Natural products to drugs: natural product-derived compounds in clinical trials

The multikinase inhibitor midostaurin (PKC412A) lacks activity in metastatic melanoma: a phase IIA clinical and biologic study

Millward, M. J., House, C. M., Bowtell, D. D. L., Webster, L. K., Olver, I., Gore, M. E., Copeman, M. C., Lynch, K., Yap, A., Wang, Y., et al. (2006) · British Journal of Cancer · doi:10.1038/sj.bjc.6603331 · Cited by 54

FORMATION OF HIGHLY ANALGESIC MORPHINE-6-GLUCURONIDE FOLLOWING PHYSIOLOGIC CONCENTRATION OF MORPHINE IN HUMAN BRAIN.

Yamada, H., Ishii, K., Ishii, Y., et al. (2003) · The Journal of Toxicological Sciences · doi:10.2131/jts.28.395 · Cited by 54

Identification, characterization and potent antitumor activity of ECO-4601, a novel peripheral benzodiazepine receptor ligand

Gourdeau, H., McAlpine, J. B., Ranger, M., Simard, B., Berger, F. R., Beaudry, F., & Falardeau, P. (2007) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-007-0544-2 · Cited by 54

Stereochemistry of Kahalalide F

Bonnard, I., Manzanares, I., & RINEHART, K. L. J. (2003) · Journal of Natural Products · doi:10.1021/np030334c · Cited by 53

Orlistat: A Review of its Use in the Management of Patients with Obesity

Curran, M. P., & Scott, L. J. (2004) · Drugs · doi:10.2165/00003495-200464240-00010 · Cited by 53

List of Drugs in Development for Neurodegenerative Diseases

Fischer, F., Matthisson, M., & Herrling, P. L. (2004) · Neurodegenerative Diseases · doi:10.1159/000077879 · Cited by 53

Drugs in development for Parkinson's disease.

Johnston, T. H., & Brotchie, J. M. (2004) · PubMed · Cited by 52

[General Articles] Cannabinoids: Mechanisms and Therapeutic Applications in the CNS

Drysdale, A. J., & Platt, B. (2003) · Current Medicinal Chemistry · doi:10.2174/0929867033456387 · Cited by 52

In Vitro Antibacterial Activity of LJC 11,036, an Active Metabolite of L-084, a New Oral Carbapenem Antibiotic with Potent Antipneumococcal Activity

Hikida, M., Itahashi, K., Igarashi, A., Shiba, T., & Kitamura, M. (1999) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.43.8.2010 · Cited by 52

A Phase I and pharmacokinetic study of squalamine, an aminosterol angiogenesis inhibitor.

Hao, D., Hammond, L. A., Eckhardt, S., Patnaik, A., Takimoto, C. H. M., Schwartz, G. H., Goetz, A. D., Tolcher, A. W., McCreery, H., Mamun, K., et al. (2003) · PubMed · Cited by 52

Differential p53-dependent mechanism of radiosensitization in vitro and in vivo by the protein kinase C-specific inhibitor PKC412.

Zaugg, K., Rocha, S., Resch, H., Hegyi, I., Oehler, C., Glanzmann, C., Fabbro, D., Bodis, S. B., & Pruschy, M. N. (2001) · PubMed · Cited by 52

Disposition of docosahexaenoic acid-paclitaxel, a novel taxane, in blood: in vitro and clinical pharmacokinetic studies.

Sparreboom, A., Wolff, A. C., Verweij, J., Zabelina, Y., van Zomeren, D. M., McIntire, G. L., Swindell, C. S., Donehower, R. C., & Baker, S. D. (2003) · PubMed · Cited by 52

Synthesis, stereochemical determination and biochemical characterization of the enantiomeric phosphate esters of the novel immunosuppressive agent FTY720

Hale, J. J., Yan, L. Y., Neway, W. E., Hajdu, R., Bergstrom, J. D., Milligan, J. A., Shei, G.-J., Chrebet, G. L., Thornton, R. A., Card, D., et al. (2004) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2004.07.020 · Cited by 51

What is in the pipeline for Gram-negative pathogens?

Talbot, G. H. (2008) · Expert Review of Anti-infective Therapy · doi:10.1586/14787210.6.1.39 · Cited by 51

Depletion of Methionine Aminopeptidase 2 Does Not Alter Cell Response to Fumagillin or Bengamides

Kim, S., LaMontagne, K. R., Sabio, M. L., Sharma, S. K., Versace, R. W., Yusuff, N., & Phillips, P. E. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-0019 · Cited by 51

Potent Activity of the HIV-1 Maturation Inhibitor Bevirimat in SCID-hu Thy/Liv Mice

Stoddart, C. A., Joshi, P., Sloan, B. A., Bare, J. C., Smith, P. C., Allaway, G. P., Wild, C. T., & Martin, D. E. (2007) · PLoS ONE · doi:10.1371/journal.pone.0001251 · Cited by 50

Morphine‐6‐glucuronide (M6G) for postoperative pain relief

Dahan, A., van Dorp, E., Smith, T., & Yassen, A. (2007) · European Journal of Pain · doi:10.1016/j.ejpain.2007.07.009 · Cited by 50

17β-(3-Furyl)-5β-androstane-3β,14β,17α-triol (PST 2238). A Very Potent Antihypertensive Agent with a Novel Mechanism of Action

Quadri, L., Bianchi, G., Cerri, A., et al. (1997) · Journal of Medicinal Chemistry · doi:10.1021/jm970162e · Cited by 50

Lisdexamfetamine

Blick, S. K. A., & Keating, G. M. (2007) · Pediatric Drugs · doi:10.2165/00148581-200709020-00007 · Cited by 50

Antitumor activity of TZT‐1027 (Soblidotin) against vascular endothelial growth factor‐secreting human lung cancer in vivo

Natsume, T., Watanabe, J., Koh, Y., Fujio, N., Ohe, Y., Horiuchi, T., Saijo, N., Nishio, K., & Kobayashi, M. (2003) · Cancer Science · doi:10.1111/j.1349-7006.2003.tb01526.x · Cited by 49

Selective action of the iminosugar isofagomine, a pharmacological chaperone for mutant forms of acid-β-glucosidase

Steet, R., Chung, S., Lee, W., Pine, C. W., Do, H., & Kornfeld, S. A. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2006.12.015 · Cited by 49

Progress in the research of artemisinin and its analogues as antimalarials: an update

Sriram, D., Rao, V. S., Sekhar, K. V. G. C., & Yogeeswari, P. (2004) · Natural Product Research · doi:10.1080/14786410310001620556 · Cited by 49

Plitidepsin Has a Dual Effect Inhibiting Cell Cycle and Inducing Apoptosis via Rac1/c-Jun NH2-Terminal Kinase Activation in Human Melanoma Cells

Muñoz-Alonso, M. J., González-Santiago, L., Zarich, N., et al. (2007) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.107.132662 · Cited by 49

Emerging echinocandins for treatment of invasive fungal infections

Turner, M., Drew, R. H., & Perfect, J. R. (2006) · Expert Opinion on Emerging Drugs · doi:10.1517/14728214.11.2.231 · Cited by 49

Telavancin: a novel lipoglycopeptide for serious Gram-positive infections

Laohavaleeson, S., Kuti, J. L., & Nicolau, D. P. (2007) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.16.3.347 · Cited by 48

New Trends in the Design of Drugs Against Alzheimer's Disease

Francotte, P., Graindorge, E., Boverie, S., Tullio, P. D., & Pirotte, B. (2004) · Current Medicinal Chemistry · doi:10.2174/0929867043364946 · Cited by 48

Antimicrobial Activity of Omiganan Pentahydrochloride against Contemporary Fungal Pathogens Responsible for Catheter-Associated Infections

Fritsche, T. R., Rhomberg, P. R., Sader, H. S., et al. (2008) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01475-07 · Cited by 48

Review of dalbavancin, a novel semisynthetic lipoglycopeptide

Kim, A., Kuti, J. L., & Nicolau, D. P. (2007) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.16.5.717 · Cited by 47

Iminosugars as Possible Broad Spectrum anti Hepatitis Virus Agents: The Glucovirs and Alkovirs

Block, T. M., & Jordan, R. (2001) · Antiviral chemistry & chemotherapy · doi:10.1177/095632020101200601 · Cited by 47

Proceedings of the First International Conference on PEP005

Ogbourne, S. M., Hampson, P., Lord, J. M., Parsons, P. G., de Witte, P. A. M., & Suhrbier, A. (2007) · Anti-Cancer Drugs · doi:10.1097/cad.0b013e3280149ec5 · Cited by 47

Natural product-like combinatorial libraries

Abreu, P. M., & Branco, P. S. (2003) · Journal of the Brazilian Chemical Society · doi:10.1590/s0103-50532003000500002 · Cited by 47

Genotoxicity and toxicity of the potential cancer‐preventive agent polyphenon E

Chang, P. Y., Mirsalis, J. C., Riccio, E. S., Bakke, J. P., Lee, P. S., Shimon, J. A., Phillips, S. J., Fairchild, D., Hara, Y., & Crowell, J. A. (2003) · Environmental and Molecular Mutagenesis · doi:10.1002/em.10129 · Cited by 47

Development potential of rifalazil

Rothstein, D. M., Hartman, A. D., Cynamon, M. H., et al. (2003) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.12.2.255 · Cited by 47

Gastroprotective Effects of DA-6034, a New Flavonoid Derivative, in Various Gastric Mucosal Damage Models

Choi, S. M., Shin, J. H., Kang, K. K., Ahn, B. O., & Yoo, M. (2007) · Digestive Diseases and Sciences · doi:10.1007/s10620-006-9657-4 · Cited by 46

A worthy adversary for malaria

O’Neill, P. M. (2004) · Nature · doi:10.1038/430838a · Cited by 46

Oritavancin: a new promising agent in the treatment of infections due to Gram-positive pathogens

Poulakou, G., & Giamarellou, H. (2008) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.17.2.225 · Cited by 45

The potential of DMXAA (ASA404) in combination with docetaxel in advanced prostate cancer

McKeage, M. J. (2007) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.17.1.23 · Cited by 45

ATM-dependent CHK2 Activation Induced by Anticancer Agent, Irofulven

Wang, J., Wiltshire, T. D., Wang, Y., Mikell, C., Burks, J., Cunningham, C., Laar, E. S. V., Waters, S. J., Reed, E., & Wang, W. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m400015200 · Cited by 44

Renal accumulation and clearance of advanced glycation end-products in type 2 diabetic nephropathy: effect of angiotensin-converting enzyme and vasopeptidase inhibition

Wihler, C., Schäfer, S., Schmid, K., Deemer, E. K., Münch, G. W., Bleich, M., Busch, A. E., Dingermann, T., Somoza, V., Baynes, J., et al. (2005) · Diabetologia · doi:10.1007/s00125-005-1837-9 · Cited by 44

Recent developments in antibacterial drug discovery: microbe-derived natural products – from collection to the clinic

Leeds, J. A., Schmitt, E. K., & Krastel, P. (2006) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.15.3.211 · Cited by 44

The Vascular Disrupting Agent, DMXAA, Directly Activates Dendritic Cells through a MyD88-Independent Mechanism and Generates Antitumor Cytotoxic T Lymphocytes

Wallace, A. F., LaRosa, D. F., Kapoor, V., Sun, J., Cheng, G., Jassar, A. S., Blouin, A., Ching, L., & Albelda, S. Μ. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-3757 · Cited by 44

Cyclophilin inhibitors in hepatitis C viral infection

Flisiak, R., Dumont, J., & Crabbé, R. (2007) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.16.9.1345 · Cited by 44

CCI-779 Wyeth.

Elit, L. M. (2002) · PubMed · Cited by 43

Cannabinoids as Neuroprotective Agents in Traumatic Brain Injury

Biegon, A. R. (2004) · Current Pharmaceutical Design · doi:10.2174/1381612043384196 · Cited by 43

Ajulemic acid (IP-751): Synthesis, proof of principle, toxicity studies, and clinical trials

Burstein, S. (2005) · The AAPS Journal · doi:10.1208/aapsj070115 · Cited by 43

Potent, acid-stable and orally active macrolide-type motilin receptor agonists, GM-611 and the derivatives

Koga, H., Sato, T., Tsuzuki, K., Onoda, H., Kuboniwa, H., & Takanashi, H. (1994) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/s0960-894x(01)80359-0 · Cited by 43

Novel camptothecin derivative BNP1350 in experimental human ovarian cancer: Determination of efficacy and possible mechanisms of resistance

van Hattum, A. H., Schlüper, H. M. M., Hausheer, F. H., et al. (2002) · International Journal of Cancer · doi:10.1002/ijc.10434 · Cited by 43

From Natural Products to Small Molecule Ketone Histone Deacetylase Inhibitors: Development of New Class Specific Agents

JONES, P. G., & Steinkühler, C. (2008) · Current Pharmaceutical Design · doi:10.2174/138161208783885317 · Cited by 43

Novel Insights and Therapeutical Applications in the Field of Inhibitors of COX-2

Kiefer, W., & Dannhardt, G. (2004) · Current Medicinal Chemistry · doi:10.2174/0929867043363668 · Cited by 43

Seeing is believing: the impact of structural genomics on antimicrobial drug discovery

Schmid, M. B. (2004) · Nature Reviews Microbiology · doi:10.1038/nrmicro978 · Cited by 42

Treatment of Streptozotocin-Induced Diabetic Rats With AVE7688, a Vasopeptidase Inhibitor

Davidson, E. P., Kleinschmidt, T. L., Oltman, C. L., Lund, D. D., & Yorek, M. A. (2007) · Diabetes · doi:10.2337/db06-1180 · Cited by 42

Distinct binding and cellular properties of synthetic (+)- and (-)-discodermolides

Hung, D. T., Nerenberg, J. B., & Schreiber, S. L. (1994) · Chemistry & Biology · doi:10.1016/1074-5521(94)90042-6 · Cited by 42

Protection against inflammatory neurodegeneration and glial cell death by 7β-hydroxy epiandrosterone, a novel neurosteroid

Dudás, B., Hanin, I., Rose, M., & Wülfert, E. (2004) · Neurobiology of Disease · doi:10.1016/j.nbd.2003.11.001 · Cited by 42

Ketolides: pharmacological profile and rational positioning in the treatment of respiratory tract infections

Françoise Van Bambeke, A., Harms, J. M., Laethem, Y. V., & Tulkens, P. M. (2008) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.9.2.267 · Cited by 42

The Art of Fusion: From Penams and Cephems to Penems

Dalhoff, A., & Thomson, C. J. (2003) · Chemotherapy · doi:10.1159/000070616 · Cited by 41

Marine natural products as therapeutic agents: Part 2

Frenz, J. L., Kohl, A. C., & Kerr, R. G. (2004) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543776.14.1.17 · Cited by 41

Phenserine, a Novel Anticholinesterase Related to Physostigmine: Total Synthesis and Biological Properties

Brossi, A., PEI, X. ‐., & Greig, N. (1996) · Australian Journal of Chemistry · doi:10.1071/ch9960171 · Cited by 41

Glycopeptide antibiotics and development of inhibitors to overcome vancomycin resistance

Gao, Y. (2001) · Natural Product Reports · doi:10.1039/b100912p · Cited by 40

Lipase-Catalyzed Regioselective Esterification of Rapamycin: Synthesis of Temsirolimus (CCI-779)

Gu, J., RUPPEN, M. E., & Cai, P. (2005) · Organic Letters · doi:10.1021/ol0514395 · Cited by 40

The evolution and role of macrolides in infectious diseases

Blondeau, J. M. (2002) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.3.8.1131 · Cited by 40

DX‐8951f: Summary of Phase I Clinical Trials

Jager, R. D., Cheverton, P., TAMANOI, K., Coyle, J. J., Ducharme, M. P., Sakamoto, N., Satomi, M., Suzuki, M., & THE DX‐8951F INVESTIGATORS (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb07044.x · Cited by 40

Structural Insight into the Self-Sacrifice Mechanism of Enediyne Resistance

Singh, S., Hager, M. H., Zhang, C., Griffith, B. R., Lee, M. S., Hallenga, K., Markley, J. L., & Thorson, J. S. (2006) · ACS Chemical Biology · doi:10.1021/cb6002898 · Cited by 40

Anidulafungin: review of a new echinocandin antifungal agent

Raasch, R. H. (2004) · Expert Review of Anti-infective Therapy · doi:10.1586/14787210.2.4.499 · Cited by 40

Anidulafungin

Murdoch, D., & Plosker, G. L. (2004) · Drugs · doi:10.2165/00003495-200464190-00011 · Cited by 40

Sharks: A Potential Source of Antiangiogenic Factors and Tumor Treatments

Cho, J., & Kim, Y. H. (2002) · Marine Biotechnology · doi:10.1007/s10126-002-0064-3 · Cited by 39

METABOLIC PROFILE OF 1,5-DICAFFEOYLQUINIC ACID IN RATS, AN IN VIVO AND IN VITRO STUDY

Yang, B., Meng, Z., Dong, J.-X., Yan, L., Zou, L., Tang, Z.-M., & Dou, G. (2005) · Drug Metabolism and Disposition · doi:10.1124/dmd.104.002154 · Cited by 39

Valine Influences Production and Complex Composition of Glycopeptide Antibiotic A40926 in Fermentations of Nonomuraea sp. ATCC 39727.

Beltrametti, F., Jovetic, S., Feroggio, M., Gastaldo, L., Selva, E., & Marinelli, F. (2004) · The Journal of Antibiotics · doi:10.7164/antibiotics.57.37 · Cited by 39

Glucuronidation of Anti-HIV Drug Candidate Bevirimat: Identification of Human UDP-glucuronosyltransferases and Species Differences

Wen, Z., Martin, D. E., Bullock, P. L., Lee, K., & Smith, P. C. (2006) · Drug Metabolism and Disposition · doi:10.1124/dmd.106.012815 · Cited by 38

The vasopeptidase inhibitor AVE7688 ameliorates Type 2 diabetic nephropathy

Sch�fer, S. G., Linz, W., Vollert, H., Biemer‐Daub, G., R�tten, H., Bleich, M., & Busch, A. E. (2004) · Diabetologia · doi:10.1007/s00125-003-1264-8 · Cited by 38

Safety and Pharmacokinetic Profile of Multiple Escalating Doses of (+)-Calanolide A, a Naturally Occurring Nonnucleoside Reverse Transcriptase Inhibitor, in Healthy HIV-Negative Volunteers

Eiznhamer, D. A., Terri, C., Ruckle Jon, L., Tolbert, D. T., Giltner, J., Bipul, D., Flavin Michael, T., Jenta, T. R. ‐., & Ze-Qi, X. (2002) · HIV Clinical Trials · doi:10.1310/9gde-f2r1-w2rl-e9fj · Cited by 38

Development potential of rifalazil and other benzoxazinorifamycins

Rothstein, D. M., Shalish, C., Murphy, C. K., Sternlicht, A. L., & Campbell, L. A. (2006) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.15.6.603 · Cited by 38

Telithromycin

Wellington, K., & Noble, S. (2004) · Drugs · doi:10.2165/00003495-200464150-00006 · Cited by 38

A Scalable Process for the Synthesis of the Bcl Inhibitor Obatoclax

Daïri, K., Yao, Y., Faley, M., Tripathy, S., Rioux, E., Billot, X., Rabouin, D., Gonzalez, G., Lavallée, J.-F., & Attardo, G. (2007) · Organic Process Research & Development · doi:10.1021/op7001613 · Cited by 37

A phase II study of milataxel: a novel taxane analogue in previously treated patients with advanced colorectal cancer

Ramanathan, R. K., Picus, J., Raftopoulos, H., Bernard, S. A., Lockhart, A. C., Frenette, G., Macdonald, J. S., Melin, S. A., Berg, D., Brescia, F., et al. (2007) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-007-0489-5 · Cited by 37

Cephalosporins in clinical development

Page, M. G. P. (2004) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.13.8.973 · Cited by 37

Retapamulin: A Semisynthetic Pleuromutilin Compound for Topical Treatment of Skin Infections in Adults and Children

Jacobs, M. R. (2007) · Future Microbiology · doi:10.2217/17460913.2.6.591 · Cited by 37

The Year's New Drugs.

Graul, A. I., & Prous, J. R. (1998) · PubMed · Cited by 37

Cellular bases of the antitumor activity of the novel taxane IDN 5109 (BAY59-8862) on hormone-refractory prostate cancer.

Cassinelli, G., Lanzi, C., Supino, R., Pratesi, G., Zuco, V., Laccabue, D., Cuccuru, G., Bombardelli, E., & Zunino, F. (2002) · PubMed · Cited by 36

Cannabinoids in Multiple Sclerosis: Do They Have a Therapeutic Role?

Killestein, J., Uitdehaag, B. M. J., & Polman, C. H. (2004) · Drugs · doi:10.2165/00003495-200464010-00001 · Cited by 36

Cyclosporine Increases Human Immunodeficiency Virus Type 1 Vector Transduction of Primary Mouse Cells

Noser, J. A., Towers, G. J., Sakuma, R., Dumont, J., Collins, M. K., & Ikeda, Y. (2006) · Journal of Virology · doi:10.1128/jvi.02427-05 · Cited by 36

Next-generation calcineurin inhibitors for ophthalmic indications

Anglade, E., Yatscoff, R. W., Foster, R. T., & Grau, U. M. (2007) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.16.10.1525 · Cited by 36

Efficacy of PLD-118, a Novel Inhibitor of Candida Isoleucyl-tRNA Synthetase, against Experimental Oropharyngeal and Esophageal Candidiasis Caused by Fluconazole-Resistant C. albicans

Petraitis, V., Petraitienė, R., Kelaher, A. M., Sarafandi, A. A., Sein, T., Mickiene, D., Bacher, J. D., Groll, A. H., & Walsh, T. J. (2004) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.48.10.3959-3967.2004 · Cited by 36

Effectiveness of the quillaja saponin semi-synthetic analog GPI-0100 in potentiating mucosal and systemic responses to recombinant HagB from Porphyromonas gingivalis

Zhang, P. (2003) · Vaccine · doi:10.1016/s0264-410x(03)00438-9 · Cited by 36

Chemical and enzymatic stability of a cyclic depsipeptide, the novel, marine-derived, anti-cancer agent kahalalide F

Sparidans, R. W., Stokvis, E., Jimeno, J. M., Lázaro, L. L., Schellens, J. H. M., & Beijnen, J. H. (2001) · Anti-Cancer Drugs · doi:10.1097/00001813-200108000-00003 · Cited by 36

Inhibition of bacterial protein synthesis by elongation-factor-Tu-binding antibiotics MDL 62,879 and efrotomycin

Landini, P., Bandera, M., Goldstein, B. P., RIPAMONTI, F., Soffientini, A., Islam, K., & Denaro, M. (1992) · Biochemical Journal · doi:10.1042/bj2830649 · Cited by 35

Relationships between DNA strand breakage and apoptotic progression upon treatment of HL-60 leukemia cells with tafluposide or etoposide

Kluza, J., Mazinghien, R., Irwin, H., Hartley, J. A., & Bailly, C. (2006) · Anti-Cancer Drugs · doi:10.1097/00001813-200602000-00006 · Cited by 35

Vinflunine, a Novel Microtubule Inhibitor, Suppresses Calmodulin Interaction with the Microtubule-Associated Protein STOP

Makarov, A. А., Tsvetkov, P. O., Villard, C., Esquieu, D., Pourroy, B., Fahy, J., Braguer, D., Peyrot, V., & Lafitte, D. (2007) · Biochemistry · doi:10.1021/bi701803s · Cited by 35

Lobeline effects on tonic and methamphetamine-induced dopamine release

Wilhelm, C., Johnson, R. A., Eshleman, A. J., & Janowsky, A. J. (2007) · Biochemical Pharmacology · doi:10.1016/j.bcp.2007.11.019 · Cited by 34

Mother nature's combinatorial libraries; their influence on the synthesis of drugs.

Kingston, D. G. I., & Newman, D. J. (2002) · PubMed · Cited by 34

In Vitro and In Vivo Antibacterial Activities of SM-216601, a New Broad-Spectrum Parenteral Carbapenem

Ueda, Y., Kanazawa, K., Eguchi, K., Takemoto, K., Eriguchi, Y., & Sunagawa, M. (2005) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.49.10.4185-4196.2005 · Cited by 32

The evolution of cancer research and drug discovery at Lilly Research Laboratories

Pearce, H. L., & Miller, M. A. (2005) · Advances in Enzyme Regulation · doi:10.1016/j.advenzreg.2005.02.017 · Cited by 32

Beyond Chicken Soup

Haseltine, W. A. (2001) · Scientific American · doi:10.1038/scientificamerican1101-56 · Cited by 32

The anticancer activity of the transcription inhibitor terameprocol (meso-tetra-O-methyl nordihydroguaiaretic acid) formulated for systemic administration

López, R., Goodman, A. B., Rhodes, M., Blomberg, J. A. L., & Heller, J. (2007) · Anti-Cancer Drugs · doi:10.1097/cad.0b013e32813148e0 · Cited by 31

Anidulafungin: a new echinocandin for candidal infections

de la Torre, P., & Reboli, A. C. (2007) · Expert Review of Anti-infective Therapy · doi:10.1586/14787210.5.1.45 · Cited by 31

Ex vivo effects of the dual topoisomerase inhibitor tafluposide (F 11782) on cells isolated from fresh tumor samples taken from patients with cancer

Sargent, J. M., Elgie, A. W., Williamson, C. J., & Hill, B. T. (2003) · Anti-Cancer Drugs · doi:10.1097/00001813-200307000-00013 · Cited by 31

The novel taxane analogs, BMS-184476 and BMS-188797, potentiate the effects of radiation therapy in vitro and in vivo against human lung cancer cells

Js, K., Amorino, G. P., Pyo, H., Cao, Q., Price, J. O., & Choy, H. (2001) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/s0360-3016(01)01658-3 · Cited by 30

Antithrombotic and Hypofibrinogenetic Therapy in Acute Ischemic Stroke: What Is the Next Step?

Sherman, D. G. (2003) · Cerebrovascular Diseases · doi:10.1159/000074806 · Cited by 30

Ketolides: an emerging treatment for macrolide-resistant respiratory infections, focusing on S. pneumoniae

Zhanel, G. G., Hisanaga, T., Nichol, K. A., Wierzbowski, A. K., & Hoban, D. J. (2003) · Expert Opinion on Emerging Drugs · doi:10.1517/14728214.8.2.297 · Cited by 30

Simultaneous determination of 1,5-dicaffeoylquinic acid and its active metabolites in human plasma by liquid chromatography–tandem mass spectrometry for pharmacokinetic studies

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Efficacy of aminocandin in the treatment of immunocompetent mice with haematogenously disseminated fluconazole-resistant candidiasis

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Ramoplanin (A-16686), a new glycolipodepsipeptide antibiotic. IV. Complete sequence determination by homonuclear 2D NMR spectroscopy.

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A Mechanistic and Kinetic Study of the β-Lactone Hydrolysis of Salinosporamide A (NPI-0052), A Novel Proteasome Inhibitor

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Incretins and their role in the management of diabetes

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Characterization of Protein Kinase chk1 Essential for the Cell Cycle Checkpoint after Exposure of Human Head and Neck Carcinoma A253 Cells to a Novel Topoisomerase I Inhibitor BNP1350

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New Therapeutic Options for Chemotherapy-Resistant Metastatic Breast Cancer

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Irofulven induces replication-dependent CHK2 activation related to p53 status

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Chk1 signaling pathways that mediated G2M checkpoint in relation to the cellular resistance to the novel topoisomerase I poison BNP1350

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Treatment with the snail peptide CGX-1007 reduces DNA damage and alters gene expression of c-fos and bcl-2 following focal ischemic brain injury in rats

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Targeting Ouabain- and Adducin-dependent mechanisms of hypertension and cardiovascular remodeling as a novel pharmacological approach

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Succinylcholine or rocuronium? A meta-analysis of the effects on intubation conditions

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Symptomatic treatment of multiple sclerosis using cannabinoids: recent advances

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Antipropionibacterial Activity of BAL19403, a Novel Macrolide Antibiotic

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Natural Products as a Source of CNS-Active Agents

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Structure Elucidation of Fumagillin-Related Natural Products

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Apoptotic pathways of epothilone BMS 310705

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OASIS-HT: Design of a Pharmacogenomic Dose-Finding Study

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Rifalazil and Other Benzoxazinorifamycins in the Treatment of Chlamydia‐Based Persistent Infections

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Understanding the Selectivity of Fumagillin for the Methionine Aminopeptidase Type II

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Comparison of the antivascular and cytotoxic activities of TZT-1027 (Soblidotin) with those of other anticancer agents

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A succulent cure to end obesity

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Lisdexamfetamine dimesylate

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Activity of a New Oral Streptogramin, XRP2868, against Gram-Positive Cocci Harboring Various Mechanisms of Resistance to Streptogramins

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Efficacy of Cethromycin, a New Ketolide, against Streptococcus pneumoniae Susceptible or Resistant to Erythromycin in a Murine Pneumonia Model

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A Single Intravenous Injection of KRN5500 (Antibiotic Spicamycin) Produces Long-Term Decreases in Multiple Sensory Hypersensitivities in Neuropathic Pain

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Effects of EDP-420 on penicillin-resistant and quinolone- and penicillin-resistant pneumococci in the rabbit meningitis model

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Efficacy of the partricin derivative SPA-S-753 against systemic murine candidosis

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Apparent receptor-mediated activation of Ca2+-dependent conductive Cl−transport by shark-derived polyaminosterols

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In VitroActivity of a New Polyene SPK-843 AgainstCandidaspp,Cryptococcus neoformansandAspergillusspp Clinical Isolates

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The use of lipid emulsions for the iv administration of a new water soluble polyene antibiotic, SPK-843

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A phase I and pharmacokinetic study of novel taxane BMS-188797 and cisplatin in patients with advanced solid tumours

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DA-125, a new antitumor agent, inhibits topoisomerase ii as topoisomerase poison and dna intercalator simultaneously

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Patents on tetracycline and tetracycline derivatives as antimicrobials: January 1998 ? October 2002

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Photochemical Approaches to Complex Chemotypes: Applications in Natural Product Synthesis

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