The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Microfluidic heart on a chip for higher throughput pharmacological studies
Open accessAbstract
We present the design of a higher throughput "heart on a chip" which utilizes a semi-automated fabrication technique to process sub millimeter sized thin film cantilevers of soft elastomers. Anisotropic cardiac microtissues which recapitulate the laminar architecture of the heart ventricle are engineered on these cantilevers. Deflection of these cantilevers, termed Muscular Thin Films (MTFs), during muscle contraction allows calculation of diastolic and systolic stresses generated by the engineered tissues. We also present the design of a reusable one channel fluidic microdevice completely built out of autoclavable materials which incorporates various features required for an optical cardiac contractility assay: metallic base which fits on a heating element for temperature control, transparent top for recording cantilever deformation and embedded electrodes for electrical field stimulation of the tissue. We employ the microdevice to test the positive inotropic effect of isoproterenol on cardiac contractility at dosages ranging from 1 nM to 100 μM. The higher throughput fluidic heart on a chip has applications in testing of cardiac tissues built from rare or expensive cell sources and for integration with other organ mimics. These advances will help alleviate translational barriers for commercial adoption of these technologies by improving the throughput and reproducibility of readout, standardization of the platform and scalability of manufacture.
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Cites
From 3D cell culture to organs-on-chips
Huh, D., Hamilton, G. A., & Ingber, D. E. (2011) · Trends in Cell Biology · doi:10.1016/j.tcb.2011.09.005 · Cited by 1,834
Ma, J., Guo, L., Fiene, S. J., Anson, B. D., Thomson, J. A., Kamp, T. J., Kolaja, K. L., Swanson, B. J., & January, C. T. (2011) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00694.2011 · Cited by 770
Muscular Thin Films for Building Actuators and Powering Devices
Feinberg, A. W., Feigel, A., Shevkoplyas, S. S., Sheehy, S., Whitesides, G. M., & Parker, K. K. (2007) · Science · doi:10.1126/science.1146885 · Cited by 765
Self-citationMicroengineered physiological biomimicry: Organs-on-Chips
Huh, D., Torisawa, Y.-S., Hamilton, G. A., Kim, H. J., & Ingber, D. E. (2012) · Lab on a Chip · doi:10.1039/c2lc40089h · Cited by 667
Ensembles of engineered cardiac tissues for physiological and pharmacological study: Heart on a chip
Grosberg, A., Alford, P. W., McCain, M. L., & Parker, K. K. (2011) · Lab on a Chip · doi:10.1039/c1lc20557a · Cited by 544
Self-citationThe impact of drug-induced QT interval prolongation on drug discovery and development
Fermini, B., & Fossa, A. A. (2003) · Nature Reviews Drug Discovery · doi:10.1038/nrd1108 · Cited by 492
A practical guide to microfluidic perfusion culture of adherent mammalian cells
Kim, L., Toh, Y.-C., Voldman, J., & Yu, H. (2007) · Lab on a Chip · doi:10.1039/b704602b · Cited by 455
Boudou, T., Legant, W. R., Mu, A., Borochin, M. A., Thavandiran, N., Radisic, M., Zandstra, P. W., Epstein, J. A., Margulies, K. B., & Chen, C. S. (2012) · Tissue Engineering Part A · doi:10.1089/ten.tea.2011.0341 · Cited by 413
Biomimetic tissues on a chip for drug discovery
Ghaemmaghami, A. M., Hancock, M. J., Harrington, H., Kaji, H., & Khademhosseini, A. (2012) · Drug Discovery Today · doi:10.1016/j.drudis.2011.10.029 · Cited by 359
The Role of Body-on-a-Chip Devices in Drug and Toxicity Studies
Esch, M. B., King, T. L., & Shuler, M. L. (2011) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-071910-124629 · Cited by 328
Cited by
Bhatia, S. N., & Ingber, D. E. (2014) · Nature Biotechnology · doi:10.1038/nbt.2989 · Cited by 3,305
Organs-on-chips at the frontiers of drug discovery
Esch, E. W., Bahinski, A., & Huh, D. (2015) · Nature Reviews Drug Discovery · doi:10.1038/nrd4539 · Cited by 1,185
Organs-on-chips: into the next decade
Low, L. A., Mummery, C., Berridge, B. R., Austin, C. P., & Tagle, D. A. (2021) · Nature Reviews Drug Discovery · doi:10.1038/s41573-020-0079-3 · Cited by 1,029
Wang, G., McCain, M. L., Yang, L., He, A., Pasqualini, F. S., Agarwal, A., Yuan, H., Jiang, D., Zhang, D., Zangi, L., et al. (2014) · Nature Medicine · doi:10.1038/nm.3545 · Cited by 837
Self-citationPhototactic guidance of a tissue-engineered soft-robotic ray
Park, S.-J., Gazzola, M., Park, K. S., Park, S., Di Santo, V., Blevins, E. L., Lind, J. U., Campbell, P. H., Dauth, S., Capulli, A. K., et al. (2016) · Science · doi:10.1126/science.aaf4292 · Cited by 721
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Metadata
- Authors
- Agarwal, A., Goss, J. A., Cho, A., McCain, M. L., & Parker, K. K.
- Venue
- Lab on a Chip
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2013
- Volume
- 13
- Issue
- 18
- Pages
- 3599
- ISSN
- 1473-0189 (ISSN-L)
- 1473-0197
- OpenAlex
- W2163307683
- Cited by
- 494
- References
- 31
- FWCI
- 20.19
- Type
- journal article
- Language
- en
- Open access
- green
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