylbenzoyl)‐1,3‐cyclohexanedione (NTBC), its toxicology and development as a drug

Lock, E. A., Ellis, M. K., Gaskin, P., Robinson, M., Auton, T. R., Provan, W. M., Smith, L. L., Prisbylla, M. P., Mutter, L. C., & Lee, D. L. (1998) · Journal of Inherited Metabolic Disease · doi:10.1023/a:1005458703363 · Cited by 109

The good and the bad effects of (−) trans-delta-9-tetrahydrocannabinol (Δ9-THC) on humans

Carlini, E. A. (2004) · Toxicon · doi:10.1016/j.toxicon.2004.05.009 · Cited by 108

Gemtuzumab ozogamicin in the treatment of acute myeloid leukemia

Giles, F. J., Estey, E. H., & O'Brien, S. M. (2003) · Cancer · doi:10.1002/cncr.11791 · Cited by 108

Effect of the Second-Generation Vascular Disrupting Agent OXi4503 on Tumor Vascularity

Salmon, H. W., & Siemann, D. W. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-0163 · Cited by 108

In Vitro Activities of the New Semisynthetic Glycopeptide Telavancin (TD-6424), Vancomycin, Daptomycin, Linezolid, and Four Comparator Agents against Anaerobic Gram-Positive Species and Corynebacterium spp

Goldstein, E. J. C., Citron, D. M., Merriam, C. V., Warren, Y. A., Tyrrell, K. L., & Fernandez, H. T. (2004) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.48.6.2149-2152.2004 · Cited by 108

Trabectedin: A Review of its Use in the Management of Soft Tissue Sarcoma and Ovarian Cancer

Carter, N. J., & Keam, S. J. (2007) · Drugs · doi:10.2165/00003495-200767150-00009 · Cited by 107

Efficacy of Selected Natural Products as Therapeutic Agents against Cancer

Banerjee, S., Wang, Z., Mohammad, M., Sarkar, F. H., & Mohammad, R. M. (2008) · Journal of Natural Products · doi:10.1021/np0705716 · Cited by 107

A phase 2 study of aztreonam lysine for inhalation to treat patients with cystic fibrosis and Pseudomonas aeruginosa infection

Retsch‐Bogart, G. Z., Burns, J. L., Otto, K., Liou, T. G., McCoy, K., Oermann, C. M., Gibson, R. L., & AZLI Phase II Study Group (2007) · Pediatric Pulmonology · doi:10.1002/ppul.20736 · Cited by 107

Glycopeptides: Update on an old successful antibiotic class

Pace, J., & Yang, G. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2005.12.005 · Cited by 107

The structure of rohitukine, the main alkaloid of (Syn. ) (meliaceae)

Harmon, A. D., Weiß, U., & Silverton, J. V. (1979) · Tetrahedron Letters · doi:10.1016/s0040-4039(01)93556-7 · Cited by 107

Salt form selection and characterization of LY333531 mesylate monohydrate

Engel, G. L., Farid, N. A., Faul, M. M., Richardson, L. A., & Winneroski, L. L. (2000) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(00)00350-1 · Cited by 107

The Targets of Currently Used Antibacterial Agents: Lessons for Drug Discovery

Lange, R., Locher, H. H., Wyss, P. C., et al. (2007) · Current Pharmaceutical Design · doi:10.2174/138161207782110408 · Cited by 107

Progress in Clinical, Pharmacological, Chemical and Structural Biological Studies of Huperzine A: A Drug of Traditional Chinese Medicine Origin for the Treatment of Alzheimers Disease

Jiang, H., Luo, X., & Bai, D. (2003) · Current Medicinal Chemistry · doi:10.2174/0929867033456747 · Cited by 106

Ramoplanin Inhibits Bacterial Transglycosylases by Binding as a Dimer to Lipid II

Hu, Y., Helm, J. S., Chen, L., Ye, X., & Walker, S. (2003) · Journal of the American Chemical Society · doi:10.1021/ja035217i · Cited by 105

Design, Synthesis, and Antimicrobial Activity of 6-O-Substituted Ketolides Active against Resistant Respiratory Tract Pathogens

Or, Y. S., Clark, R. F., Wang, S., et al. (2000) · Journal of Medicinal Chemistry · doi:10.1021/jm990618n · Cited by 104

Exenatide: A Review of Its Use in Patients with Type 2 Diabetes Mellitus (as an Adjunct to Metformin and/or a Sulfonylurea)

Cvetkovi, R. S., & Plosker, G. L. (2007) · Drugs · doi:10.2165/00003495-200767060-00008 · Cited by 104

Friulimicins. Novel Lipopeptide Antibiotics with Peptidoglycan Synthesis Inhibiting Activity from Actinoplanes friuliensis sp. nov. II. Isolation and Structural Characterization.

Vértesy, L., Ehlers, E., Kogler, H., Kurz, M. E., Meiwes, J., SEIBERT, G., VOGEL, M., & Hammann, P. (2000) · The Journal of Antibiotics · doi:10.7164/antibiotics.53.816 · Cited by 104

Antifungal Activities of Antineoplastic Agents: Saccharomyces cerevisiae as a Model System To Study Drug Action

Cardenas, M. E., Cruz, M. C., Poeta, M. D., Chung, N., Perfect, J. R., & Heitman, J. (1999) · Clinical Microbiology Reviews · doi:10.1128/cmr.12.4.583 · Cited by 103

Histone deacetylase inhibitors – a new tool to treat cancer

Somech, R., Izraeli, S., & Simon, A. J. (2004) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2004.04.006 · Cited by 101

Histone deacetylase inhibitors in clinical development

Rosato, R. R., & Grant, S. (2004) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.13.1.21 · Cited by 101

(-)-Phenylahistin Arrests Cells in Mitosis by Inhibiting Tubulin Polymerization.

Kanoh, K., KOHNO, S., Katada, J., TAKAHASHI, J., & Uno, I. (1999) · The Journal of Antibiotics · doi:10.7164/antibiotics.52.134 · Cited by 101

Distinguishing between Natural Products and Synthetic Molecules by Descriptor Shannon Entropy Analysis and Binary QSAR Calculations

Stahura, F. L., Godden, J. W., Xue, L., & Bajorath, J. (2000) · Journal of Chemical Information and Computer Sciences · doi:10.1021/ci0003303 · Cited by 101

Lipiarmycin, a new antibiotic from Actinoplanes. II. Isolation, chemical, bilogical and biochemical characterization.

Coronelli, C., White, R. J., Lancini, G., & PARENTI, F. (1975) · The Journal of Antibiotics · doi:10.7164/antibiotics.28.253 · Cited by 101

A randomized, double‐blind, four‐arm parallel‐group, placebo‐controlled Phase II/III study to investigate the clinical efficacy of two galenic formulations of Polyphenon® E in the treatment of external genital warts

Gross, G., Meyer, K., Pres, H., Thielert, C., Tawfik, H., & Mescheder, A. (2007) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/j.1468-3083.2007.02441.x · Cited by 101

Cyclic MrIA: A Stable and Potent Cyclic Conotoxin with a Novel Topological Fold that Targets the Norepinephrine Transporter

Lovelace, E. S., Armishaw, C. J., Colgrave, M. L., Wahlstrom, M. E., Alewood, P. F., Daly, N. L., & Craik, D. J. (2006) · Journal of Medicinal Chemistry · doi:10.1021/jm060299h · Cited by 100

In vivo pharmacodynamics of HMR 3270, a glucan synthase inhibitor, in a murine candidiasis model

Andes, D., Marchillo, K., Lowther, J., Bryskier, A., Stamstad, T., & Conklin, R. (2003) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.47.4.1187-1192.2003 · Cited by 100

A Tetrodotoxin-Producing Vibrio Strain, LM-1, from the Puffer Fish Fugu vermicularis radiatus

Lee, M.-J., Jeong, D.-Y., Kim, W.-S., et al. (2000) · Applied and Environmental Microbiology · doi:10.1128/aem.66.4.1698-1701.2000 · Cited by 100

Perifosine, a novel alkylphospholipid, induces p21(WAF1) expression in squamous carcinoma cells through a p53-independent pathway, leading to loss in cyclin-dependent kinase activity and cell cycle arrest.

Patel, V., Lahusen, T. J., Sy, T. H., Sausville, E. A., Gutkind, J. S., & Senderowicz, A. M. (2002) · PubMed · Cited by 99

Anti-infective research and development—problems, challenges, and solutions

Bradley, J. S., Guidos, R., Baragona, S., Bartlett, J. G., Rubinstein, E., Zhanel, G. G., Tino, M. D., Pompliano, D. L., Tally, F., Tipirneni, P., et al. (2006) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(06)70689-2 · Cited by 99

Synthetic nonpsychotropic cannabinoids with potent antiinflammatory, analgesic, and leukocyte antiadhesion activities

BURSTEIN, S. H., Audette, C. A., Breuer, A., Devane, W. A., Colodner, S., Doyle, S. A., & Mechoulam, R. (1992) · Journal of Medicinal Chemistry · doi:10.1021/jm00095a007 · Cited by 99

The Discovery and Development of Modified Penicillin- and Cephalosporin- Derived β-Lactamase Inhibitors

Buynak, J. D. (2004) · Current Medicinal Chemistry · doi:10.2174/0929867043364847 · Cited by 99

Cytotoxic and tubulin-interactive hemiasterlins from Auletta sp. and Siphonochalina spp. sponges

Gamble, W. R., Durso, N. A., Fuller, R. W., Westergaard, C. K., Johnson, T. R., Sackett, D. L., Hamel, E., Cardellina, J. H., & Boyd, M. R. (1999) · Bioorganic & Medicinal Chemistry · doi:10.1016/s0968-0896(99)00089-9 · Cited by 98

Zotarolimus (ABT-578) eluting stents

Burke, S. E., Kuntz, R. E., & Schwartz, L. B. (2006) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2006.01.021 · Cited by 98

Cinnabaramides A−G: Analogues of Lactacystin and Salinosporamide from a Terrestrial Streptomycete

Stadler, M., Bitzer, J., Mayer‐Bartschmid, A., Müller, H., Benet‐Buchholz, J., Gantner, F., Tichy, H., Reinemer, P., & Bacon, K. B. (2007) · Journal of Natural Products · doi:10.1021/np060162u · Cited by 98

Phase I trial of orally administered CEP-701, a novel neurotrophin receptor-linked tyrosine kinase inhibitor

Marshall, J. L., Kindler, H. L., Deeken, J. F., Bhargava, P., Vogelzang, N. J., Rizvi, N. A., Luhtala, T., Boylan, S., Dordal, M. S., Robertson, P., et al. (2004) · Investigational New Drugs · doi:10.1023/b:drug.0000047103.64335.b0 · Cited by 97

Antibacterials: are the new entries enough to deal with the emerging resistance problems?

Barrett, C. T., & Barrett, J. F. (2003) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2003.10.003 · Cited by 97

Biapenem

Perry, C. M., & Ibbotson, T. (2002) · Drugs · doi:10.2165/00003495-200262150-00005 · Cited by 97

Evaluation of a cyclophilin inhibitor in hepatitis C virus–infected chimeric mice in vivo†

Inoue, K., Umehara, T., Rüegg, U. T., et al. (2007) · Hepatology · doi:10.1002/hep.21587 · Cited by 96

Dalbavancin: a Novel Once-Weekly Lipoglycopeptide Antibiotic

Saravolatz, L. D., Billeter, M., Zervos, M., Chen, A. Y., Dalovisio, J. R., & Kurukularatne, C. (2008) · Clinical Infectious Diseases · doi:10.1086/526772 · Cited by 96

Liraglutide: a once-daily GLP-1 analogue for the treatment of Type 2 diabetes mellitus

Vilsbøll, T. (2007) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.16.2.231 · Cited by 96

Neurosteroids: Cerebrospinal Fluid Levels for Alzheimer’s Disease and Vascular Dementia Diagnostics

Kim, S.-B., Hill, M., Kwak, Y. T., Hampl, R., Jo, D.-H., & Morfin, R. F. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030646 · Cited by 96

Marine-derived anticancer agents in clinical trials

Schwartsmann, G., da Rocha, A. B., Mattei, J., & Lopes, R. (2003) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.12.8.1367 · Cited by 95

Peroxide Bond-Dependent Antiplasmodial Specificity of Artemisinin and OZ277 (RBx11160)

Kaiser, M., Wittlin, S., Nehrbass-Stuedli, A., Dong, Y., Wang, X., Hemphill, A. F., Matile, H., Brun, R., & Vennerstrom, J. L. (2007) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00225-07 · Cited by 95

Effect of pyridoxamine (K-163), an inhibitor of advanced glycation end products, on type 2 diabetic nephropathy in KK-Ay/Ta mice

Tanimoto, M., Gohda, T., Kaneko, S., Hagiwara, S., Murakoshi, M., Aoki, T., Yamada, K. H., Ito, T., Matsumoto, M., Horikoshi, S., et al. (2007) · Metabolism · doi:10.1016/j.metabol.2006.08.026 · Cited by 94

FTY720, an immunomodulatory sphingolipid mimetic: translation of a novel mechanism into clinical benefit in multiple sclerosis

Baumruker, T., Billich, A., & Brinkmann, V. (2007) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.16.3.283 · Cited by 94

Safety and Pharmacokinetics of Single Doses of (+)-Calanolide A, a Novel, Naturally Occurring Nonnucleoside Reverse Transcriptase Inhibitor, in Healthy, Human Immunodeficiency Virus-Negative Human Subjects

Creagh-Kirk, T., Ruckle, J., Tolbert, D. T., Giltner, J., Eiznhamer, D. A., Dutta, B., Flavin, M. T., & Xu, Z. (2001) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.45.5.1379-1386.2001 · Cited by 94

Enhanced Tumor Cell Radiosensitivity and Abrogation of G2 and S Phase Arrest by the Hsp90 Inhibitor 17-(Dimethylaminoethylamino)-17-demethoxygeldanamycin

Bull, E. E. A., Dote, H., Brady, K. J., Burgan, W. E., Carter, D. J., Cerra, M. A., Oswald, K. A., Hollingshead, M. G., Camphausen, K. A., & Tofilon, P. J. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-1212 · Cited by 94

Mixed lineage kinase activity of indolocarbazole analogues

Murakata, C., Kaneko, M., Gessner, G. W., Angeles, T. S., Ator, M. A., O’Kane, T. M., McKenna, B. A., Thomas, B. A., Mathiasen, J. R., Saporito, M. S., et al. (2002) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/s0960-894x(01)00690-4 · Cited by 93

Current immunosuppressive agents: efficacy, side effects, and utilization

Smith, J. M., Nemeth, T. L., & McDonald, R. A. (2003) · Pediatric Clinics of North America · doi:10.1016/s0031-3955(03)00121-4 · Cited by 93

The Synthetic Compound CC-5079 Is a Potent Inhibitor of Tubulin Polymerization and Tumor Necrosis Factor-α Production with Antitumor Activity

Zhang, L., Wu, L., Raymon, H. K., Chen, R. S., Corral, L. G., Shirley, M. A., Narla, R. K., Gamez, J., Muller, G. W., Stirling, D., et al. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-2083 · Cited by 93

Antimalarial efficacy and drug interactions of the novel semi-synthetic endoperoxide artemisone in vitro and in vivo

Vivas, L., Rattray, L., Stewart, L. B., et al. (2007) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkl563 · Cited by 93

Safety, Tolerance, and Pharmacokinetic Studies of OPT-80 in Healthy Volunteers following Single and Multiple Oral Doses

Shue, Y., Sears, P. S., Shangle, S., Walsh, R. B., Lee, C., Gorbach, S. L., Okumu, F. W., & Preston, R. A. (2008) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01045-07 · Cited by 93

Redefining penems

Dalhoff, A., Janjić, N., & ECHOLS, R. M. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2005.12.003 · Cited by 91

Selection of Retapamulin, a Novel Pleuromutilin for Topical Use

Rittenhouse, S. F., Biswas, S., Broskey, J. P., McCloskey, L., Moore, T. D., Vasey, S. Y., West, J. M., Zalacaín, M., Zonis, R., & Payne, D. J. (2006) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00178-06 · Cited by 90

The merger of natural product synthesis and medicinal chemistry: on the chemistry and chemical biology of epothilones

Altmann, K. (2004) · Organic & Biomolecular Chemistry · doi:10.1039/b405839a · Cited by 90

Late stage antibacterial drugs in the clinical pipeline

Projan, S. J., & Bradford, P. A. (2007) · Current Opinion in Microbiology · doi:10.1016/j.mib.2007.08.007 · Cited by 89

Inhibition of Endotoxin Response by Synthetic TLR4 Antagonists

Hawkins, L. D., Christ, W. J., & Rossignol, D. P. (2004) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026043388123 · Cited by 89

The Discovery of NVP-LAQ824: From Concept to Clinic

Remiszewski, S. (2003) · Current Medicinal Chemistry · doi:10.2174/0929867033456675 · Cited by 88

Tiacumicins, a novel complex of 18-membered macrolides. II. Isolation and structure determination.

Hochlowski, J. E., Swanson, S., RANFRANZ, L. M., Whittern, D. N., BUKO, A. M., & McAlpine, J. B. (1987) · The Journal of Antibiotics · doi:10.7164/antibiotics.40.575 · Cited by 88

Action of Celgosivir (6O-Butanoyl Castanospermine) against the Pestivirus BVDV: Implications for the Treatment of Hepatitis C

Whitby, K., Taylor, D. L., Patel, D., Ahmed, P. S., & Tyms, A. S. (2004) · Antiviral chemistry & chemotherapy · doi:10.1177/095632020401500304 · Cited by 88

Ziconotide: a new nonopioid intrathecal analgesic for the treatment of chronic pain

Wallace, M. S. (2006) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.6.10.1423 · Cited by 88

Antibiotic GE2270 A: A novel inhibitor of bacterial protein synthesis. II. Structure elucidation.

KETTENRING, J., Colombo, L., Ferrari, P., Tavecchia, P., Nebuloni, M., VÉREY, K., Gallo, G. G., & Selva, E. (1991) · The Journal of Antibiotics · doi:10.7164/antibiotics.44.702 · Cited by 87

Antiangiogenic activity of aplidine, a new agent of marine origin

Taraboletti, G., Poli, M., Dossi, R., Manenti, L., Borsotti, P., Faircloth, G. T., Broggini, M., D’Incalci, M., Ribatti, D., & Giavazzi, R. (2004) · British Journal of Cancer · doi:10.1038/sj.bjc.6601864 · Cited by 87

Natural products in drug discovery – Creating a new vision

Cordell, G. A. (2002) · Phytochemistry Reviews · doi:10.1023/a:1026094701495 · Cited by 86

Protease-Mediated Fragmentation of p-Amidobenzyl Ethers: A New Strategy for the Activation of Anticancer Prodrugs

Toki, B. E., Cerveny, C. G., Wahl, A. F., & Senter, P. D. (2002) · The Journal of Organic Chemistry · doi:10.1021/jo016187+ · Cited by 86

Omiganan Pentahydrochloride in the Front Line of Clinical Applications of Antimicrobial Peptides

Melo, M. N., Dugourd, D., & Castanho, M. A. R. B. (2006) · Recent Patents on Anti-Infective Drug Discovery · doi:10.2174/157489106777452638 · Cited by 86

PKC inhibition and diabetic microvascular complications

Clarke, M., & Dodson, P. M. (2007) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2007.09.007 · Cited by 85

Antibacterial research and development in the 21st Century – an industry perspective of the challenges

Thomson, C. J., Power, E., Rübsamen‐Waigmann, H., & Labischinski, H. (2004) · Current Opinion in Microbiology · doi:10.1016/j.mib.2004.08.009 · Cited by 84

In vitro antimicrobial activity of T-91825, a novel anti-MRSA cephalosporin, and in vivo anti-MRSA activity of its prodrug, TAK-599

Iizawa, Y., Nagai, J., Ishikawa, T., Hashiguchi, S., Nαkαo, M., Miyake, A., & Okonogi, K. (2004) · Journal of Infection and Chemotherapy · doi:10.1007/s10156-004-0309-3 · Cited by 84

Zotarolimus, a Novel Sirolimus Analogue With Potent Anti-proliferative Activity on Coronary Smooth Muscle Cells and Reduced Potential for Systemic Immunosuppression

Chen, Y., Smith, M. L., Sheets, M. P., Ballaron, S. J., Trevillyan, J. M., Burke, S. E., Rosenberg, T. A., Henry, C. L., Wagner, R., Bauch, J. L., et al. (2007) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0b013e3180325b0a · Cited by 83

Histone Deacetylase Inhibitors: From Chromatin Remodeling to Experimental Cancer Therapeutics

Arts, J. J. G., Schepper, S. D., & Emelen, K. V. (2003) · Current Medicinal Chemistry · doi:10.2174/0929867033456657 · Cited by 83

The Trk tyrosine kinase inhibitor CEP-701 (KT-5555) exhibits significant antitumor efficacy in preclinical xenograft models of human pancreatic ductal adenocarcinoma.

Miknyoczki, S. J., Chang, H., Klein–Szanto, A. J., Dionne, C. A., & Ruggeri, B. (1999) · PubMed · Cited by 83

Natural Product Origins of Hsp90 Inhibitors

Uehara, Y. (2003) · Current Cancer Drug Targets · doi:10.2174/1568009033481796 · Cited by 82

2007 FDA drug approvals: a year of flux

Hughes, B. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2514 · Cited by 82

Alkaloid homoharringtonine inhibits polypeptide chain elongation on human ribosomes on the step of peptide bond formation

Tujebajeva, R. M., Graifer, D. M., Karpova, G. G., et al. (1989) · FEBS Letters · doi:10.1016/0014-5793(89)81546-7 · Cited by 82

A phase I and pharmacokinetic study of squalamine, a novel antiangiogenic agent, in patients with advanced cancers.

Bhargava, P., Marshall, J. L., Dahut, W., Rizvi, N., Trocky, N. M., Williams, J. I., Hait, H. I., Song, S. H., Holroyd, K. J., & Hawkins, M. (2001) · PubMed · Cited by 81

Friulimicins: Novel Lipopeptide Antibiotics with Peptidoglycan Synthesis Inhibiting Activity from Actinoplanes friuliensis sp. nov. I. Taxonomic Studies of the Producing Microorganism and Fermentation.

Aretz, W., Meiwes, J., SEIBERT, G., Vobis, G., & Wink, J. M. (2000) · The Journal of Antibiotics · doi:10.7164/antibiotics.53.807 · Cited by 81

Ajulemic acid: A novel cannabinoid produces analgesia without a “high”

BURSTEIN, S. H., Karst, M., Schneider, U., & Zurier, R. B. (2004) · Life Sciences · doi:10.1016/j.lfs.2004.04.010 · Cited by 81

PG490-88, a Derivative of Triptolide, Blocks Bleomycin-Induced Lung Fibrosis

Krishna, G., Liu, K., Shigemitsu, H., Gao, M., Raffin, T. A., & Rosen, G. (2001) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64046-1 · Cited by 81

NMR Spectroscopy Tools for Structure‐Aided Drug Design

Homans, S. W. (2003) · Angewandte Chemie International Edition · doi:10.1002/anie.200300581 · Cited by 81

Localization of ‘ Candidatus Endobugula sertula’ and the bryostatins throughout the life cycle of the bryozoan Bugula neritina

Sharp, K. H., Davidson, S. K., & Haygood, M. G. (2007) · The ISME Journal · doi:10.1038/ismej.2007.78 · Cited by 80

Methylnaltrexone Mechanisms of Action and Effects on Opioid Bowel Dysfunction and Other Opioid Adverse Effects

Yuan, C. (2007) · Annals of Pharmacotherapy · doi:10.1345/aph.1k009 · Cited by 80

Phase I study of docosahexaenoic acid-paclitaxel: a taxane-fatty acid conjugate with a unique pharmacology and toxicity profile.

Wolff, A. C., Donehower, R. C., Carducci, M., Carducci, M. A., Brahmer, J. R., Zabelina, Y., Bradley, M. O., Anthony, F. H., Swindell, C. S., Witman, P. A., et al. (2003) · PubMed · Cited by 80

Antitubulin agents for the treatment of cancer – a medicinal chemistry update

Mahindroo, N., Liou, J., Chang, J., & Hsieh, H. (2006) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543776.16.5.647 · Cited by 79

Antimicrobial Activities of Ceftaroline and ME1036 Tested against Clinical Strains of Community-Acquired Methicillin-Resistant Staphylococcus aureus

Sader, H. S., Fritsche, T. R., & Jones, R. N. (2008) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01351-07 · Cited by 79

Exenatide

Barnett, A. (2007) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.8.15.2593 · Cited by 79

FK228 (depsipeptide): a HDAC inhibitor with pleiotropic antitumor activities

Konstantinopoulos, P. A., Vandoros, G. P., & Papavassiliou, A. G. (2006) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-005-0182-5 · Cited by 78

Antitumor activity of 7-[2-(N-isopropylamino)ethyl]-(20S)-camptothecin, CKD602, as a potent DNA topoisomerase I inhibitor

Lee, J., Lee, J.-M., Kim, J., Ahn, S.-K., Lee, S. J., Kim, M.-Y., Jew, S., Park, J.-G., & Hong, C. I. (1998) · Archives of Pharmacal Research · doi:10.1007/bf02975379 · Cited by 78

Everolimus

Chapman, T. M., & Perry, C. M. (2004) · Drugs · doi:10.2165/00003495-200464080-00005 · Cited by 78

DJ‐927, a novel oral taxane, overcomes P‐glycoprotein‐mediated multidrug resistance in vitro and in vivo

Shionoya, M., Jimbo, T., Kitagawa, M., Soga, T., & Tohgo, A. (2003) · Cancer Science · doi:10.1111/j.1349-7006.2003.tb01465.x · Cited by 77

Using Natural Product Inhibitors to Validate Hsp90 as a Molecular Target in Cancer

Neckers, L. (2006) · Current Topics in Medicinal Chemistry · doi:10.2174/156802606777811979 · Cited by 77

Mechanism of Antimalarial Action of the Synthetic Trioxolane RBX11160 (OZ277)

Uhlemann, A., Wittlin, S., Matile, H., Bustamante, L. Y., & Krishna, S. (2006) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01064-06 · Cited by 77

Safety and Pharmacokinetics of Bevirimat (PA-457), a Novel Inhibitor of Human Immunodeficiency Virus Maturation, in Healthy Volunteers

Martin, D. E., Blum, R. A., Wilton, J. H., Doto, J., Galbraith, H., Burgess, G. L., Smith, P. C., & Ballow, C. H. (2007) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01391-06 · Cited by 77

Modulation of protein kinase C in antitumor treatment

Hofmann, J. (2008) · Springer eBooks · doi:10.1007/bfb0117491 · Cited by 76

7‐Hydroxylated epiandrosterone (7‐OH‐EPIA) reduces ischaemia‐induced neuronal damage both in vivo and in vitro

Pringle, A. K., Schmidt, W., Deans, J. K., Wülfert, E., Reymann, K. G., & Sundström, L. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02734.x · Cited by 76

Macrolide Resistance from the Ribosome Perspective

Franceschi, F. J., Kanyo, Z. F., Sherer, E. C., et al. (2004) · Current Drug Targets - Infectious Disorders · doi:10.2174/1568005043340740 · Cited by 76

Transcriptional Activation of p21waf1/cip1 by Alkylphospholipids

Siervi, A. D., Marinissen, M. J., Diggs, J., Wang, X., Pagès, G., & Senderowicz, A. M. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-2505 · Cited by 76

Anti-MRSA β-lactams in development, with a focus on ceftobiprole: the first anti-MRSA β-lactam to demonstrate clinical efficacy

Bush, K., Heep, M., Macielag, M. J., & Noel, G. J. (2007) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.16.4.419 · Cited by 75

Caspofungin: A Review of its Use in Oesophageal Candidiasis, Invasive Candidiasis and Invasive Aspergillosis

Keating, G. M., & Figgitt, D. P. (2003) · Drugs · doi:10.2165/00003495-200363200-00008 · Cited by 75

Nonhomologous End Joining Is Essential for Cellular Resistance to the Novel Antitumor Agent, β-Lapachone

Srougi, M. C., Reinicke, K. E., Dong, Y., Bey, E. A., & Boothman, D. A. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-0935 · Cited by 75

Rosuvastatin

Scott, L. J., Curran, M. P., & Figgitt, D. P. (2004) · American Journal of Cardiovascular Drugs · doi:10.2165/00129784-200404020-00005 · Cited by 74

Formation and Antitumor Activity of PNU-159682, A Major Metabolite of Nemorubicin in Human Liver Microsomes

Quintieri, L., Geroni, C., Fantin, M., Battaglia, R., Rosato, A., Speed, W., Zanovello, P., & Floreani, M. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-1845 · Cited by 74

Marine natural products as therapeutic agents

Kerr, R. G., & Kerr, S. S. (1999) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543776.9.9.1207 · Cited by 73

Lipiarmycin, a new antibiotic from Actinoplanes. III. Mechanism of action.

SERGIO, S., PIRALI, G., White, R. J., & PARENTI, F. (1975) · The Journal of Antibiotics · doi:10.7164/antibiotics.28.543 · Cited by 73

Naturally Occurring Capsid Substitutions Render HIV-1 Cyclophilin A Independent in Human Cells and TRIM-cyclophilin-resistant in Owl Monkey Cells

Chatterji, U., Bobardt, M. D., Stanfield, R. L., Ptak, R. G., Pallansch, L. A., Ward, P., Jones, M., Stoddart, C. A., Scalfaro, P., Dumont, J., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m506314200 · Cited by 73

A Phase I Trial of Intranasal Moli1901 for Cystic Fibrosis

Zeitlin, P. L., Boyle, M., Guggino, W. B., & Molina, L. (2004) · CHEST Journal · doi:10.1378/chest.125.1.143 · Cited by 73

Differential effects on angiogenesis of two antimalarial compounds, dihydroartemisinin and artemisone: Implications for embryotoxicity

D’Alessandro, S., Gelati, M., Basilico, N., Parati, E. A., Haynes, R. K., & Taramelli, D. (2007) · Toxicology · doi:10.1016/j.tox.2007.08.084 · Cited by 72

The Nemertine Toxin Anabaseine and Its Derivative DMXBA (GTS-21): Chemical and Pharmacological Properties

Kem, W. R., Soti, F. S., Wildeboer, K. M., LeFrancois, S., MacDougall, K., Wei, D., Chou, K., & Arias, H. R. (2006) · Marine Drugs · doi:10.3390/md403255 · Cited by 72

Safety, Pharmacokinetics, Pharmacodynamics, and Plasma Lipoprotein Distribution of Eritoran (E5564) during Continuous Intravenous Infusion into Healthy Volunteers

Rossignol, D. P., Wasan, K. M., Choo, E., Yau, E. H., Wong, N., Rose, J., Moran, J., & Lynn, M. (2004) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.48.9.3233-3240.2004 · Cited by 72

Synthetic studies on the marine natural product halichondrins

Choi, H.-W., Demeke, D., Kang, F., Kishi, Y., Nakajima, K., Nowak, P., Wan, Z., & Xie, C. (2003) · Pure and Applied Chemistry · doi:10.1351/pac200375010001 · Cited by 72

Inhibition of the Norepinephrine Transporter by the Venom Peptide χ-MrIA

Sharpe, I. A., Palant, E., Schroeder, C. I., Kaye, D. M., Adams, D. J., Alewood, P. F., & Lewis, R. J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m213030200 · Cited by 72

Retapamulin

Daum, R. S., Kar, S., & Kirkpatrick, P. J. (2007) · Nature Reviews Drug Discovery · doi:10.1038/nrd2442 · Cited by 72

Trial of oral fumagillin for the treatment of intestinal microsporidiosis in patients with HIV infection

Molina, J.-M., Goguel, J., Sarfati, C., Michiels, J.-F., Desportes-Livage, I., Balkan, S., Chastang, C., Cotte, L., Maslo, C., Struxiano, A., et al. (2000) · AIDS · doi:10.1097/00002030-200007070-00006 · Cited by 71

A phase II open-label study of DHA-paclitaxel (Taxoprexin) by 2-h intravenous infusion in previously untreated patients with locally advanced or metastatic gastric or oesophageal adenocarcinoma

Jones, R. J., Hawkins, R. E., Eatock, M. M., Ferry, D. R., Eskens, F. A. L. M., Wilke, H., & Evans, T. R. J. (2007) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-007-0486-8 · Cited by 71

Asymmetric synthesis and biological evaluation of the enantiomeric isomers of the immunosuppressive FTY720-phosphate

Kiuchi, M., Adachi, K., Tomatsu, A., Chino, M., Takeda, S., Tanaka, Y., Maeda, Y., Sato, N., Mitsutomi, N., Sugahara, K., et al. (2004) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2004.10.008 · Cited by 71

Pharmaceutical development of anticancer agents derived from marine sources

Nuijen, B., Bouma, M., Manada, C., Jimeno, J. M., Schellens, J. H. M., Bult, A., & Beijnen, J. H. (2000) · Anti-Cancer Drugs · doi:10.1097/00001813-200011000-00003 · Cited by 71

The Mode of Action of Pleuromutilin Derivatives: Location and Properties of the Pleuromutilin Binding Site on Escherichia coli Ribosomes

Högenauer, G. (1975) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1975.tb03976.x · Cited by 71

Structurally simplified macrolactone analogues of halichondrin B

Seletsky, B. M., Wang, Y., Hawkins, L. D., Palme, M. H., Habgood, G. J., DiPietro, L., Towle, M. J., Salvato, K. A., Wels, B. F., Aalfs, K. K., et al. (2004) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2004.08.068 · Cited by 71

Ramoplanin: a topical lipoglycodepsipeptide antibacterial agent

Fulco, P. P., & Wenzel, R. P. (2006) · Expert Review of Anti-infective Therapy · doi:10.1586/14787210.4.6.939 · Cited by 71

Specific Modulation of Astrocyte Inflammation by Inhibition of Mixed Lineage Kinases with CEP-1347

Falsig, J., Pörzgen, P., Lotharius, J., & Leist, M. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.4.2762 · Cited by 71

Micafungin

Jarvis, B., Figgitt, D. P., & Scott, L. J. (2004) · Drugs · doi:10.2165/00003495-200464090-00004 · Cited by 71

Daptomycin

Fenton, C., Keating, G. M., & Curran, M. P. (2004) · Drugs · doi:10.2165/00003495-200464040-00009 · Cited by 71

Past, Present, and Future Hepatitis C Treatments

Foster, G. R. (2004) · Seminars in Liver Disease · doi:10.1055/s-2004-832934 · Cited by 69

A phase II trial of dolastatin-10 in recurrent platinum-sensitive ovarian carcinoma: a Gynecologic Oncology Group study

Hoffman, M. A., Blessing, J. A., & Lentz, S. S. (2003) · Gynecologic Oncology · doi:10.1016/s0090-8258(03)00007-6 · Cited by 69

Neuroimmunophilin Ligands: The Development of Novel Neuroregenerative / Neuroprotective Compounds

Gold, B. G., & Villafranca, J. E. (2003) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026033451880 · Cited by 68

Semi-synthetic glycopeptide antibacterials

Judice, J. K., & Pace, J. (2003) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2003.08.067 · Cited by 68

Potent antitumor activity and improved pharmacological profile of ST1481, a novel 7-substituted camptothecin.

Cesare, M. D., Pratesi, G., Perego, P., Carenini, N., Tinelli, S., Merlini, L., Penco, S., Pisano, C., Bucci, F., Vesci, L., et al. (2001) · PubMed · Cited by 68

A Phase II, Double-Blind, Placebo-Controlled, Ascending-Dose Study of Eritoran (E5564), a Lipid A Antagonist, in Patients Undergoing Cardiac Surgery with Cardiopulmonary Bypass

Bennett‐Guerrero, E., Grocott, H. P., Levy, J. H., Stierer, K. A., Hogue, C. W. J., Cheung, A. T., Newman, M. F., Carter, A. A., Rossignol, D. P., & Collard, C. D. (2007) · Anesthesia & Analgesia · doi:10.1213/01.ane.0000253501.07183.2a · Cited by 67

Lobelane decreases methamphetamine self-administration in rats

Neugebauer‎, N. M., Harrod, S. B., Stairs, D. J., Crooks, P. A., Dwoskin, L. P., & Bardo, M. T. (2007) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.06.003 · Cited by 67

A New Anti-MRSA Antibiotic Complex, WAP-8294A. I. Taxonomy, Isolation and Biological Activities.

Kato, A., Nakaya, S., KOKUBO, N., Aiba, Y., Ohashi, Y., Hirata, H., Fujii, K., & Harada, K. (1998) · The Journal of Antibiotics · doi:10.7164/antibiotics.51.929 · Cited by 67

In vitro Combination Treatment with Perifosine and UCN-01 Demonstrates Synergism against Prostate (PC-3) and Lung (A549) Epithelial Adenocarcinoma Cell Lines

Dasmahapatra, G. P., Didolkar, P., Alley, M. C., Ghosh, S., Sausville, E. A., & Roy, K. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-03-0534 · Cited by 67

Antibody-Targeted Chemotherapy with the Calicheamicin Conjugate hu3S193- N -Acetyl γ Calicheamicin Dimethyl Hydrazide Targets Lewisy and Eliminates Lewisy-Positive Human Carcinoma Cells and Xenografts

Boghaert, E. R., Sridharan, L., Armellino, D. C., Khandke, K. M., DiJoseph, J. F., Kunz, A., Dougher, M. M., Jiang, F., Kalyandrug, L. B., Hamann, P. R., et al. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-0037 · Cited by 66

MAC-321, a novel taxane with greater efficacy than paclitaxel and docetaxel in vitro and in vivo.

Sampath, D., Discafani, C. M., Loganzo, F., Beyer, C. F., Liu, H., Tan, X., Musto, S., Annable, T., Gallagher, P. A., Rios, C., et al. (2003) · PubMed · Cited by 65

Tumor Cells Resistant to a Microtubule-Depolymerizing Hemiasterlin Analogue, HTI-286, Have Mutations in α- or β-Tubulin and Increased Microtubule Stability

Poruchynsky, M. S., Kim, J.-H., Nogales, E., Annable, T., Loganzo, F., Greenberger, L. M., Sackett, D. L., & Fojo, T. (2004) · Biochemistry · doi:10.1021/bi049300+ · Cited by 65

Epibatidine structure–activity relationships

Carroll, F. I. (2004) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2004.02.007 · Cited by 65

Rifalazil Treats and Prevents Relapse of Clostridium difficile -Associated Diarrhea in Hamsters

Anton, P. M., O’Brien, M. J., Kokkotou, E. G., Eisenstein, B. I., Michaelis, A. F., Rothstein, D., Paraschos, S., Kelly, C. P., & Pothoulakis, C. (2004) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.48.10.3975-3979.2004 · Cited by 65

Phase II Study of Dolastatin-10 as First-Line Treatment for Advanced Colorectal Cancer

Saad, E. D., Kraut, E. H., Hoff, P. M., Moore, D. F., Jones, D., Pazdur, R., & Abbruzzese, J. L. (2002) · American Journal of Clinical Oncology · doi:10.1097/00000421-200210000-00005 · Cited by 64

.ALPHA.-Aminoadipyl-cysteinyl-valine Synthetases in .BETA.-Lactam Producing Organisms.

Martín, J. F. (2000) · The Journal of Antibiotics · doi:10.7164/antibiotics.53.1008 · Cited by 63

Brostallicin, a novel anticancer agent whose activity is enhanced upon binding to glutathione.

Geroni, C., Marchini, S., Cozzi, P., Galliera, E., Ragg, E. M., Colombo, T., Battaglia, R., Howard, M., D’Incalci, M., & Broggini, M. (2002) · PubMed · Cited by 62

Use of cethromycin, a new ketolide, for treatment of community-acquired respiratory infections

Hammerschlag, M. R., & Sharma, R. (2008) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.17.3.387 · Cited by 62

Novel inhibitors targeted to methionine aminopeptidase 2 (MetAP2) strongly inhibit the growth of cancers in xenografted nude model

Chun, E., Han, C. K., Yoon, J. H., Sim, T. B., Kim, Y., & Lee, K. (2004) · International Journal of Cancer · doi:10.1002/ijc.20687 · Cited by 62

Antitumor activity of combretastatin-A4 phosphate, a natural product tubulin inhibitor

Dorr, R. T., Dvorakova, K., Snead, K., Alberts, D. S., Salmon, S. E., & Pettit, G. R. (1996) · Investigational New Drugs · doi:10.1007/bf00210783 · Cited by 62

Miglustat

McCormack, P. L., & Goa, K. L. (2003) · Drugs · doi:10.2165/00003495-200363220-00006 · Cited by 62

Ertapenem: a Group 1 carbapenem with distinct antibacterial and pharmacological properties

Hammond, M. L. (2004) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkh203 · Cited by 61

Suppression of microtubule dynamics by discodermolide by a novel mechanism is associated with mitotic arrest and inhibition of tumor cell proliferation.

Honoré, S., Kamath, K., Braguer, D., Wilson, L., Briand, C. M., & Jordan, M. A. (2003) · PubMed · Cited by 61

Human Immunodeficiency Virus Type 1 Resistance to the Small Molecule Maturation Inhibitor 3- O -(3′,3′-Dimethylsuccinyl)-Betulinic Acid Is Conferred by a Variety of Single Amino Acid Substitutions at the CA-SP1 Cleavage Site in Gag

Zhou, J., Chen, C., & Aiken, C. (2006) · Journal of Virology · doi:10.1128/jvi.01626-06 · Cited by 60

Binding Site of the Bridged Macrolides in the Escherichia coli Ribosome

Xiong, L., Korkhin, Y., & Mankin, A. S. (2004) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.49.1.281-288.2005 · Cited by 60

Ixabepilone

Conlin, A. K., Fornier, M. N., Hudis, C. A., Kar, S., & Kirkpatrick, P. N. (2007) · Nature Reviews Drug Discovery · doi:10.1038/nrd2469 · Cited by 60

Drug induced proteome changes in Candida albicans: Comparison of the effect of β(1,3) glucan synthase inhibitors and two triazoles, fluconazole and itraconazole

Bruneau, J., Maillet, I., Tagat, E., et al. (2003) · PROTEOMICS · doi:10.1002/pmic.200390046 · Cited by 59

Histone deacetylase inhibitor NVP-LAQ824 has significant activity against myeloid leukemia cells in vitro and in vivo

Weisberg, E., Catley, L. P., Kujawa, J., Atadja, P. W., Remiszewski, S., Fuerst, P., Cavazza, C., Anderson, K. C., & Griffin, J. D. (2004) · Leukemia · doi:10.1038/sj.leu.2403519 · Cited by 59

Synthesis and Antitumor Activity of Novel C-7 Paclitaxel Ethers: Discovery of BMS-184476

Altstadt, T. J., Fairchild, C. R., Golik, J., Johnston, K., Kadow, J. F., Lee, F. Y., Long, B. H., Rose, W. C., Vyas, D. M., Wong, H., et al. (2001) · Journal of Medicinal Chemistry · doi:10.1021/jm0102607 · Cited by 58

Characterization of the Interaction of TZT‐1027, a Potent Antitumor Agent, with Tubulin

Natsume, T., Watanabe, J., Tamaoki, S., Fujio, N., Miyasaka, K., & Kobayashi, M. (2000) · Japanese Journal of Cancer Research · doi:10.1111/j.1349-7006.2000.tb01007.x · Cited by 58

Flavopiridol in the treatment of chronic lymphocytic leukemia

Christian, B. A., Grever, M. R., Byrd, J. C., & Lin, T. S. (2007) · Current Opinion in Oncology · doi:10.1097/cco.0b013e3282efb9da · Cited by 58

A Novel Combretastatin A‐4 Derivative, AC‐7700, Shows Marked Antitumor Activity against Advanced Solid Tumors and Orthotopically Transplanted Tumors

Nihei, Y., Suga, Y., Morinaga, Y., Ohishi, K., Okano, A., Ohsumi, K., Hatanaka, T., Nakagawa, R., Tsuji, T., Akiyama, Y., et al. (1999) · Japanese Journal of Cancer Research · doi:10.1111/j.1349-7006.1999.tb00850.x · Cited by 58

Pleuromutilins. Part 1 The identification of novel mutilin 14-carbamates

Brooks, G., Burgess, W., Colthurst, D., Hinks, J. D., Hunt, E., Pearson, M. J., Shea, B., Takle, A. K., Wilson, J. M., & Woodnutt, G. (2001) · Bioorganic & Medicinal Chemistry · doi:10.1016/s0968-0896(00)00338-2 · Cited by 58

Pyridoxamine Protects Proteins from Functional Damage by 3-Deoxyglucosone: Mechanism of Action of Pyridoxamine

Chetyrkin, S. V., Zhang, W., Hudson, B. G., Serianni, A. S., & Voziyan, P. (2007) · Biochemistry · doi:10.1021/bi701190s · Cited by 58

A Review of Neuroprotective Agents

Levi, M. S., & Brimble, M. A. (2004) · Current Medicinal Chemistry · doi:10.2174/0929867043364522 · Cited by 58

In Vivo Evaluation of AT-101 (R-(—)-Gossypol Acetic Acid) in Androgen-Independent Growth of VCaP Prostate Cancer Cells in Combination with Surgical Castration

Loberg, R. D., McGregor, N., Chi, Y., Sargent, E., & Pienta, K. J. (2007) · Neoplasia · doi:10.1593/neo.07778 · Cited by 57

To kill a parasite

Ridley, R. G. (2003) · Nature · doi:10.1038/424887a · Cited by 57

Efficacy of camptothecin analog DX-8951f (Exatecan Mesylate) on human pancreatic cancer in an orthotopic metastatic model.

Sun, F., Tohgo, A., Bouvet, M., Yagi, S., Nassirpour, R., Moossa, A. R., & Hoffman, R. M. (2003) · PubMed · Cited by 57

Effect of the Silybin-Phosphatidylcholine Complex (IdB 1016) on the Development of Mammary Tumors in HER-2/neu Transgenic Mice

Provinciali, M., Papalini, F., Orlando, F., Pierpaoli, S., Donnini, A., Morazzoni, P., Riva, A., & Smorlesi, A. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-2601 · Cited by 57

The synthetic oleanane triterpenoid, CDDO-methyl ester, is a potent antiangiogenic agent

Vannini, N., Lorusso, G., Cammarota, R., Barberis, M. C. P., Noonan, D. M., Sporn, M. B., & Albini, A. (2007) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-07-0451 · Cited by 57

Chartreusin, Elsamicin A and Related Anti-Cancer Antibiotics

Portugal, J. (2003) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/1568011033482215 · Cited by 56

Appetite Suppression and Weight Reduction by a Centrally Active Aminosterol

Ahima, R. S., Patel, H. R., Takahashi, N., Qi, Y., Hileman, S. M., & ZASLOFF, M. A. (2002) · Diabetes · doi:10.2337/diabetes.51.7.2099 · Cited by 56

Aplidine: A Paradigm of how to Handle the Activity and Toxicity of a Novel Marine Anticancer Poison

Tourneau, C. L., Raymond, É., & Faivre, S. J. (2007) · Current Pharmaceutical Design · doi:10.2174/138161207782360555 · Cited by 56

NMR-based methods and strategies for drug discovery

Salvatella, X., & Giralt, E. (2003) · Chemical Society Reviews · doi:10.1039/b210047a · Cited by 55

Chemical Chaperones—A New Concept in Drug Research

Kolter, T., & Wendeler, M. (2003) · ChemBioChem · doi:10.1002/cbic.200390045 · Cited by 55

Mechanism of Action of the Microtubule-Targeted Antimitotic Depsipeptide Tasidotin (Formerly ILX651) and Its Major Metabolite Tasidotin C-Carboxylate

Ray, A., Okouneva, T., Manna, T. K., Miller, H. P., Schmid, S. M., Arthaud, L. E., Ludueña, R. F., Jordan, M. A., & Wilson, L. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-3065 · Cited by 55

7-Hydroxystaurosporine (UCN-01) Inhibition of Akt Thr308 but not Ser473 Phosphorylation

Kondapaka, S. B., Zarnowski, M. J., Yver, D. R., Sausville, E. A., & Cushman, S. W. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-0772 · Cited by 55

Clinical trials of neuroprotection for Parkinson’s disease

LeWitt, P. A. (2004) · Neurology · doi:10.1212/wnl.63.7_suppl_2.s23 · Cited by 54

The exploration of macrocycles for drug discovery — an underexploited structural class

Driggers, E. M., Hale, S. P., Lee, J., & Terrett, N. K. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2590 · Cited by 1,370

Photochemical Approaches to Complex Chemotypes: Applications in Natural Product Synthesis

Kärkäs, M. D., Porco, J. A., & Stephenson, C. R. J. (2016) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00760 · Cited by 1,017

The pharmaceutical industry and natural products: historical status and new trends

David, B., Wolfender, J.-L., & Dias, D. A. (2015) · Phytochemistry Reviews · doi:10.1007/s11101-014-9367-z · Cited by 579

Flavonoids as prospective compounds for anti-cancer therapy

Ravishankar, D., Rajora, A. K., Greco, F., & Osborn, H. M. I. (2013) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2013.10.004 · Cited by 572

The Renaissance of Natural Products as Drug Candidates

Paterson, I., & Anderson, E. A. (2005) · Science · doi:10.1126/science.1116364 · Cited by 559