Oestrogen receptor-β signalling protects against transplanted skin tumour growth in the mouse
Abstract
We have reported previously that a deficiency in signalling by the non-classical oestrogen receptor-beta (Er-beta) exacerbates immunosuppression by UV radiation in the mouse. Because photoimmune suppression is a risk factor for skin cancer development, we hypothesize that Er-beta deficiency will promote skin tumour growth. Therefore we have blocked Er signalling pharmacologically in the Skh:hr-1 hairless mouse by topical treatments with the Er antagonist ICI 182,780, and genetically in haired mice by using the specific Er-beta knockout mouse (targeted mutation of the Er-beta), and examined the growth rate of 3 transplantable skin tumour cell lines in their syngeneic host mice. Two UV-induced squamous cell carcinoma (SCC) cell lines transplanted into the Skh:hr-1 recipients were found to have regressor qualities that were delayed by prior immunosuppressive solar-simulated UV (SSUV) irradiation. For the T79 SCC, regression was significantly further delayed by combined pretreatment with SSUV+ICI 182,780, and the diameters of the surviving tumours were slightly larger. For the KL3.0 SCC, both SSUV and combined SSUV+ICI 182,780 pretreatments completely inhibited tumour regression, and resulted in significantly greater tumour diameters than in unirradiated recipient mice. In heterozygous Er-beta deficient mice (Er-beta+/-), the B16/F10 melanoma grew progressively and significantly faster than in the wild type control mice (C57BL/6), and growth rate was accelerated by prior SSUV irradiation. Homozygous Er-beta-/- mice supported the most rapid B16/F10 growth that was further accelerated by prior SSUV irradiation. Therefore Er signalling, specifically by Er-beta, has a natural endogenous protective role against skin tumour growth, probably mediated via immunological pathways.
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The blocked AP-1 actions by equol may be mediated by a common mechanism involving ER β signaling.
“Finally, ER β signaling has been shown to protect against transplanted skin tumor growth in mice, which implicated a common mechanism of how the blocked AP-1 actions by equol reported by Kang et al. may be mediated [101,102].”
ER β signaling protects against transplanted skin tumor growth in mice.
“Finally, ER β signaling has been shown to protect against transplanted skin tumor growth in mice, which implicated a common mechanism of how the blocked AP-1 actions by equol reported by Kang et al. may be mediated [101,102].”
Equol dose-dependently attenuated TPA-induced activation of AP-1.
“Equol displayed a dose-dependently attenuated TPA-induced activation of AP-1, whereas, daidzein did not exert any effect when tested at the same concentrations [102].”
Daidzein did not exert any effect on TPA-induced activation of AP-1 when tested at the same concentrations as equol.
“Equol displayed a dose-dependently attenuated TPA-induced activation of AP-1, whereas, daidzein did not exert any effect when tested at the same concentrations [102].”
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- Authors
- Cho, J.-L., Allanson, M., & Reeve, V. E.
- Affiliations
- The University of Sydney (AU)
- Corresponding author
- Reeve, Vivienne E.
- ORCID
- Cho, Jun-Lae
- Venue
- Photochemical & Photobiological Sciences
- Published
- 2010-04
- Volume
- 9
- Issue
- 4
- Pages
- 608-614
- ISSN
- 1474-905X (ISSN-L)
- 1474-9092
- OpenAlex
- W2031621131
- Cited by
- 22
- References
- 28
- Citations by year
- 2024: 1 · 2023: 1 · 2021: 2 · 2020: 2 · 2018: 2 · 2017: 1 · 2016: 2 · 2015: 3 · 2014: 3 · 2012: 2
- FWCI
- 0.90
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Photochemical & Photobiological Sciences (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Cancer Council NSW
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Health Sciences › Medicine › Epidemiology › Nonmelanoma Skin Cancer Studies
- Keywords
- estrogen receptor beta, estrogen signaling, squamous cell carcinoma, melanoma, UV-induced immunosuppression, fulvestrant, tumor regression
- MeSH terms
- Fulvestrant, Animals, Cell Transformation, Neoplastic, Dermatitis, Contact, Estradiol, Female, Humans, Neoplasm Transplantation, Skin Neoplasms, Ultraviolet Rays, Cell Line, Tumor, Estrogen Receptor beta, Cell Proliferation, Mice, Gene Knockout Techniques
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