Cited by 173Luminescence and Fluorescent MaterialsQuantum Dots Synthesis And PropertiesNanoplatforms for cancer theranostics

Fluorination Enhances NIR‐II Fluorescence of Polymer Dots for Quantitative Brain Tumor Imaging

Liu, Ye, Liu, Jinfeng, Chen, Dandan, Wang, Xiaosha, Zhang, Zhe, Yang, Yicheng, Jiang, Lihui, Qi, Weizhi +6 more·2020·Angewandte Chemie International Edition

Abstract

Here, we describe a fluorination strategy for semiconducting polymers for the development of highly bright second near‐infrared region (NIR‐II) probes. Tetrafluorination yielded a fluorescence QY of 3.2 % for the polymer dots (Pdots), over a 3‐fold enhancement compared to non‐fluorinated counterparts. The fluorescence enhancement was attributable to a nanoscale fluorous effect in the Pdots that maintained the molecular planarity and minimized the structure distortion between the excited state and ground state, thus reducing the nonradiative relaxations. By performing through‐skull and through‐scalp imaging of the brain vasculature of live mice, we quantitatively analyzed the vascular morphology of transgenic brain tumors in terms of the vessel lengths, vessel branches, and vessel symmetry, which showed statistically significant differences from the wild type animals. The bright NIR‐II Pdots obtained through fluorination chemistry provide insightful information for precise diagnosis of the malignancy of the brain tumor.

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Crossref · 10.1002/anie.202007886

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Authors
Liu, Y., Liu, J., Chen, D., Wang, X., Zhang, Z., Yang, Y., Jiang, L., Qi, W., Ye, Z., He, S., Liu, Q., Xi, L., Zou, Y., & Wu, C.
Affiliations
  • Central South University (CN)
  • Southern University of Science and Technology (CN)
Corresponding author
  • Zou, Yingping
  • Wu, Changfeng
Venue
Angewandte Chemie International Edition
Publisher
Wiley
Published
2020-09-08
Volume
59
Issue
47
Pages
21049-21057
ISSN
  • 1433-7851 (ISSN-L)
  • 1521-3773
OpenAlex
W3047818792
Cited by
173
References
62
Citations by year
2026: 12 · 2025: 24 · 2024: 29 · 2023: 39 · 2022: 36 · 2021: 29 · 2020: 4
FWCI
10.50
Type
journal article
Language
en
Open access
closed
Locations
  • Angewandte Chemie International Edition (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Science, Technology and Innovation Commission of Shenzhen Municipality (KQTD20170810111314625)
  • National Natural Science Foundation of China (81771930, 51673215)
  • National Basic Research Program of China (2018YFB0407200)
Topics
  • Physical Sciences › Materials Science › Materials Chemistry › Luminescence and Fluorescent Materials
  • Physical Sciences › Materials Science › Materials Chemistry › Quantum Dots Synthesis And Properties
  • Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
Keywords
fluorination, polymer dots, NIR-II fluorescence, semiconducting polymers, fluorescence quantum yield enhancement, brain tumor imaging, cerebral vasculature, transgenic mouse model
MeSH terms
Animals, Brain Neoplasms, Fluorescence, Fluorescent Dyes, Mice, Inbred C57BL, Particle Size, Polymers, Semiconductors, Surface Properties, Molecular Structure, Quantum Dots, Mice, Halogenation, Optical Imaging

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