Hierarchical bioceramic scaffolds with 3D-plotted macropores and mussel-inspired surface nanolayers for stimulating osteogenesis
Abstract
The hierarchical structure of biomaterials plays an important role in the process of tissue reconstruction and regeneration. 3D-plotted scaffolds have been widely used for bone tissue engineering due to their controlled macropore structure and mechanical properties. However, the lack of micro- or nano-structures on the strut surface of 3D-plotted scaffolds, especially for bioceramic scaffolds, limits their biological activity. Inspired by the adhesive versatility of mussels and the active ion-chelating capacity of polydopamine, we set out to prepare a hierarchical bioceramic scaffold with controlled macropores and mussel-inspired surface nanolayers by combining the 3D-plotting technique with the polydopamine/apatite hybrid strategy in order to synergistically accelerate the osteogenesis and angiogenesis. β-Tricalcium phosphate (TCP) scaffolds were firstly 3D-plotted and then treated in dopamine-Tris/HCl and dopamine-SBF solutions to obtain TCP-DOPA-Tris and TCP-DOPA-SBF scaffolds, respectively. It was found that polydopamine/apatite hybrid nanolayers were formed on the surface of both TCP-DOPA-Tris and TCP-DOPA-SBF scaffolds and TCP-DOPA-SBF scaffolds induced apatite mineralization for the second time during the cell culture. As compared to TCP scaffolds, both TCP-DOPA-Tris and TCP-DOPA-SBF scaffolds significantly promoted the osteogenesis of bone marrow stromal cells (BMSCs) as well as the angiogenesis of human umbilical vein endothelial cells (HUVECs), and the TCP-DOPA-SBF group presented the highest in vitro osteogenic/angiogenic activity among the three groups. Furthermore, both TCP-DOPA-Tris and TCP-DOPA-SBF scaffolds significantly improved the formation of new bone in vivo as compared to TCP scaffolds without a nanostructured surface. Our results suggest that the utilization of a mussel-inspired Ca, P-chelated polydopamine nanolayer on 3D-plotted bioceramic scaffolds is a viable and effective strategy to construct a hierarchical structure for synergistically accelerating osteogenesis.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Cites
Mussel-inspired surface chemistry for multifunctional coatings
Lee, H., Dellatore, S. M., Miller, W. M., & Messersmith, P. B. (2007) · Science · doi:10.1126/science.1147241 · Cited by 10,965 · see citing works
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
Maxwell, P. H., Wiesener, M. S., Chang, G.-W., Clifford, S. C., Vaux, E. C., Cockman, M. E., Wykoff, C. C., Pugh, C. W., Maher, E. R., & Ratcliffe, P. J. (1999) · Nature · doi:10.1038/20459 · Cited by 5,180 · see citing works
Ivan, M., Kondo, K., Yang, H., Kim, W., Valiando, J., Ohh, M., Salic, A., Asara, J. M., Lane, W. S., & Kaelin Jr., W. G. (2001) · Science · doi:10.1126/science.1059817 · Cited by 4,735 · see citing works
Single-molecule mechanics of mussel adhesion
Lee, H., Scherer, N. F., & Messersmith, P. B. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605552103 · Cited by 2,112 · see citing works
A reversible wet/dry adhesive inspired by mussels and geckos
Lee, H., Lee, B. P., & Messersmith, P. B. (2007) · Nature · doi:10.1038/nature05968 · Cited by 2,043 · see citing works
Endothelial Cell Migration During Angiogenesis
Lamalice, L., Bœuf, F. L., & Huot, J. (2007) · Circulation Research · doi:10.1161/01.res.0000259593.07661.1e · Cited by 1,486 · see citing works
Yuan, Y., Hilliard, G., Ferguson, T., & Millhorn, D. E. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300463200 · Cited by 638 · see citing works
Polyphosphoprotein from the Adhesive Pads of <i>Mytilus edulis</i>
Waite, J. H., & Qin, X. (2001) · Biochemistry · doi:10.1021/bi002718x · Cited by 610 · see citing works
Influence of engineered titania nanotubular surfaces on bone cells
Popat, K. C., Leoni, L., Grimes, C. A., & Desai, T. A. (2007) · Biomaterials · doi:10.1016/j.biomaterials.2007.03.020 · Cited by 596 · see citing works
Biphasic calcium phosphate nanocomposite porous scaffolds for load-bearing bone tissue engineering
Ramay, H. R., & Zhang, M. (2004) · Biomaterials · doi:10.1016/j.biomaterials.2003.12.023 · Cited by 471 · see citing works
Wu, C., Zhou, Y., Fan, W., et al. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.11.042 · Cited by 459 · see citing works
Self-citationOne‐Step Modification of Superhydrophobic Surfaces by a Mussel‐Inspired Polymer Coating
Kang, S. M., You, I., Cho, W. K., Shon, H. K., Lee, T. G., Choi, I. S., Karp, J. M., & Lee, H. (2010) · Angewandte Chemie International Edition · doi:10.1002/anie.201004693 · Cited by 442 · see citing works
Wu, C., Luo, Y., Cuniberti, G., et al. (2011) · Acta Biomaterialia · doi:10.1016/j.actbio.2011.03.009 · Cited by 363 · see citing works
Self-citationCharacterization of Dopamine−Melanin Growth on Silicon Oxide
Bernsmann, F., Ponche, A., Ringwald, C., Hemmerlé, J., Raya, J., Bechinger, B., Voegel, J.-C., Schaaf, P., & Ball, V. (2009) · The Journal of Physical Chemistry C · doi:10.1021/jp901188h · Cited by 348 · see citing works
Thinking outside the cell: how cadherins drive adhesion
Brasch, J., Harrison, O. J., Honig, B. H., & Shapiro, L. S. (2012) · Trends in Cell Biology · doi:10.1016/j.tcb.2012.03.004 · Cited by 343 · see citing works
Breier, G., Clauss, M. A., & Risau, W. (1995) · Developmental Dynamics · doi:10.1002/aja.1002040303 · Cited by 284 · see citing works
Materials from Mussel-Inspired Chemistry for Cell and Tissue Engineering Applications
Perikamana, S. K. M., Lee, J., Lee, Y. B., Shin, Y. M., Lee, E. J., Mikos, A. G., & Shin, H. (2015) · Biomacromolecules · doi:10.1021/acs.biomac.5b00852 · Cited by 284 · see citing works
HIF-1, An Oxygen and Metal Responsive Transcription Factor
Maxwell, P. H., & Salnikow, K. (2004) · Cancer Biology & Therapy · doi:10.4161/cbt.3.1.547 · Cited by 258 · see citing works
Fugitive Inks for Direct‐Write Assembly of Three‐Dimensional Microvascular Networks
Therriault, D., Shepherd, R. F., White, S. R., & Lewis, J. A. (2005) · Advanced Materials · doi:10.1002/adma.200400481 · Cited by 236 · see citing works
Wu, C., Fan, W., Zhou, Y., Luo, Y., Gelinsky, M., Chang, J., & Xiao, Y. (2012) · Journal of Materials Chemistry · doi:10.1039/c2jm30566f · Cited by 203 · see citing works
Self-citationMechanism of bone incorporation of β-TCP bone substitute in open wedge tibial osteotomy in patients
Gaasbeek, R. D. A., Toonen, H. G., van Heerwaarden, R. J., et al. (2005) · Biomaterials · doi:10.1016/j.biomaterials.2005.04.056 · Cited by 183 · see citing works
Miao, Z., Wang, H., Yang, H., et al. (2015) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.5b06265 · Cited by 171 · see citing works
Ye, W., Wang, D., Zhang, H., et al. (2009) · Electrochimica Acta · doi:10.1016/j.electacta.2009.11.022 · Cited by 154 · see citing works
Olmo, N. (2003) · Biomaterials · doi:10.1016/s0142-9612(03)00200-x · Cited by 152 · see citing works
Zhang, Y., Xia, L., Zhai, D., Shi, M., Luo, Y., Feng, C., Fang, B., Yin, J., Chang, J., & Wu, C. (2015) · Nanoscale · doi:10.1039/c5nr05421d · Cited by 149 · see citing works
Self-citationZhang, J., Zhou, H., Yang, K. C., Yuan, Y., & Liu, C. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.08.059 · Cited by 146 · see citing works
Pore size regulates cell and tissue interactions with PLGA-CaP scaffolds used for bone engineering
Sicchieri, L. G., Crippa, G. E., de Oliveira, P. T., et al. (2011) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.422 · Cited by 144 · see citing works
Liliensiek, S. J., Campbell, S. F., Nealey, P. F., & Murphy, C. J. (2006) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.30744 · Cited by 139 · see citing works
Wu, C., Zhang, Y., Zhou, Y., et al. (2010) · Acta Biomaterialia · doi:10.1016/j.actbio.2010.12.019 · Cited by 139 · see citing works
Self-citationWu, C., Chang, J., Zhai, W., et al. (2007) · Journal of Materials Science Materials in Medicine · doi:10.1007/s10856-006-0083-0 · Cited by 137 · see citing works
Self-citationMini-review: The role of redox in Dopa-mediated marine adhesion
Nicklisch, S. C. T., & Waite, J. H. (2012) · Biofouling · doi:10.1080/08927014.2012.719023 · Cited by 134 · see citing works
Hong, Y., Chen, X., Jing, X., et al. (2009) · Advanced Materials · doi:10.1002/adma.200901656 · Cited by 125 · see citing works
Plasma-treated poly(lactic-co-glycolic acid) nanofibers for tissue engineering
Park, H., Lee, K. Y., Lee, S. J., Park, K. E., & Park, W. H. (2007) · Macromolecular Research · doi:10.1007/bf03218782 · Cited by 124 · see citing works
Nanofibrous polydopamine complex membranes for adsorption of Lanthanum (III) ions
Hong, G., Shen, L., Wang, M., Yang, Y., Wang, X., Zhu, M., & Hsiao, B. S. (2014) · Chemical Engineering Journal · doi:10.1016/j.cej.2014.01.073 · Cited by 124 · see citing works
Rao, R. B., Krafcik, K. L., Morales, A., et al. (2005) · Advanced Materials · doi:10.1002/adma.200400514 · Cited by 110 · see citing works
Wu, C., Fan, W., Chang, J., & Xiao, Y. (2011) · Journal of Materials Chemistry · doi:10.1039/c1jm12770e · Cited by 109 · see citing works
Self-citationXu, M., Zhai, D., Chang, J., et al. (2013) · Acta Biomaterialia · doi:10.1016/j.actbio.2013.09.011 · Cited by 88 · see citing works
Self-citationLou, T., Wang, X. J., Song, G., et al. (2014) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2014.06.004 · Cited by 88 · see citing works
Bernhardt, A., Despang, F., Lode, A., Demmler, A., Hanke, T., & Gelinsky, M. (2008) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.134 · Cited by 77 · see citing works
Ou, J., Wang, J., Liu, S., et al. (2009) · The Journal of Physical Chemistry C · doi:10.1021/jp9073416 · Cited by 76 · see citing works
Bourmaud, A., Riviere, J., Duigou, A. L., et al. (2009) · Polymer Testing · doi:10.1016/j.polymertesting.2009.04.006 · Cited by 74 · see citing works
Biological properties of VEGF/VPF receptors
Terman, B. I., & Dougher-Vermazen, M. (1996) · Cancer and Metastasis Reviews · doi:10.1007/bf00437468 · Cited by 73 · see citing works
Sinus lift augmentation and β-TCP: A microCT and histologic analysis on human bone biopsies
Chappard, D., Guillaume, B., Mallet, R., Pascaretti‐Grizon, F., Baslé, M. F., & Libouban, H. (2009) · Micron · doi:10.1016/j.micron.2009.12.005 · Cited by 72 · see citing works
Hierarchically porous nagelschmidtite bioceramic–silk scaffolds for bone tissue engineering
Xu, M., Li, H., Zhai, D., et al. (2015) · Journal of Materials Chemistry B · doi:10.1039/c5tb00435g · Cited by 66 · see citing works
Self-citationLiang, R., Meng, X., Liu, C., & Qiu, J. (2011) · Electrophoresis · doi:10.1002/elps.201100403 · Cited by 63 · see citing works
Li, H., Daculsi, R., Grellier, M., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016767 · Cited by 56 · see citing works
Self-citationFeng, J., Sun, M. H., Li, J., Xu, L., Liu, X., & Jiang, S. (2011) · Journal of Chromatography A · doi:10.1016/j.chroma.2011.04.018 · Cited by 35 · see citing works
He, C., Feng, W., Cao, L., & Fan, L. (2011) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.33235 · Cited by 32 · see citing works
Rokn, A., Moslemi, N., Eslami, B., et al. (2012) · PubMed · Cited by 18 · see citing works
Effects of cobalt chloride, nickel chloride, and nickel subsulfide upon erythropoiesis in rats.
Oskarsson, A., Reid, M. C., & Sunderman, F. W. (1981) · PubMed · Cited by 14 · see citing works
Qi, Q. Q., Chen, J. D., Gao, S., et al. (2011) · Advanced materials research · doi:10.4028/www.scientific.net/amr.236-238.1897 · Cited by 5 · see citing works
Flagged first, then by citations
Research works printed but not linked: 4
- Rokn, 2012, J. Dent., 9, 35
- Tan, 2015, J. Inorg. Mater., 30, 1076
- Wu, 2007, J. Mater. Sci.: Mater. Med., 18, 857
- Oskarsson, 1981, Ann. Clin. Lab. Sci., 11, 165
Cited by
Sorted by citations
Mussel-inspired polydopamine for bio-surface functionalization
Ding, Y., Floren, M. L., & Tan, W. (2016) · Biosurface and Biotribology · doi:10.1016/j.bsbt.2016.11.001 · Cited by 396 · see citing works
“Almost at the same time, Xu et al.[51] prepared a PDA-apatite hybrid nanolayer on the surfaces of the bioceramic scaffolds followed by evaluating their capability for bone regeneration in a rabbit femur defect model.”
BackgroundZirconia surface modifications for implant dentistry
Schünemann, F. H., Galárraga-Vinueza, M. E., Magini, R. D. S., et al. (2019) · Materials Science and Engineering C · doi:10.1016/j.msec.2019.01.062 · Cited by 309 · see citing works
Polydopamine-assisted surface modification for orthopaedic implants
Jia, L., Han, F., Wang, H., Zhu, C., Guo, Q., Li, J., Zhao, Z., Zhang, Q., Zhu, X., & Li, B. (2019) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2019.04.001 · Cited by 168 · see citing works
Lee, S. J., Lee, H., Kim, S.-Y., Seok, J. M., Lee, J. H., Kim, W. D., Kwon, I. K., Park, S., & Park, S. A. (2018) · Nanoscale · doi:10.1039/c8nr04037k · Cited by 106 · see citing works
Thompson, B. R., Horozov, T. S., Stoyanov, S. D., et al. (2019) · Journal of Materials Chemistry A · doi:10.1039/c8ta09750j · Cited by 92 · see citing works
Liu, W., Zhang, G., Wu, J., Zhang, Y., Liu, J., Luo, H., & Shao, L. (2020) · Journal of Nanobiotechnology · doi:10.1186/s12951-019-0570-3 · Cited by 91 · see citing works
3D Printing of Hot Dog‐Like Biomaterials with Hierarchical Architecture and Distinct Bioactivity
Li, T., Zhai, D., Ma, B., Xue, J., Zhao, P., Chang, J., Gelinsky, M., & Wu, C. (2019) · Advanced Science · doi:10.1002/advs.201901146 · Cited by 83 · see citing works
Self-citationBioceramic Scaffolds with Antioxidative Functions for ROS Scavenging and Osteochondral Regeneration
Deng, C., Zhou, Q., Zhang, M., Li, T., Chen, H., Xu, C. W., Feng, Q., Wang, X., Yin, F., Cheng, Y., et al. (2022) · Advanced Science · doi:10.1002/advs.202105727 · Cited by 75 · see citing works
Self-citation3D Cell Culture—Can It Be As Popular as 2D Cell Culture?
Sun, M., Liu, A., Yang, X.-F., Gong, J.-X., Yu, M.-F., Yao, X., Wang, H., & He, Y. (2021) · Advanced NanoBiomed Research · doi:10.1002/anbr.202000066 · Cited by 66 · see citing works
Brunello, G., Panda, S., Schiavon, L., Sivolella, S., Biasetto, L., & FABBRO, M. D. (2020) · Materials · doi:10.3390/ma13071500 · Cited by 68 · see citing works
Healing of osteoporotic bone defects by micro-/nano-structured calcium phosphate bioceramics
Zhao, R., Chen, S., Yuan, B., et al. (2019) · Nanoscale · doi:10.1039/c8nr09417a · Cited by 63 · see citing works
Self-citationTian, T., Xie, W., Gao, W., Wang, G., Zeng, L., Miao, G., Lei, B., Lin, Z., & Chen, X. (2019) · Frontiers in Chemistry · doi:10.3389/fchem.2019.00186 · Cited by 59 · see citing works
“In recent years, bone tissue engineering scaffolds play a more and more important role in bone repair field due to the growing market demand (Xu et al., 2016; Zhao et al., 2018a), due to the drawbacks in autologous and allograft bone graft (Zhang et al., 2017).”
BackgroundIon Therapy: A Novel Strategy for Acute Myocardial Infarction
Yi, M., Li, H., Wang, X., Yan, J., Gao, L., He, Y. N., Zhong, X., Cai, Y., Feng, W., Wen, Z., et al. (2018) · Advanced Science · doi:10.1002/advs.201801260 · Cited by 57 · see citing works
Self-citationZhuang, H., Lin, R., Liu, Y., Zhang, M., Zhai, D., Huan, Z., & Wu, C. (2019) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.9b01095 · Cited by 56 · see citing works
Self-citationPolydopamine-Modified functional materials promote bone regeneration
Wang, J., Cui, Y., Zhang, B., Sun, S., Xu, H., Yao, M., Wu, D., & Wang, Y. (2024) · Materials & Design · doi:10.1016/j.matdes.2024.112655 · Cited by 56 · see citing works
Yu, Y., Sun, Y., Zhou, X., Mao, Y., Liu, Y., Ye, L., Kuang, L., Yang, J., & Deng, Y. (2020) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2020.111492 · Cited by 49 · see citing works
Advancement in ceramic biomaterials for dental implants
Upadhyay, A., Pradhan, L., Yenurkar, D., Kumar, K., & Mukherjee, S. (2024) · International Journal of Applied Ceramic Technology · doi:10.1111/ijac.14772 · Cited by 46 · see citing works
Lemos, R., Maia, F. R., Reis, R. L., & Oliveira, J. M. (2021) · Advanced NanoBiomed Research · doi:10.1002/anbr.202100116 · Cited by 44 · see citing works
Li, Q., Feng, C., Cao, Q., et al. (2023) · Regenerative Biomaterials · doi:10.1093/rb/rbad013 · Cited by 38 · see citing works
“polydopamine nanolayer [122, 123] and polyethyleneimine/hepa-”
Xue, J., Feng, C., Xia, L., et al. (2018) · Chemistry of Materials · doi:10.1021/acs.chemmater.8b01272 · Cited by 36 · see citing works
Self-citationQiu, X., Li, S., Li, X., et al. (2022) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2022.112424 · Cited by 35 · see citing works
Surface Modifications for Zirconia Dental Implants: A Review
Sun, L. W., & Hong, G. (2021) · Frontiers in Dental Medicine · doi:10.3389/fdmed.2021.733242 · Cited by 34 · see citing works
Kao, C., Chen, Y., Ng, H.-Y., Lee, A. K.-X., Huang, T., Lin, T., & Hsu, T.-T. (2018) · Materials · doi:10.3390/ma11091664 · Cited by 32 · see citing works
“Xu’s study showed that self-assembled biocomposites of Ca-P/PDA nanolayers were able to solve problems of bio-inert scaffolds by improving levels of bioactivity, for application in bone regeneration studies [17].”
BackgroundNanomaterial-assisted theranosis of bone diseases
Zheng, K., Bai, J., Yang, H., Xu, Y., Pan, G., Wang, H., & Geng, D. (2022) · Bioactive Materials · doi:10.1016/j.bioactmat.2022.12.014 · Cited by 32 · see citing works
“The common method is incorporating nanoparticles, nanosheets or nanofibers with different natural or synthetic materials, such as graphene oxide [318], bioceramics [319], silk fibroin [320],”
MethodElkhenany, H. A., Soliman, M. W., Atta, D., & El‐Badri, N. (2024) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.37833 · Cited by 29 · see citing works
Synthetic bone graft substitutes: Calcium-based biomaterials
Díez-Escudero, A., Español, M., & Ginebra, M. (2019) · Elsevier eBooks · doi:10.1016/b978-0-08-102478-2.00006-4 · Cited by 27 · see citing works
Zhang, W., Wang, S., Ge, S., et al. (2018) · Royal Society Open Science · doi:10.1098/rsos.172310 · Cited by 27 · see citing works
“There were no significant differences between different samples at 4 days, but osteoblast on sTi/PDA/AgNP-M and pTi/PDA/AgNP-M presented higher ALP activity than other samples at 7 days and 10 days, indicating that the mineralized surfaces could induce osteoblast differentiation, one explanation for this is that calci…”
BackgroundLiu, J., Cui, Y., Kuang, Y., Xu, S., Lu, Q., Diao, J., & Zhao, N. (2021) · Journal of Materials Chemistry B · doi:10.1039/d1tb00063b · Cited by 26 · see citing works
Yang, Z., Li, X., Zhang, B., et al. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.854693 · Cited by 25 · see citing works
Mussel-inspired silver-nanoparticle coating on porous titanium surfaces to promote mineralization
Chen, J., Mei, M. L., Li, Q., & Chu, C.-H. (2016) · RSC Advances · doi:10.1039/c6ra20673e · Cited by 22 · see citing works
Wang, G. (2020) · Materials Letters · doi:10.1016/j.matlet.2020.128131 · Cited by 16 · see citing works
Tan, L., Ye, Z., Zhuang, W., et al. (2023) · Regenerative Therapy · doi:10.1016/j.reth.2023.09.015 · Cited by 15 · see citing works
“The calcium phosphate/PDA coating has a nano-scale porous topography, which is good for BMSCs behavior and osteogenesis in vivo [54].”
BackgroundSelf-citationSrinivasan, G., Manickam, A., Sivakumar, S., et al. (2025) · Journal of Materials Science Materials in Engineering · doi:10.1186/s40712-025-00294-9 · Cited by 14 · see citing works
“Xu et al. (2016) demonstrated that PDA-coated 3D-printed bio-ceramic scaffolds can significantly accelerate osteogenesis, highlighting their potential in bone-related applications.”
Endowing polyetheretherketone with anti-inflammatory ability and improved osteogenic ability
Yu, Y., Xie, K., Xie, L., & Deng, Y. (2020) · Journal of Biomaterials Science Polymer Edition · doi:10.1080/09205063.2020.1815634 · Cited by 14 · see citing works
Wang, Y., Wang, Z., Yu, X., Zhang, M., Wang, X., Zhou, Y., Yao, Q., & Wu, C. (2023) · Journal of Materials Chemistry B · doi:10.1039/d2tb02056d · Cited by 11 · see citing works
Self-citationZhou, Y., Chang, D., & Chang, J. (2017) · International Journal of Applied Ceramic Technology · doi:10.1111/ijac.12749 · Cited by 11 · see citing works
Self-citationMicroporous Biodegradable Films Promote Therapeutic Angiogenesis
Hendow, E. K., Moazen, M., Iacoviello, F., Bozec, L., Pellet‐Many, C., & Day, R. M. (2020) · Advanced Healthcare Materials · doi:10.1002/adhm.202000806 · Cited by 11 · see citing works
Hierarchical bioceramic scaffold for tissue engineering: A review
Mamat, N., Darus, F., Isa, R. M., Mariatti, M., & Kawashita, M. (2017) · International Journal of Polymeric Materials · doi:10.1080/00914037.2017.1291507 · Cited by 7 · see citing works
Biotechnologies from Marine Bivalves
Venier, P., Gerdol, M., Domeneghetti, S., Sharma, N., Pallavicini, A., & Rosani, U. (2018) · Springer eBooks · doi:10.1007/978-3-319-96776-9_6 · Cited by 7 · see citing works
Tian, T., Hu, Q. C., Shi, M., et al. (2023) · Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials · doi:10.1016/j.jmbbm.2023.106093 · Cited by 5 · see citing works
Progress of Bioceramic and Bioglass Bone Scaffolds for Load-Bearing Applications
Yang, J. (2018) · Springer eBooks · doi:10.1007/978-3-319-89542-0_18 · Cited by 5 · see citing works
- Authors
- Xu, M., Zhai, D., Xia, L., Li, H., Chen, S., Fang, B., Chang, J., & Wu, C.
- Affiliations
- Chinese Academy of Sciences (CN)
- Shanghai Jiao Tong University (CN)
- Huashan Hospital (CN)
- Corresponding author
- Wu, Chengtie
- Venue
- Nanoscale
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2016
- Volume
- 8
- Issue
- 28
- Pages
- 13790-13803
- ISSN
- 2040-3364 (ISSN-L)
- 2040-3372
- OpenAlex
- W2423147219
- Semantic Scholar
- 658c8441acfcc59800365190ba82c5cde0d1174d
- Cited by
- 41
- References
- 51
- Citations by year
- 2025: 1 · 2024: 3 · 2023: 4 · 2022: 4 · 2021: 4 · 2020: 6 · 2019: 8 · 2018: 7 · 2017: 2 · 2016: 2
- FWCI
- 2.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nanoscale (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Keywords
- bioceramic scaffolds, 3D-printed scaffolds, beta-tricalcium phosphate, polydopamine, mussel-inspired surface modification, bone formation, angiogenesis, bone tissue engineering, macropore structure, mesenchymal stem cells, human umbilical vein endothelial cells, apatite mineralization, hierarchical surface structures
- MeSH terms
- Animals, Biocompatible Materials, Humans, Osteogenesis, Stromal Cells, Tissue Engineering, Nanostructures, Bivalvia, Tissue Scaffolds, Human Umbilical Vein Endothelial Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
