Zinc ions modulate protein tyrosine phosphatase 1B activity
Open accessAbstract
A novel mechanism by which Zn 2+modulates PTP1B activity encompasses the binding to the closed and phospho-intermediate forms only.
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Zinc's regulatory actions on protein tyrosine phosphatase activity in IGF-1 signaling pathways suggest its potential role in mitigating insulin resistance.
“Zinc’s regulatory actions on protein tyrosine phosphatase activity in insulin-like growth factor-1 (IGF-1) signaling pathways suggest its potential role in mitigating insulin resistance [152].”
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- Authors
- Bellomo, E., Massarotti, A., Hogstrand, C., & Maret, W.
- Affiliations
- King's College London (GB)
- Università degli Studi del Piemonte Orientale “Amedeo Avogadro” (IT)
- King's College London
- Corresponding author
- Bellomo, Elisa
- Venue
- Metallomics
- Publisher
- Oxford University Press (OUP)
- Published
- 2014
- Volume
- 6
- Issue
- 7
- Pages
- 1229-1239
- ISSN
- 1756-5901 (ISSN-L)
- 1756-591X
- OpenAlex
- W2029553840
- Cited by
- 108
- References
- 60
- Citations by year
- 2026: 8 · 2025: 3 · 2024: 6 · 2023: 11 · 2022: 6 · 2021: 13 · 2020: 5 · 2019: 9 · 2018: 8 · 2017: 10 · 2016: 16 · 2015: 8 · 2014: 4 · 2013: 1
- FWCI
- 5.19
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- Metallomics (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Research Portal (King's College London) (submittedVersion, cc-by)
- Funders
- Biotechnology and Biological Sciences Research Council (BB/K001442/1)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Keywords
- zinc ions, PTP1B, enzyme inhibition, zinc binding site, enzyme kinetics, insulin signaling, leptin signaling
- MeSH terms
- Binding Sites, Edetic Acid, Enzyme Inhibitors, Humans, Receptor, Insulin, Zinc, Receptors, Leptin, Protein Tyrosine Phosphatase, Non-Receptor Type 1, Molecular Docking Simulation
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