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Cited by 119Garlic and Onion StudiesAntifungal resistance and susceptibilityEssential Oils and Antimicrobial Activity

An overview of the antifungal properties of allicin and its breakdown products-the possibility of a safe and effective antifungal prophylactic

Davis, Stephen R·2005·Mycoses
DOI 10.1111/j.1439-0507.2004.01076.x
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Abstract

Summary: Reports about the safe and successful intravenous (i.v.) use of garlic derivatives in China against invasive fungal infections have been made, but little has been done to seriously investigate the in vivo use of these derivatives in the West. Laboratories have demonstrated impressive in vitro MICs using allitridium, one of these derivatives, against a range of medically important fungi. In addition, it has been demonstrated that allitridium shows in vitro synergy with amphotericin B, one of the main i.v. antifungal agents. Some of the breakdown products of allicin, the main parent antifungal compound in garlic, have been investigated for their general antimicrobial, anticancer and anticholesterol properties, and it appears that there is a common mode of action that underlies these activities. It appears that these small molecules have the ability to cross cell membranes and combine with sulfur‐containing molecular groups in amino acids and proteins, thus interfering with cell metabolism. It has been suggested that the reason human cells are not poisoned by allicin derivatives is that they contain glutathione, a sulfur‐containing amino acid that combines with the allicin derivative, thus preventing cell damage. In addition to their biochemical mechanism, these derivatives appear to stimulate cellular immunity, an important ability lacking in conventional antifungal chemotherapy. These derivatives appear to be safe, cheap, wide‐spectrum and immunostimulatory, as well as possibly synergistic with conventional antifungal therapy, making them ideal candidates for investigation into their use as prophylactic antifungal agents.

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Crossref · 10.1111/j.1439-0507.2004.01076.x

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34 of 34 references verified0 citation errors · 0 not checkable

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  • Traditionally, garlic and its related compounds have been stated to have several biological activities including anticarcinogenic, antioxidant, antidiabetic, renoprotective, anti-atherosclerotic, antibacterial, antifungal, and antihypertensive activities.

    “Traditionally, garlic and its related compounds have been stated to have several biological activities including anticarcinogenic, antioxidant [46], antidiabetic, renoprotective, anti-atherosclerotic, antibacterial, antifungal [47], and antihypertensive activities [17].”

    From Chemical Constituents and Pharmacological Activities of Garlic (Allium sativum L.): A Review (2020) · cites this paper as [47]

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Authors
Davis, S. R.
Affiliations
Women's and Children's Hospital (AU)
Corresponding author
Davis, Stephen R
Venue
Mycoses
Publisher
Wiley
Published
2005-03
Volume
48
Issue
2
Pages
95-100
ISSN
  • 0027-5557 (ISSN-L)
  • 0933-7407
  • 1439-0507
DOI
10.1111/j.1439-0507.2004.01076.x
OpenAlex
W2008092645
Cited by
119
References
34
Citations by year
2026: 4 · 2025: 2 · 2024: 14 · 2023: 6 · 2022: 7 · 2021: 2 · 2020: 6 · 2019: 4 · 2018: 2 · 2017: 4 · 2016: 5 · 2015: 7 · 2014: 8 · 2013: 9 · 2012: 5
FWCI
0.29
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 1 d)
Locations
  • Mycoses (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Garlic and Onion Studies
  • Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Essential Oils and Antimicrobial Activity
Keywords
allicin, antifungal activity, invasive fungal infections, antifungal prophylaxis, amphotericin B synergy, glutathione, sulfur compounds, mechanism of action, intravenous antifungal therapy
MeSH terms
Amphotericin B, Antifungal Agents, Disulfides, Drug Synergism, Drug Therapy, Combination, Fungi, Humans, Immunity, Cellular, Mycoses, Sulfinic Acids

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