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Inertial microfluidics
Abstract
Despite the common wisdom that inertia does not contribute to microfluidic phenomena, recent work has shown a variety of useful effects that depend on fluid inertia for applications in enhanced mixing, particle separation, and bioparticle focusing. Due to the robust, fault-tolerant physical effects employed and high rates of operation, inertial microfluidic systems are poised to have a critical impact on high-throughput separation applications in environmental cleanup and physiological fluids processing, as well as bioparticle focusing applications in clinical diagnostics. In this review I will discuss the recent accelerated progress in developing prototype inertial microfluidic systems for a variety of applications and attempt to clarify the fundamental fluid dynamic effects that are being exploited. Finally, since this a nascent area of research, I will suggest some future promising directions exploiting fluid inertia on the microscale.
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Citations
Cited by
Amini, H., Lee, W., & Di Carlo, D. (2014) · Lab on a Chip · doi:10.1039/c4lc00128a · Cited by 722
Self-citationMicrofluidics for cell separation
Bhagat, A. A. S., Bow, H., Hou, H. W., Tan, S. J., Han, J., & Lim, C. T. (2010) · Medical & Biological Engineering & Computing · doi:10.1007/s11517-010-0611-4 · Cited by 632
Hydrodynamic mechanisms of cell and particle trapping in microfluidics
Karimi, A., Yazdi, S., & Ardekani, A. M. (2013) · Biomicrofluidics · doi:10.1063/1.4799787 · Cited by 384
Fundamentals and application of magnetic particles in cell isolation and enrichment: a review
Plouffe, B. D., Murthy, S. K., & Lewis, L. H. (2015) · Reports on Progress in Physics · doi:10.1088/0034-4885/78/1/016601 · Cited by 334
Industrial lab-on-a-chip: Design, applications and scale-up for drug discovery and delivery
Vladisavljević, G. T., Khalid, N., Neves, M. A., Kuroiwa, T., Nakajima, M., Uemura, K., Ichikawa, S., & Kobayashi, I. (2013) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2013.07.017 · Cited by 313
Metadata
- Authors
- Di Carlo, D.
- Venue
- Lab on a Chip
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2009
- Volume
- 9
- Issue
- 21
- Pages
- 3038
- ISSN
- 1473-0189 (ISSN-L)
- 1473-0197
- OpenAlex
- W4253260323
- Cited by
- 1,627
- References
- 0
- FWCI
- 26.79
- Type
- journal article
- Language
- en
- Open access
- closed
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