Natural products to drugs: natural product-derived compounds in clinical trials

Induction of Morphological and Biochemical Apoptosis following Prolonged Mitotic Blockage by Halichondrin B Macrocyclic Ketone Analog E7389

Kuznetsov, G., Towle, M. J., Cheng, H., Kawamura, T., TenDyke, K., Liu, D., Kishi, Y., Yu, M. J., & Littlefield, B. A. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-1169 · Cited by 262

NPI-2358 is a tubulin-depolymerizing agent: in-vitro evidence for activity as a tumor vascular-disrupting agent

Nicholson, B., Lloyd, G. K., Miller, B. R., Palladino, M. A., Kiso, Y., Hayashi, Y., & Neuteboom, S. T. C. (2006) · Anti-Cancer Drugs · doi:10.1097/01.cad.0000182745.01612.8a · Cited by 260

Artemisone—A Highly Active Antimalarial Drug of the Artemisinin Class

Haynes, R. K., Fugmann, B., Stetter, J., Rieckmann, K., Heilmann, H., Chan, H., Cheung, M., Lam, W., Wong, H., Croft, S. L., et al. (2006) · Angewandte Chemie International Edition · doi:10.1002/anie.200503071 · Cited by 260

Chemistry and biology of natural and designed enediynes.

Nicolaou, K. C., Smith, A. L., & Yue, E. W. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.13.5881 · Cited by 258

Structures of the didemnins, antiviral and cytotoxic depsipeptides from a Caribbean tunicate

Rinehart, K. L., Gloer, J. B., Cook, J. C., Mizsak, S. A., & Scahill, T. A. (1981) · Journal of the American Chemical Society · doi:10.1021/ja00397a055 · Cited by 256

Antitumor Activity of 3-Ingenyl Angelate

Ogbourne, S. M., Suhrbier, A., Jones, B., Cozzi, S.-J., Boyle, G. M., Morris, M., McAlpine, D., Johns, J., Scott, T. M., Sutherland, K. P., et al. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-2837 · Cited by 255

The β-lactam antibiotics: past, present, and future

Demain, A. L., & Elander, R. P. (1999) · Antonie van Leeuwenhoek · doi:10.1023/a:1001738823146 · Cited by 254

Effects of Pyridoxamine in Combined Phase 2 Studies of Patients with Type 1 and Type 2 Diabetes and Overt Nephropathy

Williams, M. E., Bolton, W. K., Khalifah, R. G., Degenhardt, T. P., Schotzinger, R. J., & McGill, J. B. (2007) · American Journal of Nephrology · doi:10.1159/000108104 · Cited by 253

Tacrolimus and pimecrolimus: From clever prokaryotes to inhibiting calcineurin and treating atopic dermatitis

Nghiem, P., Pearson, G., & Langley, R. G. (2002) · Journal of the American Academy of Dermatology · doi:10.1067/mjd.2002.120942 · Cited by 251

A selective N-type calcium channel antagonist protects against neuronal loss after global cerebral ischemia.

Valentino, K., Newcomb, R., Gadbois, T., Singh, T., Bowersox, S., Bitner, S., Justice, A., Yamashiro, D., Hoffman, B. B., & Ciaranello, R. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.16.7894 · Cited by 249

The discovery of aspirin: a reappraisal

Sneader, W. (2000) · BMJ · doi:10.1136/bmj.321.7276.1591 · Cited by 249

Fumagillin Treatment of Intestinal Microsporidiosis

Molina, J.-M., Tourneur, M., Sarfati, C., Chevret, S., de Gouvello, A., Gobert, J.-G., Balkan, S., & Derouin, F. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa012924 · Cited by 247

Structure of acid β-glucosidase with pharmacological chaperone provides insight into Gaucher disease

Lieberman, R. L., Wustman, B. A., Huertas, P., Powe, A. C., Pine, C. W., Khanna, R., Schlossmacher, M. G., Ringe, D., & Petsko, G. A. (2007) · Nature Chemical Biology · doi:10.1038/nchembio850 · Cited by 245

Empirical antibacterial drug discovery—Foundation in natural products

Singh, S. B., & Barrett, J. F. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2005.12.016 · Cited by 245

Is There a Role for ??-Glucosidase Inhibitors in the Prevention of Type 2 Diabetes Mellitus?

Scheen, A. J. (2003) · Drugs · doi:10.2165/00003495-200363100-00002 · Cited by 242

In vitro inhibition and intracellular enhancement of lysosomal α‐galactosidase A activity in Fabry lymphoblasts by 1‐deoxygalactonojirimycin and its derivatives

Asano, N., Ishii, S., Kizu, H., Ikeda, K., Yasuda, K., Kato, A., Martin, O. R., & Fan, J. (2000) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.2000.01457.x · Cited by 242

Synthetic oleanane and ursane triterpenoids with modified rings A and C: a series of highly active inhibitors of nitric oxide production in mouse macrophages

Honda, T., Rounds, B. V., Bore, L., Finlay, H. J., Favaloro, Suh, N., Wang, Y., Sporn, M. B., & Gribble, G. W. (2000) · Journal of Medicinal Chemistry · doi:10.1021/jm0002230 · Cited by 241

Inhibition of peptide bond formation by pleuromutilins: the structure of the 50S ribosomal subunit from Deinococcus radiodurans in complex with tiamulin

Schlünzen, F., Pyetan, E., Fucini, P., Yonath, A., & Harms, J. M. (2004) · Molecular Microbiology · doi:10.1111/j.1365-2958.2004.04346.x · Cited by 240

Safety, Pharmacokinetics, and Effects on Cognitive Function of Multiple Doses of GTS-21 in Healthy, Male Volunteers

Kitagawa, H., Takenouchi, T., Azuma, R., Wesnes, K. A., Kramer, W. G., Clody, D. E., & Burnett, A. L. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300028 · Cited by 238

Kahalalide F: a bioactive depsipeptide from the sacoglossan mollusk Elysia rufescens and the green alga Bryopsis sp

Hamann, M. T., & Scheuer, P. J. (1993) · Journal of the American Chemical Society · doi:10.1021/ja00066a061 · Cited by 237

The role of the iminosugar N‐butyldeoxynojirimycin (miglustat) in the management of type I (non‐neuronopathic) Gaucher disease: A position statement

Cox, T. M., Aerts, J. M. F. G., Andria, G., Beck, M., Belmatoug, N., Bembi, B., Chertkoff, R., Vom Dahl, S., Elstein, D., Erikson, A., et al. (2003) · Journal of Inherited Metabolic Disease · doi:10.1023/a:1025902113005 · Cited by 236

Caspofungin: the first representative of a new antifungal class

Letscher-Bru, V. (2003) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkg117 · Cited by 235

Macrolide Antibiotics: Binding Site, Mechanism of Action, Resistance

Gaynor, M., & Mankin, A. (2003) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026033452159 · Cited by 235

The role of natural products in a modern drug discovery program

Strohl, W. R. (2000) · Drug Discovery Today · doi:10.1016/s1359-6446(99)01443-9 · Cited by 234

Development of 17-allylamino-17-demethoxygeldanamycin hydroquinone hydrochloride (IPI-504), an anti-cancer agent directed against Hsp90

Sydor, J. R., Normant, E., Pien, C. S., Porter, J. R., Ge, J., Grenier, L., Pak, R. H., Ali, J. A., Dembski, M. S., Hudak, J., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0608372103 · Cited by 231

The Antibiotic Pipeline — Challenges, Costs, and Values

Wenzel, R. P. (2004) · New England Journal of Medicine · doi:10.1056/nejmp048093 · Cited by 230

Cannabinoids and brain injury: therapeutic implications

Mechoulam, R. (2002) · Trends in Molecular Medicine · doi:10.1016/s1471-4914(02)02276-1 · Cited by 229

Cannabis, Pain, and Sleep: Lessons from Therapeutic Clinical Trials of Sativex®, a Cannabis‐Based Medicine

Russo, E. B., Guy, G. W., & Robson, P. J. (2007) · Chemistry & Biodiversity · doi:10.1002/cbdv.200790150 · Cited by 228

A shot in the arm

Leeb, M. (2004) · Nature · doi:10.1038/431892a · Cited by 225

From Artemisinin to New Artemisinin Antimalarials: Biosynthesis, Extraction, Old and New Derivatives, Stereochemistry and Medicinal Chemistry Requirements

Haynes, R. (2006) · Current Topics in Medicinal Chemistry · doi:10.2174/156802606776743129 · Cited by 224

Natural products as a screening resource

Harvey, A. L. (2007) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2007.08.012 · Cited by 223

Drug discovery from natural products

Gullo, V. P., McAlpine, J., Lam, K. S., Baker, D., & Petersen, F. (2006) · Journal of Industrial Microbiology & Biotechnology · doi:10.1007/s10295-006-0107-2 · Cited by 222

Two new classes of conopeptides inhibit the α1-adrenoceptor and noradrenaline transporter

Sharpe, I. A., Gehrmann, J., Loughnan, M. L., Thomas, L., Adams, D. A., Atkins, A., Palant, E., Craik, D. J., Adams, D. J., Alewood, P. F., et al. (2001) · Nature Neuroscience · doi:10.1038/nn0901-902 · Cited by 220

Synthesis, Chromatographic Resolution, and Anti-Human Immunodeficiency Virus Activity of (±)-Calanolide A and Its Enantiomers

Flavin, M. T., Rizzo, J. D., Khilevich, A., Kucherenko, A., Sheinkman, A. K., Vilaychack, V., Lin, L., Chen, W., Greenwood, E. M., Pengsuparp, T., et al. (1996) · Journal of Medicinal Chemistry · doi:10.1021/jm950797i · Cited by 219

A novel mechanism of action and potential use for lobeline as a treatment for psychostimulant abuse

Dwoskin, L. P., & Crooks, P. A. (2002) · Biochemical Pharmacology · doi:10.1016/s0006-2952(01)00899-1 · Cited by 219

In Vitro and In Vivo Properties of Ro 63-9141, a Novel Broad-Spectrum Cephalosporin with Activity against Methicillin-Resistant Staphylococci

Hebeisen, P., Heinze-Krauss, I., Angehrn, P., Hohl, P., Page, M. G. P., & Then, R. L. (2001) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.45.3.825-836.2001 · Cited by 219

The iminosugar isofagomine increases the activity of N370S mutant acid β-glucosidase in Gaucher fibroblasts by several mechanisms

Steet, R. A., Chung, S., Wustman, B., Powe, A., Do, H., & Kornfeld, S. A. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605928103 · Cited by 218

Preclinical studies of the pan-Bcl inhibitor obatoclax (GX015-070) in multiple myeloma

Trudel, S., Li, Z. H., Rauw, J., Tiedemann, R. E., Wen, X. Y., & Stewart, A. K. (2007) · Blood · doi:10.1182/blood-2006-10-047951 · Cited by 218

Combretastatins: from natural products to drug discovery

Cirla, A., & Mann, J. (2003) · Natural Product Reports · doi:10.1039/b306797c · Cited by 218

Synthesis and Immunosuppressive Activity of 2-Substituted 2-Aminopropane-1,3-diols and 2-Aminoethanols

Kiuchi, M., Adachi, K., Kohara, T., Minoguchi, M., Hanano, T., Aoki, Y., Mishina, T., Arita, M., Nakao, N., Ohtsuki, M., et al. (2000) · Journal of Medicinal Chemistry · doi:10.1021/jm000173z · Cited by 217

NVP-LAQ824 is a potent novel histone deacetylase inhibitor with significant activity against multiple myeloma

Catley, L., Weisberg, E., Tai, Y.-T., Atadja, P., Remiszewski, S., Hideshima, T., Mitsiades, N., Shringarpure, R., LeBlanc, R., Chauhan, D., et al. (2003) · Blood · doi:10.1182/blood-2003-01-0233 · Cited by 216

Cancer Therapy with ß-Lapachone

Pardee, A., Li, Y., & Li, C. (2002) · Current Cancer Drug Targets · doi:10.2174/1568009023333854 · Cited by 215

Glycopeptide Antibiotics: from Conventional Molecules to New Derivatives

Van Bambeke, F., Van Laethem, Y., Courvalin, P., & Tulkens, P. M. (2004) · Drugs · doi:10.2165/00003495-200464090-00001 · Cited by 213

A Tale of Two Tumor Targets: Topoisomerase I and Tubulin. The Wall and Wani Contribution to Cancer Chemotherapy

Cragg, G. M., & Newman, D. J. (2004) · Journal of Natural Products · doi:10.1021/np030420c · Cited by 210

Characterization of the Interaction of Ingenol 3-Angelate with Protein Kinase C

Kedei, N., Lundberg, D. J., Toth, A., Welburn, P., Garfield, S. H., & Blumberg, P. M. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-3403 · Cited by 209

The psychopharmacology of huperzine A: an alkaloid with cognitive enhancing and neuroprotective properties of interest in the treatment of Alzheimer's disease

Zangara, A. (2003) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(03)00111-4 · Cited by 208

Cantuzumab Mertansine, a Maytansinoid Immunoconjugate Directed to the CanAg Antigen: A Phase I, Pharmacokinetic, and Biologic Correlative Study

Tolcher, A. W., Ochoa, L., Hammond, L. A., Patnaik, A., Edwards, T., Takimoto, C., Smith, L., de Bono, J., Schwartz, G., Mays, T., et al. (2003) · Journal of Clinical Oncology · doi:10.1200/jco.2003.05.137 · Cited by 206

The Echinocandins

Cappelletty, D., & Eiselstein‐McKitrick, K. (2007) · Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy · doi:10.1592/phco.27.3.369 · Cited by 205

Phenserine regulates translation of β-amyloid precursor protein mRNA by a putative interleukin-1 responsive element, a target for drug development

Shaw, K. T. Y., Utsuki, T., Rogers, J., Yu, Q.-S., Sambamurti, K., Brossi, A., Ge, Y.-W., Lahiri, D. K., & Greig, N. H. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.131152998 · Cited by 205

Design and synthesis of 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid, a novel and highly active inhibitor of nitric oxide production in mouse macrophages

Honda, T., Rounds, B. V., Gribble, G. W., Suh, N., Wang, Y., & Sporn, M. B. (1998) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/s0960-894x(98)00479-x · Cited by 204

CEP-1347 (KT7515), a Semisynthetic Inhibitor of the Mixed Lineage Kinase Family

Maroney, A. C., Finn, J. P., Connors, T. J., Durkin, J. T., Angeles, T., Gessner, G., Xu, Z., Meyer, S. L., Savage, M. J., Greene, L. A., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m011601200 · Cited by 204

Enzymatic and chemical modifications of lipopeptide antibiotic A21978C: The synthesis and evaluation of daptomycin (LY146032).

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Gamma-carboxyglutamate in a neuroactive toxin.

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Reviews Of Anti‐infective Agents: Anidulafungin: A Novel Echinocandin

Vazquez, J. A., & Sobel, J. D. (2006) · Clinical Infectious Diseases · doi:10.1086/505204 · Cited by 199

Peripheral TRPV1 Receptors As Targets for Drug Development: New Molecules and Mechanisms

Szallasi, A., & Gunthorpe, M. (2008) · Current Pharmaceutical Design · doi:10.2174/138161208783330754 · Cited by 199

Inhibition of the oncogene product p185erbB-2 in vitro and in vivo by geldanamycin and dihydrogeldanamycin derivatives

Schnur, R. C., Corman, M. L., Gallaschun, R. J., Cooper, B. A., Dee, M. F., Doty, J. L., Muzzi, M. L., Moyer, J. D., & DiOrio, C. I. (1995) · Journal of Medicinal Chemistry · doi:10.1021/jm00019a010 · Cited by 199

Crystal Structure and Molecular Modeling of 17-DMAG in Complex with Human Hsp90

Jez, J. M., Chen, J. C.-H., Rastelli, G., Stroud, R. M., & Santi, D. V. (2003) · Chemistry & Biology · doi:10.1016/s1074-5521(03)00075-9 · Cited by 197

Deoxynojirimycin: synthesis and biological activity

Hughes, A. B., & Rudge, A. J. (1994) · Natural Product Reports · doi:10.1039/np9941100135 · Cited by 197

Development of semisynthetic triterpenoid saponin derivatives with immune stimulating activity

Marciani, D. J., Press, J. B., Reynolds, R. C., Pathak, A. K., Pathak, V., Gundy, L. E., Farmer, J. T., Koratich, M. S., & May, R. D. (2000) · Vaccine · doi:10.1016/s0264-410x(00)00118-3 · Cited by 196

Contulakin-G, an O-Glycosylated Invertebrate Neurotensin

Craig, A. G., Norberg, T., Griffin, D., Hoeger, C., Akhtar, M., Schmidt, K., Low, W., Dykert, J., Richelson, E., Navarro, V., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.20.13752 · Cited by 196

Potential antitumor agents. 61. Structure-activity relationships for in vivo colon 38 activity among disubstituted 9-oxo-9H-xanthene-4-acetic acids

Rewcastle, G. W., Atwell, G. J., Zhuang, L., Baguley, B. C., & Denny, W. A. (1991) · Journal of Medicinal Chemistry · doi:10.1021/jm00105a034 · Cited by 194

Combretastatin A4 phosphate: background and current clinical status

Young, S. L., & Chaplin, D. J. (2004) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.13.9.1171 · Cited by 192

Natural products as immunosuppressive agents

Mann, J. (2001) · Natural Product Reports · doi:10.1039/b001720p · Cited by 192

Phenserine and ring C hetero‐analogues: Drug candidates for the treatment of Alzheimer's disease

Greig, N. H., Pei, X., Soncrant, T. T., Ingram, D. K., & Brossi, A. (1995) · Medicinal Research Reviews · doi:10.1002/med.2610150103 · Cited by 192

Microbial natural products as a source of antifungals

Vicente, M. F., Basilio, A., Cabello, A., & Peláez, F. (2003) · Clinical Microbiology and Infection · doi:10.1046/j.1469-0691.2003.00489.x · Cited by 191

Design, Synthesis, and Biological Evaluation of Hydroquinone Derivatives of 17-Amino-17-demethoxygeldanamycin as Potent, Water-Soluble Inhibitors of Hsp90

Ge, J., Normant, E., Porter, J. R., Ali, J. A., Dembski, M. S., Gao, Y., Georges, A. T., Grenier, L., Pak, R. H., Patterson, J., et al. (2006) · Journal of Medicinal Chemistry · doi:10.1021/jm0603116 · Cited by 191

Kahalalide F, a new marine-derived compound, induces oncosis in human prostate and breast cancer cells.

Suárez, Y., González, L. E., Cuadrado, A., Berciano, M., Lafarga, M., & Múñoz, A. (2003) · PubMed · Cited by 191

Homoharringtonine: History, current research, and future directions

Kantarjian, H. M., Talpaz, M., Santini, V., Murgo, A., Cheson, B., & O'Brien, S. M. (2001) · Cancer · doi:10.1002/1097-0142(20010915)92:6<1591::aid-cncr1485>3.0.co;2-u · Cited by 190

Will mTOR inhibitors make it as cancer drugs?

Sawyers, C. L. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00275-7 · Cited by 190

Antineoplastic agents from natural sources: achievements and future directions

Cragg, G. M., & Newman, D. J. (2000) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.9.12.2783 · Cited by 190

Diversity of the Neurotoxic Conus Peptides: A Model for Concerted Pharmacological Discovery

Olivera, B. M., & Teichert, R. W. (2007) · Molecular Interventions · doi:10.1124/mi.7.5.7 · Cited by 189

Betulinic acid derivatives as HIV-1 antivirals

AIKEN, C., & CHEN, C. (2005) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2004.11.001 · Cited by 188

Cutting the cost of drug development?

Rawlins, M. D. (2004) · Nature Reviews Drug Discovery · doi:10.1038/nrd1347 · Cited by 187

Medicines from nature: are natural products still relevant to drug discovery?

Harvey, A. (1999) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(99)01346-2 · Cited by 186

Pladienolides, New Substances from Culture of Streptomyces platensis Mer-11107 III. In Vitro and In Vivo Antitumor Activities

MIZUI, Y., SAKAI, T., IWATA, M., UENAKA, T., OKAMOTO, K., SHIMIZU, H., YAMORI, T., YOSHIMATSU, K., & ASADA, M. (2004) · The Journal of Antibiotics · doi:10.7164/antibiotics.57.188 · Cited by 185

The Ketolides: A Critical Review

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Nonpsychotropic cannabinoid acts as a functional N-methyl-D-aspartate receptor blocker.

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Cholecystokinin antagonists: Pharmacological and therapeutic potential

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A Novel α-Conotoxin Identified by Gene Sequencing Is Active in Suppressing the Vascular Response to Selective Stimulation of Sensory Nerves in Vivo

Sandall, D. W., Satkunanathan, N., Keays, D. A., Polidano, M. A., Liping, X., Pham, V., Down, J. G., Khalil, Z., Livett, B. G., & Gayler, K. R. (2003) · Biochemistry · doi:10.1021/bi034043e · Cited by 182

Reductive Alkylation of Glycopeptide Antibiotics: Synthesis and Antibacterial Activity.

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Antiproliferative and proapoptotic activities of triptolide (PG490), a natural product entering clinical trials, on primary cultures of human prostatic epithelial cells.

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Tumor targeting by covalent conjugation of a natural fatty acid to paclitaxel.

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The Biology Behind mTOR Inhibition in Sarcoma

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The pleuromutilin drugs tiamulin and valnemulin bind to the RNA at the peptidyl transferase centre on the ribosome

Poulsen, S. M., Karlsson, M., Johansson, L. B., & Vester, B. (2001) · Molecular Microbiology · doi:10.1046/j.1365-2958.2001.02595.x · Cited by 179

New Marine Derived Anticancer Therapeutics ─ A Journey from the Sea to Clinical Trials

Jimeno, J., Faircloth, G., Sousa-Faro, J. F., Scheuer, P., & Rinehart, K. (2004) · Marine Drugs · doi:10.3390/md201014 · Cited by 179

The chemistry and biology of the bryostatin antitumour macrolides

Hale, K. J., Hummersone, M. G., Manaviazar, S., & Frigerio, M. (2002) · Natural Product Reports · doi:10.1039/b009211h · Cited by 178

Geldanamycin and 17-allylamino-17-demethoxygeldanamycin potentiate the in vitro and in vivo radiation response of cervical tumor cells via the heat shock protein 90-mediated intracellular signaling and cytotoxicity.

Bisht, K. S., Bradbury, C. M., Mattson, D., Kaushal, A., Sowers, A. L., Markovina, S. S., Ortiz, K. L., Sieck, L., Isaacs, J. S., Brechbiel, M. W., et al. (2003) · PubMed · Cited by 178

Translation and Protein Synthesis: Macrolides

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Neutrophils Are a Key Component of the Antitumor Efficacy of Topical Chemotherapy with Ingenol-3-Angelate

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Marine pharmacology in 2001–2: antitumour and cytotoxic compounds

Mayer, A. M. S., & Gustafson, K. R. (2004) · European Journal of Cancer · doi:10.1016/j.ejca.2004.09.005 · Cited by 177

Next generation topoisomerase I inhibitors: Rationale and biomarker strategies

Teicher, B. A. (2008) · Biochemical Pharmacology · doi:10.1016/j.bcp.2007.10.016 · Cited by 176

Phenoxodiol – an isoflavone analog – induces apoptosis in chemoresistant ovarian cancer cells

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