Expanding proteomics into the analysis of chiral drugs

Large-scale analysis of the yeast proteome by multidimensional protein identification technology

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Direct analysis of protein complexes using mass spectrometry

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An Automated Multidimensional Protein Identification Technology for Shotgun Proteomics

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Chiral Drugs. An Overview

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From genomics to proteomics

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Quantitative profiling of differentiation-induced microsomal proteins using isotope-coded affinity tags and mass spectrometry

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From Proteins to Proteomes: Large Scale Protein Identification by Two-Dimensional Electrophoresis and Arnino Acid Analysis

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Role of Pharmacokinetics and Metabolism in Drug Discovery and Development

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Complementary Profiling of Gene Expression at the Transcriptome and Proteome Levels in Saccharomyces cerevisiae

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Putting chirality to work: the strategy of chiral switches

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Studies on the relationship between chemical constitution and physiological action

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Global analysis of the Deinococcus radiodurans proteome by using accurate mass tags

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Molecular cloning of two isoforms of the plasma membrane Ca2+-transporting ATPase from rat brain. Structural and functional domains exhibit similarity to Na+,K+- and other cation transport ATPases.

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Pharmacodynamic and pharmacokinetic differences between drug enantiomers in humans: An overview

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Analysis of protein expression (secretome) by human and mouse preimplantation embryos

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Quantitative Chemical Proteomics for Identifying Candidate Drug Targets

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Quantitative proteomic analysis of Myc oncoprotein function

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Chiral switches

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Integrated global profiling of cancer

Hanash, S. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1414 · Cited by 138 · see citing works

Intellectual property and chirality of drugs

Agranat, I., & Caner, H. (1999) · Drug Discovery Today · doi:10.1016/s1359-6446(99)01363-x · Cited by 131 · see citing works

Pharmacology of chiral compounds: 2-arylpropionic acid derivatives.

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Chirality: a blueprint for the future

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Targeting Therapy for Breast Carcinoma by ATP Synthase Inhibitor Aurovertin B

Huang, T., Chang, H., Hsu, C., Kuo, W., Chang, K., & Juan, H. (2008) · Journal of Proteome Research · doi:10.1021/pr700742h · Cited by 111 · see citing works

Chiral Inversion of Drugs: Coincidence or Principle?

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Mapping the Integrin-Linked Kinase Interactome Using SILAC

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Relationships Between Stereostructure and Pharmacological Activities

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Regulation of G protein-coupled receptor kinase subtypes by calcium sensor proteins

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Heart Disease, Clinical Proteomics and Mass Spectrometry

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Stereoselectivity of drug action

Triggle, D. J. (1997) · Drug Discovery Today · doi:10.1016/s1359-6446(97)01010-6 · Cited by 63 · see citing works

Comparative Proteomics Analysis of Vascular Smooth Muscle Cells Incubated with S- and R-Enantiomers of Atenolol Using iTRAQ-coupled Two-dimensional LC-MS/MS

Sui, J., Zhang, J., Tan, T. L., Ching, C. B., & Chen, W. N. (2008) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m700485-mcp200 · Cited by 52 · see citing works

Three-dimensional pharmacology, a subject ranging from ignorance to overstatements.

Waldeck, B. (2003) · Acta Pharmacologica et Toxicologica · doi:10.1046/j.1600-0773.2003.pto930502.x · Cited by 45 · see citing works

Identification of a novel interaction between the Ca2+-binding protein S100A11 and the Ca2+- and phospholipid-binding protein annexin A6

Chang, N., Sutherland, C., Hesse, E., Winkfein, R. J., Wiehler, W. B., Pho, M., Veillette, C., Li, S., Wilson, D. P., Kiss, E., et al. (2006) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00439.2006 · Cited by 41 · see citing works

Analytical Characterization of Chiral Drug−Protein Interactions: Comparison between the Optical Biosensor (Surface Plasmon Resonance) Assay and the HPLC Perturbation Method

Arnell, R., Ferraz, N., & Fornstedt, T. (2006) · Analytical Chemistry · doi:10.1021/ac051802l · Cited by 41 · see citing works

iTRAQ-Coupled 2D LC−MS/MS Analysis on Protein Profile in Vascular Smooth Muscle Cells Incubated with S- and R-Enantiomers of Propranolol: Possible Role of Metabolic Enzymes Involved in Cellular Anabolism and Antioxidant Activity

Sui, J., Tan, T. L., Zhang, J., Ching, C. B., & Chen, W. N. (2007) · Journal of Proteome Research · doi:10.1021/pr0605926 · Cited by 39 · see citing works

Protein profile in neuroblastoma cells incubated with S ‐ and R ‐enantiomers of ibuprofen by iTRAQ‐coupled 2‐D LC‐MS/MS analysis: Possible action of induced proteins on Alzheimer's disease

Zhang, J., Sui, J., Ching, C. B., & Chen, W. N. (2008) · PROTEOMICS · doi:10.1002/pmic.200700556 · Cited by 32 · see citing works

A proteomics analysis of cellular proteins associated with HBV genotype-specific HBX: potential in identification of early diagnostic markers for HCC

Tan, T. L., & Chen, W. N. (2005) · Journal of Clinical Virology · doi:10.1016/j.jcv.2004.12.015 · Cited by 32 · see citing works

Enantiomers of Neuroactive Steroids Support a Specific Interaction with the GABA-C Receptor as the Mechanism of Steroid Action

Li, W., Covey, D. F., Alakoskela, J.-M. I., Kinnunen, P. K. J., & Steinbach, J. H. (2006) · Molecular Pharmacology · doi:10.1124/mol.106.022863 · Cited by 25 · see citing works

Enantioselective analytical methods in pharmacokinetics with specific reference to genetic polymorphic metabolism.

Marzo, A., & Heftmann, E. (2002) · Journal of Biochemical and Biophysical Methods · doi:10.1016/s0165-022x(02)00128-8 · Cited by 24 · see citing works

Microassay of propranolol enantiomers and conjugates in human plasma and urine by high-performance liquid chromatography after chiral derivatization for pharmacokinetic study

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Comparative Proteomic Analysis of Extracellular Proteins Reveals Secretion of T-Kininogen from Vascular Smooth Muscle Cells in Response to Incubation with S-Enantiomer of Propranolol

Sui, J., Zhang, J., Ching, C. B., & Chen, W. N. (2008) · Molecular Pharmaceutics · doi:10.1021/mp800012x · Cited by 18 · see citing works

The real Gordian knot: Racemic mixtures versus pure enantiomers

Szelenyi, I., Geißlinger, G., Polymeropoulos, E. E., Paul, W., Herbst, M., & Brune, K. (1998) · Drug News & Perspectives · doi:10.1358/dnp.1998.11.3.863651 · Cited by 17 · see citing works

Stereoisomerism and Drug Action in the Nervous System

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Protein fishing with chiral molecular baits

Kawamura, A., & Hindi, S. (2005) · Chirality · doi:10.1002/chir.20169 · Cited by 12 · see citing works

Expedited mapping of the ligandable proteome using fully functionalized enantiomeric probe pairs

Wang, Y., Dix, M. M., Bianco, G., Remsberg, J. R., Lee, H.-Y., Kalocsay, M., Gygi, S. P., Forli, S., Vite, G., Lawrence, R. M., et al. (2019) · Nature Chemistry · doi:10.1038/s41557-019-0351-5 · Cited by 179 · see citing works

The Proteomics Big Challenge for Biomarkers and New Drug-Targets Discovery

Savino, R., Paduano, S., Preianò, M., & Terracciano, R. (2012) · International Journal of Molecular Sciences · doi:10.3390/ijms131113926 · Cited by 74 · see citing works

31P Nuclear Magnetic Resonance Spectroscopy for Monitoring Organic Reactions and Organic Compounds

Anghinoni, J. M., Irum, Rashid, H. U., Lenardao, E. J., & Silva, M. S. (2024) · The Chemical Record · doi:10.1002/tcr.202400132 · Cited by 8 · see citing works

Enzyme Stereospecificity as a Powerful Tool in Searching for New Enzymes

Škarydová, L., Skarka, A., Solich, P., & Wsól, V. (2010) · Current Drug Metabolism · doi:10.2174/138920010791636194 · Cited by 8 · see citing works

Re-Engineering P(V) Chemical Warfare: Harnessing Stereogenic Phosphorus-Azoles for Protein Ligand Discovery In VivoPreprint

Grams, R. J., Murtagh1, O. L., Ware, M. L., Vasylevskyi, S., & Hsu, K. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.01.27.702106 · Cited by 1 · see citing works

Comparative LC-MS analysis of proteomics profile in cells incubated with S- or R-Ibuprofen and its inhibitory effect on angiogenesis induced by HBV replication

Zhang, J. (2011) · doi:10.32657/10356/48622

Proteomics profile of cellular response to chiral drugs: Prospects for pharmaceutical applications

Ching, C. B., Zhang, J., Sui, J., & Chen, W. N. (2009) · PROTEOMICS · doi:10.1002/pmic.200900094 · Cited by 4 · see citing works

Application and Development of Proteomics in Drug Research

Li-fe, P. (2006) · Medical Recapitulate

Proteomics in drug research

Hamacher, M. (2006)

Application of Proteomics in Drug Research

Lian, Y. (2004) · Bulletin of Science and Technology

Proteomics: key technology in drug discovery

Celis, J. E. (1998) · Drug Discovery Today · doi:10.1016/s1359-6446(98)01184-2 · Cited by 12 · see citing works