Electrospun composite nanofiber-based transmucosal patch for anti-diabetic drug delivery
Abstract
The intention of the present investigation was to develop an oral formulation for an anti-diabetic drug that not only could deliver it in the active form but also provide a sustained and controlled release profile. A biodegradable poly(vinyl alcohol) (PVA) and sodium alginate (NaAlg) electrospun composite nanofiber based transmucosal patch was developed and the anti-diabetic drug insulin was loaded in it by active loading. The drug entrapment in the composite nanofibers during the processing was confirmed by scanning electron microscopy, atomic force microscopy, X-ray diffraction and Fourier transform infrared spectroscopy. The in vivo studies were carried on male Wistar rats by the sublingual route. The mucoadhesive strength results confirmed that the drug loaded PVA-NaAlg nanofiber patch had the highest strength among the PVA, PVA-NaAlg and drug loaded PVA-NaAlg samples, due to its higher water holding capacity. The in vitro activity provided a sustained and controlled release pattern of the drug from the nanofiber patch. In vivo activity validated the fact that insulin was delivered in its active state and showed appreciable results when compared to the commercial formulation. The insulin release follows first order kinetics followed by an initial burst release necessary to produce the desired therapeutic activity. Furthermore an encapsulation efficacy of 99% of the experimental formulation provides sufficient indication that the composite nanofibers serve as an ideal carrier for the delivery of insulin via the sublingual route. Thus the present investigation gives impetus to work in the direction of delivering anti-diabetic drugs (proteins and peptides) via the oral route using electrospun composite nanofiber transmucosal patches.
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Drug-loaded nanofibers significantly lower blood glucose level in diabetic male Wistar rats and show better efficiency in controlling diabetes than commercial formulation.
“The in vivo study confirmed the effectiveness of the drug-loaded nanofibers, as a significant lowering of the blood glucose level was observed in diabetic male Wistar rats. Furthermore, the patch showed better efficiency in controlling diabetes than did the commercial formulation.”
From Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles (2019) · cites this paper as [85]
Insulin-loaded PVA-alginate composite nanofiber patch shows sustained and controlled release of insulin in vitro, with ~100% drug release within 12 h following first-order kinetics with initial burst.
“The in vitro drug release study confirmed a sustained and controlled release pattern of the insulin from the nanofiber (Fig. 2a) and ~100% drug release from the patch occurred within 12 h. The release pattern follows first-order kinetics with an initial burst release of the drug.”
From Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles (2019) · cites this paper as [85]
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Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles
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- Authors
- Sharma, A., Gupta, A., Rath, G., Goyal, A., Mathur, R. B., & Dhakate, S. R.
- Affiliations
- Indo Soviet Friendship College of Pharmacy (IN)
- Council of Scientific and Industrial Research (IN)
- Corresponding author
- Dhakate, S. R.
- Venue
- Journal of Materials Chemistry B
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2013
- Volume
- 1
- Issue
- 27
- Pages
- 3410
- ISSN
- 2050-750X (ISSN-L)
- 2050-7518
- OpenAlex
- W1967686679
- Cited by
- 108
- References
- 40
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 8 · 2023: 8 · 2022: 14 · 2021: 13 · 2020: 11 · 2019: 9 · 2018: 4 · 2017: 8 · 2016: 7 · 2015: 4 · 2014: 8 · 2013: 1
- FWCI
- 2.54
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Materials Chemistry B (publishedVersion)
- PubMed (publishedVersion)
- IR@NPL (CSIR-The National Physical Laboratory(NPL)) (acceptedVersion)
- Funders
- Department of Science and Technology, Ministry of Science and Technology, India
- Israel Science Foundation
- Topics
- Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
- Keywords
- electrospun nanofibers, sublingual drug delivery, insulin delivery, polyvinyl alcohol, sodium alginate, composite nanofibers, mucoadhesion, sustained drug release, encapsulation efficiency, oral protein delivery, antidiabetic drugs
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