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Hyaluronic acid modified mesoporous silica nanoparticles for targeted drug delivery to CD44-overexpressing cancer cells

Yu, Meihua, Jambhrunkar, Siddharth, Thorn, Peter, Chen, Jiezhong, Gu, Wenyi, Yu, Chengzhong·2013·Nanoscale
DOI 10.1039/c2nr32145a
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Abstract

In this paper, a targeted drug delivery system has been developed based on hyaluronic acid (HA) modified mesoporous silica nanoparticles (MSNs). HA-MSNs possess a specific affinity to CD44 over-expressed on the surface of a specific cancer cell line, HCT-116 (human colon cancer cells). The cellular uptake performance of fluorescently labelled MSNs with and without HA modification has been evaluated by confocal microscopy and fluorescence-activated cell sorter (FACS) analysis. Compared to bare MSNs, HA-MSNs exhibit a higher cellular uptake via HA receptor mediated endocytosis. An anticancer drug, doxorubicin hydrochloride (Dox), has been loaded into MSNs and HA-MSNs as drug delivery vehicles. Dox loaded HA-MSNs show greater cytotoxicity to HCT-116 cells than free Dox and Dox-MSNs due to the enhanced cell internalization behavior of HA-MSNs. It is expected that HA-MSNs have a great potential in targeted delivery of anticancer drugs to CD44 over-expressing tumors.

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Metadata

Authors
Yu, M., Jambhrunkar, S., Thorn, P., Chen, J., Gu, W., & Yu, C.
Venue
Nanoscale
Publisher
Royal Society of Chemistry (RSC)
Published
2013
Volume
5
Issue
1
Pages
178-183
ISSN
  • 2040-3364
  • 2040-3372
DOI
10.1039/c2nr32145a
Cited by
316
References
1
Language
en

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CoChat. (2026). Citation check: Hyaluronic acid modified mesoporous silica nanoparticles for targeted drug delivery to CD44-overexpressing cancer cells. https://app.cochat.ai/papers/10.1039/c2nr32145a
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Yu, M., Jambhrunkar, S., Thorn, P., Chen, J., Gu, W., & Yu, C. (2013). Hyaluronic acid modified mesoporous silica nanoparticles for targeted drug delivery to CD44-overexpressing cancer cells. Nanoscale. https://doi.org/10.1039/c2nr32145a