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Depiction of metabolome changes in histidine-starved Escherichia coli by CE-TOFMS
Abstract
Metabolic changes in response to histidine starvation were observed in histidine-auxotrophic Escherichia coli using a capillary electrophoresistime-of-flight mass spectrometry (CE-TOFMS)-based metabolomics technique. Prior to the analysis, we prepared an E. coli metabolome list of 727 metabolites reported in the literature. An improved method for metabolite extraction was developed, which resulted in higher extraction efficiency in phosphate-rich metabolites, e.g., ATP and GTP. Based on the results, 375 charged, hydrophilic intermediates in primary metabolisms were analysed simultaneously, providing quantitative data of 198 metabolites. We confirmed that the intracellular levels of intermediates in histidine biosynthesis are rapidly accumulated in response to a drop in histidine level under histidine-starved conditions. Simultaneously, disciplined responses were observed in the glycolysis, tricarboxylic acid cycle, and amino acid and nucleotide biosynthesis pathways as regulated by amino acid starvation.
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Construction of Escherichia coli K‐12 in‐frame, single‐gene knockout mutants: the Keio collection
Baba, T., Ara, T., Hasegawa, M., Takai, Y., Okumura, Y., Baba, M., Datsenko, K. A., Tomita, M., Wanner, B. L., & Mori, H. (2006) · Molecular Systems Biology · doi:10.1038/msb4100050 · Cited by 7,858
Self-citationEymann, C., Homuth, G., Scharf, C., & Hecker, M. (2002) · Journal of Bacteriology · doi:10.1128/jb.184.9.2500-2520.2002 · Cited by 306
Cited by
Kuehnbaum, N. L., & Britz-McKibbin, P. (2013) · Chemical Reviews · doi:10.1021/cr300484s · Cited by 354
Impact of intestinal microbiota on intestinal luminal metabolome
Matsumoto, M., Kibe, R., Ooga, T., Aiba, Y., Kurihara, S., Sawaki, E., Koga, Y., & Benno, Y. (2012) · Scientific Reports · doi:10.1038/srep00233 · Cited by 334
Host‐microbe interactions: Profiles in the transcriptome, the proteome, and the metabolome
Nguyen, T., Sedghi, L., Ganther, S., Malone, E., Kamarajan, P., & Kapila, Y. L. (2020) · Periodontology 2000 · doi:10.1111/prd.12316 · Cited by 51
Osakunor, D. N. M., Mduluza, T., Osei-Hyiaman, D., Burgess, K., Woolhouse, M. E. J., & Mutapi, F. (2020) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0008866 · Cited by 20
Mutoh, N., Moriya, M., Xu, C., Kato, K., Arai, S., Iwabuchi, N., Tanaka, M., Jinghua, Y., Itamura, R., Sakatani, K., et al. (2024) · Behavioural Brain Research · doi:10.1016/j.bbr.2023.114820 · Cited by 15
Metadata
- Authors
- Ohashi, Y., Hirayama, A., Ishikawa, T., Nakamura, S., Shimizu, K., Ueno, Y., Tomita, M., & Soga, T.
- Venue
- Molecular BioSystems
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-11-15
- Volume
- 4
- Issue
- 2
- Pages
- 135-147
- ISSN
- 1742-2051 (ISSN-L)
- 1742-206X
- OpenAlex
- W2067284696
- Cited by
- 290
- References
- 2
- FWCI
- 3.35
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ohashi, Y., Hirayama, A., Ishikawa, T., Nakamura, S., Shimizu, K., Ueno, Y., Tomita, M., & Soga, T. (2007). Depiction of metabolome changes in histidine-starved Escherichia coli by CE-TOFMS. Molecular BioSystems. https://doi.org/10.1039/b714176a
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