The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Hyaluronic acid-based hydrogels: from a natural polysaccharide to complex networks
Open accessAbstract
Hyaluronic acid (HA) is one of nature's most versatile and fascinating macromolecules. Being an essential component of the natural extracellular matrix (ECM), HA plays an important role in a variety of biological processes. Inherently biocompatible, biodegradable and non-immunogenic, HA is an attractive starting material for the construction of hydrogels with desired morphology, stiffness and bioactivity. While the interconnected network extends to the macroscopic level in HA bulk gels, HA hydrogel particles (HGPs, microgels or nanogels) confine the network to microscopic dimensions. Taking advantage of various scaffold fabrication techniques, HA hydrogels with complex architecture, unique anisotropy, tunable viscoelasticity and desired biologic outcomes have been synthesized and characterized. Physical entrapment and covalent integration of hydrogel particles in a secondary HA network give rise to hybrid networks that are hierarchically structured and mechanically robust, capable of mediating cellular activities through the spatial and temporal presentation of biological cues. This review highlights recent efforts in converting a naturally occurring polysaccharide to drug releasing hydrogel particles, and finally, complex and instructive macroscopic networks. HA-based hydrogels are promising materials for tissue repair and regeneration.
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Self-citationProgress in tissue engineering
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Designing degradable hydrogels for orthogonal control of cell microenvironments
Kharkar, P. M., Kiick, K. L., & Kloxin, A. M. (2013) · Chem. Soc. Rev. · doi:10.1039/c3cs60040h · Cited by 717
Photopolymerizable Biomaterials and Light-Based 3D Printing Strategies for Biomedical Applications
Yu, C., Schimelman, J., Wang, P., Miller, K. L., Ma, X., You, S., Guan, J., Sun, B., Zhu, W., & Chen, S. (2020) · Chemical Reviews · doi:10.1021/acs.chemrev.9b00810 · Cited by 579
Hydrogel scaffolds for tissue engineering: the importance of polymer choice
Spicer, C. D. (2020) · Polymer Chemistry · doi:10.1039/c9py01021a · Cited by 527
Lou, J., Stowers, R., Nam, S., Xia, Y., & Chaudhuri, O. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2017.11.004 · Cited by 523
Metadata
- Authors
- Xu, X., Jha, A. K., Harrington, D. A., Farach-Carson, M. C., & Jia, X.
- Venue
- Soft Matter
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2012
- Volume
- 8
- Issue
- 12
- Pages
- 3280
- ISSN
- 1744-683X (ISSN-L)
- 1744-6848
- OpenAlex
- W2057948801
- Cited by
- 601
- References
- 5
- FWCI
- 11.24
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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