Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 345

The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.

Designs for life: protocell models in the laboratory

Dzieciol, Alicja J., Mann, Stephen·2012·Chem. Soc. Rev.
DOI 10.1039/c1cs15211d
Open this paper in CoChat — free account

Abstract

Compartmentalization of primitive biochemical reactions within membrane-bound water micro-droplets is considered an essential step in the origin of life. In the absence of complex biochemical machinery, the hypothetical precursors to the first biological cells (protocells) would be dependent on the self-organization of their components and physicochemical conditions of the environment to attain a basic level of autonomy and evolutionary viability. Many researchers consider the self-organization of lipid and fatty acid molecules into bilayer vesicles as a simple form of membrane-based compartmentalization that can be developed for the experimental design and construction of plausible protocell models. In this tutorial review, we highlight some of the recent advances and issues concerning the construction of simple cell-like systems in the laboratory. Overcoming many of the current scientific challenges should lead to new types of chemical bio-reactors and artificial cell-like entities, and bring new insights concerning the possible pathways responsible for the origin of life.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1039/c1cs15211d

Cites

16 of 16 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Research works printed but not linked: 21

  1. Mazzarello, 1999, Nat. Cell Biol., 1, E13, 10.1038/8964 · DOI · Paper page
  2. A. I. Oparin , The Origin of Life, Macmillan, New York, 1938
  3. P. L. Luisi , The Emergence of Life, Cambridge University Press, 2006 · DOI · Paper page
  4. Lacey, 1999, CHEMTRACTS—Biochemistry and Molecular Biology, 12, 398
  5. F. J. Dyson , Origins of Life, Cambridge University Press, 1985
  6. Mann, 2008, Angew. Chem., Int. Ed., 47, 5307, 10.1002/anie.200705538 · DOI · Paper page
  7. Fraser, 1995, Science, 270, 397, 10.1126/science.270.5235.397 · DOI · Paper page
  8. B. Alberts , et al., Molecular Biology of the Cell, Garland Sciences, New York, 5th edn, 2008
  9. Szostak, 2001, Nature, 409, 387, 10.1038/35053176 · DOI · Paper page
  10. Schrum, 2010, Cold Spring Harbor Perspect. Biol., 2, 15, 10.1101/cshperspect.a002212 · DOI · Paper page
  11. Israelachvili, 1977, Biochim. Biophys. Acta, Biomembr., 470, 185, 10.1016/0005-2736(77)90099-2 · DOI · Paper page
  12. R. Zana , Encyclopedia of Supramolecular Chemistry, Taylor & Francis, 2004
  13. Lawless, 1979, Nature, 282, 396, 10.1038/282396a0 · DOI · Paper page
  14. Walde, 2010, BioEssays, 32, 296, 10.1002/bies.200900141 · DOI
  15. Reeves, 1969, J. Cell. Physiol., 73, 49, 10.1002/jcp.1040730108 · DOI · Paper page
  16. Luisi, 2005, Naturwissenschaften, 93, 1, 10.1007/s00114-005-0056-z · DOI · Paper page
  17. Kuruma, 2009, Biochim. Biophys. Acta, Biomembr., 1788, 567, 10.1016/j.bbamem.2008.10.017 · DOI
  18. Walde, 1994, J. Am. Chem. Soc., 116, 7541, 10.1021/ja00096a010 · DOI
  19. Stano, 2010, Chem. Commun., 46, 3639, 10.1039/b913997d · DOI · Paper page
  20. Berclaz, 2001, J. Phys. Chem. B, 105, 1056, 10.1021/jp001298i · DOI
  21. Oberholzer, 1995, Biochem. Biophys. Res. Commun., 207, 250, 10.1006/bbrc.1995.1180 · DOI · Paper page

Cited by

See all 345

Metadata

Authors
Dzieciol, A. J., & Mann, S.
Venue
Chem. Soc. Rev.
Publisher
Royal Society of Chemistry (RSC)
Published
2012
Volume
41
Issue
1
Pages
79-85
ISSN
  • 0306-0012 (ISSN-L)
  • 1460-4744
DOI
10.1039/c1cs15211d
OpenAlex
W2132859930
Cited by
345
References
16
FWCI
1.93
Type
journal article
Language
en
Open access
closed

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.