Light-controlled nitric oxide delivering molecular assemblies

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Photo-antimicrobial polymeric films releasing nitric oxide with fluorescence reporting under visible light

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Nitric Oxide-Photodelivering Materials with Multiple Functionalities: From Rational Design to Therapeutic Applications

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A NO photoreleasing supramolecular hydrogel with bactericidal action

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Functionalised solids delivering bioactive nitric oxide gas for therapeutic applications

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Enhancing doxorubicin anticancer activity with a novel polymeric platform photoreleasing nitric oxide

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A High‐Performing Metal‐Free Photoactivatable Nitric Oxide Donor with a Green Fluorescent Reporter

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Unconventional Non‐Aqueous Emulsions for the Encapsulation of a Phototriggerable NO‐Donor Complex in Polymer Nanoparticles

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Synthesis and Characterization of Nitric Oxide-Releasing Platinum(IV) Prodrug and Polymeric Micelle Triggered by Light

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Phototherapeutic Release of Nitric Oxide with Engineered Nanoconstructs

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Facile Coordination-Precipitation Route to Insoluble Metal Roussin’s Black Salts for NIR-Responsive Release of NO for Anti-Metastasis

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Photocontrollable nitric oxide (NO) and nitroxyl (HNO) donors and their release mechanisms

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A molecular hybrid producing simultaneously singlet oxygen and nitric oxide by single photon excitation with green light

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NIR-Triggered Theranostic Bi2S3 Light Transducer for On-Demand NO Release and Synergistic Gas/Photothermal Combination Therapy of Tumors.

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Radical Frustrated Lewis Pairs

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Nitric oxide leads to cytoskeletal reorganization in the retinal pigment epithelium under oxidative stress

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Photo-degradable micelles for co-delivery of nitric oxide and doxorubicin

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Red-Light-Photosensitized NO Release and Its Monitoring in Cancer Cells with Biodegradable Polymeric Nanoparticles

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Light-triggered NO release from a nanofibrous non-woven

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Light Harvesting and Photoemission by Nanoparticles for Photodynamic Therapy

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Nanotechnology Allied to Nitric Oxide Release Materials for Dermatological Applications

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Human nitric oxide biomarker as potential NO donor in conjunction with superparamagnetic iron oxide @ gold core shell nanoparticles for cancer therapeutics

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Contact Lenses Delivering Nitric Oxide under Daylight for Reduction of Bacterial Contamination

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Multifunctional Molecular Hybrids Photoreleasing Nitric Oxide: Advantages, Pitfalls, and Opportunities

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Quantum dot photosensitizers. Interactions with transition metal centers

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Design, Synthesis, and Antibacterial Activity of a Multivalent Polycationic Calix[4]arene–NO Photodonor Conjugate

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Tuning the Hydrophobicity of a Mitochondria‐Targeted NO Photodonor

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Confined photo-release of nitric oxide with simultaneous two-photon fluorescence tracking in a cellular system

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A Three‐Color Fluorescent Supramolecular Nanoassembly of Phototherapeutics Activable by Two‐Photon Excitation with Near‐Infrared Light

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New perspectives on the reactions of metal nitrosyls with thiolates as nucleophiles

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Nanoscale lipid vesicles functionalized with a nitro-aniline derivative for photoinduced nitric oxide (NO) delivery

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Recent advances on the development of NO-releasing molecules (NORMs) for biomedical applications

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Further Observations on Visual Perception: The Influence of Pathologies Upon the Absorption of Light and Emission of Bioluminescence

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Visible light-triggered nitric oxide release from near-infrared fluorescent nanospheric vehicles

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Harnessing Multi‐Modal Exciton Migration in Hybrid Halide Perovskite for Photocatalytic Amplification of Nitric Oxide and Hydroxyl Radicals toward Bacterial Killing and Biofilm Disruption

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Photo-Controlled Release of NO and CO with Inorganic and Organometallic Complexes

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Cyclodextrin-based nanoconstructs for photoactivated therapies

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A Host–Guest Supramolecular Complex with Photoregulated Delivery of Nitric Oxide and Fluorescence Imaging Capacity in Cancer Cells

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Light‐Activated Release of Nitric Oxide with Fluorescence Reporting in Living Cells

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Protein Nanocage-Based Photo-Controlled Nitric Oxide Releasing Platform

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Reduction of copper(ii) complexes of tridentate ligands by nitric oxide and fluorescent detection of NO in methanol and water media

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Polymer nanoparticles with electrostatically loaded multicargo for combined cancer phototherapy

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A Multifunctional Bichromophoric Nanoaggregate for Fluorescence Imaging and Simultaneous Photogeneration of RNOS and ROS

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Multifunctional Nanotherapeutics for Photothermal Combination Therapy of Cancer

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Recent progress in synthesis and application of furoxan

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Sensitization of NO‐Releasing Ruthenium Complexes to Visible Light

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Reversible Capture of Small Molecules On Bimetallaborane Clusters: Synthesis, Structural Characterization, and Photophysical Aspects

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Combination of PDT and NOPDT with a Tailored BODIPY Derivative

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S‐Nitroso‐β‐Cyclodextrins as New Bimodal Carriers: Preparation, Detailed Characterization, Nitric‐Oxide Release, and Molecular Encapsulation

Piras, L., Theodossiou, T. A., Manouilidou, M. D., Lazarou, Y. G., Sortino, S., & Yannakopoulou, K. (2013) · Chemistry - An Asian Journal · doi:10.1002/asia.201300543 · Cited by 20

Solution or solid – it doesn't matter: visible light-induced CO release reactivity of zinc flavonolato complexes

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Gold nanoparticles decorated with a photoactivable nitric oxide donor/cyclodextrin host/guest complex

Kandoth, N., Vittorino, E., & Sortino, S. (2010) · New Journal of Chemistry · doi:10.1039/c0nj00690d · Cited by 19

A multifunctional β-cyclodextrin-conjugate photodelivering nitric oxide with fluorescence reporting

Benkovics, G., Pérez-Lloret, M., Afonso, D., Darcsi, A., Béni, S., Fenyvesi, É., Malanga, M., & Sortino, S. (2017) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2017.05.023 · Cited by 19

Synthesis and evaluation of novel O 2 -derived diazeniumdiolates as photochemical and real-time monitoring nitric oxide delivery agents

Luo, X., Wu, J., Lv, T., Lai, Y., Zhang, H., Lu, J., Zhang, Y., & Huang, Z. (2017) · Organic Chemistry Frontiers · doi:10.1039/c7qo00695k · Cited by 19

A efficient light-controlled nitric oxide releaser in aqueous solution and its red fluorescence imaging in lysosome

Shen, R., & Qian, Y. (2020) · Dyes and Pigments · doi:10.1016/j.dyepig.2020.108247 · Cited by 19

Novel Sigma Receptor Ligand–Nitric Oxide Photodonors: Molecular Hybrids for Double-Targeted Antiproliferative Effect

Amata, E., Dichiara, M., Arena, E., Pittalà, V., Pistarà, V., Cardile, V., Graziano, A. C. E., Fraix, A., Marrazzo, A., Sortino, S., et al. (2017) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.7b00791 · Cited by 19

Regulation of Nitric Oxide (NO) Release by Membrane Fluidity in Ruthenium Nitrosyl Complex-Embedded Phospholipid Vesicles

Sharma, N., Jose, D. A., Jain, N., Parmar, S., Srivastav, A., Chawla, J., Naziruddin, A. R., & Mariappan, C. R. (2022) · Langmuir · doi:10.1021/acs.langmuir.2c02457 · Cited by 18

A Molecular Hybrid for Mitochondria‐Targeted NO Photodelivery

Sodano, F., Gazzano, E., Fraix, A., Rolando, B., Lazzarato, L., Russo, M., Blangetti, M., Riganti, C., Fruttero, R., Gasco, A., et al. (2017) · ChemMedChem · doi:10.1002/cmdc.201700608 · Cited by 18

A photothermal responsive system accelerating nitric oxide release to enhance bone repair by promoting osteogenesis and angiogenesis

Cheng, Y., Huo, Y., Yu, Y., Duan, P., Dong, X., Yu, Z., Cheng, Q., Dai, H., & Pan, Z. (2024) · Materials Today Bio · doi:10.1016/j.mtbio.2024.101180 · Cited by 17

Photoresponsive Vesicles Enabling Sequential Release of Nitric Oxide (NO) and Gentamicin for Efficient Biofilm Eradication

Duan, Y., Zhang, M., Shen, Z., Zhang, M., Zheng, B., Cheng, S., & Hu, J. (2021) · Macromolecular Rapid Communications · doi:10.1002/marc.202000759 · Cited by 17

Photorelease of triplet and singlet oxygen from dioxygen complexes

Wagnerová, D. M., & Lang, K. (2011) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2011.06.017 · Cited by 17

Red‐Light‐Mediated Photoredox Catalysis Enables Self‐Reporting Nitric Oxide Release for Efficient Antibacterial Treatment

Shen, Z., Zheng, S., Xiao, S., Shen, R., Liu, S., & Hu, J. (2021) · Angewandte Chemie · doi:10.1002/ange.202107155 · Cited by 17

Layer-by-layer assembled gold nanoparticles with a tunable payload of a nitric oxide photocage

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Mixed β-γ-Cyclodextrin Branched Polymer with Multiple Photo-Chemotherapeutic Cargos

Laneri, F., Seggio, M., Parisi, C., Béni, S., Fraix, A., Malanga, M., & Sortino, S. (2023) · ACS Applied Polymer Materials · doi:10.1021/acsapm.3c01157 · Cited by 16

Mechanisms of the Antineoplastic Effects of New Fluoroquinolones in 2D and 3D Human Breast and Bladder Cancer Cell Lines

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A multi-photoresponsive molecular-hybrid for dual-modal photoinactivation of cancer cells

Fraix, A., Guglielmo, S., Cardile, V., Graziano, A. C. E., Gref, R., Rolando, B., Fruttero, R., Gasco, A., & Sortino, S. (2014) · RSC Advances · doi:10.1039/c4ra08250h · Cited by 16

New Strategy for Controlled Release of Nitric Oxide

Seabra, A. B., Marcato, P. D., de Paula, L. B., & Durán, N. (2012) · Journal of nano research · doi:10.4028/www.scientific.net/jnanor.20.61 · Cited by 17

Biofriendly Route to Near-Infrared-Active Gold Nanotriangles and Nanoflowers through Nitric Oxide Photorelease for Photothermal Applications

Nocito, G., Petralia, S., Malanga, M., Béni, S., Calabrese, G., Parenti, R., Sabrina Conoci, A., & Sortino, S. (2019) · ACS Applied Nano Materials · doi:10.1021/acsanm.9b01925 · Cited by 16

Quantitative Modeling Extends the Antibacterial Activity of Nitric Oxide

Sivaloganathan, D. M., & Brynildsen, M. P. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00330 · Cited by 16

Doxorubicin–NO Releaser Molecular Hybrid Activatable by Green Light to Overcome Resistance in Breast Cancer Cells

Parisi, C., Moret, F., Fraix, A., Menilli, L., Failla, M., Sodano, F., Conte, C., Quaglia, F., Reddi, E., & Sortino, S. (2022) · ACS Omega · doi:10.1021/acsomega.1c03988 · Cited by 16

Photo-responsive antibacterial metal organic frameworks

Yan, X., Lin, Z., He, S., Chen, Y., & Chen, L. (2025) · Journal of Materials Chemistry B · doi:10.1039/d5tb00105f · Cited by 15

Regenerating aged bone marrow via a nitric oxide nanopump

Li, K., Hu, S., Li, H., Lin, W., Zhao, D., Xu, Z., Pan, C., Wang, H., Li, D., Liu, J., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-61256-5 · Cited by 15

Visible‐Light‐Driven NO Release from Postmodified MOFs via Photoinduced Electron Transfer for Antibacterial Application

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Selenium nanoparticles as catalysts for nitric oxide generation

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Are in situ formulations the keys for the therapeutic future of S-nitrosothiols?

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NO Photoreleaser-Deoxyadenosine and -Bile Acid Derivative Bioconjugates as Novel Potential Photochemotherapeutics

Navacchia, M. L., Fraix, A., Chinaglia, N., Gallerani, E., Perrone, D., Cardile, V., Graziano, A. C. E., Capobianco, M. L., & Sortino, S. (2016) · ACS Medicinal Chemistry Letters · doi:10.1021/acsmedchemlett.6b00257 · Cited by 15

Light-activated generation of nitric oxide (NO) and sulfite anion radicals (SO 3 ˙ − ) from a ruthenium( ii ) nitrosylsulphito complex

Roveda, A. C., Santos, W. G., Souza, M. L., Adelson, C. N., Gonçalves, F. S., Castellano, E. E., Garino, C., Franco, D. W., & Cardoso, D. R. (2019) · Dalton Transactions · doi:10.1039/c9dt01432b · Cited by 15

Light-triggered and cysteine-mediated nitric oxide release from a biodegradable starch-based film

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Photofunctional multilayer films by assembling naked silver nanoparticles and a tailored nitric oxide photodispenser at water/air interface

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Simultaneous supramolecular activation of NO photodonor/photosensitizer ensembles by a calix[4]arene nanoreactor

Bari, I. D., Granata, G., Consoli, G. M. L., & Sortino, S. (2018) · New Journal of Chemistry · doi:10.1039/c8nj03704c · Cited by 15

“Three-Bullets” Loaded Mesoporous Silica Nanoparticles for Combined Photo/Chemotherapy

Tessaro, A. L., Fraix, A., da Silva, A. C. P., Gazzano, E., Riganti, C., & Sortino, S. (2019) · Nanomaterials · doi:10.3390/nano9060823 · Cited by 15

Enhancing the Anticancer Activity of Sorafenib through Its Combination with a Nitric Oxide Photodelivering β-Cyclodextrin Polymer

Laneri, F., Graziano, A. C. E., Seggio, M., Fraix, A., Malanga, M., Béni, S., Longobardi, G., Conte, C., Quaglia, F., & Sortino, S. (2022) · Molecules · doi:10.3390/molecules27061918 · Cited by 14

A molecular dyad delivered by biodegradable polymeric nanoparticles for combined PDT and NO-PDT in cancer cells

Parisi, C., Longobardi, G., Graziano, A. C. E., Fraix, A., Conte, C., Quaglia, F., & Sortino, S. (2022) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2022.106050 · Cited by 14

Investigation of pH-responsive properties of polymeric micelles with a core-forming block having pendant cyclic ketal groups

Jiang, S., Yao, Y. X., Nie, Y., Yang, J., & Yang, J. H. (2011) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2011.08.013 · Cited by 14

Photochemical reagents for the study of metalloproteins by flash photolysis

Rosell, F. I., & Mauk, A. G. (2010) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2010.11.025 · Cited by 14

Nitric oxide-releasing ruthenium nanoparticles

Ho, C., Liao, K.-J., Lok, C., & Che, C. (2011) · Chemical Communications · doi:10.1039/c1cc13830h · Cited by 14

Photo-triggered NO release of nitrosyl complexes bearing first-row transition metals and therapeutic applications

Sun, S., Choe, J., & Cho, J. (2024) · Chemical Science · doi:10.1039/d4sc06820c · Cited by 13

A fluorescent probe with an ultra-rapid response to nitric oxide

Parisi, C., Pastore, A., Stornaiuolo, M., & Sortino, S. (2024) · Journal of Materials Chemistry B · doi:10.1039/d4tb00064a · Cited by 13

An Efficient Photoinduced Deprotection of Aromatic Acetals and Ketals

Thévenet, D., & Neier, R. (2011) · Helvetica Chimica Acta · doi:10.1002/hlca.201000333 · Cited by 13

Graphene oxide nanohybrid that photoreleases nitric oxide

Marino, N., Petralia, S., Pérez-Lloret, M., Mosinger, J., Sabrina Conoci, A., & Sortino, S. (2016) · Journal of Materials Chemistry B · doi:10.1039/c6tb01599a · Cited by 13

A calix[4]arene-based ternary supramolecular nanoassembly with improved fluoroquinolone photostability and enhanced NO photorelease

Fraix, A., Afonso, D., Consoli, G. M. L., & Sortino, S. (2019) · Photochemical & Photobiological Sciences · doi:10.1039/c9pp00011a · Cited by 13

NO release regulated by doxorubicin as the green light-harvesting antenna

Fraix, A., Parisi, C., Failla, M., Chegaev, K. Y., Spyrakis, F., Lazzarato, L., Fruttero, R., Gasco, A., & Sortino, S. (2020) · Chemical Communications · doi:10.1039/d0cc02512g · Cited by 13

Photocatalytic Activation Strategy for Sequential Prodrug Release to Overcome Resistant Biofilms

Shen, Z., Luo, S., Ding, H., Jin, Y., Zhou, Z., Qiujun, 阮. R., Gan, G., Liu, S., & Hu, J. (2026) · Journal of the American Chemical Society · doi:10.1021/jacs.5c19856 · Cited by 12

Supramolecular red-light-photosensitized nitric oxide release with fluorescence self-reporting within biocompatible nanocarriers

Laneri, F., Parisi, C., Seggio, M., Fraix, A., Longobardi, G., Catanzano, O., Quaglia, F., & Sortino, S. (2024) · Journal of Materials Chemistry B · doi:10.1039/d4tb00325j · Cited by 12

Synthesis and Characterization of Guanidinylated CO-Releasing Micelles Based on Biodegradable Polycarbonate

Li, Z., Wang, S., Zhao, L., Feng, S., & Che, H. (2024) · Biomacromolecules · doi:10.1021/acs.biomac.4c00542 · Cited by 12

On the photorelease of nitric oxide by nitrobenzene derivatives: A CASPT2//CASSCF model

Giussani, A., & Worth, G. A. (2022) · The Journal of Chemical Physics · doi:10.1063/5.0125460 · Cited by 12

Visible light-activatable cyclodextrin-conjugates for the efficient delivery of nitric oxide with fluorescent reporter and their inclusion complexes with betaxolol

Seggio, M., Payamifar, S., Fraix, A., Kalydi, E., Kasal, P., Catanzano, O., Conte, C., Quaglia, F., & Sortino, S. (2021) · New Journal of Chemistry · doi:10.1039/d1nj00039j · Cited by 11

Nitric Oxide-Photodelivering Materials with Multiple Functionalities: From Rational Design to Therapeutic Applications

Parisi, C., Laneri, F., Martins, T. J., Fraix, A., & Sortino, S. (2024) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.4c13478 · Cited by 31

Phototherapeutic Release of Nitric Oxide with Engineered Nanoconstructs

Fraix, A., Marino, N., & Sortino, S. (2015) · Topics in current chemistry · doi:10.1007/978-3-319-22942-3_8 · Cited by 29

ChemInform Abstract: Light‐Controlled Nitric Oxide Delivering Molecular Assemblies

Sortino, S. (2010) · ChemInform · doi:10.1002/chin.201046264

Nitric oxide photoreleasing nanoconstructs with multiple photofunctionalities

Fraix, A., Kandoth, N., & Sortino, S. (2013) · Photochemistry · doi:10.1039/9781849737722-00302 · Cited by 2

Nitric Oxide-Donating Materials and Their Potential in Pharmacological Applications for Site-Specific Nitric Oxide Delivery

Eroy‐Reveles, A. A., & Mascharak, P. K. (2009) · Future Medicinal Chemistry · doi:10.4155/fmc.09.111 · Cited by 75