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Cited by 109Bone Tissue Engineering MaterialsTissue Engineering and Regenerative MedicinePolymer Surface Interaction Studies

Mussel-inspired porous SiO2 scaffolds with improved mineralization and cytocompatibility for drug delivery and bone tissue engineering

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Wu, Chengtie, Fan, Wei, Chang, Jiang, Xiao, Yin·2011·Journal of Materials Chemistry
DOI 10.1039/c1jm12770e
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Abstract

Porous SiO2 scaffolds with mesopore structure (named as MS scaffolds) have been proposed as suitable for bone tissue engineering due to their excellent drug-delivery ability; however, the mineralization and cytocompatibility of MS scaffolds are far from optimal for bone tissue engineering, and it is also unclear how the delivery of drugs from MS scaffolds affects osteoblastic cells. The aims of the present study were to improve the mineralization and cytocompatibility of MS scaffolds by coating mussel-inspired polydopamine on the pore walls of scaffolds. The effects of polydopamine modification on MS scaffolds were investigated with respect to apatite mineralization and the attachment, proliferation and differentiation of bone marrow stromal cells (BMSCs), as was the release profile of the drug dexamethasone (DEX). Our results show that polydopamine can readily coat the pore walls of MS scaffolds and that polydopamine-modified MS scaffolds have a significantly improved apatite-mineralization ability as well as better attachment and proliferation of BMSCs in the scaffolds, compared to controls. Polydopamine modification did not alter the release profile of DEX from MS scaffolds but the sustained delivery of DEX significantly improved alkaline phosphatase (ALP) activity of BMSCs in the scaffolds. These results suggest that polydopamine modification is a viable option to enhance the bioactivity of bone tissue engineering scaffolds and, further, that DEX-loaded polydopamine MS scaffolds have potential uses as a release system to enhance the osteogenic properties of bone tissue engineering applications.

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Cited by

Sorted by citations

Authors
Wu, C., Fan, W., Chang, J., & Xiao, Y.
Affiliations
  • Queensland University of Technology (AU)
  • Chinese Academy of Sciences (CN)
Corresponding author
  • Wu, Chengtie
  • Xiao, Yin
ORCID
Venue
Journal of Materials Chemistry
Publisher
Royal Society of Chemistry (RSC)
Published
2011
Volume
21
Issue
45
Pages
18300
ISSN
  • 0959-9428 (ISSN-L)
  • 1364-5501
DOI
10.1039/c1jm12770e
OpenAlex
W1521709065
Cited by
109
References
2
Citations by year
2026: 2 · 2025: 3 · 2024: 2 · 2023: 4 · 2022: 3 · 2021: 3 · 2020: 5 · 2019: 4 · 2018: 11 · 2017: 7 · 2016: 12 · 2015: 16 · 2014: 17 · 2013: 11 · 2012: 9
FWCI
7.01
Type
journal article
Language
en
Open access
Locations
  • Journal of Materials Chemistry (publishedVersion)
  • QUT ePrints (Queensland University of Technology) (submittedVersion)
  • Institute of Health and Biomedical Innovation
Funders
National Natural Science Foundation of China (30730034)
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
  • Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
  • Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
Keywords
mesoporous silica, apatite mineralization, bone tissue engineering, mesenchymal stem cells, dexamethasone release, drug delivery, osteogenic differentiation, alkaline phosphatase activity, cytocompatibility, bioactive scaffolds

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