The DOI matches its Crossref record; 133 of the 134 references it cites were found in a registry or an index.
Bioinorganic chemistry of copper and zinc ions coordinated to amyloid-β peptide
Abstract
In the present perspective, we give a critical review on the coordination chemistry of the metal ions copper and zinc to the amyloid-beta (Abeta) peptide; such complexes have been linked to Alzheimer's disease. We focus on two main issues: the identification of the coordination sphere of the Cu(ii) and Zn(ii) ions and the affinity of these metal ions towards the peptide. With the aim to come up with as few as possible valuable structural models and binding affinity values, we critically review the divergent propositions reported in the literature and take into account the experimental differences and the limits of the methods used in the published studies. We propose that: (i) the conditional dissociation constant of the Cu(Abeta) complexes lies in the range of 10 pM to 100 nM, with a preference for the region between 100 pM to 1 nM. (ii) Two most likely coordination modes for the predominant form of the Cu(Abeta) complexes at physiological pH can be retained, both being 3N1O distorted square planar. In the first model, the Cu(ii) ion is coordinated by the Ntau atoms of the three His residues and the carboxylate of the Asp1. In the second model, both the N-terminus and the carboxylate functions of Asp1 are ligated together with the Ntau of His6 and of His13 (or His14). An equilibrium between these two forms at room temperature, and a preferentially freezing out of the second one would explain most of the divergences in the published results (in particular, between those obtai…
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In the citing paper
“Post-mortem examination of the brain suggested that bio-available metals (i.e., copper, zinc, and iron) are found in high concentration in the amyloid plaques.”
From The effect of Cu2+ and Zn2+ on the Aβ42 peptide aggregation and cellular toxicity (2013) · cites this paper as [13]
In the citing paper
“as well as lead to formation of reactive oxygen species (ROS) and oxidative stress.3,26–31,33–36”
From Bifunctional Compounds for Controlling Metal-Mediated Aggregation of the Aβ42Peptide (2012) · cites this paper as [26]
In the citing paper
“Thus, these metal ions have been shown to promote Aβ40 aggregation,23–27,29–32”
From Bifunctional Compounds for Controlling Metal-Mediated Aggregation of the Aβ42Peptide (2012) · cites this paper as [26]
In the citing paper
“These pM values represent approximate dissociation constants and compare favorably with the Kd values reported for Cu-Aβ (nM-μM) and Zn-Aβ (μM).26,29,31,57,76,79,80”
From Bifunctional Compounds for Controlling Metal-Mediated Aggregation of the Aβ42Peptide (2012) · cites this paper as [26]
In the citing paper
“This is in contrast with a large number of reports showing the aggregation-promoting effect of metal ions on the Aβ peptide.23–27,29–32,37,38”
From Bifunctional Compounds for Controlling Metal-Mediated Aggregation of the Aβ42Peptide (2012) · cites this paper as [26]
Citations
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1 of the 134 references couldn’t be matched to a known paper.
Research works printed but not linked: 3
- Multhaup, 1999, Met. Ions Biol. Syst., 36, 365
- Sayre, 2005, Ann Ist Super Sanita, 41, 143
- Krezel, 2008, J. Biol. Chem., 13, 401
Cited by
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Bioinorganic Chemistry of Alzheimer’s Disease
Kepp, K. P. (2012) · Chemical Reviews · doi:10.1021/cr300009x · Cited by 683
Savelieff, M. G., Nam, G., Kang, J., Lee, H. J., Lee, M., & Lim, M. H. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00138 · Cited by 612
Copper, zinc and iron in neurodegenerative diseases (Alzheimer's, Parkinson's and prion diseases)
Kozłowski, H., Łuczkowski, M., Remelli, M., & Valensin, D. (2012) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2012.03.013 · Cited by 446
Chen, B., Yu, P., Chan, W. N., Xie, F., Zhang, Y., Liang, L., Leung, K. T., Lo, K. W., Yu, J., Tse, G. M. K., et al. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01679-y · Cited by 420
Viles, J. H. (2012) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2012.05.003 · Cited by 404
Metadata
- Authors
- Faller, P., & Hureau, C.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Faller, Peter
- Venue
- Dalton Trans.
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2009
- Issue
- 7
- Pages
- 1080-1094
- ISSN
- 1477-9226 (ISSN-L)
- 1477-9234
- OpenAlex
- W2062820102
- Cited by
- 530
- References
- 134
- Citations by year
- 2026: 12 · 2025: 19 · 2024: 17 · 2023: 20 · 2022: 14 · 2021: 25 · 2020: 23 · 2019: 29 · 2018: 34 · 2017: 37 · 2016: 25 · 2015: 28 · 2014: 36 · 2013: 40 · 2012: 58
- FWCI
- 4.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Dalton Transactions (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Oncology › Metal complexes synthesis and properties
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Keywords
- amyloid-beta, copper(II) complexes, zinc(II) complexes, metal-peptide coordination, Alzheimer's disease, coordination sphere, dissociation constant, binding affinity, square-planar coordination, histidine ligands, structural model
- MeSH terms
- Alzheimer Disease, Copper, Humans, Peptide Fragments, Zinc, Chemistry, Bioinorganic, Amyloid beta-Peptides
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