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Cited by 390

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Click chemistry under non-classical reaction conditions

Kappe, C. Oliver, Van der Eycken, Erik·2010·Chem. Soc. Rev.
DOI 10.1039/b901973c
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Abstract

First described almost a decade ago, "click" reactions such as the Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) are widely used today in organic and medicinal chemistry, in the polymer and material science field, and in chemical biology. While most click reactions can be performed at room temperature there are instances where some form of process intensification is required. In this tutorial review, aimed at the synthetic chemistry community, examples of click chemistry carried out under non-classical reaction conditions, such as for example applying microwave heating or continuous flow processing will be highlighted.

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Metadata

Authors
Kappe, C. O., & Van der Eycken, E.
Venue
Chem. Soc. Rev.
Publisher
Royal Society of Chemistry (RSC)
Published
2010
Volume
39
Issue
4
Pages
1280-1290
ISSN
  • 0306-0012 (ISSN-L)
  • 1460-4744
DOI
10.1039/b901973c
OpenAlex
W2093251697
Cited by
390
References
1
FWCI
0.79
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Click chemistry under non-classical reaction conditions. https://app.cochat.ai/papers/10.1039/b901973c
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Kappe, C. O., & Van der Eycken, E. (2010). Click chemistry under non-classical reaction conditions. Chem. Soc. Rev. https://doi.org/10.1039/b901973c

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