Anticancer steroids: linking natural and semi-synthetic compounds

New Cytotoxic Steroids from the Indian Ocean Sponge Axinella cf. bidderi

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Novel Steroidal Vinyl Fluorides as Inhibitors of Steroid C17(20) Lyase

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Stereoselective synthesis of some 17β-dihydrooxazinyl steroids, as novel presumed inhibitors of 17α-hydroxylase-C17,20-lyase

Woelfling, J., Oravecz, É. A., Ondré, D., Mernyák, E., Schneider, G., Tóth, I., Szécsi, M., & Julesz, J. (2006) · Steroids · doi:10.1016/j.steroids.2006.05.011 · Cited by 32

Enantiospecific Interactions between Cholesterol and Phospholipids

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Antiproliferative cardenolides from Periploca graeca

Spera, D., Siciliano, T., Tommasi, N. D., Braca, A., & Vessières, A. (2007) · Planta Medica · doi:10.1055/s-2007-967133 · Cited by 32

High-Throughput Screening Identifies Cardiac Glycosides as Potent Inhibitors of Human Tissue Kallikrein Expression: Implications for Cancer Therapies

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Inhibitory effects of ursodeoxycholic acid on N-methylnitrosourea-induced colon carcinogenesis and colonic mucosal telomerase activity in F344 rats.

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TAS-108, a Novel Oral Steroidal Antiestrogenic Agent, Is a Pure Antagonist on Estrogen Receptor α and a Partial Agonist on Estrogen Receptor β with Low Uterotrophic Effect

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A chenodeoxycholic derivative, HS-1200, induces apoptosis and cell cycle modulation via Egr-1 gene expression control on human hepatoma cells

Park, S.-E., Lee, S. W., Hossain, M. A., Kim, M. Y., Kim, M. K., Ahn, E. Y., Park, Y. C., Suh, H., Kim, G., Choi, Y. H., et al. (2008) · Cancer Letters · doi:10.1016/j.canlet.2008.04.038 · Cited by 31

Steroselective synthesis of some steroidal oxazolines, as novel potential inhibitors of 17α-hydroxylase-C17,20-lyase

Ondré, D., Woelfling, J., Tóth, I., Szécsi, M., Julesz, J., & Schneider, G. (2009) · Steroids · doi:10.1016/j.steroids.2009.08.001 · Cited by 30

New steroidal lactones as 5α-reductase inhibitors and antagonists for the androgen receptor

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Bile acid-based polyaminocarboxylate conjugates as targeted antitumor agents

Chong, H., Song, H. A., Ma, X., Lim, S., Sun, X. Y., & Mhaske, S. B. (2009) · Chemical Communications · doi:10.1039/b823000e · Cited by 30

Novel bile acid derivatives (BANBs) with cytostatic activity obtained by conjugation of their side chain with nitrogenated bases

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Synthesis of regioisomeric 17β-N-phenylpyrazolyl steroid derivatives and their inhibitory effect on 17α-hydroxylase/C17,20-lyase

Iványi, Z., Woelfling, J., Görbe, T., Szécsi, M., Wittmann, T., & Schneider, G. (2010) · Steroids · doi:10.1016/j.steroids.2010.02.013 · Cited by 30

Cytotoxic cardenolides from the stems of Periploca forrestii

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Synthesis of novel C17 steroidal carbamates

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Nonpolar and Short Side Chain Groups at C-11β of Estradiol Result in Antiestrogens

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Side‐chain oxysterol regulation of 3‐Hydroxy‐3‐methylglutaryl Coenzyme A reductase activity

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Cellular toxicity of oxycholesterols

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Lack of enantiomeric specificity in the effects of anesthetic steroids on lipid bilayers

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Treatment of U937 cells with bufalin induces the translocation of casein kinase 2 and modulates the activity of topoisomerase II prior to the induction of apoptosis.

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Aromatase inhibitors and breast cancer prevention

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In vivo and in vitro effect of novel 4,16-pregnadiene-6,20-dione derivatives, as 5α-reductase inhibitors

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Synthesis and Evaluation of 17α-20E-21-(4-Substituted phenyl)-19-norpregna-1,3,5(10),20-tetraene-3,17β-diols as Probes for the Estrogen Receptor α Hormone Binding Domain

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Competitive product inhibition of aromatase by natural estrogens

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The effect of ursodeoxycholic acid on glycochenodeoxycholic acid-induced apoptosis in rat hepatocytes

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Digitoxin, in non-toxic concentrations, inhibits proliferation and induces cell death in prostate cancer cell lines

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C19-Steroids as androgen receptor modulators: Design, discovery, and structure-activity relationship of new steroidal androgen receptor antagonists

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Discovery of a novel hybrid from finasteride and epristeride as 5α-reductase inhibitor

Yao, Z., Xu, Y., Zhang, M., Jiang, S., Nicklaus, M. C., & Liao, C. (2010) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2010.10.112 · Cited by 26

Inhibitory Effects of Cholesterol Derivatives on DNA Polymerase and Topoisomerase Activities, and Human Cancer Cell Growth

Ishimaru, C., Yonezawa, Y., Kuriyama, I., Nishida, M., Yoshida, H., & Mizushina, Y. (2008) · Lipids · doi:10.1007/s11745-007-3149-y · Cited by 26

(17.ALPHA.,20E)-17,20-[(1-Methoxyethylidene)bis(oxy)]-3-oxo-19-norpregna-4,20-diene-21-carboxylic Acid Methyl Ester (YK11) Is a Partial Agonist of the Androgen Receptor

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Vitamin D Analogs as Anti-Carcinogenic Agents

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Cell membrane localization of sterols with conventional and unusual side chains in two marine demonsponges

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Combination Therapy of Heparin–Deoxycholic Acid Conjugate and Doxorubicin against Squamous Cell Carcinoma and B16F10 Melanoma

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Dietary Vitamin D Intake and Cancers of the Colon and Rectum: A Case-Control Study in Italy

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Cytotoxic and HIF-1α Inhibitory Compounds from Crossosoma bigelovii

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Mixed steroidal tetraoxanes induce apoptotic cell death in tumor cells

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Toxicity of cholesterol oxides on cultured neuroretinal cells

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Antiproliferative, low-calcemic, fluorinated sulfone analogs of 1α,25-dihydroxyvitamin D3: Chemical synthesis and biological evaluation

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Proapoptotic Effect on Normal and Tumor Intestinal Cells of Cytostatic Drugs with Enterohepatic Organotropism

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Efficacy on anaplastic thyroid carcinoma of valproic acid alone or in combination with doxorubicin, a synthetic chenodeoxycholic acid derivative, or lactacystin

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Withaferin A suppresses the expression of vascular endothelial growth factor in Ehrlich ascites tumor cells via Sp1 transcription factor

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3D-QSAR studies on unsaturated 4-azasteroids as human 5α-reductase inhibitors: A self organizing molecular field analysis approach

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Oxidized Derivatives of Dihydrobrassicasterol: Cytotoxic and Apoptotic Potential in U937 and HepG2 Cells

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Bile Reflux in the Constellation of Gastroesophageal Reflux Disease

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Cytotoxic Cardenolides from Streptocaulon griffithii

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Molecular interactions of progesterone derivatives with 5α-reductase types 1 and 2 and androgen receptors

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Synthesis of steroidal quinones and hydroquinones from bile acids by Barton radical decarboxylation and benzoquinone addition. Studies on their cytotoxic and antifungal activities

Siless, G. E., Knott, M. E., Derita, M., Zacchino, S. A., Puricelli, L., & Palermo, J. A. (2011) · Steroids · doi:10.1016/j.steroids.2011.09.012 · Cited by 20

Mechanism for aromatase inactivation by a suicide substrate, androst-4-ene-3,6,17-trione

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Calcitriol derivatives with two different side chains at C-20

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Cardiac Glycosides

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Time-dependent inactivation of steroid C17(20) lyase by 17β-cyclopropyl ether-substituted steroids

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Synthesis of ent-25-hydroxycholesterol

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Synthesis and evaluation of 11β-(4-Substituted phenyl) estradiol analogs: Transition from estrogen receptor agonists to antagonists

Hanson, R. N., Hua, E., Hendricks, J. A., Labaree, D. C., & Hochberg, R. B. (2012) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2012.04.041 · Cited by 19

Comparative cytotoxic and cytoprotective effects of taurohyodeoxycholic acid (THDCA) and tauroursodeoxycholic acid (TUDCA) in HepG2 cell line

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A time-dependent inactivation of aromatase by 19-oxygenated androst-4-ene-3,6,17-triones

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TAS-108: A Novel Steroidal Antiestrogen

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Evaluation of the first Ergocalciferol-derived, non hypercalcemic anti-cancer agent MT19c in ovarian cancer SKOV-3 cell lines

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Self-organizing molecular field analysis on pregnane derivatives as human steroidal 5α-reductase inhibitors

Aggarwal, S., Thareja, S., Bhardwaj, T. R., & Kumar, M. (2010) · Steroids · doi:10.1016/j.steroids.2010.02.005 · Cited by 17

Synthesis and Evaluation of (17α,20Z)-21-(4-Substituted-phenyl)-19-norpregna-1,3,5(10),20-tetraene-3,17β-diols as Ligands for the Estrogen Receptor-α Hormone Binding Domain: Comparison with 20E-Isomers

Hanson, R. N., Friel, C. J., Dilis, R., Hughes, A., & DeSombre, E. R. (2005) · Journal of Medicinal Chemistry · doi:10.1021/jm040157s · Cited by 17

Steroid derivatives as pure antagonists of the androgen receptor

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Novel C-6 substituted and unsubstituted pregnane derivatives as 5α-reductase inhibitors and their effect on hamster flank organs diameter size

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17β-Arylsulfonamides of 17β-aminoestra-1,3,5(10)-trien-3-ol as highly potent inhibitors of steroid sulfatase

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Oxidised Products of Cholesterol: Their Role in Apoptosis

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Digitoxin, at concentrations commonly found in the plasma of cardiac patients, antagonizes etoposide and idarubicin activity in K562 leukemia cells

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A new cytotoxic cholesterol sulfate from marine spongeHalichondria rugosa

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New ester derivatives of dehydroepiandrosterone as 5α-reductase inhibitors

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Bile acids in serum and bile of patients with cholesterol gallstone

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Solid Phase Synthesis of 17α-E/Z-(X-Phenyl)-Vinyl Estradiols Using the Stille Coupling Reaction

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Aromatic esters of progesterone as 5α-reductase and prostate growth inhibitors

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Calcitriol derivatives with two different side-chains at C-20. Part 4: Further chain modifications that alter VDR-dependent monocytic differentiation potency in human leukemia cells

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Targeting the estrogen receptor with metal-carbonyl derivatives of estradiol

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3-Carboxy-20-keto steroids are dual uncompetitive inhibitors of human steroid 5α-reductase types 1 and 2

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A new cytotoxic bufadienolide from Chinese medicine Chansu

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Biochemical and computational insights into the anti-aromatase activity of natural catechol estrogens

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Use of functional assays to detect and quantify functional selectivity

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Synthesis and evaluation of 17α-E-20-(heteroaryl)norpregn-1,3,5(10),20 tetraene-3,17β-diols [17α-(heteroaryl)vinyl estradiols] as ligands for the estrogen receptor-α ligand binding domain (ERα-LBD)

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Synthesis and biological activity of progesterone derivatives as 5α-reductase inhibitors, and their effect on hamster prostate weight

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Determination of rat 5α-reductase type 1 isozyme activity and its inhibition by novel steroidal oxazolines

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Diosgenin: Recent Highlights on Pharmacology and Analytical Methodology

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Synthesis, characterization and biological evaluation of bile acid-aromatic/heteroaromatic amides linked via amino acids as anti-cancer agents

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Production of 14α-hydroxysteroids by a recombinant Saccharomyces cerevisiae biocatalyst expressing of a fungal steroid 14α-hydroxylation system

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