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Epigenome analyses using BAC microarrays identify evolutionary conservation of tissue-specific methylation of SHANK3

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Shank2 Deletion in Parvalbumin Neurons Leads to Moderate Hyperactivity, Enhanced Self-Grooming and Suppressed Seizure Susceptibility in Mice

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Oxytocin as a Modulator of Synaptic Plasticity: Implications for Neurodevelopmental Disorders

Rajamani, K. T., Wagner, S., Grinevich, V., & Harony-Nicolas, H. (2018) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2018.00017 · Cited by 53 · see citing works

Studying Autism in Rodent Models: Reconciling Endophenotypes with Comorbidities

Argyropoulos, A., Gilby, K. L., & Hill‐Yardin, E. L. (2013) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2013.00417 · Cited by 51 · see citing works

Uncovering the Functional Link Between SHANK3 Deletions and Deficiency in Neurodevelopment Using iPSC-Derived Human Neurons

Huang, G., Chen, S., Chen, X., Zheng, J., Xu, Z., Torshizi, A. D., Gong, S., Chen, Q., Ma, X., Yu, J., et al. (2019) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2019.00023 · Cited by 50 · see citing works

Genetic risk factors for autism-spectrum disorders: a systematic review based on systematic reviews and meta-analysis

Wei, H., Zhu, Y., Wang, T., Zhang, X., Zhang, K., & Zhang, Z. (2021) · Journal of Neural Transmission · doi:10.1007/s00702-021-02360-w · Cited by 51 · see citing works

Shank Proteins Differentially Regulate Synaptic Transmission

Shi, R., Redman, P. T., Ghose, D., Hwang, H., Liu, Y., Ren, X., Ding, L. J., Liu, M., Jones, K. J., & Xu, W. (2017) · eNeuro · doi:10.1523/eneuro.0163-15.2017 · Cited by 50 · see citing works

GABA Neuronal Deletion of Shank3 Exons 14–16 in Mice Suppresses Striatal Excitatory Synaptic Input and Induces Social and Locomotor Abnormalities

Yoo, T., Cho, H., Lee, J., Park, H., Yoo, Y.-E., Yang, E., Kim, J. Y., Kim, H., & Kim, E. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00341 · Cited by 48 · see citing works

Striatal Transcriptome and Interactome Analysis of Shank3-overexpressing Mice Reveals the Connectivity between Shank3 and mTORC1 Signaling

Lee, Y., Kim, S. G., Lee, B., Zhang, Y., Kim, Y., Kim, S., Kim, E., Kang, H., & Han, K. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00201 · Cited by 46 · see citing works

Translational neurobiology in Shank mutant mice - Model systems for neuropsychiatric disorders

Schmeißer, M. J. (2015) · Annals of Anatomy - Anatomischer Anzeiger · doi:10.1016/j.aanat.2015.03.006 · Cited by 44 · see citing works

Structural dynamics of dendritic spines: Molecular composition, geometry and functional regulation

Ebrahimi, S., & Okabe, S. (2014) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2014.06.002 · Cited by 46 · see citing works

microRNA-34a (miRNA-34a) Mediated Down-Regulation of the Post-synaptic Cytoskeletal Element SHANK3 in Sporadic Alzheimer's Disease (AD)

Zhao, Y., Jaber, V. R., LeBeauf, A., Sharfman, N. M., & Lukiw, W. J. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.00028 · Cited by 44 · see citing works

SHANK3 deficiency leads to myelin defects in the central and peripheral nervous system

Malara, M., Lutz, A.-K., Incearap, B., Bauer, H. F., Cursano, S., Volbracht, K., Lerner, J. J., Pandey, R., Delling, J. P., Ioannidis, V., et al. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04400-4 · Cited by 47 · see citing works

Modulation of behavior by scaffolding proteins of the post-synaptic density

Gao, C., Tronson, N. C., & Radulović, J. (2013) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2013.04.014 · Cited by 41 · see citing works

Shank3 Mice Carrying the Human Q321R Mutation Display Enhanced Self-Grooming, Abnormal Electroencephalogram Patterns, and Suppressed Neuronal Excitability and Seizure Susceptibility

Yoo, Y.-E., Yoo, T., Lee, S., Lee, J., Kim, D., Han, H.-M., Bae, Y.-C., & Kim, E. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00155 · Cited by 41 · see citing works

Integrative Brain Transcriptome Analysis Reveals Region-Specific and Broad Molecular Changes in Shank3-Overexpressing Mice

Jin, C., Kang, H., Ryu, J. R., Kim, S., Zhang, Y., Lee, Y., Kim, Y., & Han, K. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00250 · Cited by 41 · see citing works

Shank3 Exons 14–16 Deletion in Glutamatergic Neurons Leads to Social and Repetitive Behavioral Deficits Associated With Increased Cortical Layer 2/3 Neuronal Excitability

Yoo, T., Cho, H., Park, H., Lee, J., & Kim, E. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00458 · Cited by 41 · see citing works

Zinc is a key regulator of gastrointestinal development, microbiota composition and inflammation with relevance for autism spectrum disorders

Sauer, A. K., Malijauskaite, S., Meleady, P., Boeckers, T. M., McGourty, K., & Grabrucker, A. M. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-021-04052-w · Cited by 41 · see citing works

Selective Localization of Shanks to VGLUT1-Positive Excitatory Synapses in the Mouse Hippocampus

Heise, C., Schroeder, J. C., Schoen, M., Halbedl, S., Reim, D., Woelfle, S., Kreutz, M. R., Schmeißer, M. J., & Boeckers, T. M. (2016) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2016.00106 · Cited by 40 · see citing works

Neurodevelopmental synaptopathies: Insights from behaviour in rodent models of synapse gene mutations

Luo, J. K., Norris, R. H. C., Gordon, S. L., & Nithianantharajah, J. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.12.001 · Cited by 40 · see citing works

The Role of Zinc and NMDA Receptors in Autism Spectrum Disorders

Lee, K. C., Mills, Z., Cheung, P. Y., Cheyne, J. E., & Montgomery, J. M. (2022) · Pharmaceuticals · doi:10.3390/ph16010001 · Cited by 40 · see citing works

Investigation of SHANK3 in schizophrenia

Cortabitarte, A. D. S., Degenhardt, F., Strohmaier, J., Lang, M., Weiß, B., Roeth, R., Giegling, I., Heilmann‐Heimbach, S., Hofmann, A., Rujescu, D., et al. (2017) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32528 · Cited by 39 · see citing works

Brain Lateralization in Mice Is Associated with Zinc Signaling and Altered in Prenatal Zinc Deficient Mice That Display Features of Autism Spectrum Disorder

Grabrucker, S., Haderspeck, J., Sauer, A. K., Kittelberger, N., Asoglu, H., Abaei, A., Rasche, V., Schön, M., Boeckers, T. M., & Grabrucker, A. M. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00450 · Cited by 39 · see citing works

Excitatory synapses and gap junctions cooperate to improve Pv neuronal burst firing and cortical social cognition in Shank2-mutant mice

Lee, E., Lee, S., Shin, J. J., Choi, W., Chung, C., Lee, S., Kim, J., Ha, S., Kim, R., Yoo, T., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-25356-2 · Cited by 36 · see citing works

SHANK2 Mutations Result in Dysregulation of the ERK1/2 Pathway in Human Induced Pluripotent Stem Cells-Derived Neurons and Shank2(−/−) Mice

Lutz, A.-K., Arévalo, A. P., Ioannidis, V., Stirmlinger, N., Demestre, M., Delorme, R., Bourgeron, T., & Boeckers, T. M. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.773571 · Cited by 37 · see citing works

Developmental impaired Akt signaling in the Shank1 and Shank3 double knock-out mice

Mossa, A., Pagano, J., Ponzoni, L., Tozzi, A., Vezzoli, E., Sciaccaluga, M., Costa, C., Beretta, S., Francolini, M., Sala, M., et al. (2021) · Molecular Psychiatry · doi:10.1038/s41380-020-00979-x · Cited by 37 · see citing works

Effects of Trace Metal Profiles Characteristic for Autism on Synapses in Cultured Neurons

Hagmeyer, S., Mangus, K., Boeckers, T. M., & Grabrucker, A. M. (2015) · Neural Plasticity · doi:10.1155/2015/985083 · Cited by 39 · see citing works

Defective synaptic transmission and structure in the dentate gyrus and selective fear memory impairment in the Rsk2 mutant mouse model of Coffin–Lowry syndrome

Morice, É., Farley, S., Poirier, R., Dallérac, G. M., Chagneau, C., Pannetier, S., Hanauer, A., Davis, S., Vaillend, C., & Laroche, S. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2013.05.016 · Cited by 36 · see citing works

Integrative Analysis of Brain Region-specific Shank3 Interactomes for Understanding the Heterogeneity of Neuronal Pathophysiology Related to SHANK3 Mutations

Lee, Y., Kang, H., Lee, B., Zhang, Y., Kim, Y., Kim, S., Kim, W.-K., & Han, K. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00110 · Cited by 36 · see citing works

Proteomic Analysis of Brain Region and Sex-Specific Synaptic Protein Expression in the Adult Mouse Brain

Distler, U., Schumann, S., Kesseler, H.-G., Pielot, R., Smalla, K., Sielaff, M., Schmeißer, M. J., & Tenzer, S. (2020) · Cells · doi:10.3390/cells9020313 · Cited by 35 · see citing works

Heterogeneity of Cell Surface Glutamate and GABA Receptor Expression in Shank and CNTN4 Autism Mouse Models

Heise, C., Preuss, J. M., Schroeder, J. C., Battaglia, C. R., Kolibius, J., Schmid, R., Kreutz, M. R., Kas, M. J., Burbach, J. P. H., & Boeckers, T. M. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00212 · Cited by 35 · see citing works

Autism-associated SHANK3 missense point mutations impact conformational fluctuations and protein turnover at synapses

Bucher, M., Niebling, S., Han, Y., Molodenskiy, D., Hassani Nia, F., Kreienkamp, H.-J., Svergun, D., Kim, E., Kostyukova, A. S., Kreutz, M. R., et al. (2021) · eLife · doi:10.7554/elife.66165 · Cited by 33 · see citing works

A role for synaptic zinc in ProSAP/Shank PSD scaffold malformation in autism spectrum disorders

Grabrucker, A. M. (2013) · Developmental Neurobiology · doi:10.1002/dneu.22089 · Cited by 103 · see citing works

Shank synaptic scaffold proteins: keys to understanding the pathogenesis of autism and other synaptic disorders

Sala, C., Vicidomini, C., Bigi, I., Mossa, A., & Verpelli, C. (2015) · Journal of Neurochemistry · doi:10.1111/jnc.13232 · Cited by 173 · see citing works

Shankopathies: Shank Protein Deficiency-Induced Synaptic Diseases

(2020) · Frontiers research topics · doi:10.3389/978-2-88963-567-2

ProSAP/Shank proteins – a family of higher order organizing molecules of the postsynaptic density with an emerging role in human neurological disease

Boeckers, T. M., Bockmann, J., Kreutz, M. R., & Gundelfinger, E. D. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.00931.x · Cited by 349 · see citing works

Characterization of the ProSAP1/Shank2 knock-out mouse

Kübler, A. (2019) · OPen Access Repositorium der Universität Ulm (OPARU) (Ulm University) · doi:10.18725/oparu-34967