Cited by 537Alzheimer's disease research and treatmentsMetal complexes synthesis and propertiesTrace Elements in Health

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Bioinorganic chemistry of copper and zinc ions coordinated to amyloid-β peptide

Faller, Peter, Hureau, Christelle·2009·Dalton Trans.

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Abstract

In the present perspective, we give a critical review on the coordination chemistry of the metal ions copper and zinc to the amyloid-beta (Abeta) peptide; such complexes have been linked to Alzheimer's disease. We focus on two main issues: the identification of the coordination sphere of the Cu(ii) and Zn(ii) ions and the affinity of these metal ions towards the peptide. With the aim to come up with as few as possible valuable structural models and binding affinity values, we critically review the divergent propositions reported in the literature and take into account the experimental differences and the limits of the methods used in the published studies. We propose that: (i) the conditional dissociation constant of the Cu(Abeta) complexes lies in the range of 10 pM to 100 nM, with a preference for the region between 100 pM to 1 nM. (ii) Two most likely coordination modes for the predominant form of the Cu(Abeta) complexes at physiological pH can be retained, both being 3N1O distorted square planar. In the first model, the Cu(ii) ion is coordinated by the Ntau atoms of the three His residues and the carboxylate of the Asp1. In the second model, both the N-terminus and the carboxylate functions of Asp1 are ligated together with the Ntau of His6 and of His13 (or His14). An equilibrium between these two forms at room temperature, and a preferentially freezing out of the second one would explain most of the divergences in the published results (in particular, between those obtai…

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Authors: Faller, P., & Hureau, C.
Affiliations: Centre National de la Recherche Scientifique (FR)
Corresponding author: Faller, Peter
ORCID: Faller, Peter
Hureau, Christelle
Venue: Dalton Trans.
Publisher: Royal Society of Chemistry (RSC)
Published: 2009
Issue: 7
Pages: 1080-1094
ISSN: 1477-9226 (ISSN-L)
1477-9234
DOI: 10.1039/b813398k
OpenAlex: W2062820102
Cited by: 530
References: 134
Citations by year: 2026: 12 · 2025: 19 · 2024: 17 · 2023: 20 · 2022: 14 · 2021: 25 · 2020: 23 · 2019: 29 · 2018: 34 · 2017: 37 · 2016: 25 · 2015: 28 · 2014: 36 · 2013: 40 · 2012: 58
FWCI: 4.03
Type: journal article
Language: en
Open access: closed
Locations: Dalton Transactions (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Oncology › Metal complexes synthesis and properties
Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
Keywords: amyloid-beta, copper(II) complexes, zinc(II) complexes, metal-peptide coordination, Alzheimer's disease, coordination sphere, dissociation constant, binding affinity, square-planar coordination, histidine ligands, structural model
MeSH terms: Alzheimer Disease, Copper, Humans, Peptide Fragments, Zinc, Chemistry, Bioinorganic, Amyloid beta-Peptides

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Bioinorganic chemistry of copper and zinc ions coordinated to amyloid-β peptide

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