Highly luminescent, fluorinated semiconducting polymer dots for cellular imaging and analysis
Open accessAbstract
A highly fluorescent fluorinated semiconducting polymer dot (Pdot) with a quantum yield of up to 49% was developed. The fluorinated Pdot was eight times brighter in cell-labeling applications than its non-fluorinated counterpart, and was rod shaped rather than spherical.
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Fluorination minimizes structural distortions between the excited and ground states, which enhances the fluorescence quantum yield of Pdots.
“Thus, structural distortions between the excited and ground states are minimized by this substitution, which enhance the Φfl of Pdots.170,175,176”
From The Pursuit of Shortwave Infrared-Emitting Nanoparticles with Bright Fluorescence through Molecular Design and Excited-State Engineering of Molecular Aggregates (2022) · cites this paper as [175]
The passage beginning “We decided to investigate” (indexed under Abstract; page unavailable) reports that fluorination increased Pdot quantum yield relative to the non-fluorinated analog. The passage beginning “To determine whether” proposes a rigid, extended polymer chain that minimizes aggregation-induced quenching, but does not say fluorination minimizes structural distortions between excited and ground states. That specific mechanism is unsupported. (LLM, conf=0.87)
Experimental — accuracy not yet measuredFluorination introduces higher degrees of main-chain planarity, rigidity order, and packing tightness in conjugated polymers.
“In general, fluorination introduces higher degrees of main-chain planarity, rigidity order, and packing tightness.”
From The Pursuit of Shortwave Infrared-Emitting Nanoparticles with Bright Fluorescence through Molecular Design and Excited-State Engineering of Molecular Aggregates (2022) · cites this paper as [175]
In the passage on Pdot shapes (labelled Abstract in our copy; no page given), the paper reports that fluorinated polymers can pack more strongly and proposes that fluorine interactions may produce a more rigid, extended backbone in its particular Pdots. It does not establish greater main-chain planarity or order, and the claim states these effects as a general consequence of fluorination rather than a proposed explanation for this system. (LLM, conf=0.84)
Experimental — accuracy not yet measured
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Cites
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Fluorination Enhances NIR‐II Fluorescence of Polymer Dots for Quantitative Brain Tumor Imaging
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“170,175,176 In addition, the fluorination of CPs affects their energy levels and intra-and intermolecular interactions.”
- Authors
- Zhang, Y., Yu, J., Gallina, M. E., Sun, W., Rong, Y., & Chiu, D. T.
- Affiliations
- University of Washington (US)
- Corresponding author
- Chiu, Daniel T.
- Venue
- Chemical Communications
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2013
- Volume
- 49
- Issue
- 74
- Pages
- 8256
- ISSN
- 1359-7345 (ISSN-L)
- 1364-548X
- PMC
- PMC5599121
- OpenAlex
- W2014555070
- Cited by
- 48
- References
- 24
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 3 · 2023: 4 · 2022: 1 · 2021: 2 · 2020: 8 · 2019: 3 · 2018: 2 · 2017: 6 · 2016: 5 · 2015: 5 · 2014: 6 · 2012: 1
- FWCI
- 2.41
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Chemical Communications (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of General Medical Sciences (R01GM085485, GM085485)
- Topics
- Physical Sciences › Materials Science › Materials Chemistry › Quantum Dots Synthesis And Properties
- Physical Sciences › Materials Science › Materials Chemistry › Luminescence and Fluorescent Materials
- Physical Sciences › Engineering › Electrical and Electronic Engineering › Organic Electronics and Photovoltaics
- Keywords
- polymer dots, quantum yield, cell imaging, cell labeling, fluorescent nanomaterials, rod-shaped nanoparticles, luminescence
- MeSH terms
- Flow Cytometry, Humans, Hydrocarbons, Fluorinated, Polymers, Semiconductors, Molecular Structure, Microscopy, Confocal, Quantum Dots, Luminescence, Molecular Imaging, MCF-7 Cells
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