Cited by 278Photochromic and Fluorescence ChemistryNitric Oxide and Endothelin EffectsPhotopolymerization techniques and applications

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Light-controlled nitric oxide delivering molecular assemblies

Sortino, Salvatore·2010·Chemical Society Reviews

DOI 10.1039/b908663n

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Abstract

The multiple roles nitric oxide (NO) plays as a bioregulatory, anticancer, antimicrobial and antioxidant agent has triggered an explosive interest in recent years in compounds able to deliver this diatomic radical for therapeutic purposes. A major issue associated with NO donors is the precise control of the NO release, which effect is highly concentration and flux dependent. Light represents a convenient non-invasive on/off trigger to deliver NO on demand since it allows the accurate control of site, timing and dosage. The assembling of NO photodonors through different approaches may lead to intriguing light-responsive molecular constructs including nanostructured films, polymers, gels, nanoparticles and molecular conjugates which exhibit promising potential in view of practical applications. This tutorial review illustrates the recent research from our and other laboratories towards the fabrication of these molecular assemblies, highlighting the logical design and the relevance in the biomedical field. Therefore, this review is aimed to be a source of inspiration for a wide range of scientists belonging to the chemical, materials science and biochemical communities, facing the common challenge of fabricating controllable NO dispensers.

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Authors: Sortino, S.
Affiliations: University of Catania (IT)
Corresponding author: Sortino, Salvatore
ORCID: Sortino, Salvatore
Venue: Chemical Society Reviews
Publisher: Royal Society of Chemistry (RSC)
Published: 2010
Volume: 39
Issue: 8
Pages: 2903
ISSN: 0306-0012 (ISSN-L)
1460-4744
DOI: 10.1039/b908663n
OpenAlex: W2086971976
Cited by: 277
References: 64
Citations by year: 2026: 14 · 2025: 14 · 2024: 21 · 2023: 15 · 2022: 16 · 2021: 15 · 2020: 22 · 2019: 19 · 2018: 18 · 2017: 22 · 2016: 17 · 2015: 18 · 2014: 11 · 2013: 22 · 2012: 13
FWCI: 0.85
Type: journal article
Language: en
Open access: closed
Locations: Chemical Society Reviews (publishedVersion)
PubMed (publishedVersion)
Topics: Physical Sciences › Materials Science › Materials Chemistry › Photochromic and Fluorescence Chemistry
Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Physical Sciences › Chemistry › Organic Chemistry › Photopolymerization techniques and applications
Keywords: nitric oxide donors, molecular assembly, nanostructured films, polymers, gels, nanoparticles, on-demand drug delivery, biomedical applications
MeSH terms: Light, Nitric Oxide, Polymers, Drug Delivery Systems, Nanoparticles

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