Cited by 597Proteoglycans and glycosaminoglycans researchNanoparticle-Based Drug DeliveryHydrogels: synthesis, properties, applications

Hyaluronic acid targeting of CD44 for cancer therapy: from receptor biology to nanomedicine

Mattheolabakis, George, Milane, Lara, Singh, Amit, Amiji, Mansoor M.·2015·Journal of Drug Targeting

Abstract

Cluster of differentiation-44 (CD44) is a ubiquitously present glycoprotein on the surface of mammalian cells that plays a significant role in a number of biological functions. Since the discovery that the receptor is over-expressed in a variety of solid tumors, such as pancreatic, breast and lung cancer, many studies have focused on methods for targeting CD44 in an attempt to improve drug delivery and discrimination between healthy and malignant tissue, while reducing residual toxicity and off-target accumulation. In this review, we describe CD44 receptor biology and its involvement in the different stages of tumor growth and metastasis, as well as methods currently used for targeting the receptor. Hyaluronic acid, the primary CD44 binding molecule, has proved a significant ally in developing nanocarriers that demonstrate preferential tumor accumulation and increased cell uptake. We outline a number of research approaches from the current literature that take advantage of hyaluronic acid's targeting ability and describe the possible advantages for each approach. The value of CD44 targeting can be easily appreciated from the number of different approaches that have reached clinical trials.

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Crossref · 10.3109/1061186x.2015.1052072

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Authors
Mattheolabakis, G., Milane, L., Singh, A., & Amiji, M. M.
Affiliations
Northeastern University (US)
Corresponding author
Amiji, Mansoor M.
Venue
Journal of Drug Targeting
Published
2015-09-14
Volume
23
Issue
7-8
Pages
605-618
ISSN
  • 1026-7158 (ISSN-L)
  • 1061-186X
  • 1029-2330
OpenAlex
W1909499926
Cited by
597
References
121
Citations by year
2026: 51 · 2025: 67 · 2024: 64 · 2023: 71 · 2022: 89 · 2021: 73 · 2020: 52 · 2019: 48 · 2018: 46 · 2017: 25 · 2016: 11
FWCI
2.74
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of drug targeting (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5u01ca151452-05)
  • National Cancer Institute (U01- CA151452, R21CA179652)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
Keywords
CD44, hyaluronic acid, receptor targeting, tumor targeting, nanocarriers, drug delivery, metastasis, tumor growth, cancer therapy, clinical trials
MeSH terms
Animals, Antineoplastic Agents, Humans, Hyaluronic Acid, Neoplasms, Gene Expression Regulation, Neoplastic, Drug Delivery Systems, Hyaluronan Receptors, Nanoparticles

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