The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Automated cell culture in high density tubeless microfluidic device arrays
Abstract
Microfluidics is poised to have an impact on life sciences research. However, current microfluidic methods are not compatible with existing laboratory liquid dispensing and detection infrastructure. This incompatibility is a barrier to adoption of microfluidic systems and calls for improved approaches that will enhance performance and promote acceptance of microfluidic systems in the life sciences. Ease of use, standardized interfaces and automation remain critical challenges. We present a platform based on surface tension effects, where the difference in pressure inside drops of unequal volume drives flow in passive structures. We show integration with existing laboratory infrastructure, microfluidic operations such as pumping, routing and compartmentalization without discrete micro-components as well as cell patterning in both monolayer and three-dimensional cell culture.
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Citations
Cites
The origins and the future of microfluidics
Whitesides, G. M. (2006) · Nature · doi:10.1038/nature05058 · Cited by 9,687
A microfluidic platform for 3-dimensional cell culture and cell-based assays
Kim, M. S., Yeon, J. H., & Park, J.-K. (2007) · Biomedical Microdevices · doi:10.1007/s10544-006-9016-4 · Cited by 166
Berthier, E., Warrick, J., Yu, H., & Beebe, D. J. (2008) · Lab on a Chip · doi:10.1039/b717422e · Cited by 114
Self-citation
Cited by
Multicellular tumor spheroids: An underestimated tool is catching up again
Hirschhaeuser, F., Menne, H., Dittfeld, C., West, J., Mueller-Klieser, W., & Kunz-Schughart, L. A. (2010) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2010.01.012 · Cited by 1,674
Organs-on-chips at the frontiers of drug discovery
Esch, E. W., Bahinski, A., & Huh, D. (2015) · Nature Reviews Drug Discovery · doi:10.1038/nrd4539 · Cited by 1,185
Engineers are from PDMS-land, Biologists are from Polystyrenia
Berthier, E., Young, E. W. K., & Beebe, D. (2012) · Lab on a Chip · doi:10.1039/c2lc20982a · Cited by 799
Self-citationFundamentals of microfluidic cell culture in controlled microenvironments
Young, E. W. K., & Beebe, D. J. (2010) · Chemical Society Reviews · doi:10.1039/b909900j · Cited by 615
Self-citationA microfluidic device for a pharmacokinetic–pharmacodynamic (PK–PD) model on a chip
Sung, J. H., Kam, C., & Shuler, M. L. (2010) · Lab on a Chip · doi:10.1039/b917763a · Cited by 484
Metadata
- Authors
- Meyvantsson, I., Warrick, J. W., Hayes, S., Skoien, A., & Beebe, D. J.
- Venue
- Lab on a Chip
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2008
- Volume
- 8
- Issue
- 5
- Pages
- 717
- ISSN
- 1473-0189 (ISSN-L)
- 1473-0197
- OpenAlex
- W1991952399
- Cited by
- 172
- References
- 3
- FWCI
- 13.86
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
