The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Biocompatible surfactants for water-in-fluorocarbon emulsions
Open accessAbstract
Drops of water-in-fluorocarbon emulsions have great potential for compartmentalizing both in vitro and in vivo biological systems; however, surfactants to stabilize such emulsions are scarce. Here we present a novel class of fluorosurfactants that we synthesize by coupling oligomeric perfluorinated polyethers (PFPE) with polyethyleneglycol (PEG). We demonstrate that these block copolymer surfactants stabilize water-in-fluorocarbon oil emulsions during all necessary steps of a drop-based experiment including drop formation, incubation, and reinjection into a second microfluidic device. Furthermore, we show that aqueous drops stabilized with these surfactants can be used for in vitro translation (IVT), as well as encapsulation and incubation of single cells. The compatability of this emulsion system with both biological systems and polydimethylsiloxane (PDMS) microfluidic devices makes these surfactants ideal for a broad range of high-throughput, drop-based applications.
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Lipinski, C. A., Lombardo, F., Dominy, B. W., & Feeney, P. J. (2001) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(00)00129-0 · Cited by 18,139
Solvent Compatibility of Poly(dimethylsiloxane)-Based Microfluidic Devices
Lee, J. N., Park, C., & Whitesides, G. M. (2003) · Analytical Chemistry · doi:10.1021/ac0346712 · Cited by 2,643
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Mark, D., Haeberle, S., Roth, G., von Stetten, F., & Zengerle, R. (2010) · Chemical Society Reviews · doi:10.1039/b820557b · Cited by 1,647
Seemann, R., Brinkmann, M., Pfohl, T., & Herminghaus, S. (2012) · Reports on Progress in Physics · doi:10.1088/0034-4885/75/1/016601 · Cited by 1,049
Quan, P.-L., Sauzade, M., & Brouzes, E. (2018) · Sensors · doi:10.3390/s18041271 · Cited by 664
In vivo quantification of spatially varying mechanical properties in developing tissues
Serwane, F., Mongera, A., Rowghanian, P., Kealhofer, D. A., Lucio, A. A., Hockenbery, Z. M., & Campàs, O. (2017) · Nature Methods · doi:10.1038/nmeth.4101 · Cited by 367
Droplet microfluidics: recent developments and future applications
Casadevall i Solvas, X., & deMello, A. (2011) · Chem. Commun. · doi:10.1039/c0cc02474k · Cited by 353
Metadata
- Authors
- Holtze, C., Rowat, A. C., Agresti, J. J., Hutchison, J. B., Angilè, F. E., Schmitz, C. H. J., Köster, S., Duan, H., Humphry, K. J., Scanga, R. A., Johnson, J. S., Pisignano, D., & Weitz, D. A.
- Venue
- Lab on a Chip
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2008
- Volume
- 8
- Issue
- 10
- Pages
- 1632
- ISSN
- 1473-0189 (ISSN-L)
- 1473-0197
- OpenAlex
- W2152249986
- Cited by
- 670
- References
- 2
- FWCI
- 19.40
- Type
- journal article
- Language
- en
- Open access
- green
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- Holtze, C., Rowat, A. C., Agresti, J. J., Hutchison, J. B., Angilè, F. E., Schmitz, C. H. J., Köster, S., Duan, H., Humphry, K. J., Scanga, R. A., Johnson, J. S., Pisignano, D., & Weitz, D. A. (2008). Biocompatible surfactants for water-in-fluorocarbon emulsions. Lab on a Chip. https://doi.org/10.1039/b806706f
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