The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.
Near-infrared light sensitive polypeptide block copolymer micelles for drug delivery
Abstract
A new biocompatible block copolymer (BCP) composed of poly(ethylene oxide) (PEO) and poly(L-glutamic acid) bearing a number of 6-bromo-7-hydroxycoumarin-4-ylmethyl groups, PEO114-b-P(LGA0.62-co-COU0.38)34, was prepared for near-infrared (NIR) light-induced drug delivery. We demonstrate that micelles of PEO114-b-P(LGA0.62-co-COU0.38)34 could be disrupted by 794 nm NIR light excitation via two-photon absorption. This was linked to the high two-photon absorption cross-section of the coumarin moiety. Disruption followed from the NIR light-induced removal of coumarin groups from the polypeptide block that shifted the hydrophilic–hydrophobic balance toward the destabilization of the micelles in aqueous solution. Using NIR light-triggered disruption of BCP micelles, we investigated the release of an antibacterial drug (Rifampicin) and an anticancer drug (Paclitaxel) loaded into the photosensitive BCP micelles. We found that the two drugs could be released effectively upon NIR light exposure of the micellar solution. To our knowledge, this is the first study of NIR light-triggered disruption of biocompatible polypeptide BCP micelles and its use for drug release. This is a step forward towards light-controllable drug delivery applications.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Citations
Cites
Nanocarriers as an emerging platform for cancer therapy
Peer, D., Karp, J. M., Hong, S., Farokhzad, O. C., Margalit, R., & Langer, R. (2007) · Nature Nanotechnology · doi:10.1038/nnano.2007.387 · Cited by 8,710
Nanoparticle therapeutics: an emerging treatment modality for cancer
Davis, M. E., Chen, Z., & Shin, D. M. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2614 · Cited by 4,233
Block copolymer micelles for drug delivery: design, characterization and biological significance
Kataoka, K., Harada, A., & Nagasaki, Y. (2001) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(00)00124-1 · Cited by 3,506
Gold nanocages covered by smart polymers for controlled release with near-infrared light
Yavuz, M. S., Cheng, Y., Chen, J., Cobley, C. M., Zhang, Q., Rycenga, M., Xie, J., Kim, C., Song, K. H., Schwartz, A. G., et al. (2009) · Nature Materials · doi:10.1038/nmat2564 · Cited by 1,404
Nishiyama, N., & Kataoka, K. (2006) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2006.05.006 · Cited by 1,064
Physical stimuli-responsive polymeric micelles for anti-cancer drug delivery
Rapoport, N. (2007) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2007.05.009 · Cited by 1,002
Stimuli-responsive polypeptide vesicles by conformation-specific assembly
Bellomo, E. G., Wyrsta, M. D., Pakstis, L., Pochan, D. J., & Deming, T. J. (2004) · Nature Materials · doi:10.1038/nmat1093 · Cited by 752
Pluronic® block copolymers for overcoming drug resistance in cancer
Kabanov, A. V., Batrakova, E. V., & Alakhov, V. Y. (2002) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(02)00047-9 · Cited by 637
Furuta, T., Wang, S. S. ‐., Dantzker, J. L. M., Dore, T. M., Bybee, W. J., Callaway, E. M., Denk, W. T., & Tsien, R. Y. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.4.1193 · Cited by 635
You, J., Zhang, G., & Li, C. (2010) · ACS Nano · doi:10.1021/nn901181c · Cited by 597
Flagged first, then by citations
Cited by
Sorted by citations
Ghezzi, M., Pescina, S., Padula, C., Santi, P., Del Favero, E., Cantù, L., & Nicoli, S. (2021) · Journal of Controlled Release · doi:10.1016/j.jconrel.2021.02.031 · Cited by 1,135
Iron Oxide Based Nanoparticles for Multimodal Imaging and Magnetoresponsive Therapy
Lee, N., Yoo, D., Ling, D., Cho, M. H., Hyeon, T., & Cheon, J. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00112 · Cited by 1,020
Visible-to-NIR-Light Activated Release: From Small Molecules to Nanomaterials
Weinstain, R., Slanina, T., Kand, D., & Klán, P. (2020) · Chemical Reviews · doi:10.1021/acs.chemrev.0c00663 · Cited by 658
Photo-responsive block copolymer micelles: design and behavior
Gohy, J., & Zhao, Y. (2013) · Chemical Society Reviews · doi:10.1039/c3cs35469e · Cited by 533
Light-Responsive Block Copolymer Micelles
Zhao, Y. (2012) · Macromolecules · doi:10.1021/ma300094t · Cited by 497
Metadata
- Authors
- Kumar, S., Allard, J.-F., Morris, D., Dory, Y. L., Lepage, M., & Zhao, Y.
- Affiliations
- Université de Sherbrooke (CA)
- Corresponding author
- Dory, Yves L.
- Lepage, Martin
- Zhao, Yue
- Venue
- Journal of Materials Chemistry
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2012
- Volume
- 22
- Issue
- 15
- Pages
- 7252
- ISSN
- 0959-9428 (ISSN-L)
- 1364-5501
- OpenAlex
- W2095976477
- Cited by
- 146
- References
- 56
- Citations by year
- 2026: 3 · 2025: 9 · 2024: 8 · 2023: 5 · 2022: 9 · 2021: 8 · 2020: 7 · 2019: 8 · 2018: 16 · 2017: 11 · 2016: 15 · 2015: 13 · 2014: 16 · 2013: 14 · 2012: 4
- FWCI
- 6.10
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Materials Chemistry (publishedVersion)
- Funders
- Canada Research Chairs
- Natural Sciences and Engineering Research Council of Canada
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Chemistry › Organic Chemistry › Advanced Polymer Synthesis and Characterization
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Keywords
- near-infrared light-triggered drug release, two-photon absorption, poly(ethylene oxide), poly(L-glutamic acid), hydrophilic-hydrophobic balance, rifampicin, paclitaxel, antibacterial drug delivery, anticancer drug delivery
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
