The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Interactions of Zn(ii) and Cu(ii) ions with Alzheimer's amyloid-beta peptide. Metal ion binding, contribution to fibrillization and toxicity
Open accessAbstract
Amyloid-β peptides (Aβ) are key molecules in Alzheimer's disease (AD) pathology as they form amyloid plaques that are primary hallmarks of AD. There is increasing evidence demonstrating that the biometals zinc(ii) and copper(ii) interact with Aβpeptides and have an influence on their fibrillization and toxicity. Zinc and copper ions are abundantly present in the synaptic areas of the brain, and it is likely that the age-related dyshomeostasis of these biometals is associated with AD pathology. In this review we summarize the knowledge of the interactions of zinc and copper ions with Aβpeptides, their role in Aβ fibrillization and toxicity and provide a critical analysis of the conflicting results in the field. Copper ions entrapped in Aβfibrils are electrochemically active and can generate ROS in the presence of hydrogen peroxide and reducing agents. This might provide a key for understanding the putative role of copper in Aβ toxicity and AD pathology. In this review we summarize the knowledge of the interactions of zinc and copper ions with amyloid-β peptides, their role in fibrillization and toxicity and provide a critical analysis of the conflicting results in the field.
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1 retracted
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Cited by
Metabolism and functions of copper in brain
Scheiber, I. F., Mercer, J. F. B., & Dringen, R. (2014) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2014.01.002 · Cited by 506
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Untangling Amyloid-β, Tau, and Metals in Alzheimer’s Disease
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Postsynaptic ProSAP/Shank scaffolds in the cross-hair of synaptopathies
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Rodríguez-Rodríguez, C., Telpoukhovskaia, M., & Orvig, C. (2012) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2012.03.008 · Cited by 151
Metadata
- Authors
- Tõugu, V., Tiiman, A., & Palumaa, P.
- Venue
- Metallomics
- Publisher
- Oxford University Press (OUP)
- Published
- 2011
- Volume
- 3
- Issue
- 3
- Pages
- 250
- ISSN
- 1756-5901 (ISSN-L)
- 1756-591X
- OpenAlex
- W2163399017
- Cited by
- 225
- References
- 31
- FWCI
- 15.22
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Tõugu, V., Tiiman, A., & Palumaa, P. (2011). Interactions of Zn(ii) and Cu(ii) ions with Alzheimer's amyloid-beta peptide. Metal ion binding, contribution to fibrillization and toxicity. Metallomics. https://doi.org/10.1039/c0mt00073f
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