Cited by 108Protein Tyrosine PhosphatasesProtease and Inhibitor MechanismsProtein Kinase Regulation and GTPase Signaling

Zinc ions modulate protein tyrosine phosphatase 1B activity

Open access
Bellomo, Elisa, Massarotti, Alberto, Hogstrand, Christer, Maret, Wolfgang·2014·Metallomics

Abstract

A novel mechanism by which Zn 2+modulates PTP1B activity encompasses the binding to the closed and phospho-intermediate forms only.

Integrity signals

Registry

Crossref · 10.1039/c4mt00086b

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60 of 60 references verified0 citation errors · 0 not checkable

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Authors
Bellomo, E., Massarotti, A., Hogstrand, C., & Maret, W.
Affiliations
  • King's College London (GB)
  • Università degli Studi del Piemonte Orientale “Amedeo Avogadro” (IT)
  • King's College London
Corresponding author
Bellomo, Elisa
Venue
Metallomics
Published
2014
Volume
6
Issue
7
Pages
1229-1239
ISSN
  • 1756-5901 (ISSN-L)
  • 1756-591X
OpenAlex
W2029553840
Cited by
108
References
60
Citations by year
2026: 8 · 2025: 3 · 2024: 6 · 2023: 11 · 2022: 6 · 2021: 13 · 2020: 5 · 2019: 9 · 2018: 8 · 2017: 10 · 2016: 16 · 2015: 8 · 2014: 4 · 2013: 1
FWCI
5.19
Type
journal article
Language
en
Open access
Licence
cc-by-nc
Locations
  • Metallomics (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • Research Portal (King's College London) (submittedVersion, cc-by)
Funders
Biotechnology and Biological Sciences Research Council (BB/K001442/1)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Keywords
zinc ions, PTP1B, enzyme inhibition, zinc binding site, enzyme kinetics, insulin signaling, leptin signaling
MeSH terms
Binding Sites, Edetic Acid, Enzyme Inhibitors, Humans, Receptor, Insulin, Zinc, Receptors, Leptin, Protein Tyrosine Phosphatase, Non-Receptor Type 1, Molecular Docking Simulation

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