Cited by 38Mangiferin and Mango ExtractsAdipokines, Inflammation, and Metabolic DiseasesPhytochemicals and Antioxidant Activities

Mango fruit peel and flesh extracts affect adipogenesis in 3T3-L1 cells

Taing, Meng-Wong, Pierson, Jean-Thomas, Hoang, Van L. T., Shaw, Paul N., Dietzgen, Ralf G., Gidley, Michael J., Roberts-Thomson, Sarah J., Monteith, Gregory R.·2012·Food & Function

Abstract

Obesity is associated with many chronic disease states, such as diabetes mellitus, coronary disease and certain cancers, including those of the breast and colon. There is a growing body of evidence that links phytochemicals with the inhibition of adipogenesis and protection against obesity. Mangoes (Mangifera indica L.) are tropical fruits that are rich in a diverse array of bioactive phytochemicals. In this study, methanol extracts of peel and flesh from three archetypal mango cultivars; Irwin, Nam Doc Mai and Kensington Pride, were assessed for their effects on a 3T3-L1 pre-adipocyte cell line model of adipogenesis. High content imaging was used to assess: lipid droplets per cell, lipid droplet area per cell, lipid droplet integrated intensity, nuclei count and nuclear area per cell. Mango flesh extracts from the three cultivars did not inhibit adipogenesis; peel extracts from both Irwin and Nam Doc Mai, however, did so with the Nam Doc Mai extract most potent at inhibiting adipogenesis. Peel extract from Kensington Pride promoted adipogenesis. The inhibition of adipogenesis by Irwin (100 μg mL(-1)) and Nam Doc Mai peel extracts (50 and 100 μg mL(-1)) was associated with an increase in the average nuclear area per cell; similar effects were seen with resveratrol, suggesting that these extracts may act through pathways similar to resveratrol. These results suggest that differences in the phytochemical composition between mango cultivars may influence their effectiveness in inhibiting adipogenesis, and points to mango fruit peel as a potential source of nutraceuticals.

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Crossref · 10.1039/c2fo30073g

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  • M. indica peel extracts effectively hinder adipogenesis in vitro in a dose-dependent manner in 3T3-L1 adipocytes via AMPK signaling.

    “In this way, Taing et al. [82] and Fang et al. [81] concluded that extracts from M. indica peel effectively hinder adipogenesis in vitro in a dose-dependent manner by suppressing mitotic clonal expansion, genes linked to mitochondrial biogenesis, and fatty acid oxidation in 3T3-L1 adipocytes via AMP-activated protein kinase (AMPK) signaling.”

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Authors
Taing, M.-W., Pierson, J.-T., Hoang, V. L. T., Shaw, P. N., Dietzgen, R. G., Gidley, M. J., Roberts-Thomson, S. J., & Monteith, G. R.
Affiliations
The University of Queensland (AU)
Corresponding author
Monteith, Gregory R.
Venue
Food & Function
Published
2012
Volume
3
Issue
8
Pages
828
ISSN
  • 2042-6496 (ISSN-L)
  • 2042-650X
OpenAlex
W2085598567
Cited by
38
References
47
Citations by year
2026: 2 · 2023: 3 · 2022: 2 · 2020: 3 · 2019: 3 · 2018: 3 · 2017: 2 · 2016: 4 · 2015: 8 · 2014: 4 · 2013: 3 · 2012: 1
FWCI
12.42
Type
journal article
Language
en
Open access
closed
Locations
  • Food & Function (publishedVersion)
  • PubMed (publishedVersion)
  • Queensland Department of Agriculture and Fisheries archive of scientific and research publications (Queensland Department of Agriculture and Fisheries) (submittedVersion)
Funders
Australian Research Council
Topics
  • Health Sciences › Medicine › Complementary and alternative medicine › Mangiferin and Mango Extracts
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
Keywords
mango, fruit peel, fruit pulp, adipogenesis, 3T3-L1 preadipocytes, obesity, phytochemicals, mango cultivars, Irwin, Kensington Pride, lipid droplets, nuclear area, resveratrol, nutraceuticals
MeSH terms
Resveratrol, Animals, Cell Nucleus, Fruit, Plant Extracts, Species Specificity, Stilbenes, Adipocytes, Mangifera, 3T3-L1 Cells, Adipogenesis, Mice

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