Host‐microbe interactions: Profiles in the transcriptome, the proteome, and the metabolome
Open accessAbstract
Periodontal studies using transcriptomics, proteomics, and metabolomics encompass the collection of mRNA transcripts, proteins, and small‐molecule chemicals in the context of periodontal health and disease. The number of studies using these approaches has significantly increased in the last decade and they have provided new insight into the pathogenesis and host‐microbe interactions that define periodontal diseases. This review provides an overview of current molecular findings using ‐omic approaches that underlie periodontal disease, including modulation of the host immune response, tissue homeostasis, and complex metabolic processes of the host and the oral microbiome. Integration of these ‐omic approaches will broaden our perspective of the molecular mechanisms involved in periodontal disease, advancing and improving the diagnosis and treatment of various stages and forms of periodontal disease.
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Metatranscriptomics, or sequencing of mRNA in a sample, provides a snapshot of transcriptionally active microbes.
“Metatranscriptomics, or sequencing of mRNA in a sample, provides a snapshot of transcriptionally active microbes.89”
From The oral microbiome: Role of key organisms and complex networks in oral health and disease (2021) · cites this paper as [89]
Metabolomics provides insight into the metabolic and functional activities of the host and its microbiome and intricate interspecies interactions encoded within this pangenome.
“Metabolomics provides insight into the metabolic and functional activities of the host and its microbiome and intricate interspecies interactions encoded within this pangenome.89”
From The oral microbiome: Role of key organisms and complex networks in oral health and disease (2021) · cites this paper as [89]
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Analysis of protein expression in periodontal pocket tissue: a preliminary study
Monari, E., Cuoghi, A., Bellei, E., Bergamini, S., Lucchi, A., Tomasi, A., Cortellini, P., Zaffe, D., & Bertoldi, C. (2015) · Proteome Science · doi:10.1186/s12953-015-0089-y · Cited by 20 · see citing works
Proteomic analysis of Porphyromonas gingivalis exposed to nicotine and cotinine
Cogo, K., de Andrade, A., Labate, C. A., et al. (2012) · Journal of Periodontal Research · doi:10.1111/j.1600-0765.2012.01494.x · Cited by 19 · see citing works
S100A2 Level Changes Are Related to Human Periodontitis
Heo, S., Choi, Y., Lee, J., Lee, J., & Cho, J. (2011) · Molecules and Cells · doi:10.1007/s10059-011-0132-5 · Cited by 18 · see citing works
Bengtsson, T., Zhang, B., Selegård, R., Wiman, E., Aili, D., & Khalaf, H. (2017) · Pathogens and Disease · doi:10.1093/femspd/ftx064 · Cited by 17 · see citing works
Mizuno, N., Niitani, M., Shiba, H., Iwata, T., Hayashi, I., Kawaguchi, H., & Kurihara, H. (2011) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.2010.01693.x · Cited by 15 · see citing works
Batschkus, S., Cingoez, G., Urlaub, H., Miosge, N., Kirschneck, C., Meyer-Marcotty, P., & Lenz, C. (2017) · Clinical Oral Investigations · doi:10.1007/s00784-017-2213-0 · Cited by 11 · see citing works
Ferreira, C. L., Nunes, C. M. M., Bernardo, D. V., et al. (2018) · Journal of Periodontal Research · doi:10.1111/jre.12584 · Cited by 11 · see citing works
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The oral microbiome: Role of key organisms and complex networks in oral health and disease
Sedghi, L., DiMassa, V., Harrington, A., Lynch, S. V., & Kapila, Y. L. (2021) · Periodontology 2000 · doi:10.1111/prd.12393 · Cited by 755 · see citing works
Self-citation
- Authors
- Nguyen, T., Sedghi, L., Ganther, S., Malone, E., Kamarajan, P., & Kapila, Y. L.
- Affiliations
- University of California, San Francisco (US)
- Corresponding author
- Kapila, Yvonne L.
- Venue
- Periodontology 2000
- Publisher
- Wiley
- Published
- 2019-12-18
- Volume
- 82
- Issue
- 1
- Pages
- 115-128
- ISSN
- 0906-6713 (ISSN-L)
- 1600-0757
- PMC
- PMC7968888
- OpenAlex
- W2996023322
- Cited by
- 51
- References
- 101
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 12 · 2023: 8 · 2022: 7 · 2021: 5 · 2020: 5 · 2019: 1
- FWCI
- 0.64
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Periodontology 2000 (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institutes of Health (F30DE027598, T32DE007306, R01 DE025225)
- Topics
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Health Sciences › Medicine › Urology › Periodontal Regeneration and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- host-microbe interactions, periodontal disease, transcriptomics, proteomics, metabolomics, oral microbiota, host immune response, periodontal disease pathogenesis
- MeSH terms
- Humans, Proteome, Proteomics, Metabolomics, Metabolome, Transcriptome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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